Protein Information

General Information of the Protein

Protein ID	PT02519
Protein Name	Histamine H4 receptor
Gene Name	HRH4
Sequence	MSESNGTDVLPLTAQVPLAFLMSLLAFAITIGNAVVILAFVADRNLRHRSNYFFLNLAISDFFVGVISIPLYIPHTLFNWNFGSGICMFWLITDYLLCTASVYSIVLISYDRYQSVSNAVRYRAQHTGILKIVAQMVAVWILAFLVNGPMILASDSWKNSTNTEECEPGFVTEWYILAITAFLEFLLPVSLVVYFSVQIYWSLWKRGSLSRCPSHAGFIATSSRGTGHSRRTGLACRTSLPGLKEPAASLHSESPRGKSSLLVSLRTHMSGSIIAFKVGSFCRSESPVLHQREHVELLRGRKLARSLAVLLSAFAICWAPYCLFTIVLSTYRRGERPKSIWYSIAFWLQWFNSLINPFLYPLCHRRFQKAFWKILCVTKQPAPSQTQSVSS Show/Hide
Organism	Rattus norvegicus, Rat
Protein Classification	Membrane receptor > Family A G protein-coupled receptor > Small molecule receptor (family A GPCR) > Monoamine receptor > Histamine receptor
Function	The H4 subclass of histamine receptors could mediate the histamine signals in peripheral tissues. Displays a significant level of constitutive activity (spontaneous activity in the absence of agonist) (By similarity). Show/Hide
Uniprot ID	Q91ZY1
Ensembl ID	ENSG00000134489
Subcellular Location	Cell membrane

