General Information of the Protein
| Protein ID |
PT01054
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| Protein Name |
Prostaglandin D2 receptor
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| Secondarily Protein Name |
Prostanoid DP receptor
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| Gene Name |
PTGDR
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| Sequence |
MKSPFYRCQNTTSVEKGNSAVMGGVLFSTGLLGNLLALGLLARSGLGWCSRRPLRPLPSVFYMLVCGLTVTDLLGKCLLSPVVLAAYAQNRSLRVLAPALDNSLCQAFAFFMSFFGLSSTLQLLAMALECWLSLGHPFFYRRHITLRLGALVAPVVSAFSLAFCALPFMGFGKFVQYCPGTWCFIQMVHEEGSLSVLGYSVLYSSLMALLVLATVLCNLGAMRNLYAMHRRLQRHPRSCTRDCAEPRADGREASPQPLEELDHLLLLALMTVLFTMCSLPVIYRAYYGAFKDVKEKNRTSEEAEDLRALRFLSVISIVDPWIFIIFRSPVFRIFFHKIFIRPLRYRSRCSNSTNMESSL
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| Organism |
Homo sapiens, Human
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| Protein Classification |
Membrane receptor
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Family A G protein-coupled receptor
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Small molecule receptor (family A GPCR)
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Lipid-like ligand receptor (family A GPCR)
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Prostanoid receptor
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| Function |
Receptor for prostaglandin D2 (PGD2). The activity of this receptor is mainly mediated by G(s) proteins that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. A mobilization of calcium is also observed, but without formation of inositol 1,4,5-trisphosphate (By similarity). Involved in PLA2G3-dependent maturation of mast cells. PLA2G3 is secreted by immature mast cells and acts on nearby fibroblasts upstream to PTDGS to synthesize PGD2, which in turn promotes mast cell maturation and degranulation via PTGDR (By similarity).
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| Uniprot ID |
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| Subcellular Location |
Cell membrane
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Map of Molecular Bioactivity Related to the Protein
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Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity |
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Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000011 , CHO
Biochemical Assays
Clinical Information about the Protein
Target 1 ( Prostaglandin D2 receptor (PTGDR) )
| Target Type | Clinical trial Target | ||||
|---|---|---|---|---|---|
| Disease | 5 Target-related Diseases | 5 | |||
| 1 | Asthma [ICD-11: CA23] | ||||
| 2 | Allergy [ICD-11: 4A80-4A85] | ||||
| 3 | Solid tumour/cancer [ICD-11: 2A00-2F9Z] | ||||
| 4 | Coronary heart disease [ICD-11: BA80.Z] | ||||
| 5 | Rhinitis [ICD-11: FA20] | ||||
| Approved Drug(s) | 1 Approved Drug | 1 | |||
| 1 | LAROPIPRANT | Phase 4 | |||
| Clinical Trial Drug(s) | 4 Clinical Trial Drugs | 4 | |||
| 1 | Setipiprant | Phase 3 | |||
| 2 | AMG 853 | Phase 2 | |||
| 3 | S-555739 | Phase 2 | |||
| 4 | PGF2alpha | Clinical trial | |||
| Discontinued Drug(s) | 1 Discontinued Drug | 1 | |||
| 1 | S-5751 | Discontinued in Phase 2 | |||
Similar Protein(s) and Bioactivity Statistics
50% Identity
| Protein ID | Protein Name | Protein Organism | |
| PT02987 | Prostaglandin D2 receptor | Mus musculus, Mouse | |
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