General Information of the Compound
Compound ID
CP0952246
Compound Name
(4S)-8-(3-(2,3-Dichlorophenyl)-1H-pyrazolo[3,4-b]-pyrazin-6-yl-2-oxa-8-azaspiro[4.5]-decan-4-amine
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Structure
Formula
C19H20Cl2N6O
Molecular Weight
419.316
Canonical SMILES
N[C@@H]1COCC12CCN(c1cnc3c(-c4cccc(Cl)c4Cl)n[nH]c3n1)CC2
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InChI
InChI=1S/C19H20Cl2N6O/c20-12-3-1-2-11(15(12)21)16-17-18(26-25-16)24-14(8-23-17)27-6-4-19(5-7-27)10-28-9-13(19)22/h1-3,8,13H,4-7,9-10,22H2,(H,24,25,26)/t13-/m1/s1
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InChIKey
SIKKESBUGBWVRF-CYBMUJFWSA-N
Physicochemical Property
logP
3.2708
Rotatable Bonds
2
Heavy Atom Count
28
Polar Areas
92.95
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
6
Complexity
28

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 132166974
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01346, Tyrosine-protein phosphatase non-receptor type 11
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000269 KYSE-520 Homo sapiens (Human)  1
1
IC50 = 40 nM
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