Protein Information

General Information of the Protein

Protein ID	PT01367
Protein Name	Prostaglandin E2 receptor EP3 subtype
Secondarily Protein Name	PGE2-R Prostanoid EP3 receptor
Gene Name	PTGER3
Sequence	MKETRGYGGDAPFCTRLNHSYTGMWAPERSAEARGNLTRPPGSGEDCGSVSVAFPITMLLTGFVGNALAMLLVSRSYRRRESKRKKSFLLCIGWLALTDLVGQLLTTPVVIVVYLSKQRWEHIDPSGRLCTFFGLTMTVFGLSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLGVWLAVLAFALLPVLGVGQYTVQWPGTWCFISTGRGGNGTSSSHNWGNLFFASAFAFLGLLALTVTFSCNLATIKALVSRCRAKATASQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLIMMLKMIFNQTSVEHCKTHTEKQKECNFFLIAVRLASLNQILDPWVYLLLRKILLRKFCQIRYHTNNYASSSTSLPCQCSSTLMWSDHLER Show/Hide
Organism	Homo sapiens, Human
Protein Classification	Membrane receptor > Family A G protein-coupled receptor > Small molecule receptor (family A GPCR) > Lipid-like ligand receptor (family A GPCR) > Prostanoid receptor
Function	Receptor for prostaglandin E2 (PGE2) (PubMed:8307176, PubMed:7883006, PubMed:8117308, PubMed:8135729, PubMed:7981210). The activity of this receptor can couple to both the inhibition of adenylate cyclase mediated by G(i) proteins, and to an elevation of intracellular calcium (PubMed:7883006, PubMed:8117308, PubMed:8135729, PubMed:7981210). Required for normal development of fever in response to pyrinogens, including IL1B, prostaglandin E2 and bacterial lipopolysaccharide (LPS). Required for normal potentiation of platelet aggregation by prostaglandin E2, and thus plays a role in the regulation of blood coagulation. Required for increased HCO3(-) secretion in the duodenum in response to mucosal acidification, and thereby contributes to the protection of the mucosa against acid-induced ulceration. Not required for normal kidney function, normal urine volume and osmolality (By similarity). Show/Hide
Uniprot ID	Primary ID: P43115 Secondarily ID: B0AZN4 B1AK19 B5BUP5 O00326 Q12943 Q12944 Q12945 Q147X8 Q16546 Q5CZ59 Q5CZ61 Q5CZ62 Q5CZ63 Q5CZ64 Show/Hide
Ensembl ID	ENSG00000050628
HGNC ID	HGNC:9595
Subcellular Location	Cell membrane

Map of Molecular Bioactivity Related to the Protein

Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity

Table of Molecular Bioactivities Related to the Protein

Cell Line ID: CL000011 , CHO

Cell Line Info

Compound ID	Compound Name	Compound Formula
CP0414301 Compound Info	(Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E,3R)-3-hydroxy-4-phenoxybut-1-enyl]cyclopentyl]-N-methylsulfonylhept-5-enamide Show/Hide	C23H33NO7S	1
1	EC50 = 0.34 nM Bioactivity Info	TI LI LO TS
CP0182637 Compound Info	2-[2-[(4S)-4-[(E,3R)-3-[1-(4-fluorobutyl)cyclobutyl]-3-hydroxyprop-1-enyl]-2-oxo-1,3-oxazolidin-3-yl]ethylsulfanyl]-1,3-thiazole-4-carboxylic acid Show/Hide	C20H27FN2O5S2	1
