General Information of the Compound
Compound ID
CP0573031
Compound Name
(4R)-8-[6-amino-5-(2-amino-3-chloropyridin-4-yl)sulfanylpyrazin-2-yl]-8-azaspiro[4.5]decan-4-amine
    Show/Hide
Structure
Formula
C18H24ClN7S
Molecular Weight
405.959
Canonical SMILES
N[C@@H]1CCCC11CCN(CC1)c1cnc(Sc2ccnc(N)c2Cl)c(N)n1
    Show/Hide
InChI
InChI=1S/C18H24ClN7S/c19-14-11(3-7-23-15(14)21)27-17-16(22)25-13(10-24-17)26-8-5-18(6-9-26)4-1-2-12(18)20/h3,7,10,12H,1-2,4-6,8-9,20H2,(H2,21,23)(H2,22,25)/t12-/m1/s1
    Show/Hide
InChIKey
YXXCYOPEUVHPLV-GFCCVEGCSA-N
Physicochemical Property
logP
2.9384
Rotatable Bonds
3
Heavy Atom Count
27
Polar Areas
119.97
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
8
Complexity
27

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 118238414
ChEMBL ID
CHEMBL4747789
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01346, Tyrosine-protein phosphatase non-receptor type 11
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000269 KYSE-520 Homo sapiens (Human)  1
1
IC50 = 24 nM
   TI
   LI
   LO
   TS
Cell Viability or Cytotoxicity Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000269 KYSE-520 Homo sapiens (Human)  1
1
IC50 = 123 nM
   TI
   LI
   LO
   TS