Protein Information

General Information of the Protein

Protein ID	PT02987
Protein Name	Prostaglandin D2 receptor
Secondarily Protein Name	Prostanoid DP receptor
Gene Name	PTGDR
Sequence	MNESYRCQTSTWVERGSSATMGAVLFGAGLLGNLLALVLLARSGLGSCRPGPLHPPPSVFYVLVCGLTVTDLLGKCLISPMVLAAYAQNQSLKELLPASGNQLCETFAFLMSFFGLASTLQLLAMAVECWLSLGHPFFYQRHVTLRRGVLVAPVVAAFCLAFCALPFAGFGKFVQYCPGTWCFIQMIHKERSFSVIGFSVLYSSLMALLVLATVVCNLGAMYNLYDMHRRQRHYPHRCSRDRAQSGSDYRHGSLHPLEELDHFVLLALMTVLFTMCSLPLIYRAYYGAFKLENKAEGDSEDLQALRFLSVISIVDPWIFIIFRTSVFRMLFHKVFTRPLIYRNWSSHSQQSNVESTL Show/Hide
Organism	Mus musculus, Mouse
Protein Classification	Membrane receptor > Family A G protein-coupled receptor > Small molecule receptor (family A GPCR) > Lipid-like ligand receptor (family A GPCR) > Prostanoid receptor
Function	Receptor for prostaglandin D2 (PGD2). The activity of this receptor is mainly mediated by G(s) proteins that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. A mobilization of calcium is also observed, but without formation of inositol 1,4,5-trisphosphate (By similarity). Involved in PLA2G3-dependent maturation of mast cells. PLA2G3 is secreted by immature mast cells and acts on nearby fibroblasts upstream to PTDGS to synthesize PGD2, which in turn promotes mast cell maturation and degranulation via PTGDR (PubMed:23624557). Show/Hide
Uniprot ID	Primary ID: P70263 Secondarily ID: A2RSY4 Q8CCM3 Show/Hide
Ensembl ID	ENSG00000168229
Subcellular Location	Cell membrane