1	EC50 = 0.7 nM Bioactivity Info	TI LI LO TS
CP0847317 Compound Info	2-{(2R,4aR,5R,6R,7aS)-6-hydroxy-5-[(1E,3R)-3-hydroxy-4-phenoxy-1-buten-1-yl]octahydrocyclopenta[b]pyran-2-yl}-1,3-thiazole-4-carboxylic acid Show/Hide	C22H25NO6S	1
1	EC50 = 0.8 nM Bioactivity Info	TI LI LO TS
CP0415590 Compound Info	2-[2-[(1R,2R)-2-[(E,4S)-4-hydroxy-4-methyloct-1-enyl]-5-oxocyclopentyl]ethylsulfanyl]-1,3-thiazole-4-carboxylic acid Show/Hide	C20H29NO4S2	1
1	EC50 = 0.8 nM Bioactivity Info	TI LI LO TS
CP0451962 Compound Info	(Z)-7-[(1R,2R,3R)-3-hydroxy-2-[(E,3R)-3-hydroxy-4-phenoxybut-1-enyl]-5-oxocyclopentyl]hept-5-enoic acid Show/Hide	C22H28O6	1
1	EC50 = 0.89 nM Bioactivity Info	TI LI LO TS
CP0523517 Compound Info	2-[2-[(1R,2R)-2-[(E,4S)-4-hydroxy-4-methylnon-1-enyl]-5-oxocyclopentyl]ethylsulfanyl]-1,3-thiazole-4-carboxylic acid Show/Hide	C21H31NO4S2	1
1	EC50 = 0.91 nM Bioactivity Info	TI LI LO TS
CP0415586 Compound Info	2-[2-[(1R,2R)-2-[(E,4S)-5-cyclopentyl-4-hydroxy-4-methylpent-1-enyl]-5-oxocyclopentyl]ethylsulfanyl]-1,3-thiazole-4-carboxylic acid Show/Hide	C22H31NO4S2	1
1	EC50 = 1 nM Bioactivity Info	TI LI LO TS
CP0446134 Compound Info	4-[(3R,5aR,6R,7R,8aS)-7-hydroxy-6-[(E,3R)-3-hydroxy-4-phenoxybut-1-enyl]-3,4,5,5a,6,7,8,8a-octahydro-2H-cyclopenta[b]oxepin-3-yl]butanoic acid Show/Hide	C23H32O6	1
1	EC50 = 2.3 nM Bioactivity Info	TI LI LO TS
CP0055947 Compound Info	(15S)-prostaglandin E2 Show/Hide	C20H32O5	1
1	EC50 = 2.5 nM Bioactivity Info	TI LI LO TS
CP0415587 Compound Info	2-[2-[(1R,2R)-2-[(E)-4-hydroxy-4-methylnon-1-enyl]-5-oxocyclopentyl]ethylsulfanyl]-1,3-thiazole-4-carboxylic acid Show/Hide	C21H31NO4S2	1
1	EC50 = 2.7 nM Bioactivity Info	TI LI LO TS
CP0415589 Compound Info	2-[2-[(1R,2R)-2-[(E,4S)-8-fluoro-4-hydroxy-4-methyloct-1-enyl]-5-oxocyclopentyl]ethylsulfanyl]-1,3-thiazole-4-carboxylic acid Show/Hide	C20H28FNO4S2	1
1	EC50 = 3 nM Bioactivity Info	TI LI LO TS
CP0482357 Compound Info	2-[2-[(4S)-4-[(E)-4-hydroxy-4-methylnon-1-enyl]-2-oxo-1,3-oxazolidin-3-yl]ethylsulfanyl]-1,3-thiazole-4-carboxylic acid Show/Hide	C19H28N2O5S2	1
1	EC50 = 3.3 nM Bioactivity Info	TI LI LO TS
CP0407879 Compound Info	2-[2-[(1R,2R)-2-[(E,4S)-4-hydroxy-4,7,7-trimethyloct-1-enyl]-5-oxocyclopentyl]ethylsulfanyl]-1,3-thiazole-4-carboxylic acid Show/Hide	C22H33NO4S2	1
1	EC50 = 3.4 nM Bioactivity Info	TI LI LO TS
CP0450782 Compound Info	2-[2-[(1R,5R)-2-oxo-5-[(E,4S)-7,7,7-trifluoro-4-hydroxy-4-methylhept-1-enyl]cyclopentyl]ethylsulfanyl]-1,3-thiazole-4-carboxylic acid Show/Hide	C19H24F3NO4S2	1
1	EC50 = 3.5 nM Bioactivity Info	TI LI LO TS
CP0858586 Compound Info	4-((2S,4aR,5R,6R,7aS)-6-hydroxy-5-((R,E)-3-hydroxy-4-phenoxybut-1-enyl)octahydrocyclopenta[b]pyran-2-yl)butanoic acid Show/Hide	C22H30O6	1