Map of Molecular Bioactivity Related to the Protein

Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity

Table of Molecular Bioactivities Related to the Protein

Cell Line ID: CL000006 , HEK293

Cell Line Info

Compound ID	Compound Name	Compound Formula
CP0041262 Compound Info	5-chloro-2-[(4-methylpiperazin-1-yl)carbonyl]-1H-indole Show/Hide	C14H16ClN3O	3
1	EC50 = 2.57 nM Bioactivity Info	TI LI LO TS
2	EC50 = 42.66 nM Bioactivity Info	TI LI LO TS
3	Ki = 2.692 nM Bioactivity Info	TI LI LO TS
CP0094765 Compound Info	14-fluoro-6-(piperazin-1-yl)-3,5-diazatricyclo[9.4.0.0^{2,7}]pentadeca-1(15),2(7),3,5,11,13-hexaen-4-amine Show/Hide	C17H20FN5	2
1	EC50 = 6.026 nM Bioactivity Info	TI LI LO TS
2	Ki = 1.445 nM Bioactivity Info	TI LI LO TS
CP0173066 Compound Info	2,4-diamino-5,6-disubstituted pyrimidine, 11 Show/Hide	C18H23N5	2
1	EC50 = 6.607 nM Bioactivity Info	TI LI LO TS
2	Ki = 5.129 nM Bioactivity Info	TI LI LO TS
CP0173068 Compound Info	2,4-diamino-5,6-disubstituted pyrimidine, 12 Show/Hide	C17H21N5	2
1	EC50 = 9.333 nM Bioactivity Info	TI LI LO TS
2	Ki = 3.631 nM Bioactivity Info	TI LI LO TS
CP0205085 Compound Info	2,4-diamino-5,6-disubstituted pyrimidine, 10 Show/Hide	C17H21N5	2
1	EC50 = 10 nM Bioactivity Info	TI LI LO TS
2	Ki = 3.802 nM Bioactivity Info	TI LI LO TS
CP0198951 Compound Info	2,4-diamino-5,6-disubstituted pyrimidine, 9 Show/Hide	C17H21N5	2
1	EC50 = 14.79 nM Bioactivity Info	TI LI LO TS
2	Ki = 7.586 nM Bioactivity Info	TI LI LO TS
CP0921847 Compound Info	4-(2,6-difluoropyridin-3-yl)-6-(4-methylpiperazin-1-yl)pyrimidin-2-amine Show/Hide	C14H16F2N6	1
1	EC50 = 15.49 nM Bioactivity Info	TI LI LO TS
CP0247209 Compound Info	2,4-diamino-5,6-disubstituted pyrimidine, 6 Show/Hide	C17H21N5	2
1	EC50 = 15.49 nM Bioactivity Info	TI LI LO TS
2	Ki = 5.37 nM Bioactivity Info	TI LI LO TS
CP0926263 Compound Info	(R)-4-(3-(methylamino)pyrrolidin-1-yl)-5H-indeno[1,2-d]pyrimidin-2-amine Show/Hide	C16H19N5	1
1	EC50 = 19.05 nM Bioactivity Info	TI LI LO TS
CP0318899 Compound Info	2,4-diamino-5,6-disubstituted pyrimidine, 8 Show/Hide	C15H17N5	2
1	EC50 = 19.95 nM Bioactivity Info	TI LI LO TS
2	Ki = 4.786 nM Bioactivity Info	TI LI LO TS
CP0247208 Compound Info	2,4-diamino-5,6-disubstituted pyrimidine, 7 Show/Hide	C16H19N5	2
1	EC50 = 23.99 nM Bioactivity Info	TI LI LO TS
2	Ki = 9.12 nM Bioactivity Info	TI LI LO TS
CP0173069 Compound Info	5-chloro-2-(piperazin-1-ylcarbonyl)-1H-indole Show/Hide	C13H14ClN3O	2
1	EC50 = 30.9 nM Bioactivity Info	TI LI LO TS
2	Ki = 3.981 nM Bioactivity Info	TI LI LO TS
CP0850029 Compound Info	4-(3-Chlorophenyl)-6-(4-methylpiperazin-1-yl)pyrimidin-2-ylamine Show/Hide	C15H18ClN5	1
1	EC50 = 31.62 nM Bioactivity Info	TI LI LO TS
CP0383812 Compound Info	4-(4-chlorophenyl)-6-(4-methylpiperazin-1-yl)pyrimidin-2-amine Show/Hide	C15H18ClN5	1
1	EC50 = 37.15 nM Bioactivity Info	TI LI LO TS
CP0259827 Compound Info	4-(4-methylpiperazin-1-yl)-6-phenylpyrimidin-2-amine Show/Hide	C15H19N5	2