Map of Molecular Bioactivity Related to the Protein

Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity

Table of Molecular Bioactivities Related to the Protein

Cell Line ID: CL000011 , CHO

Cell Line Info

Compound ID	Compound Name	Compound Formula
CP0375083 Compound Info	2-[5-fluoro-1-[2-fluoro-4-[[(2S)-4-methyl-2,3-dihydro-1,4-benzoxazin-2-yl]methoxy]benzoyl]-2-methylindol-3-yl]acetic acid Show/Hide	C28H24F2N2O5	2
1	IC50 = 0.7 nM Bioactivity Info	TI LI LO TS
2	Ki = 3.8 nM Bioactivity Info	TI LI LO TS
CP0387921 Compound Info	2-[4-chloro-3-[[2,6-dimethyl-4-[[(2S)-4-methyl-2,3-dihydro-1,4-benzoxazin-2-yl]methoxy]benzoyl]amino]phenyl]-2-methylpropanoic acid Show/Hide	C29H31ClN2O5	1
1	IC50 = 0.7 nM Bioactivity Info	TI LI LO TS
CP0427970 Compound Info	1-[4-chloro-3-[[2,6-dimethyl-4-[[(2S)-4-methyl-2,3-dihydro-1,4-benzoxazin-2-yl]methoxy]benzoyl]amino]phenyl]cyclopropane-1-carboxylic acid Show/Hide	C29H29ClN2O5	1
1	IC50 = 1 nM Bioactivity Info	TI LI LO TS
CP0425413 Compound Info	2-[2-methyl-1-[2-methyl-4-[[(2S)-4-methyl-2,3-dihydro-1,4-benzoxazin-2-yl]methoxy]benzoyl]indol-3-yl]acetic acid Show/Hide	C29H28N2O5	2
1	IC50 = 1.1 nM Bioactivity Info	TI LI LO TS
2	Ki = 3.5 nM Bioactivity Info	TI LI LO TS
CP0482039 Compound Info	2-[2-fluoro-5-[[2-methyl-4-[[(2S)-4-methyl-2,3-dihydro-1,4-benzoxazin-2-yl]methoxy]benzoyl]amino]phenyl]acetic acid Show/Hide	C26H25FN2O5	2
1	IC50 = 1.2 nM Bioactivity Info	TI LI LO TS
2	Ki = 15 nM Bioactivity Info	TI LI LO TS
CP0392025 Compound Info	2-[4-chloro-3-[[2-chloro-4-[[(2S)-4-methyl-2,3-dihydro-1,4-benzoxazin-2-yl]methoxy]benzoyl]amino]phenyl]-2,2-difluoroacetic acid Show/Hide	C25H20Cl2F2N2O5	1
1	IC50 = 1.4 nM Bioactivity Info	TI LI LO TS
CP0495770 Compound Info	2-[4-chloro-3-[[4-[[(3R)-2,3-dihydro-1-benzofuran-3-yl]methoxy]-2,6-dimethylbenzoyl]amino]phenyl]acetic acid Show/Hide	C26H24ClNO5	1
1	IC50 = 1.5 nM Bioactivity Info	TI LI LO TS
CP0431698 Compound Info	2-[1-[2-chloro-4-[[(2S)-4-methyl-2,3-dihydro-1,4-benzoxazin-2-yl]methoxy]benzoyl]-5-fluoro-2-methylindol-3-yl]acetic acid Show/Hide	C28H24ClFN2O5	2
1	IC50 = 1.6 nM Bioactivity Info	TI LI LO TS
2	Ki = 5.2 nM Bioactivity Info	TI LI LO TS
CP0378355 Compound Info	2-[5-fluoro-2-methyl-1-[4-[[(2S)-4-methyl-2,3-dihydro-1,4-benzoxazin-2-yl]methoxy]benzoyl]indol-3-yl]acetic acid Show/Hide	C28H25FN2O5	2
1	IC50 = 1.8 nM Bioactivity Info	TI LI LO TS
2	Ki = 5.7 nM Bioactivity Info	TI LI LO TS
CP0524934 Compound Info	2-[1-[4-[[(3R)-2,3-dihydro-1-benzofuran-3-yl]methoxy]-2-methylbenzoyl]-5-fluoro-2-methylindol-3-yl]acetic acid Show/Hide	C28H24FNO5	2
1	IC50 = 1.8 nM Bioactivity Info	TI LI LO TS
2	Ki = 5.4 nM Bioactivity Info	TI LI LO TS
CP0395400 Compound Info	2-[4-fluoro-3-[[2-methyl-4-[[(2S)-4-methyl-2,3-dihydro-1,4-benzoxazin-2-yl]methoxy]benzoyl]amino]phenyl]acetic acid Show/Hide	C26H25FN2O5	2
1	IC50 = 1.8 nM Bioactivity Info	TI LI LO TS