1	EC50 = 3.6 nM Bioactivity Info	TI LI LO TS
CP0089845 Compound Info	4-[(3S,5aR,6R,7R,8aS)-7-hydroxy-6-[(E,3R)-3-hydroxy-4-phenoxybut-1-enyl]-3,4,5,5a,6,7,8,8a-octahydro-2H-cyclopenta[b]oxepin-3-yl]butanoic acid Show/Hide	C23H32O6	1
1	EC50 = 4 nM Bioactivity Info	TI LI LO TS
CP0398632 Compound Info	4-[(2R,4aR,5R,6R,7aS)-6-hydroxy-5-[(E,3R)-3-hydroxy-4-phenoxybut-1-enyl]-2,3,4,4a,5,6,7,7a-octahydrocyclopenta[b]pyran-2-yl]butanoic acid Show/Hide	C22H30O6	1
1	EC50 = 4.1 nM Bioactivity Info	TI LI LO TS
CP0415588 Compound Info	2-[2-[(4S)-4-[(E)-5-cyclohexyl-4-hydroxy-4-methylpent-1-enyl]-2-oxo-1,3-oxazolidin-3-yl]ethylsulfanyl]-1,3-thiazole-4-carboxylic acid Show/Hide	C21H30N2O5S2	1
1	EC50 = 8.8 nM Bioactivity Info	TI LI LO TS
CP0383051 Compound Info	5-[(5aR,6R,7R,8aS)-7-hydroxy-6-[(E,3R)-3-hydroxy-4-phenoxybut-1-enyl]-5,5a,6,7,8,8a-hexahydro-2H-cyclopenta[b]oxepin-3-yl]pentanoic acid Show/Hide	C24H32O6	1
1	EC50 = 13 nM Bioactivity Info	TI LI LO TS
CP0396047 Compound Info	2-[2-[(1R,2R)-2-[(E,4R)-4-hydroxy-4-methylnon-1-enyl]-5-oxocyclopentyl]ethylsulfanyl]-1,3-thiazole-4-carboxylic acid Show/Hide	C21H31NO4S2	1
1	EC50 = 16 nM Bioactivity Info	TI LI LO TS
CP0517457 Compound Info	3-[(2R,5aR,6R,7R,8aS)-7-hydroxy-6-[(E,3R)-3-hydroxy-4-phenoxybut-1-enyl]-3,4,5,5a,6,7,8,8a-octahydro-2H-cyclopenta[b]oxepin-2-yl]propanoic acid Show/Hide	C22H30O6	1
1	EC50 = 18 nM Bioactivity Info	TI LI LO TS
CP0398630 Compound Info	3-[(2S,5aR,6R,7R,8aS)-7-hydroxy-6-[(E,3R)-3-hydroxy-4-phenoxybut-1-enyl]-3,4,5,5a,6,7,8,8a-octahydro-2H-cyclopenta[b]oxepin-2-yl]propanoic acid Show/Hide	C22H30O6	1
1	EC50 = 27 nM Bioactivity Info	TI LI LO TS
CP0407877 Compound Info	2-[2-[(1R,2R)-2-[(E,4R)-5-cyclopentyl-4-hydroxy-4-methylpent-1-enyl]-5-oxocyclopentyl]ethylsulfanyl]-1,3-thiazole-4-carboxylic acid Show/Hide	C22H31NO4S2	1
1	EC50 = 32 nM Bioactivity Info	TI LI LO TS
CP0407876 Compound Info	2-[2-[(4S,5S)-4-[(E)-5-cyclohexyl-4-hydroxy-4-methylpent-1-enyl]-5-methyl-2-oxo-1,3-oxazolidin-3-yl]ethylsulfanyl]-1,3-thiazole-4-carboxylic acid Show/Hide	C22H32N2O5S2	1
1	EC50 = 36 nM Bioactivity Info	TI LI LO TS
CP0504418 Compound Info	5-[(3R,5aR,6R,7R,8aS)-7-hydroxy-6-[(E,3R)-3-hydroxy-4-phenoxybut-1-enyl]-3,4,5,5a,6,7,8,8a-octahydro-2H-cyclopenta[b]oxepin-3-yl]pentanoic acid Show/Hide	C24H34O6	1
1	EC50 = 130 nM Bioactivity Info	TI LI LO TS
CP0862926 Compound Info	2-{(2R,4aR,5R,6R,7aS)-6-hydroxy-5-[(1E)-4-phenoxy-1-buten-1-yl]octahydrocyclopenta[b]pyran-2-yl}-1,3-thiazole-4-carboxylic acid Show/Hide	C22H25NO5S	1
1	EC50 = 260 nM Bioactivity Info	TI LI LO TS
CP0847322 Compound Info	2-{(2R,4aR,5R,6R,7aS)-6-hydroxy-5-[(1E)-5-phenoxy-1-penten-1-yl]octahydrocyclopenta[b]pyran-2-yl}-1,3-thiazole-4-carboxylic acid Show/Hide	C23H27NO5S	1
