General Information of the Compound
Compound ID
CP0344064
Compound Name
6-amino-2-[(3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl]-5-(3-chloro-2-methylpyridin-4-yl)sulfanyl-3-methylpyrimidin-4-one
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Structure
Formula
C20H27ClN6O2S
Molecular Weight
450.996
Canonical SMILES
C[C@@H]1OCC2(CCN(CC2)c2nc(N)c(Sc3ccnc(C)c3Cl)c(=O)n2C)[C@@H]1N
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InChI
InChI=1S/C20H27ClN6O2S/c1-11-14(21)13(4-7-24-11)30-15-17(23)25-19(26(3)18(15)28)27-8-5-20(6-9-27)10-29-12(2)16(20)22/h4,7,12,16H,5-6,8-10,22-23H2,1-3H3/t12-,16+/m0/s1
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InChIKey
PMWMMYBAECEPMB-BLLLJJGKSA-N
Physicochemical Property
logP
2.20312
Rotatable Bonds
3
Heavy Atom Count
30
Polar Areas
112.29
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
9
Complexity
30

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 124150550
ChEMBL ID
CHEMBL4442335
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01346, Tyrosine-protein phosphatase non-receptor type 11
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000269 KYSE-520 Homo sapiens (Human)  1
1
IC50 = 28 nM
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