1	EC50 = 39.81 nM Bioactivity Info	TI LI LO TS
2	Ki = 14.13 nM Bioactivity Info	TI LI LO TS
CP0845898 Compound Info	4-(4-Methylpiperazin-1-yl)pyrimidine-2,5-diamine Show/Hide	C9H16N6	1
1	EC50 = 42.66 nM Bioactivity Info	TI LI LO TS
CP0913525 Compound Info	4-(4-Methylpiperazin-1-yl)-6-m-tolylpyrimidin-2-ylamine Show/Hide	C16H21N5	1
1	EC50 = 42.66 nM Bioactivity Info	TI LI LO TS
CP0866966 Compound Info	4-(2-Methoxyphenyl)-6-(4-methylpiperazin-1-yl)pyrimidin-2-ylamine Show/Hide	C16H21N5O	1
1	EC50 = 43.65 nM Bioactivity Info	TI LI LO TS
CP0894476 Compound Info	4-(4-Methylpiperazin-1-yl)-6-piperidin-1-ylpyrimidin-2-ylamine Show/Hide	C14H24N6	1
1	EC50 = 46.77 nM Bioactivity Info	TI LI LO TS
CP0229853 Compound Info	2,4-diamino-5,6-disubstituted pyrimidine, 14 Show/Hide	C19H25N5	2
1	EC50 = 54.95 nM Bioactivity Info	TI LI LO TS
2	Ki = 4.467 nM Bioactivity Info	TI LI LO TS
CP0894471 Compound Info	4-(4-Methylpiperazin-1-yl)-6-p-tolylpyrimidin-2-ylamine Show/Hide	C16H21N5	1
1	EC50 = 56.23 nM Bioactivity Info	TI LI LO TS
CP0068173 Compound Info	2-Aminopyrimidine analog., 4 Show/Hide	C16H18N6	3
1	EC50 = 58.88 nM Bioactivity Info	TI LI LO TS
2	EC50 = 4677.35 nM Bioactivity Info	TI LI LO TS
3	Ki = 275.42 nM Bioactivity Info	TI LI LO TS
CP0911631 Compound Info	4-[2-Amino-5-methyl-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]benzonitrile Show/Hide	C17H20N6	1
1	EC50 = 58.88 nM Bioactivity Info	TI LI LO TS
CP0919099 Compound Info	5-Methyl-4-(4-methylpiperazin-1-yl)pyrimidin-2-ylamine Show/Hide	C10H17N5	1
1	EC50 = 66.07 nM Bioactivity Info	TI LI LO TS
CP0896297 Compound Info	4-tert-butyl-6-(4-methylpiperazin-1-yl)pyrimidin-2-ylamine Show/Hide	C13H23N5	1
1	EC50 = 67.61 nM Bioactivity Info	TI LI LO TS
CP0171840 Compound Info	4-(4-Methylpiperazin-1-yl)-6-pyrrolidin-1-ylpyrimidin-2-ylamine Show/Hide	C13H22N6	1
1	EC50 = 69.18 nM Bioactivity Info	TI LI LO TS
CP0880836 Compound Info	4-(2-methoxypyridin-3-yl)-6-(4-methylpiperazin-1-yl)pyrimidin-2-amine Show/Hide	C15H20N6O	1
1	EC50 = 93.33 nM Bioactivity Info	TI LI LO TS
CP0850028 Compound Info	4-(3-Methoxyphenyl)-6-(4-methylpiperazin-1-yl)pyrimidin-2-ylamine Show/Hide	C16H21N5O	1
1	EC50 = 102.33 nM Bioactivity Info	TI LI LO TS
CP0850031 Compound Info	4-(1-Methyl-1H-imidazol-4-yl)-6-(4-methylpiperazin-1-yl)pyrimidin-2-ylamine Show/Hide	C13H19N7	1
1	EC50 = 102.33 nM Bioactivity Info	TI LI LO TS
CP0425035 Compound Info	4-(4-methylpiperazin-1-yl)pyrimidin-2-amine Show/Hide	C9H15N5	1
1	EC50 = 114.82 nM Bioactivity Info	TI LI LO TS
CP0845917 Compound Info	4-(4-methoxyphenyl)-6-(4-methylpiperazin-1-yl)pyrimidin-2-amine Show/Hide	C16H21N5O	1
1	EC50 = 114.82 nM Bioactivity Info	TI LI LO TS
CP0894475 Compound Info	6-(4-Methylpiperazin-1-yl)-N4-phenylpyrimidine-2,4-diamine Show/Hide	C15H20N6	1
1	EC50 = 117.49 nM Bioactivity Info	TI LI LO TS
CP0913526 Compound Info	4-(4-methylpiperazin-1-yl)-6-(naphthalen-2-yl)pyrimidin-2-amine Show/Hide	C19H21N5	1