1	EC50 = 360 nM Bioactivity Info	TI LI LO TS
CP0414303 Compound Info	5-[(3S,5aR,6R,7R,8aS)-7-hydroxy-6-[(E,3R)-3-hydroxy-4-phenoxybut-1-enyl]-3,4,5,5a,6,7,8,8a-octahydro-2H-cyclopenta[b]oxepin-3-yl]pentanoic acid Show/Hide	C24H34O6	1
1	EC50 = 540 nM Bioactivity Info	TI LI LO TS
CP0446135 Compound Info	3-[(3S,5aR,6R,7R,8aS)-7-hydroxy-6-[(E,3R)-3-hydroxy-4-phenoxybut-1-enyl]-3,4,5,5a,6,7,8,8a-octahydro-2H-cyclopenta[b]oxepin-3-yl]propanoic acid Show/Hide	C22H30O6	1
1	EC50 = 870 nM Bioactivity Info	TI LI LO TS
CP0847320 Compound Info	2-[(2R,4aR,5R,6R,7aS)-6-hydroxy-5-(2-phenoxyethyl)octahydrocyclopenta[b]pyran-2-yl]-1,3-thiazole-4-carboxylic acid Show/Hide	C20H23NO5S	1
1	EC50 = 1400 nM Bioactivity Info	TI LI LO TS
CP0432223 Compound Info	3-[(5aR,6R,7R,8aS)-7-hydroxy-6-[(E,3R)-3-hydroxy-4-phenoxybut-1-enyl]-5,5a,6,7,8,8a-hexahydro-2H-cyclopenta[b]oxepin-3-yl]propanoic acid Show/Hide	C22H28O6	1
1	EC50 = 2700 nM Bioactivity Info	TI LI LO TS
CP0387603 Compound Info	2-[2-[(2R)-2-[(E,3S)-3-hydroxy-4-phenylbut-1-enyl]-5-oxopyrrolidin-1-yl]ethylsulfanyl]-1,3-thiazole-4-carboxylic acid Show/Hide	C20H22N2O4S2	1
1	EC50 = 3000 nM Bioactivity Info	TI LI LO TS
CP0432213 Compound Info	CHEBI:60782 Show/Hide	C23H29F3O6	1
1	EC50 = 3400 nM Bioactivity Info	TI LI LO TS
CP0414304 Compound Info	4-[(5aR,6R,7R,8aS)-7-hydroxy-6-[(E,3R)-3-hydroxy-4-phenoxybut-1-enyl]-5,5a,6,7,8,8a-hexahydro-2H-cyclopenta[b]oxepin-3-yl]butanoic acid Show/Hide	C23H30O6	1
1	EC50 = 4700 nM Bioactivity Info	TI LI LO TS
CP0377468 Compound Info	3-[(3R,5aR,6R,7R,8aS)-7-hydroxy-6-[(E,3R)-3-hydroxy-4-phenoxybut-1-enyl]-3,4,5,5a,6,7,8,8a-octahydro-2H-cyclopenta[b]oxepin-3-yl]propanoic acid Show/Hide	C22H30O6	1
1	EC50 = 4800 nM Bioactivity Info	TI LI LO TS
CP0870958 Compound Info	2-[(2R,4aR,5R,6R,7aS)-6-hydroxy-5-(3-phenoxypropyl)octahydrocyclopenta[b]pyran-2-yl]-1,3-thiazole-4-carboxylic acid Show/Hide	C21H25NO5S	1
1	EC50 = 5800 nM Bioactivity Info	TI LI LO TS
CP0398631 Compound Info	6-[(5aR,6R,7R,8aS)-7-hydroxy-6-[(E,3R)-3-hydroxy-4-phenoxybut-1-enyl]-5,5a,6,7,8,8a-hexahydro-2H-cyclopenta[b]oxepin-3-yl]hexanoic acid Show/Hide	C25H34O6	1
1	EC50 = 6400 nM Bioactivity Info	TI LI LO TS
CP0847318 Compound Info	2-{(2R,4aR,5R,6R,7aS)-6-hydroxy-5-[(1E)-3-phenoxy-1-propen-1-yl]octahydrocyclopenta[b]pyran-2-yl}-1,3-thiazole-4-carboxylic acid Show/Hide	C21H23NO5S	1
1	EC50 = 7600 nM Bioactivity Info	TI LI LO TS
CP0432222 Compound Info	(Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E,3S)-3-hydroxy-5-phenylpent-1-enyl]cyclopentyl]hept-5-enoic acid Show/Hide	C23H32O5	1
1	EC50 = 8600 nM Bioactivity Info	TI LI LO TS