2	Ki = 19 nM Bioactivity Info	TI LI LO TS
CP0388266 Compound Info	2-[1-[2-chloro-4-[[(2S)-4-methyl-2,3-dihydro-1,4-benzoxazin-2-yl]methoxy]benzoyl]-2-methylindol-3-yl]acetic acid Show/Hide	C28H25ClN2O5	2
1	IC50 = 2.2 nM Bioactivity Info	TI LI LO TS
2	Ki = 4.4 nM Bioactivity Info	TI LI LO TS
CP0388465 Compound Info	2-[1-[4-[[(2R)-1-ethyl-2,3-dihydroindol-2-yl]methoxy]-2-methylbenzoyl]-2-methylindol-3-yl]acetic acid Show/Hide	C30H30N2O4	2
1	IC50 = 2.2 nM Bioactivity Info	TI LI LO TS
2	Ki = 4.8 nM Bioactivity Info	TI LI LO TS
CP0400679 Compound Info	2-[2-methyl-1-[4-[[(2S)-4-methyl-2,3-dihydro-1,4-benzoxazin-2-yl]methoxy]benzoyl]indol-4-yl]acetic acid Show/Hide	C28H26N2O5	3
1	IC50 = 2.4 nM Bioactivity Info	TI LI LO TS
2	Ki = 10 nM Bioactivity Info	TI LI LO TS
3	Ki = 16 nM Bioactivity Info	TI LI LO TS
CP0426665 Compound Info	2-[1-[2-fluoro-4-[[(2S)-4-methyl-2,3-dihydro-1,4-benzoxazin-2-yl]methoxy]benzoyl]-2-methylindol-3-yl]acetic acid Show/Hide	C28H25FN2O5	2
1	IC50 = 2.5 nM Bioactivity Info	TI LI LO TS
2	Ki = 3.8 nM Bioactivity Info	TI LI LO TS
CP0522197 Compound Info	2-[1-[2,5-dimethyl-4-[[(2S)-4-methyl-2,3-dihydro-1,4-benzoxazin-2-yl]methoxy]benzoyl]-5-fluoro-2-methylindol-3-yl]acetic acid Show/Hide	C30H29FN2O5	2
1	IC50 = 2.8 nM Bioactivity Info	TI LI LO TS
2	Ki = 14 nM Bioactivity Info	TI LI LO TS
CP0388265 Compound Info	2-[1-[4-[(1-ethyl-2,3-dihydroindol-2-yl)methoxy]-2-methylbenzoyl]-2-methylindol-3-yl]acetic acid Show/Hide	C30H30N2O4	2
1	IC50 = 3.1 nM Bioactivity Info	TI LI LO TS
2	Ki = 22 nM Bioactivity Info	TI LI LO TS
CP0428289 Compound Info	2-[5-chloro-2-methyl-1-[4-[[(2S)-4-methyl-2,3-dihydro-1,4-benzoxazin-2-yl]methoxy]benzoyl]indol-3-yl]acetic acid Show/Hide	C28H25ClN2O5	2
1	IC50 = 3.1 nM Bioactivity Info	TI LI LO TS
2	Ki = 29 nM Bioactivity Info	TI LI LO TS
CP0375086 Compound Info	2-[5-fluoro-2-methyl-1-[2-methyl-4-[[(2S)-4-methyl-2,3-dihydro-1,4-benzoxazin-2-yl]methoxy]benzoyl]indol-3-yl]acetic acid Show/Hide	C29H27FN2O5	2
1	IC50 = 3.2 nM Bioactivity Info	TI LI LO TS
2	Ki = 2.7 nM Bioactivity Info	TI LI LO TS
CP0494477 Compound Info	2-[3-[[2-methyl-4-[[(2S)-4-methyl-2,3-dihydro-1,4-benzoxazin-2-yl]methoxy]benzoyl]amino]phenyl]acetic acid Show/Hide	C26H26N2O5	2
1	IC50 = 3.3 nM Bioactivity Info	TI LI LO TS
2	Ki = 18 nM Bioactivity Info	TI LI LO TS
CP0387733 Compound Info	2-[3-methyl-5-[[2-methyl-4-[[(2S)-4-methyl-2,3-dihydro-1,4-benzoxazin-2-yl]methoxy]benzoyl]amino]phenyl]acetic acid Show/Hide	C27H28N2O5	2
1	IC50 = 3.4 nM Bioactivity Info	TI LI LO TS
2	Ki = 8.4 nM Bioactivity Info	TI LI LO TS
CP0440837 Compound Info	2-[3-[[2,6-dimethyl-4-[[(2S)-4-methyl-2,3-dihydro-1,4-benzoxazin-2-yl]methoxy]benzoyl]amino]phenyl]acetic acid Show/Hide	C27H28N2O5	1
1	IC50 = 3.5 nM Bioactivity Info	TI LI LO TS
CP0526898 Compound Info	2-[1-[4-[[(3R)-2,3-dihydro-1,4-benzodioxin-3-yl]methoxy]-2-methylbenzoyl]-2-methylindol-3-yl]acetic acid Show/Hide	C28H25NO6	2
