General Information of the Protein
Protein ID
PT00122
Protein Name
Histamine H4 receptor
Gene Name
HRH4
Sequence
MLANNSTIALTSIKISLTFLMSLLAIAIMLGNVVVILAFIVDRNLRHRSNYFFLNLAIADFFVGAIAIPLYIPSSLTYWTSGKQACVFWLITDYLLCTASVYNIVLISYDRYQSVSNAVWYRAQHSGTWKIATQMVAVWIFSFMTNGPMILISDSWQNSTTECEPGFLKKWYFALPTSLLEFLIPILLVAYFSAHIYWSLWKREKLSRCLSHPVLPSDSSSSDHGHSCRQDPDSRATLPARKETTASLGSDKSRRKSSLLFSIRAYKNSNVIASKMGFLSHSDSLALQQREHIELFRARKLAKSLAILLAAFAICWAPYSLTTVIYSFFPERNLTKSTWYHTAFWLQWFNSFVNPFLYPLCHKRFQKAFLKILPVRRQSTPPHNRSIST
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Organism
Cavia porcellus, Guinea pig
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Small molecule receptor (family A GPCR)
>
Monoamine receptor
>
Histamine receptor
Uniprot ID
Q91ZY3
Ensembl ID
ENSG00000134489
Subcellular Location
Cell membrane
Membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000025 , HEK-293T
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0220828
 Compound Info 
4-N-(cyclopropylmethyl)-6-[(3R)-3-(methylamino)pyrrolidin-1-yl]pyrimidine-2,4-diamine
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C13H22N6
  1
1
Ki = 123.03 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0041262
 Compound Info 
5-chloro-2-[(4-methylpiperazin-1-yl)carbonyl]-1H-indole
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C14H16ClN3O
  1
1
Ki = 1071.52 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Similar Protein(s) and Bioactivity Statistics
50% Identity
Protein ID Protein Name Protein Organism
PT02519 Histamine H4 receptor Rattus norvegicus, Rat
 Protein Info 
PT04730 Histamine H4 receptor Mus musculus, Mouse
 Protein Info