CP0391092 Compound Info	2-[(2R,4aR,5S,6R,7aS)-5-[(4-chloro-3-methylphenoxy)methyl]-6-hydroxy-2,3,4,4a,5,6,7,7a-octahydrocyclopenta[b]pyran-2-yl]-1,3-oxazole-4-carboxylic acid Show/Hide	C20H22ClNO6	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0391098 Compound Info	4-[(2R,4aR,5S,6R,7aS)-5-[(4-chloro-3-methylphenoxy)methyl]-6-hydroxy-2,3,4,4a,5,6,7,7a-octahydrocyclopenta[b]pyran-2-yl]thiophene-2-carboxylic acid Show/Hide	C21H23ClO5S	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0401698 Compound Info	2-[(2R,4aR,5S,6S,7aS)-5-[(4-chloro-3-methylphenoxy)methyl]-6-methoxy-2,3,4,4a,5,6,7,7a-octahydrocyclopenta[b]pyran-2-yl]-1,3-thiazole-4-carboxylic acid Show/Hide	C21H24ClNO5S	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0401699 Compound Info	2-[(2R,4aR,5S,6R,7aS)-5-[(4-chloro-3-methylphenoxy)methyl]-6-hydroxy-2,3,4,4a,5,6,7,7a-octahydrocyclopenta[b]pyran-2-yl]-1,3-thiazole-4-carboxylic acid Show/Hide	C20H22ClNO5S	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0401700 Compound Info	2-[(2R,4aR,5S,6S,7aS)-5-[(4-chloro-3-methylphenoxy)methyl]-6-hydroxy-2,3,4,4a,5,6,7,7a-octahydrocyclopenta[b]pyran-2-yl]-1,3-thiazole-4-carboxylic acid Show/Hide	C20H22ClNO5S	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0401702 Compound Info	2-[(2R,4aR,5S,6S,7aS)-5-[(4-chloro-3-methylphenoxy)methyl]-6-fluoro-2,3,4,4a,5,6,7,7a-octahydrocyclopenta[b]pyran-2-yl]-1,3-thiazole-4-carboxylic acid Show/Hide	C20H21ClFNO4S	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0407410 Compound Info	4-[(2R,4aR,5S,6R,7aS)-5-[(4-chloro-3-methylphenoxy)methyl]-6-hydroxy-2,3,4,4a,5,6,7,7a-octahydrocyclopenta[b]pyran-2-yl]furan-2-carboxylic acid Show/Hide	C21H23ClO6	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0434444 Compound Info	5-[(2R,4aR,5S,6R,7aS)-5-[(4-chloro-3-methylphenoxy)methyl]-6-hydroxy-2,3,4,4a,5,6,7,7a-octahydrocyclopenta[b]pyran-2-yl]furan-2-carboxylic acid Show/Hide	C21H23ClO6	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0380278 Compound Info	2-[(2R,4aR,5S,6R,7aS)-6-hydroxy-5-(phenoxymethyl)-2,3,4,4a,5,6,7,7a-octahydrocyclopenta[b]pyran-2-yl]-1,3-thiazole-4-carboxylic acid Show/Hide	C19H21NO5S	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0926294 Compound Info	2-[6-(8-fluoro-2-naphthyl)-2-oxo-1H-pyridin-3-yl]-N-isopropyl-3-methyl-butanamide Show/Hide	C23H25FN2O2	2
1	IC50 = 1.5 nM Bioactivity Info	TI LI LO TS
2	Ki = 1.1 nM Bioactivity Info	TI LI LO TS
CP0953685 Compound Info	6-(8-fluoro-2-naphthyl)-3-[(1S)-2-methyl-1-[[(3S)-2-oxopyrrolidin-3-yl]methyl]propyl]-1H-pyridin-2-one Show/Hide	C24H25FN2O2	2
1	IC50 = 1.8 nM Bioactivity Info	TI LI LO TS
2	Ki = 1 nM Bioactivity Info	TI LI LO TS