1	IC50 = 3.8 nM Bioactivity Info	TI LI LO TS
2	Ki = 22 nM Bioactivity Info	TI LI LO TS
CP0508011 Compound Info	2-[5-[[2-chloro-4-[[(2S)-4-methyl-2,3-dihydro-1,4-benzoxazin-2-yl]methoxy]benzoyl]amino]-2-methylphenyl]acetic acid Show/Hide	C26H25ClN2O5	2
1	IC50 = 3.9 nM Bioactivity Info	TI LI LO TS
2	Ki = 17 nM Bioactivity Info	TI LI LO TS
CP0376006 Compound Info	2-[2,5-dimethyl-1-[4-[[(2S)-4-methyl-2,3-dihydro-1,4-benzoxazin-2-yl]methoxy]benzoyl]indol-3-yl]acetic acid Show/Hide	C29H28N2O5	2
1	IC50 = 4.3 nM Bioactivity Info	TI LI LO TS
2	Ki = 28 nM Bioactivity Info	TI LI LO TS
CP0380709 Compound Info	2-[4-chloro-3-[[2-chloro-4-[[(2S)-4-methyl-2,3-dihydro-1,4-benzoxazin-2-yl]methoxy]benzoyl]amino]phenyl]acetic acid Show/Hide	C25H22Cl2N2O5	2
1	IC50 = 4.3 nM Bioactivity Info	TI LI LO TS
2	Ki = 13 nM Bioactivity Info	TI LI LO TS
CP0400399 Compound Info	2-[4-chloro-3-[[4-[[(3R)-2,3-dihydro-1,4-benzodioxin-3-yl]methoxy]-2,6-dimethylbenzoyl]amino]phenyl]acetic acid Show/Hide	C26H24ClNO6	1
1	IC50 = 4.3 nM Bioactivity Info	TI LI LO TS
CP0377711 Compound Info	2-[4-methyl-3-[[2-methyl-4-[[(2S)-4-methyl-2,3-dihydro-1,4-benzoxazin-2-yl]methoxy]benzoyl]amino]phenyl]acetic acid Show/Hide	C27H28N2O5	2
1	IC50 = 4.6 nM Bioactivity Info	TI LI LO TS
2	Ki = 31 nM Bioactivity Info	TI LI LO TS
CP0440293 Compound Info	2-[3-[[2,6-dimethyl-4-[[(2S)-4-methyl-2,3-dihydro-1,4-benzoxazin-2-yl]methoxy]benzoyl]amino]-4-methylphenyl]acetic acid Show/Hide	C28H30N2O5	1
1	IC50 = 4.8 nM Bioactivity Info	TI LI LO TS
CP0395341 Compound Info	2-[4-chloro-3-[[2,5-dimethyl-4-[[(2S)-4-methyl-2,3-dihydro-1,4-benzoxazin-2-yl]methoxy]benzoyl]amino]phenyl]acetic acid Show/Hide	C27H27ClN2O5	1
1	IC50 = 5.1 nM Bioactivity Info	TI LI LO TS
CP0504886 Compound Info	2-[3-[[2-chloro-4-[[(2S)-4-methyl-2,3-dihydro-1,4-benzoxazin-2-yl]methoxy]benzoyl]amino]-5-methylphenyl]acetic acid Show/Hide	C26H25ClN2O5	2
1	IC50 = 5.4 nM Bioactivity Info	TI LI LO TS
2	Ki = 12 nM Bioactivity Info	TI LI LO TS
CP0494490 Compound Info	2-[3-fluoro-5-[[2-methyl-4-[[(2S)-4-methyl-2,3-dihydro-1,4-benzoxazin-2-yl]methoxy]benzoyl]amino]phenyl]acetic acid Show/Hide	C26H25FN2O5	2
1	IC50 = 5.6 nM Bioactivity Info	TI LI LO TS
2	Ki = 7.4 nM Bioactivity Info	TI LI LO TS
CP0428349 Compound Info	2-[3-[[2,5-dimethyl-4-[[(2S)-4-methyl-2,3-dihydro-1,4-benzoxazin-2-yl]methoxy]benzoyl]amino]-4-methylphenyl]acetic acid Show/Hide	C28H30N2O5	1
1	IC50 = 5.7 nM Bioactivity Info	TI LI LO TS
CP0387918 Compound Info	2-[3-[[2-chloro-4-[[(2S)-4-methyl-2,3-dihydro-1,4-benzoxazin-2-yl]methoxy]benzoyl]amino]-4-methylphenyl]acetic acid Show/Hide	C26H25ClN2O5	2
1	IC50 = 6 nM Bioactivity Info	TI LI LO TS
2	Ki = 26 nM Bioactivity Info	TI LI LO TS
CP0424871 Compound Info	2-[2-methyl-5-[[2-methyl-4-[[(2S)-4-methyl-2,3-dihydro-1,4-benzoxazin-2-yl]methoxy]benzoyl]amino]phenyl]acetic acid Show/Hide	C27H28N2O5	2
1	IC50 = 6.1 nM Bioactivity Info	TI LI LO TS