1	EC50 = 173.78 nM Bioactivity Info	TI LI LO TS
CP0851269 Compound Info	4-(4-Methylpiperazin-1-yl)-6-o-tolylpyrimidin-2-ylamine Show/Hide	C16H21N5	1
1	EC50 = 177.83 nM Bioactivity Info	TI LI LO TS
CP0915568 Compound Info	4-(2,6-Dimethoxyphenyl)-6-(4-methylpiperazin-1-yl)pyrimidin-2-ylamine Show/Hide	C17H23N5O2	1
1	EC50 = 194.98 nM Bioactivity Info	TI LI LO TS
CP0921848 Compound Info	4-(4-Methylpiperazin-1-yl)-6-pyridin-3-ylpyrimidin-2-ylamine Show/Hide	C14H18N6	1
1	EC50 = 208.93 nM Bioactivity Info	TI LI LO TS
CP0387512 Compound Info	6-(4-Methylpiperazin-1-yl)pyrimidine-2,4-diamine Show/Hide	C9H16N6	1
1	EC50 = 218.78 nM Bioactivity Info	TI LI LO TS
CP0894604 Compound Info	4-(4-Methylpiperazin-1-yl)-6-(1-methyl-1H-pyrazol-4-yl)pyrimidin-2-ylamine Show/Hide	C13H19N7	1
1	EC50 = 218.78 nM Bioactivity Info	TI LI LO TS
CP0880854 Compound Info	4-(4-methylpiperazin-1-yl)-6-(pyridin-4-yl)pyrimidin-2-amine Show/Hide	C14H18N6	1
1	EC50 = 229.09 nM Bioactivity Info	TI LI LO TS
CP0915555 Compound Info	3-[2-Amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]benzonitrile Show/Hide	C16H18N6	1
1	EC50 = 234.42 nM Bioactivity Info	TI LI LO TS
CP0915556 Compound Info	4-(4-Methoxypyridin-3-yl)-6-(4-methylpiperazin-1-yl)pyrimidin-2-ylamine Show/Hide	C15H20N6O	1
1	EC50 = 234.42 nM Bioactivity Info	TI LI LO TS
CP0286034 Compound Info	2-Aminopyrimidine analog., 25 Show/Hide	C15H16N6	2
1	EC50 = 245.47 nM Bioactivity Info	TI LI LO TS
2	Ki = 338.84 nM Bioactivity Info	TI LI LO TS
CP0858872 Compound Info	4-tert-Butyl-6-(4-ethylpiperazin-1-yl)pyrimidin-2-ylamine Show/Hide	C14H25N5	1
1	EC50 = 245.47 nM Bioactivity Info	TI LI LO TS
CP0462563 Compound Info	4-tert-butyl-6-(4-methylpiperazin-1-yl)-1,3,5-triazin-2-amine Show/Hide	C12H22N6	1
1	EC50 = 251.19 nM Bioactivity Info	TI LI LO TS
CP0896072 Compound Info	4-(4-Iodophenyl)-6-(4-methylpiperazin-1-yl)pyrimidin-2-ylamine Show/Hide	C15H18IN5	1
1	EC50 = 275.42 nM Bioactivity Info	TI LI LO TS
CP0867841 Compound Info	4-tert-Butyl-6-(2-dimethylamino-ethoxy)-pyrimidin-2-ylamine Show/Hide	C12H22N4O	1
1	EC50 = 302 nM Bioactivity Info	TI LI LO TS
CP0894606 Compound Info	4-Adamantan-1-yl-6-(4-methylpiperazin-1-yl)pyrimidin-2-ylamine Show/Hide	C19H29N5	1
1	EC50 = 316.23 nM Bioactivity Info	TI LI LO TS
CP0896349 Compound Info	4-(4-Methylpiperazin-1-yl)-6-morpholin-4-ylpyrimidin-2-ylamine Show/Hide	C13H22N6O	1
1	EC50 = 338.84 nM Bioactivity Info	TI LI LO TS
CP0896308 Compound Info	N4,N4-Diethyl-6-(4-methylpiperazin-1-yl)pyrimidine-2,4-diamine Show/Hide	C13H24N6	1
1	EC50 = 354.81 nM Bioactivity Info	TI LI LO TS
CP0870498 Compound Info	4-Methyl-6-(4-methylpiperazin-1-yl)pyrimidin-2-ylamine Show/Hide	C10H17N5	1
1	EC50 = 363.08 nM Bioactivity Info	TI LI LO TS
CP0850150 Compound Info	4-(1H-Imidazol-4-yl)-6-(4-methylpiperazin-1-yl)pyrimidin-2-ylamine Show/Hide	C12H17N7	1
1	EC50 = 389.05 nM Bioactivity Info	TI LI LO TS