CP0963582 Compound Info	2-[6-(8-fluoro-2-naphthyl)-2-oxo-1H-pyridin-3-yl]-3-methyl-N-(1-methylsulfonyl-4-piperidyl)butanamide Show/Hide	C26H30FN3O4S	2
1	IC50 = 2.2 nM Bioactivity Info	TI LI LO TS
2	Ki = 2 nM Bioactivity Info	TI LI LO TS
CP0911039 Compound Info	2-[6-(8-fluoro-2-naphthyl)-2-oxo-1H-pyridin-3-yl]-3-methyl-N-tetrahydropyran-4-yl-butanamide Show/Hide	C25H27FN2O3	2
1	IC50 = 3.2 nM Bioactivity Info	TI LI LO TS
2	Ki = 2.4 nM Bioactivity Info	TI LI LO TS
CP0926328 Compound Info	N-(1,1-dioxothian-4-yl)-2-[6-(8-fluoro-2-naphthyl)-2-oxo-1H-pyridin-3-yl]-3-methyl-butanamide Show/Hide	C25H27FN2O4S	2
1	IC50 = 5.9 nM Bioactivity Info	TI LI LO TS
2	Ki = 2.6 nM Bioactivity Info	TI LI LO TS
CP0953595 Compound Info	2-[6-(8-fluoro-2-naphthyl)-2-oxo-1H-pyridin-3-yl]-3-methyl-N-(1-methylbenzimidazol-5-yl)butanamide Show/Hide	C28H25FN4O2	2
1	IC50 = 6.3 nM Bioactivity Info	TI LI LO TS
2	Ki = 3.6 nM Bioactivity Info	TI LI LO TS
CP0928198 Compound Info	(Z)-5-(2-cyclopentyl-2-(6-(8-fluoronaphthalen-2-yl)-2-oxo-1,2-dihydropyridin-3-yl)ethylidene)oxazolidine-2,4-dione Show/Hide	C25H21FN2O4	1
1	IC50 = 7 nM Bioactivity Info	TI LI LO TS
CP0871062 Compound Info	(Z)-5-(2-cyclohexyl-2-(6-(8-fluoronaphthalen-2-yl)-2-oxo-1,2-dihydropyridin-3-yl)ethylidene)oxazolidine-2,4-dione Show/Hide	C26H23FN2O4	1
1	IC50 = 8 nM Bioactivity Info	TI LI LO TS
CP0926331 Compound Info	6-(8-fluoro-2-naphthyl)-3-[2-methyl-1-[(Z)-(2-oxopyrrolidin-3-ylidene)methyl]propyl]-1H-pyridin-2-one Show/Hide	C24H23FN2O2	2
1	IC50 = 8.1 nM Bioactivity Info	TI LI LO TS
2	Ki = 5.3 nM Bioactivity Info	TI LI LO TS
CP0957032 Compound Info	6-(8-fluoro-2-naphthyl)-3-[2-methyl-1-[(E)-(2-oxopyrrolidin-3-ylidene)methyl]propyl]-1H-pyridin-2-one Show/Hide	C24H23FN2O2	2
1	IC50 = 8.7 nM Bioactivity Info	TI LI LO TS
2	Ki = 2.2 nM Bioactivity Info	TI LI LO TS
CP0871063 Compound Info	(Z,S)-5-(2-(6-(8-fluoronaphthalen-2-yl)-2-oxo-1,2-dihydropyridin-3-yl)-3-methylbutylidene)oxazolidine-2,4-dione Show/Hide	C23H19FN2O4	1
1	IC50 = 9 nM Bioactivity Info	TI LI LO TS
CP0966323 Compound Info	syn-6-(8-Fluoronaphthalen-2-yl)-2-oxo-1,2-dihydropyridin-3-yl)-3-methylbutyl)thiazolidine-2,4-dione Show/Hide	C23H21FN2O3S	1
1	IC50 = 9 nM Bioactivity Info	TI LI LO TS
CP0953684 Compound Info	2-[6-(8-fluoro-2-naphthyl)-2-oxo-1H-pyridin-3-yl]-N-methoxy-3-methyl-butanamide Show/Hide	C21H21FN2O3	2
1	IC50 = 9.7 nM Bioactivity Info	TI LI LO TS
2	Ki = 2.9 nM Bioactivity Info	TI LI LO TS
CP0964594 Compound Info	(Z,R)-5-(2-(6-(8-fluoronaphthalen-2-yl)-2-oxo-1,2-dihydropyridin-3-yl)-3-methylbutylidene)oxazolidine-2,4-dione Show/Hide	C23H19FN2O4	1
1	IC50 = 10 nM Bioactivity Info	TI LI LO TS
CP0953683 Compound Info	6-(8-fluoro-2-naphthyl)-3-[2-methyl-1-(thiazol-2-ylamino)propyl]-1H-pyridin-2-one Show/Hide	C22H20FN3OS	2
