(5S)-5-[[3-(2-morpholin-4-ylpyridin-4-yl)-1H-indazol-5-yl]amino]-5,6,7,8-tetrahydronaphthalene-2-carbonitrile

(5S)-5-[[3-(2,6-dimethylpyridin-4-yl)-1H-indazol-5-yl]amino]-5,6,7,8-tetrahydronaphthalene-2-carbonitrile

(5S)-5-[[3-(2-methylpyridin-4-yl)-1H-indazol-5-yl]amino]-5,6,7,8-tetrahydronaphthalene-2-carbonitrile

cis-2,6-Dimethyl-4-(6-(5-(1-methylcyclopropoxy)-1H-indazol-3-yl)pyrimidin-4-yl)morpholine

(5R)-5-[[3-(2-methylpyridin-4-yl)-1H-indazol-5-yl]amino]-5,6,7,8-tetrahydronaphthalene-2-carbonitrile

4-[[3-(2-methylpyridin-4-yl)-1H-indazol-5-yl]amino]benzene-1,3-dicarbonitrile

4-[[(1R)-1-cyclopropylethyl]amino]-7-pyridin-4-ylcinnoline-3-carboxamide

4-[[(1R)-1-cyclopropylethyl]amino]-7-(4-methylsulfonylphenyl)cinnoline-3-carboxamide

(5R)-5-[[3-(2,6-dimethylpyridin-4-yl)-1H-indazol-5-yl]amino]-5,6,7,8-tetrahydronaphthalene-2-carbonitrile

(5S)-5-[(3-pyridin-4-yl-1H-indazol-5-yl)amino]-5,6,7,8-tetrahydronaphthalene-2-carbonitrile

4-[[(2R)-butan-2-yl]amino]-7-(4-methylsulfonylphenyl)cinnoline-3-carboxamide

(4R)-4-[[3-(2,6-dimethylpyridin-4-yl)-1H-indazol-5-yl]amino]-3,4-dihydro-2H-chromene-7-carbonitrile

4-(propan-2-ylamino)-6-(1H-pyrazol-4-yl)cinnoline-3-carboxamide

(5R)-5-[[3-(2-morpholin-4-ylpyridin-4-yl)-1H-indazol-5-yl]amino]-5,6,7,8-tetrahydronaphthalene-2-carbonitrile

7-(1-methylpyrazol-4-yl)-4-(propan-2-ylamino)quinoline-3-carbonitrile

2-[[3-(2-methylpyridin-4-yl)-1H-indazol-5-yl]amino]benzonitrile

4-[(3-pyridin-4-yl-1H-indazol-5-yl)amino]-3,4-dihydro-2H-chromene-7-carbonitrile

1-[(3-pyridin-4-yl-1H-indazol-5-yl)amino]-2,3-dihydro-1H-indene-5-carbonitrile

7-(4-methylsulfonylphenyl)-4-(propan-2-ylamino)cinnoline-3-carboxamide

4-[3-cyano-4-(propan-2-ylamino)quinolin-7-yl]-N-methylbenzenesulfonamide

4-(propan-2-ylamino)-7-pyridin-4-ylcinnoline-3-carboxamide

4-(propan-2-ylamino)-7-(1,2-thiazol-4-yl)cinnoline-3-carboxamide

(5R)-5-[[3-(1-methylpyrazol-4-yl)-1H-indazol-5-yl]amino]-5,6,7,8-tetrahydronaphthalene-2-carbonitrile

(5R)-5-[(3-pyridin-4-yl-1H-indazol-5-yl)amino]-5,6,7,8-tetrahydronaphthalene-2-carbonitrile

(4R)-4-[(3-pyridin-4-yl-1H-indazol-5-yl)amino]-3,4-dihydro-2H-chromene-7-carbonitrile

