General Information of the Compound
| Compound ID |
CP0010057
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| Compound Name |
2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl-1H-indol-3-yl}acetic acid
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| Synonyms |
53-86-1
Aconip
Aconip (TN)
Amuno
Apo-Indomethacin
Arthrexin
Artracin
Artrinovo
Artrivia
Bonidin
Bonidon
Bonidon Gel
Catlep
Chibro-amuno
Chrono-indicid
Chrono-indocid
Confortid
D
DESMETHYL INDOMETHACIN
Dolcidium
Dolcidium PL;Flexin continus
Dolovin
Durametacin
Elmetacin
Hicin
I 7378
IMN
IN1454
Idomethine
Imbrilon
Inacid
Indacin
Indameth
Indmethacine
Indo-Lemmon
Indo-Spray
Indo-phlogont
Indo-rectolmin
Indo-tablinen
Indochron E-R (TN)
Indocid
Indocid (TN)
Indocid (pharmaceutical)
Indocid Pda
Indocid Sr
Indocin
Indocin (TN)
Indocin I.V
Indocin I.VIndocin Sr
Indocin-SR (TN)
Indolar SR
Indomecol
Indomed
Indomee
Indomet 140
Indometacin
Indometacin (JP15/INN)
Indometacina
Indometacina [INN-Spanish]
Indometacine
Indometacine [INN-French]
Indometacinum
Indometacinum [INN-Latin]
Indometacyna
Indometacyna [Polish]
Indomethacin
Indomethacin & MAP-30
Indomethacin (USP)
Indomethacin [USAN:BAN]
Indomethacin, Indochron E-R, Indocin-SR, Indocid, Indocin, Indomethacin
Indomethacine
Indomethacinum
Indomethancin
Indomethazine
Indomethegan
Indomethine
Indometicina
Indometicina [Spanish]
Indomo
Indomod
Indoptic
Indoptol
Indorektal
Indoxen
Inflazon
Infrocin
Inteban sp
Lausit
Liometacen
Metacen
Metartril
Methazine
Metindol
Mezolin
Miametan
Mikametan
Mobilan
Novo-Methacin
Novomethacin
Reumacide
Rhemacin LA
Rheumacin LA
Sadoreum
Tannex
Vonum
indometacin
indomethacin
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| Structure |
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| Formula |
C19H16ClNO4
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| Molecular Weight |
357.793
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| Canonical SMILES |
COc1ccc2n(C(=O)c3ccc(Cl)cc3)c(C)c(CC(O)=O)c2c1
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| InChI |
InChI=1S/C19H16ClNO4/c1-11-15(10-18(22)23)16-9-14(25-2)7-8-17(16)21(11)19(24)12-3-5-13(20)6-4-12/h3-9H,10H2,1-2H3,(H,22,23)
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| InChIKey |
CGIGDMFJXJATDK-UHFFFAOYSA-N
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| CAS |
53-86-1
37242-43-6
91853-74-6
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| Physicochemical Property |
"RO5" indicates the cutoff set by lipinski's rule of five: (1) Molecular weight less than 500 Dalton; (2) xlogp less than 5; (3) No more than 5 hbonddonor (Hydrogen Bond Donor Count); (4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count); (5) No more than 10 rotbonds (Rotatable Bond Count). Show/Hide
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Map of Molecular Bioactivity Related to the Compound
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Map of Molecular Bioactivity Related to the Compound Compound Cell Line Protein Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity |
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Table of Molecular Bioactivities Related to the Compound
Protein ID: PT03222, ATP-binding cassette sub-family C member 3
Protein ID: PT05334, ATP-binding cassette sub-family C member 4
Protein ID: PT04542, Bile salt export pump
Protein ID: PT02932, Cytochrome c oxidase subunit 2
Protein ID: PT02516, Multidrug resistance-associated protein 1
Protein ID: PT01718, Nitric oxide synthase, inducible
Protein ID: PT02209, Organic anion transporter 3
Protein ID: PT01743, Polyunsaturated fatty acid 5-lipoxygenase
Protein ID: PT02987, Prostaglandin D2 receptor
Protein ID: PT01171, Prostaglandin D2 receptor 2
Protein ID: PT02988, Prostaglandin E2 receptor EP1 subtype
Protein ID: PT02989, Prostaglandin E2 receptor EP2 subtype
Protein ID: PT02345, Prostaglandin E2 receptor EP3 subtype
Protein ID: PT02346, Prostaglandin E2 receptor EP4 subtype
Protein ID: PT01898, Prostaglandin G/H synthase 1
Protein ID: PT00940, Prostaglandin G/H synthase 1
Cell-based Assay
Biochemical Assays
Protein ID: PT01062, Prostaglandin G/H synthase 2
Protein ID: PT00901, Prostaglandin G/H synthase 2
Cell-based Assay
Biochemical Assays
Protein ID: PT01065, Serine/threonine-protein kinase mTOR
Protein ID: PT04064, Solute carrier family 22 member 6
Protein ID: PT06206, Solute carrier family 22 member 7
Protein ID: PT03566, Solute carrier organic anion transporter family member 1B1
Protein ID: PT03657, Solute carrier organic anion transporter family member 1B3
Protein ID: PT05061, Uracil nucleotide/cysteinyl leukotriene receptor
Cell Viability or Cytotoxicity Assay
| Cell Line ID | Cell Line Name | Cell Line Organism | |
| CL000014 | RAW 264.7 | Mus musculus (Mouse) | 2 |
| 1 |
IC50 > 80000 nM
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TI
LI
LO
TS
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| 2 |
IC50 > 100000 nM
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TI
LI
LO
TS
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Clinical Information about the Compound
Drug 1 ( Indomethacin )
| Drug Name | Indomethacin | ||
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| Company | Recordati Rare Diseases Inc | ||
| Indication | |||
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