1	IC50 = 10 nM Bioactivity Info	TI LI LO TS
2	Ki = 9.4 nM Bioactivity Info	TI LI LO TS
CP0943549 Compound Info	(Z)-5-(2-(6-(8-Fluoronaphthalen-2-yl)-2-oxo-1,2-dihydropyridin-3-yl)-3-methylbutylidene)-1-methylimidazolidine-2,4-dione Show/Hide	C24H22FN3O3	1
1	IC50 = 11 nM Bioactivity Info	TI LI LO TS
CP0947526 Compound Info	6-(8-fluoro-2-naphthyl)-3-[2-methyl-1-[(2-oxo-1-piperidyl)methyl]propyl]-1H-pyridin-2-one Show/Hide	C25H27FN2O2	2
1	IC50 = 11 nM Bioactivity Info	TI LI LO TS
2	Ki = 2.5 nM Bioactivity Info	TI LI LO TS
CP0911037 Compound Info	2-[6-(8-fluoro-2-naphthyl)-2-oxo-1H-pyridin-3-yl]-N-[2-[2-(2-methoxyethoxy)ethoxy]ethyl]-3-methyl-butanamide Show/Hide	C27H33FN2O5	2
1	IC50 = 12 nM Bioactivity Info	TI LI LO TS
2	Ki = 5 nM Bioactivity Info	TI LI LO TS
CP0953582 Compound Info	6-(8-fluoro-2-naphthyl)-3-[2-methyl-1-(morpholinomethyl)propyl]-1H-pyridin-2-one Show/Hide	C24H27FN2O2	2
1	IC50 = 14 nM Bioactivity Info	TI LI LO TS
2	Ki = 4.1 nM Bioactivity Info	TI LI LO TS
CP0958536 Compound Info	anti-3-(1-(1H-imidazol-2-yl)-2-methylpropyl)-6-(8-fluoronaphthalen-2-yl)pyridin-2(1H)-one Show/Hide	C23H21FN2O4	1
1	IC50 = 15 nM Bioactivity Info	TI LI LO TS
CP0911036 Compound Info	3-[6-(8-fluoro-2-naphthyl)-2-oxo-1H-pyridin-3-yl]-N-isopropyl-4-methyl-pentanamide Show/Hide	C24H27FN2O2	2
1	IC50 = 15 nM Bioactivity Info	TI LI LO TS
2	Ki = 5.8 nM Bioactivity Info	TI LI LO TS
CP0869878 Compound Info	anti-(6-(8-fluoronaphthalen-2-yl)-2-oxo-1,2-dihydropyridin-3-yl)-3-methylbutyl)thiazolidine-2,4-dione Show/Hide	C23H21FN2O3S	1
1	IC50 = 17 nM Bioactivity Info	TI LI LO TS
CP0911031 Compound Info	6-(8-fluoro-2-naphthyl)-3-[2-methyl-1-(4H-1,2,4-triazol-3-ylmethyl)propyl]-1H-pyridin-2-one Show/Hide	C22H21FN4O	2
1	IC50 = 17 nM Bioactivity Info	TI LI LO TS
2	Ki = 10 nM Bioactivity Info	TI LI LO TS
CP0959579 Compound Info	(Z)-5-(2-(6-(8-fluoronaphthalen-2-yl)-2-oxo-1,2-dihydropyridin-3-yl)-3-methylbutylidene)oxazolidine-2,4-dione Show/Hide	C23H19FN2O4	1
1	IC50 = 21 nM Bioactivity Info	TI LI LO TS
CP0960239 Compound Info	6-(8-fluoro-2-naphthyl)-3-[2-methyl-1-(4H-1,2,4-triazol-3-yl)propyl]-1H-pyridin-2-one Show/Hide	C21H19FN4O	2
1	IC50 = 21 nM Bioactivity Info	TI LI LO TS
2	Ki = 12 nM Bioactivity Info	TI LI LO TS
CP0958537 Compound Info	(Z)-5-(3-Ethyl-2-(6-(8-fluoronaphthalen-2-yl)-2-oxo-1,2-dihydropyridin-3-yl)pentylidene)oxazolidine-2,4-dione Show/Hide	C25H23FN2O4	1
1	IC50 = 23 nM Bioactivity Info	TI LI LO TS
CP0960240 Compound Info	2-[6-(8-fluoro-2-naphthyl)-2-oxo-1H-pyridin-3-yl]-N-(2-hydroxyethyl)-3-methyl-butanamide Show/Hide	C22H23FN2O3	2
1	IC50 = 23 nM Bioactivity Info	TI LI LO TS
2	Ki = 3.7 nM Bioactivity Info	TI LI LO TS