4-[(3-pyridin-4-yl-1H-indazol-5-yl)amino]benzene-1,3-dicarbonitrile

3-fluoro-2-[(3-pyridin-4-yl-1H-indazol-5-yl)amino]benzonitrile

7-(4-morpholin-4-ylsulfonylphenyl)-4-(propan-2-ylamino)quinoline-3-carbonitrile

7-(4-methylsulfonylphenyl)-4-(propan-2-ylamino)quinoline-3-carbonitrile

4-(azetidin-1-yl)-7-(1-methylpyrazol-4-yl)quinoline-3-carbonitrile

5-methyl-2-[(3-pyridin-4-yl-1H-indazol-5-yl)amino]benzonitrile

7-(2-methyl-1,3-thiazol-5-yl)-4-(propan-2-ylamino)quinoline-3-carbonitrile

N-(2-nitrophenyl)-3-pyridin-4-yl-1H-indazol-5-amine

2-fluoro-6-[(3-pyridin-4-yl-1H-indazol-5-yl)amino]benzonitrile

2-[(3-pyridin-4-yl-1H-indazol-5-yl)amino]benzonitrile

2-[[3-(2-methoxypyridin-4-yl)-1H-indazol-5-yl]amino]benzonitrile

N-(3,4-dihydro-2H-chromen-4-yl)-3-pyridin-4-yl-1H-indazol-5-amine

4-[[(1R)-1-cyclopropylethyl]amino]-7-[4-(2-oxo-1,3-oxazol-3-yl)phenyl]quinoline-3-carbonitrile

(5R)-5-[(6-fluoro-3-pyridin-4-yl-1H-indazol-5-yl)amino]-5,6,7,8-tetrahydronaphthalene-2-carbonitrile

(4R)-4-[[3-(2-methylpyridin-4-yl)-1H-indazol-5-yl]amino]-3,4-dihydro-2H-chromene-7-carbonitrile

2-methyl-3-[[(3-pyridin-4-yl-1H-indazol-5-yl)amino]methyl]benzonitrile

4-[(3-pyridin-4-yl-1H-indazol-5-yl)amino]benzonitrile

3-nitro-4-[(3-pyridin-4-yl-1H-indazol-5-yl)oxy]benzonitrile

4-(dimethylamino)-7-(4-methylsulfonylphenyl)quinoline-3-carbonitrile

3-nitro-4-[(3-pyridin-4-yl-1H-indazol-5-yl)amino]benzonitrile

7-(4-methylsulfonylphenyl)-4-piperidin-1-ylquinoline-3-carbonitrile

7-(6-methylsulfonylpyridin-3-yl)-4-(propan-2-ylamino)quinoline-3-carbonitrile

3-[[(3-pyridin-4-yl-1H-indazol-5-yl)amino]methyl]benzonitrile

(5R)-5-[[3-(2-methoxypyridin-4-yl)-1H-indazol-5-yl]amino]-5,6,7,8-tetrahydronaphthalene-2-carbonitrile

7-(5-chlorothiophen-2-yl)-4-(propan-2-ylamino)quinoline-3-carbonitrile

5-fluoro-2-[(3-pyridin-4-yl-1H-indazol-5-yl)amino]benzonitrile

5-methoxy-2-[(3-pyridin-4-yl-1H-indazol-5-yl)amino]benzonitrile

(5R)-5-[[3-pyridin-4-yl-6-(trifluoromethyl)-1H-indazol-5-yl]amino]-5,6,7,8-tetrahydronaphthalene-2-carbonitrile