2	Ki = 11 nM Bioactivity Info	TI LI LO TS
CP0429496 Compound Info	2-[2-methyl-1-[2-methyl-4-[(1-methyl-2,3-dihydroindol-2-yl)methoxy]benzoyl]indol-3-yl]acetic acid Show/Hide	C29H28N2O4	1
1	IC50 = 6.2 nM Bioactivity Info	TI LI LO TS
CP0501236 Compound Info	2-[1-[4-[[(2S)-2,3-dihydro-1-benzofuran-2-yl]methoxy]-2-methylbenzoyl]-2-methylindol-3-yl]acetic acid Show/Hide	C28H25NO5	2
1	IC50 = 7 nM Bioactivity Info	TI LI LO TS
2	Ki = 7.1 nM Bioactivity Info	TI LI LO TS
CP0488203 Compound Info	2-[4-chloro-3-[[2-chloro-4-[[(2S)-4-methyl-2,3-dihydro-1,4-benzoxazin-2-yl]methoxy]benzoyl]amino]phenyl]-2-methylpropanoic acid Show/Hide	C27H26Cl2N2O5	1
1	IC50 = 7 nM Bioactivity Info	TI LI LO TS
CP0390164 Compound Info	2-[3-[[2-chloro-4-[[(2S)-4-methyl-2,3-dihydro-1,4-benzoxazin-2-yl]methoxy]benzoyl]amino]-4-fluorophenyl]acetic acid Show/Hide	C25H22ClFN2O5	2
1	IC50 = 7.4 nM Bioactivity Info	TI LI LO TS
2	Ki = 17 nM Bioactivity Info	TI LI LO TS
CP0392026 Compound Info	2-[4-chloro-3-[[2,6-dimethyl-4-[[(2S)-4-methyl-2,3-dihydro-1,4-benzoxazin-2-yl]methoxy]benzoyl]amino]phenyl]acetic acid Show/Hide	C27H27ClN2O5	2
1	IC50 = 7.6 nM Bioactivity Info	TI LI LO TS
2	Ki = 6.4 nM Bioactivity Info	TI LI LO TS
CP0390792 Compound Info	2-[3-[[2,3-dimethyl-4-[[(2S)-4-methyl-2,3-dihydro-1,4-benzoxazin-2-yl]methoxy]benzoyl]amino]-4-methylphenyl]acetic acid Show/Hide	C28H30N2O5	1
1	IC50 = 12 nM Bioactivity Info	TI LI LO TS
CP0492364 Compound Info	2-[4-chloro-3-[[4-[[(2S)-2,3-dihydro-1-benzofuran-2-yl]methoxy]-2,6-dimethylbenzoyl]amino]phenyl]acetic acid Show/Hide	C26H24ClNO5	1
1	IC50 = 14 nM Bioactivity Info	TI LI LO TS
CP0380708 Compound Info	2-[2-methoxy-5-[[2-methyl-4-[[(2S)-4-methyl-2,3-dihydro-1,4-benzoxazin-2-yl]methoxy]benzoyl]amino]phenyl]acetic acid Show/Hide	C27H28N2O6	2
1	IC50 = 20 nM Bioactivity Info	TI LI LO TS
2	Ki = 24 nM Bioactivity Info	TI LI LO TS
CP0387919 Compound Info	2-[3-[[2-chloro-4-[[(2S)-4-methyl-2,3-dihydro-1,4-benzoxazin-2-yl]methoxy]benzoyl]amino]phenyl]acetic acid Show/Hide	C25H23ClN2O5	2
1	IC50 = 20 nM Bioactivity Info	TI LI LO TS
2	Ki = 16 nM Bioactivity Info	TI LI LO TS
CP0387895 Compound Info	2-[3-[[2,3-dimethyl-4-[[(2S)-4-methyl-2,3-dihydro-1,4-benzoxazin-2-yl]methoxy]benzoyl]amino]phenyl]acetic acid Show/Hide	C27H28N2O5	1
1	IC50 = 22 nM Bioactivity Info	TI LI LO TS
CP0387920 Compound Info	2-[4-chloro-3-[[2,6-dimethyl-4-[[(3R)-5-methyl-2,3-dihydro-1-benzofuran-3-yl]methoxy]benzoyl]amino]phenyl]acetic acid Show/Hide	C27H26ClNO5	1
1	IC50 = 24 nM Bioactivity Info	TI LI LO TS
CP0427969 Compound Info	1-[4-chloro-3-[[2,5-dimethyl-4-[[(2S)-4-methyl-2,3-dihydro-1,4-benzoxazin-2-yl]methoxy]benzoyl]amino]phenyl]cyclopropane-1-carboxylic acid Show/Hide	C29H29ClN2O5	1
1	IC50 = 26 nM Bioactivity Info	TI LI LO TS
CP0456656 Compound Info	2-[3-[[4-(1,3-benzodioxol-2-ylmethoxy)-2,6-dimethylbenzoyl]amino]-4-chlorophenyl]acetic acid Show/Hide	C25H22ClNO6	1