CP0171842 Compound Info	4-N-benzyl-6-(4-methylpiperazin-1-yl)pyrimidine-2,4-diamine Show/Hide	C16H22N6	1
1	EC50 = 489.78 nM Bioactivity Info	TI LI LO TS
CP0845342 Compound Info	N4-Methyl-6-(4-methylpiperazin-1-yl)pyrimidine-2,4-diamine Show/Hide	C10H18N6	1
1	EC50 = 489.78 nM Bioactivity Info	TI LI LO TS
CP0913421 Compound Info	5-Methoxy-4-(4-methylpiperazin-1-yl)pyrimidin-2-ylamine Show/Hide	C10H17N5O	1
1	EC50 = 630.96 nM Bioactivity Info	TI LI LO TS
CP0939133 Compound Info	4-(3-Iodophenyl)-6-(4-methylpiperazin-1-yl)pyrimidin-2-ylamine Show/Hide	C15H18IN5	1
1	EC50 = 891.25 nM Bioactivity Info	TI LI LO TS
CP0913756 Compound Info	4-tert-Butyl-6-(4-methylpiperazin-1-yl)pyrimidine Show/Hide	C13H22N4	1
1	EC50 = 933.25 nM Bioactivity Info	TI LI LO TS
CP0896300 Compound Info	6-tert-Butyl-N4-(2-dimethylaminoethyl)-N4-methyl-pyrimidine-2,4-diamine Show/Hide	C13H25N5	1
1	EC50 = 1122.02 nM Bioactivity Info	TI LI LO TS
CP0850030 Compound Info	2-[2-Amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]benzonitrile Show/Hide	C16H18N6	1
1	EC50 = 1202.26 nM Bioactivity Info	TI LI LO TS
CP0866962 Compound Info	4,6-Bis-(4-methylpiperazin-1-yl)pyrimidin-2-ylamine Show/Hide	C14H25N7	1
1	EC50 = 1348.96 nM Bioactivity Info	TI LI LO TS
CP0896311 Compound Info	2-Amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-ol Show/Hide	C9H15N5O	1
1	EC50 = 1479.11 nM Bioactivity Info	TI LI LO TS
CP0896302 Compound Info	6-tert-Butyl-N4-(2-dimethylaminoethyl)pyrimidine-2,4-diamine Show/Hide	C12H23N5	1
1	EC50 = 1778.28 nM Bioactivity Info	TI LI LO TS
CP0880855 Compound Info	4-(4-Methylpiperazin-1-yl)-6-(1H-pyrazol-4-yl)pyrimidin-2-ylamine Show/Hide	C12H17N7	1
1	EC50 = 1819.7 nM Bioactivity Info	TI LI LO TS
CP0915588 Compound Info	4-[6-Amino-4-(4-methylpiperazin-1-yl)pyridin-2-yl]benzonitrile Show/Hide	C17H19N5	1
1	EC50 = 1862.09 nM Bioactivity Info	TI LI LO TS
CP0866965 Compound Info	4-Iodo-6-(4-methylpiperazin-1-yl)pyrimidin-2-ylamine Show/Hide	C9H14IN5	1
1	EC50 = 2041.74 nM Bioactivity Info	TI LI LO TS
CP0919449 Compound Info	4-tert-butyl-6-(piperazin-1-yl)-2-(1H-pyrrol-1-yl)pyrimidine Show/Hide	C16H23N5	1
1	EC50 = 2290.87 nM Bioactivity Info	TI LI LO TS
CP0926568 Compound Info	4-tert-Butyl-6-[4-(2-dimethylaminoethyl)piperazin-1-yl]pyrimidin-2-ylamine Show/Hide	C16H30N6	1
1	EC50 = 2398.83 nM Bioactivity Info	TI LI LO TS
CP0896347 Compound Info	N4,N4-Dimethyl-6-(4-methylpiperazin-1-yl)pyrimidine-2,4-diamine Show/Hide	C11H20N6	1
1	EC50 = 3019.95 nM Bioactivity Info	TI LI LO TS
CP0911632 Compound Info	2'-Methoxy-6-(4-methylpiperazin-1-yl)-[4,5']bipyrimidinyl-2-ylamine Show/Hide	C14H19N7O	1
1	EC50 = 3235.94 nM Bioactivity Info	TI LI LO TS
CP0896070 Compound Info	4-tert-Butyl-6-(1-methylpiperidin-4-yl)pyrimidin-2-ylamine Show/Hide	C14H24N4	1
1	EC50 = 3630.78 nM Bioactivity Info	TI LI LO TS
CP0918790 Compound Info	4-(3-Dimethylaminopyrrolidin-1-yl)-6-(4-methylpiperazin-1-yl)pyrimidin-2-ylamine Show/Hide	C15H27N7	1
