General Information of the Compound
Compound ID
CP0577262
Compound Name
US11104675, Example 9
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Structure
Formula
C20H23Cl3N4O2
Molecular Weight
457.789
Canonical SMILES
C[C@@H]1OCC2(CCN(CC2)c2nc(C)n(-c3cccc(Cl)c3Cl)c(=O)c2Cl)[C@@H]1N
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InChI
InChI=1S/C20H23Cl3N4O2/c1-11-17(24)20(10-29-11)6-8-26(9-7-20)18-16(23)19(28)27(12(2)25-18)14-5-3-4-13(21)15(14)22/h3-5,11,17H,6-10,24H2,1-2H3/t11-,17+/m0/s1
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InChIKey
IHKHKMXWPFOHFR-APPDUMDISA-N
Physicochemical Property
logP
3.83372
Rotatable Bonds
2
Heavy Atom Count
29
Polar Areas
73.38
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
6
Complexity
29

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 146364426
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01346, Tyrosine-protein phosphatase non-receptor type 11
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000269 KYSE-520 Homo sapiens (Human)  1
1
IC50 = 48 nM
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