1	IC50 = 27 nM Bioactivity Info	TI LI LO TS
CP0494491 Compound Info	2-[2-methyl-3-[[2-methyl-4-[[(2S)-4-methyl-2,3-dihydro-1,4-benzoxazin-2-yl]methoxy]benzoyl]amino]phenyl]acetic acid Show/Hide	C27H28N2O5	2
1	IC50 = 28 nM Bioactivity Info	TI LI LO TS
2	Ki = 59 nM Bioactivity Info	TI LI LO TS
CP0466860 Compound Info	2-[3-[[2,5-dimethyl-4-[[(2S)-4-methyl-2,3-dihydro-1,4-benzoxazin-2-yl]methoxy]benzoyl]amino]phenyl]acetic acid Show/Hide	C27H28N2O5	1
1	IC50 = 28 nM Bioactivity Info	TI LI LO TS
CP0455189 Compound Info	2-[1-[2,3-dimethyl-4-[[(2S)-4-methyl-2,3-dihydro-1,4-benzoxazin-2-yl]methoxy]benzoyl]-5-fluoro-2-methylindol-3-yl]acetic acid Show/Hide	C30H29FN2O5	1
1	IC50 = 32 nM Bioactivity Info	TI LI LO TS
CP0424942 Compound Info	2-[5-[[2-chloro-4-[[(2S)-4-methyl-2,3-dihydro-1,4-benzoxazin-2-yl]methoxy]benzoyl]amino]-2-methoxyphenyl]acetic acid Show/Hide	C26H25ClN2O6	2
1	IC50 = 41 nM Bioactivity Info	TI LI LO TS
2	Ki = 36 nM Bioactivity Info	TI LI LO TS
CP0388263 Compound Info	2-[5-fluoro-2-methyl-1-[3-methyl-4-[[(2S)-4-methyl-2,3-dihydro-1,4-benzoxazin-2-yl]methoxy]benzoyl]indol-3-yl]acetic acid Show/Hide	C29H27FN2O5	2
1	IC50 = 42 nM Bioactivity Info	TI LI LO TS
2	Ki = 59 nM Bioactivity Info	TI LI LO TS
CP0431700 Compound Info	2-[1-[4-(1,3-benzodioxol-2-ylmethoxy)-2-methylbenzoyl]-2-methylindol-3-yl]acetic acid Show/Hide	C27H23NO6	1
1	IC50 = 43 nM Bioactivity Info	TI LI LO TS
CP0456657 Compound Info	2-[4-chloro-3-[[2,5-dimethyl-4-[[(2S)-4-methyl-2,3-dihydro-1,4-benzoxazin-2-yl]methoxy]benzoyl]amino]phenyl]-2-methylpropanoic acid Show/Hide	C29H31ClN2O5	1
1	IC50 = 43 nM Bioactivity Info	TI LI LO TS
CP0374553 Compound Info	2-[2-methyl-1-[4-(2-phenoxyethoxy)benzoyl]indol-4-yl]acetic acid Show/Hide	C26H23NO5	2
1	IC50 = 50 nM Bioactivity Info	TI LI LO TS
2	Ki = 10 nM Bioactivity Info	TI LI LO TS
CP0460176 Compound Info	2-[5-[[2-chloro-4-[[(2S)-4-methyl-2,3-dihydro-1,4-benzoxazin-2-yl]methoxy]benzoyl]amino]-2-fluorophenyl]acetic acid Show/Hide	C25H22ClFN2O5	2
1	IC50 = 50 nM Bioactivity Info	TI LI LO TS
2	Ki = 25 nM Bioactivity Info	TI LI LO TS
CP0456655 Compound Info	2-[4-chloro-3-[[2,3-dimethyl-4-[[(2S)-4-methyl-2,3-dihydro-1,4-benzoxazin-2-yl]methoxy]benzoyl]amino]phenyl]acetic acid Show/Hide	C27H27ClN2O5	2
1	IC50 = 54 nM Bioactivity Info	TI LI LO TS
2	Ki = 28 nM Bioactivity Info	TI LI LO TS
CP0425410 Compound Info	2-[5-fluoro-1-[3-methoxy-4-[[(2S)-4-methyl-2,3-dihydro-1,4-benzoxazin-2-yl]methoxy]benzoyl]-2-methylindol-3-yl]acetic acid Show/Hide	C29H27FN2O6	1
1	IC50 = 68 nM Bioactivity Info	TI LI LO TS
CP0425412 Compound Info	2-[1-[4-[[(3R)-2,3-dihydro-1-benzofuran-3-yl]methoxy]-2-methylbenzoyl]-2-methylindol-3-yl]acetic acid Show/Hide	C28H25NO5	2
1	IC50 = 72 nM Bioactivity Info	TI LI LO TS
2	Ki = 43 nM Bioactivity Info	TI LI LO TS
CP0486399 Compound Info	2-[2-methyl-1-[4-(2-phenylethoxy)benzoyl]indol-4-yl]acetic acid Show/Hide	C26H23NO4	2