1	EC50 = 3630.78 nM Bioactivity Info	TI LI LO TS
CP0858873 Compound Info	4-tert-Butyl-2-methoxy-6-(4-methylpiperazin-1-yl)pyrimidine Show/Hide	C14H24N4O	1
1	EC50 = 4677.35 nM Bioactivity Info	TI LI LO TS
CP0896299 Compound Info	2-tert-Butyl-6-(4-methylpiperazin-1-yl)pyrimidin-4-ylamine Show/Hide	C13H23N5	1
1	EC50 = 4677.35 nM Bioactivity Info	TI LI LO TS
CP0913757 Compound Info	[4-tert-Butyl-6-(4-methylpiperazin-1-yl)pyrimidin-2-yl]methylamine Show/Hide	C14H25N5	1
1	EC50 = 5128.61 nM Bioactivity Info	TI LI LO TS
CP0915587 Compound Info	4-[2-Amino-5-methoxy-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]benzonitrile Show/Hide	C17H20N6O	1
1	EC50 = 5128.61 nM Bioactivity Info	TI LI LO TS
CP0851286 Compound Info	4-Imidazol-1-yl-6-(4-methylpiperazin-1-yl)pyrimidin-2-ylamine Show/Hide	C12H17N7	1
1	EC50 = 7943.28 nM Bioactivity Info	TI LI LO TS
CP0867842 Compound Info	6-tert-Butyl-2-(4-methylpiperazin-1-yl)pyrimidin-4-ylamine Show/Hide	C13H23N5	1
1	EC50 = 7943.28 nM Bioactivity Info	TI LI LO TS
CP0896073 Compound Info	6-(4-Methylpiperazin-1-yl)-[4,5']bipyrimidinyl-2-ylamine Show/Hide	C13H17N7	1
1	EC50 = 7943.28 nM Bioactivity Info	TI LI LO TS
CP0845344 Compound Info	4-(4-Methylpiperazin-1-yl)-5-phenylpyrimidin-2-ylamine Show/Hide	C15H19N5	1
1	EC50 = 8317.64 nM Bioactivity Info	TI LI LO TS
CP0916702 Compound Info	4-tert-butyl-2-chloro-6-(4-methylpiperazin-1-yl)pyrimidine Show/Hide	C13H21ClN4	1
1	EC50 = 8709.64 nM Bioactivity Info	TI LI LO TS
CP0851271 Compound Info	4-(4-Methylpiperazin-1-yl)-6-phenylsulfanylpyrimidin-2-ylamine Show/Hide	C15H19N5S	1
1	EC50 = 8912.51 nM Bioactivity Info	TI LI LO TS
CP0894474 Compound Info	6-tert-Butyl-N4-(3-dimethylamino-propyl)-N4-methyl-pyrimidine-2,4-diamine Show/Hide	C14H27N5	1
1	EC50 = 9772.37 nM Bioactivity Info	TI LI LO TS
CP0866961 Compound Info	4-Methoxy-6-(4-methylpiperazin-1-yl)pyrimidin-2-ylamine Show/Hide	C10H17N5O	1
1	EC50 = 10471.29 nM Bioactivity Info	TI LI LO TS
CP0850149 Compound Info	1-[2-Amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]imidazolidin-2-one Show/Hide	C12H19N7O	1
1	EC50 = 12302.69 nM Bioactivity Info	TI LI LO TS
CP0851247 Compound Info	1-[2-Amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]-1H-pyridin-2-one Show/Hide	C14H18N6O	1
1	EC50 = 14125.38 nM Bioactivity Info	TI LI LO TS
CP0896558 Compound Info	4-Chloro-6-(4-methylpiperazin-1-yl)pyrimidin-2-ylamine Show/Hide	C9H14ClN5	1
1	EC50 = 16982.44 nM Bioactivity Info	TI LI LO TS
CP0896307 Compound Info	[4-tert-Butyl-6-(4-methylpiperazin-1-yl)pyrimidin-2-yl]dimethylamine Show/Hide	C15H27N5	1
1	EC50 = 18197.01 nM Bioactivity Info	TI LI LO TS
CP0896306 Compound Info	4-tert-Butyl-6-(4-methylpiperazin-1-yl)pyrimidin-2-ol Show/Hide	C13H22N4O	1
1	EC50 = 22908.68 nM Bioactivity Info	TI LI LO TS
CP0916701 Compound Info	4-tert-Butyl-6-(4-methylpiperidin-1-yl)pyrimidin-2-ylamine Show/Hide	C14H24N4	1
1	EC50 = 23442.29 nM Bioactivity Info	TI LI LO TS

