General Information of the Compound
Compound ID
CP0567854
Compound Name
[6-[(3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl]-3-[3-chloro-2-(propylamino)pyridin-4-yl]-2H-pyrazolo[3,4-b]pyrazin-5-yl]methanol
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Structure
Formula
C23H31ClN8O2
Molecular Weight
487.008
Canonical SMILES
CCCNc1nccc(-c2n[nH]c3nc(N4CCC5(CO[C@@H](C)[C@H]5N)CC4)c(CO)nc23)c1Cl
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InChI
InChI=1S/C23H31ClN8O2/c1-3-7-26-20-16(24)14(4-8-27-20)17-18-21(31-30-17)29-22(15(11-33)28-18)32-9-5-23(6-10-32)12-34-13(2)19(23)25/h4,8,13,19,33H,3,5-7,9-12,25H2,1-2H3,(H,26,27)(H,29,30,31)/t13-,19+/m0/s1
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InChIKey
QGJXABHATSMIPN-ORAYPTAESA-N
Physicochemical Property
logP
2.7151
Rotatable Bonds
6
Heavy Atom Count
34
Polar Areas
138.1
Hydrogen Bond Donor Count
4
Hydrogen Bond Acceptor Count
9
Complexity
34

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 168274970
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01346, Tyrosine-protein phosphatase non-receptor type 11
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000269 KYSE-520 Homo sapiens (Human)  1
1
IC50 = 2 nM
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