1	IC50 = 120 nM Bioactivity Info	TI LI LO TS
2	Ki = 1.8 nM Bioactivity Info	TI LI LO TS
CP0424870 Compound Info	2-[3-[[4-[[(2S)-4-methyl-2,3-dihydro-1,4-benzoxazin-2-yl]methoxy]benzoyl]amino]phenyl]acetic acid Show/Hide	C25H24N2O5	2
1	IC50 = 220 nM Bioactivity Info	TI LI LO TS
2	Ki = 310 nM Bioactivity Info	TI LI LO TS
CP0485456 Compound Info	2-[1-(4-butoxybenzoyl)-2-methylindol-4-yl]acetic acid Show/Hide	C22H23NO4	2
1	IC50 = 300 nM Bioactivity Info	TI LI LO TS
2	Ki = 10 nM Bioactivity Info	TI LI LO TS
CP0442227 Compound Info	2-[2-methyl-1-(4-phenylmethoxybenzoyl)indol-4-yl]acetic acid Show/Hide	C25H21NO4	2
1	IC50 = 1300 nM Bioactivity Info	TI LI LO TS
2	Ki = 60 nM Bioactivity Info	TI LI LO TS
CP0388261 Compound Info	2-[2-methyl-1-[4-[[(2S)-4-methyl-2,3-dihydro-1,4-benzoxazin-2-yl]methoxy]benzoyl]indol-3-yl]acetic acid Show/Hide	C28H26N2O5	1
1	Ki = 7.7 nM Bioactivity Info	TI LI LO TS
CP0387731 Compound Info	2-[4-chloro-3-[[2-methyl-4-[[(2S)-4-methyl-2,3-dihydro-1,4-benzoxazin-2-yl]methoxy]benzoyl]amino]phenyl]acetic acid Show/Hide	C26H25ClN2O5	1
1	Ki = 7.7 nM Bioactivity Info	TI LI LO TS
CP0486387 Compound Info	2-[1-[4-(1,3-benzodioxol-2-ylmethoxy)benzoyl]-2-methylindol-4-yl]acetic acid Show/Hide	C26H21NO6	1
1	Ki = 9.4 nM Bioactivity Info	TI LI LO TS
CP0378356 Compound Info	2-[5-methoxy-2-methyl-1-[4-[[(2S)-4-methyl-2,3-dihydro-1,4-benzoxazin-2-yl]methoxy]benzoyl]indol-3-yl]acetic acid Show/Hide	C29H28N2O6	1
1	Ki = 9.9 nM Bioactivity Info	TI LI LO TS
CP0439527 Compound Info	2-[1-[4-[[(3R)-2,3-dihydro-1,4-benzodioxin-3-yl]methoxy]benzoyl]-2-methylindol-4-yl]acetic acid Show/Hide	C27H23NO6	1
1	Ki = 10 nM Bioactivity Info	TI LI LO TS
CP0451828 Compound Info	2-[1-[4-(2,3-dihydro-1-benzofuran-2-ylmethoxy)benzoyl]-2-methylindol-4-yl]acetic acid Show/Hide	C27H23NO5	1
1	Ki = 20 nM Bioactivity Info	TI LI LO TS
CP0486394 Compound Info	2-[1-[4-(3,4-dihydro-2H-chromen-2-ylmethoxy)benzoyl]-2-methylindol-4-yl]acetic acid Show/Hide	C28H25NO5	1
1	Ki = 60 nM Bioactivity Info	TI LI LO TS
CP0442380 Compound Info	2-[1-[4-[[(3S)-2,3-dihydro-1,4-benzodioxin-3-yl]methoxy]benzoyl]-2-methylindol-4-yl]acetic acid Show/Hide	C27H23NO6	1
1	Ki = 120 nM Bioactivity Info	TI LI LO TS
CP0501234 Compound Info	2-[2-methyl-1-[3-methyl-4-[[(2S)-4-methyl-2,3-dihydro-1,4-benzoxazin-2-yl]methoxy]benzoyl]indol-3-yl]acetic acid Show/Hide	C29H28N2O5	1
1	Ki = 140 nM Bioactivity Info	TI LI LO TS
CP0445848 Compound Info	2-[2-methyl-1-[4-(3-phenylpropoxy)benzoyl]indol-4-yl]acetic acid Show/Hide	C27H25NO4	1
1	Ki = 170 nM Bioactivity Info	TI LI LO TS
CP0445860 Compound Info	2-[1-[4-(3,4-dihydro-2H-chromen-3-ylmethoxy)benzoyl]-2-methylindol-4-yl]acetic acid Show/Hide	C28H25NO5	1
1	Ki = 180 nM Bioactivity Info	TI LI LO TS
CP0437055 Compound Info	2-[1-[4-[[(2S)-7-fluoro-4-methyl-2,3-dihydro-1,4-benzoxazin-2-yl]methoxy]benzoyl]-2-methylindol-4-yl]acetic acid Show/Hide	C28H25FN2O5	1