Cell Line ID: CL000025 , HEK-293T

Cell Line Info

Cell Line ID: CL000956 , HEK293-SF-rH4R-His6-CRE-Luc

Cell Line Info

Cell Line ID: CL000910 , HEK293T-beta-arr2-rH4R

Cell Line Info

Cell Line ID: CL000909 , HEK293T-SF-His6-CRE-Luc

Cell Line Info

Cell Line ID: CL000013 , Sf9

Cell Line Info

Cell Line ID: CL000074 , SK-N-MC

Cell Line Info

Biochemical Assays

Compound ID	Compound Name	Compound Formula
CP0041262 Compound Info	5-chloro-2-[(4-methylpiperazin-1-yl)carbonyl]-1H-indole Show/Hide	C14H16ClN3O	3
1	EC50 = 741.31 nM
2	Ki = 2.4 nM
3	Ki = 6 nM
CP0036920 Compound Info	2-(1H-imidazol-4-yl)ethan-1-amine Show/Hide	C5H9N3	3
1	EC50 = 52480.75 nM
2	Kd = 134 nM
3	Ki = 136 nM
CP0229853 Compound Info	2,4-diamino-5,6-disubstituted pyrimidine, 14 Show/Hide	C19H25N5	1
1	Ki = 4.467 nM
CP0220828 Compound Info	4-N-(cyclopropylmethyl)-6-[(3R)-3-(methylamino)pyrrolidin-1-yl]pyrimidine-2,4-diamine Show/Hide	C13H22N6	1
1	Ki = 54.95 nM
CP0058845 Compound Info	4-[(3R)-3-aminopyrrolidin-1-yl]-6-propan-2-ylpyrimidin-2-amine Show/Hide	C11H19N5	1
1	Ki = 188 nM

Similar Protein(s) and Bioactivity Statistics

50% Identity

Protein ID	Protein Name	Protein Organism
PT00122	Histamine H4 receptor	Cavia porcellus, Guinea pig	Protein Info
PT04730	Histamine H4 receptor	Mus musculus, Mouse	Protein Info

Cite

About MolBiC

Correspondence

Prof. Feng ZHU

Prof. Leo, Lianyi Han