5-[(3-pyridin-4-yl-1H-indazol-5-yl)amino]naphthalene-2-carbonitrile

2-methyl-6-[(3-pyridin-4-yl-1H-indazol-5-yl)amino]benzonitrile

3-methyl-2-[(3-pyridin-4-yl-1H-indazol-5-yl)amino]benzonitrile

3-[(1S)-1-[(3-pyridin-4-yl-1H-indazol-5-yl)amino]ethyl]benzonitrile

3-methoxy-2-[(3-pyridin-4-yl-1H-indazol-5-yl)amino]benzonitrile

2-[(3-pyridin-4-yl-1H-indazol-5-yl)oxy]benzonitrile

3-methyl-4-[(3-pyridin-4-yl-1H-indazol-5-yl)oxy]benzonitrile

4-[[(3-pyridin-4-yl-1H-indazol-5-yl)amino]methyl]benzonitrile

3-nitro-4-[(2-oxo-1,3-dihydrobenzimidazol-5-yl)amino]benzonitrile

4-methyl-2-[(3-pyridin-4-yl-1H-indazol-5-yl)amino]benzonitrile

4-fluoro-2-[(3-pyridin-4-yl-1H-indazol-5-yl)amino]benzonitrile

4-methoxy-2-[(3-pyridin-4-yl-1H-indazol-5-yl)amino]benzonitrile

4-[methyl-(3-pyridin-4-yl-1H-indazol-5-yl)amino]benzene-1,3-dicarbonitrile

4-[(3-pyridin-4-yl-1H-indazol-5-yl)oxy]benzene-1,3-dicarbonitrile

3-nitro-4-[(2-oxo-3-pyridin-4-yl-1H-benzimidazol-5-yl)amino]benzonitrile

3-nitro-2-[(3-pyridin-4-yl-1H-indazol-5-yl)amino]benzonitrile

3-chloro-4-[(3-pyridin-4-yl-1H-indazol-5-yl)amino]benzonitrile

[4-[[4-(cyclopropylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]-2-fluoro-5-methoxyphenyl]-morpholin-4-ylmethanone

[2-chloro-5-methoxy-4-[[4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]phenyl]-morpholin-4-ylmethanone

[3-methoxy-4-[[4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]phenyl]-morpholin-4-ylmethanone

[4-[[4-(ethylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]-2-fluoro-5-methoxyphenyl]-morpholin-4-ylmethanone

4-[[4-(ethylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]-2-fluoro-N-(2-hydroxy-2-methylpropyl)-5-methoxybenzamide

[5-methoxy-2-methyl-4-[[4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]phenyl]-morpholin-4-ylmethanone

[4-[[5-bromo-4-(methylamino)pyrimidin-2-yl]amino]-3-methoxyphenyl]-morpholin-4-ylmethanone

[2-fluoro-5-methoxy-4-[[4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]phenyl]-morpholin-4-ylmethanone

[5-[[4-(ethylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]-4-methoxypyridin-2-yl]-morpholin-4-ylmethanone

US9499542, 14

2-fluoro-3-(4-morpholin-4-yl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)benzonitrile

[2,5-dimethoxy-4-[[4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]phenyl]-morpholin-4-ylmethanone

5-[[4-(ethylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]-2-(2-hydroxy-2-methylpropyl)-6-methoxy-3H-isoindol-1-one

[5-chloro-2-methoxy-4-[[4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]phenyl]-morpholin-4-ylmethanone

3-(4-morpholin-4-yl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)benzonitrile

[5-chloro-4-[[4-(ethylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]-2-methoxyphenyl]-morpholin-4-ylmethanone

2-N-(5-fluoro-2-methoxy-4-methylsulfonylphenyl)-4-N-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine

BDBM50396041

[2-fluoro-3-methoxy-4-[[4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]phenyl]-morpholin-4-ylmethanone

[5-chloro-2-methyl-4-[[4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]phenyl]-morpholin-4-ylmethanone

2-N-[4-methoxy-6-(oxan-4-yl)pyridin-3-yl]-4-N-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine

4-amino-7-methyl-2-[[5-methyl-1-[(3S)-oxolan-3-yl]pyrazol-4-yl]amino]-6-[(2R)-2-methylpyrrolidin-1-yl]pyrrolo[2,3-d]pyrimidine-5-carbonitrile

[4-[(5-bromo-4-methoxypyrimidin-2-yl)amino]-3-methoxyphenyl]-morpholin-4-ylmethanone

4-amino-2-[(3-chloro-1-methylpyrazol-4-yl)amino]-7-methyl-6-[(2R)-2-methylpyrrolidin-1-yl]pyrrolo[2,3-d]pyrimidine-5-carbonitrile

[5-fluoro-2-methoxy-4-[[4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]phenyl]-morpholin-4-ylmethanone

[4-[(5-chloro-4-methoxypyrimidin-2-yl)amino]-3-methoxyphenyl]-morpholin-4-ylmethanone

US9499542, 22

6-[(1-methylpyrazol-3-yl)amino]-4-(6-methylpyridin-2-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile

4-amino-7-methyl-2-[[5-methyl-1-[(3R)-oxolan-3-yl]pyrazol-4-yl]amino]-6-[(2R)-2-methylpyrrolidin-1-yl]pyrrolo[2,3-d]pyrimidine-5-carbonitrile

US9499542, 13

3-[4-(dimethylamino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile

6-[(4-chloro-1-methylpyrazol-3-yl)amino]-4-(5-methylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile

6-[(4-chloro-1-methylpyrazol-3-yl)amino]-4-(6-methylpyridin-2-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile

2-N-[2-chloro-4-(1-methyltetrazol-5-yl)phenyl]-4-N-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine

