General Information of the Compound
Compound ID
CP0967552
Compound Name
(6-((3S,4S)-4-Amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl)-3-(2,3-dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazin-5-yl)methanol
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Structure
Formula
C21H24Cl2N6O2
Molecular Weight
463.369
Canonical SMILES
C[C@@H]1OCC2(CCN(c3nc4[nH]nc(-c5cccc(Cl)c5Cl)c4nc3CO)CC2)[C@@H]1N
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InChI
InChI=1S/C21H24Cl2N6O2/c1-11-18(24)21(10-31-11)5-7-29(8-6-21)20-14(9-30)25-17-16(27-28-19(17)26-20)12-3-2-4-13(22)15(12)23/h2-4,11,18,30H,5-10,24H2,1H3,(H,26,27,28)/t11-,18+/m0/s1
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InChIKey
WRHXPUBAPLIIDL-BBATYDOGSA-N
Physicochemical Property
logP
3.1516
Rotatable Bonds
3
Heavy Atom Count
31
Polar Areas
113.18
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
7
Complexity
31

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 152310635
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01346, Tyrosine-protein phosphatase non-receptor type 11
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000269 KYSE-520 Homo sapiens (Human)  1
1
IC50 = 0.4 nM
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