General Information of the Compound
Compound ID
CP0915587
Compound Name
4-[2-Amino-5-methoxy-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]benzonitrile
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Structure
Formula
C17H20N6O
Molecular Weight
324.388
Canonical SMILES
COc1c(-c2ccc(C#N)cc2)nc(N)nc1N1CCN(C)CC1
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InChI
InChI=1S/C17H20N6O/c1-22-7-9-23(10-8-22)16-15(24-2)14(20-17(19)21-16)13-5-3-12(11-18)4-6-13/h3-6H,7-10H2,1-2H3,(H2,19,20,21)
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InChIKey
QMVUOQUUMBCXID-UHFFFAOYSA-N
Physicochemical Property
logP
1.35788
Rotatable Bonds
3
Heavy Atom Count
24
Polar Areas
91.3
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
7
Complexity
24

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 25129878
SID: 56454235
ChEMBL ID
CHEMBL493103
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02519, Histamine H4 receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
EC50 = 5128.61 nM
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