2-[2-methoxy-4-(morpholine-4-carbonyl)anilino]-4-(methylamino)pyrimidine-5-carbonitrile

3-[4-[2-(cyanomethyl)morpholin-4-yl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile

4-amino-2-[(1,3-dimethylpyrazol-4-yl)amino]-7-methyl-6-[(2R)-2-methylpyrrolidin-1-yl]pyrrolo[2,3-d]pyrimidine-5-carbonitrile

4-amino-2-[[1-(2-hydroxy-2-methylpropyl)-5-methylpyrazol-4-yl]amino]-7-methyl-6-[(2R)-2-methylpyrrolidin-1-yl]pyrrolo[2,3-d]pyrimidine-5-carbonitrile

4-amino-2-[[1-[(3-hydroxyoxetan-3-yl)methyl]-5-methylpyrazol-4-yl]amino]-7-methyl-6-[(2R)-2-methylpyrrolidin-1-yl]pyrrolo[2,3-d]pyrimidine-5-carbonitrile

3-[4-[(2S)-2-methylmorpholin-4-yl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile

US9499542, 20

6-[(1-methylpyrazol-3-yl)amino]-4-(2-methylpyridin-4-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile

3-[4-[(2S)-2-(5-methyl-1,2,4-oxadiazol-3-yl)morpholin-4-yl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile

4-amino-7-methyl-2-[[3-methyl-1-(oxetan-3-yl)pyrazol-4-yl]amino]-6-[(2R)-2-methylpyrrolidin-1-yl]pyrrolo[2,3-d]pyrimidine-5-carbonitrile

4-[5-(3-chlorophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]morpholine

6-[(1,4-dimethylpyrazol-3-yl)amino]-4-(5-methylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile

4-amino-2-[[1-(2-hydroxy-2-methylpropyl)-3-methylpyrazol-4-yl]amino]-7-methyl-6-[(2R)-2-methylpyrrolidin-1-yl]pyrrolo[2,3-d]pyrimidine-5-carbonitrile

3-(4-piperidin-1-yl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)benzonitrile

4-amino-7-methyl-2-[[5-methyl-1-(oxetan-3-yl)pyrazol-4-yl]amino]-6-[(2R)-2-methylpyrrolidin-1-yl]pyrrolo[2,3-d]pyrimidine-5-carbonitrile

4-(5-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)morpholine

3-[4-[(3S)-3-methylpiperidin-1-yl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile

US9499542, 23

6-[(4-chloro-1-methylpyrazol-3-yl)amino]-4-(2-methylpyridin-4-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile

4-[5-(5-methylpyridin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]morpholine

6-(5-chloro-2-methoxyphenyl)sulfanyl-3-(1-methylpyrazol-4-yl)-[1,2,4]triazolo[4,3-b]pyridazine

4-amino-2-[[1-[(3-hydroxyoxetan-3-yl)methyl]-3-methylpyrazol-4-yl]amino]-7-methyl-6-[(2R)-2-methylpyrrolidin-1-yl]pyrrolo[2,3-d]pyrimidine-5-carbonitrile

4-amino-2-[(1,5-dimethylpyrazol-4-yl)amino]-7-methyl-6-[(2R)-2-methylpyrrolidin-1-yl]pyrrolo[2,3-d]pyrimidine-5-carbonitrile

4-[5-(1-methylpyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]morpholine

6-(4-morpholin-4-yl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)pyridine-2-carbonitrile

3-[4-[(2R)-2-methylmorpholin-4-yl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile

6-(2,5-dimethoxyphenyl)sulfanyl-3-(1-methylpyrazol-4-yl)-[1,2,4]triazolo[4,3-b]pyridazine

3-[4-[2-(3-methyl-1,2,4-oxadiazol-5-yl)morpholin-4-yl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile

6-(2,5-dimethoxyphenyl)sulfanyl-3-(1-methylpyrazol-4-yl)imidazo[1,2-b]pyridazine

[4-[[5-fluoro-4-(methylamino)pyrimidin-2-yl]amino]-3-methoxyphenyl]-morpholin-4-ylmethanone

3-(4-pyrrolidin-1-yl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)benzonitrile

6-(2,5-dimethoxyphenyl)sulfanyl-3-(5-methoxypyridin-3-yl)-[1,2,4]triazolo[4,3-b]pyridazine