1	Ki = 230 nM Bioactivity Info	TI LI LO TS
CP0485482 Compound Info	2-[2-methyl-1-[4-[[(2R)-4-methyl-2,3-dihydro-1,4-benzoxazin-2-yl]methoxy]benzoyl]indol-4-yl]acetic acid Show/Hide	C28H26N2O5	1
1	Ki = 230 nM Bioactivity Info	TI LI LO TS
CP0375085 Compound Info	2-[1-[3-fluoro-4-[[(2S)-4-methyl-2,3-dihydro-1,4-benzoxazin-2-yl]methoxy]benzoyl]-2-methylindol-3-yl]acetic acid Show/Hide	C28H25FN2O5	1
1	Ki = 240 nM Bioactivity Info	TI LI LO TS
CP0501235 Compound Info	2-[1-[3-methoxy-4-[[(2S)-4-methyl-2,3-dihydro-1,4-benzoxazin-2-yl]methoxy]benzoyl]-2-methylindol-3-yl]acetic acid Show/Hide	C29H28N2O6	1
1	Ki = 340 nM Bioactivity Info	TI LI LO TS
CP0499126 Compound Info	2-[1-[2,5-dimethyl-4-[[(2S)-4-methyl-2,3-dihydro-1,4-benzoxazin-2-yl]methoxy]benzoyl]-2-methylindol-3-yl]acetic acid Show/Hide	C30H30N2O5	1
1	Ki = 360 nM Bioactivity Info	TI LI LO TS
CP0508259 Compound Info	2-[1-[2,3-dimethyl-4-[[(2S)-4-methyl-2,3-dihydro-1,4-benzoxazin-2-yl]methoxy]benzoyl]-2-methylindol-3-yl]acetic acid Show/Hide	C30H30N2O5	1
1	Ki = 380 nM Bioactivity Info	TI LI LO TS
CP0534788 Compound Info	2-[1-[3-chloro-4-[[(2S)-4-methyl-2,3-dihydro-1,4-benzoxazin-2-yl]methoxy]benzoyl]-2-methylindol-3-yl]acetic acid Show/Hide	C28H25ClN2O5	1
1	Ki = 380 nM Bioactivity Info	TI LI LO TS
CP0482040 Compound Info	2-[3-[[4-[[(2S)-4-methyl-2,3-dihydro-1,4-benzoxazin-2-yl]methoxy]phenyl]sulfonylamino]phenyl]acetic acid Show/Hide	C24H24N2O6S	1
1	Ki = 430 nM Bioactivity Info	TI LI LO TS
CP0426154 Compound Info	2-[3-[methyl-[4-[[(2S)-4-methyl-2,3-dihydro-1,4-benzoxazin-2-yl]methoxy]benzoyl]amino]phenyl]acetic acid Show/Hide	C26H26N2O5	1
1	Ki = 760 nM Bioactivity Info	TI LI LO TS
CP0375591 Compound Info	2-[3-[ethyl-[4-[[(2S)-4-methyl-2,3-dihydro-1,4-benzoxazin-2-yl]methoxy]benzoyl]amino]phenyl]acetic acid Show/Hide	C27H28N2O5	1
1	Ki = 770 nM Bioactivity Info	TI LI LO TS
CP0432807 Compound Info	2-[1-[4-[[(2S)-4-methyl-2,3-dihydro-1,4-benzoxazin-2-yl]methoxy]benzoyl]indol-4-yl]acetic acid Show/Hide	C27H24N2O5	1
1	Ki = 1700 nM Bioactivity Info	TI LI LO TS
CP0431260 Compound Info	2-[3-[[4-[[(2S)-4-methyl-2,3-dihydro-1,4-benzoxazin-2-yl]methoxy]phenyl]carbamoyl]phenyl]acetic acid Show/Hide	C25H24N2O5	1
1	Ki = 5300 nM Bioactivity Info	TI LI LO TS
CP0010057 Compound Info	2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl-1H-indol-3-yl}acetic acid Show/Hide	C19H16ClNO4	1
1	Ki > 10000 nM Bioactivity Info	TI LI LO TS

Biochemical Assays

Compound ID	Compound Name	Compound Formula
CP0010057 Compound Info	2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl-1H-indol-3-yl}acetic acid Show/Hide	C19H16ClNO4	2
1	IC50 > 10000 nM
2	Ki > 10000 nM

Similar Protein(s) and Bioactivity Statistics

50% Identity

Protein ID	Protein Name	Protein Organism
PT01054	Prostaglandin D2 receptor	Homo sapiens, Human	Protein Info

Cite

About MolBiC

Correspondence

Prof. Feng ZHU

Prof. Leo, Lianyi Han