CP0965351 Compound Info	2-[6-(8-fluoro-2-naphthyl)-2-oxo-1H-pyridin-3-yl]-3-methyl-N-(4-pyridyl)butanamide Show/Hide	C25H22FN3O2	2
1	IC50 = 24 nM Bioactivity Info	TI LI LO TS
2	Ki = 5.7 nM Bioactivity Info	TI LI LO TS
CP0898452 Compound Info	(Z)-5-(2-(6-(8-fluoronaphthalen-2-yl)-2-oxo-1,2-dihydropyridin-3-yl)-3-methylbutylidene)thiazolidine-2,4-dione Show/Hide	C23H19FN2O3S	1
1	IC50 = 27 nM Bioactivity Info	TI LI LO TS
CP0928197 Compound Info	syn-3-(1-(1H-imidazol-2-yl)-2-methylpropyl)-6-(8-fluoronaphthalen-2-yl)pyridin-2(1H)-one Show/Hide	C23H21FN2O4	1
1	IC50 = 27 nM Bioactivity Info	TI LI LO TS
CP0911042 Compound Info	6-(8-fluoro-2-naphthyl)-3-[2-methyl-1-(2-oxoimidazolidin-1-yl)propyl]-1H-pyridin-2-one Show/Hide	C22H22FN3O2	2
1	IC50 = 28 nM Bioactivity Info	TI LI LO TS
2	Ki = 9.1 nM Bioactivity Info	TI LI LO TS
CP0561451 Compound Info	6-(1-ethyl-4-fluoroindazol-6-yl)-3-[3-(1H-1,2,4-triazol-5-yl)pentan-3-yl]-1H-pyridin-2-one Show/Hide	C21H23FN6O	2
1	IC50 = 29 nM Bioactivity Info	TI LI LO TS
2	Ki = 17 nM Bioactivity Info	TI LI LO TS
CP0957900 Compound Info	5-(2-(6-(8-Fluoronaphthalen-2-yl)-2-oxo-1,2-dihydropyridin-3-yl)-3-methylbutyl)imidazolidine-2,4-dione Show/Hide	C23H22FN3O3	1
1	IC50 = 31 nM Bioactivity Info	TI LI LO TS
CP0556955 Compound Info	(5Z)-5-[2-ethyl-2-[6-(1-ethyl-4-fluoroindazol-6-yl)-2-oxo-1H-pyridin-3-yl]butylidene]-1,3-oxazolidine-2,4-dione Show/Hide	C23H23FN4O4	1
1	IC50 = 33 nM Bioactivity Info	TI LI LO TS
CP0959429 Compound Info	(Z)-5-(2-cyclopropyl-2-(6-(8-fluoronaphthalen-2-yl)-2-oxo-1,2-dihydropyridin-3-yl)ethylidene)oxazolidine-2,4-dione Show/Hide	C23H17FN2O4	1
1	IC50 = 33 nM Bioactivity Info	TI LI LO TS
CP0911030 Compound Info	6-(8-fluoro-2-naphthyl)-3-[1-(1H-imidazol-2-yl)-2-methyl-propyl]-1H-pyridin-2-one Show/Hide	C22H20FN3O	2
1	IC50 = 33 nM Bioactivity Info	TI LI LO TS
2	Ki = 7.3 nM Bioactivity Info	TI LI LO TS
CP0558942 Compound Info	6-(8-fluoronaphthalen-2-yl)-3-[3-(1H-1,2,4-triazol-5-yl)pentan-3-yl]-1H-pyridin-2-one Show/Hide	C22H21FN4O	2
1	IC50 = 36 nM Bioactivity Info	TI LI LO TS
2	Ki = 19 nM Bioactivity Info	TI LI LO TS
CP0953583 Compound Info	6-(8-fluoro-2-naphthyl)-3-[2-methyl-1-(4-methyl-1H-imidazol-2-yl)propyl]-1H-pyridin-2-one Show/Hide	C23H22FN3O	2
1	IC50 = 36 nM Bioactivity Info	TI LI LO TS
2	Ki = 12 nM Bioactivity Info	TI LI LO TS
CP0926330 Compound Info	(E)-[1-[1-[6-(8-fluoro-2-naphthyl)-2-oxo-1H-pyridin-3-yl]-2-methyl-propyl]imidazolidin-2-ylidene]cyanamide Show/Hide	C23H22FN5O	2
1	IC50 = 38 nM Bioactivity Info	TI LI LO TS
2	Ki = 23 nM Bioactivity Info	TI LI LO TS
CP0966326 Compound Info	(Z)-5-(3-(6-(8-fluoronaphthalen-2-yl)-2-oxo-1,2-dihydropyridin-3-yl)-4-methylpentan-2-ylidene)oxazolidine-2,4-dione Show/Hide	C24H21FN2O4	1
1	IC50 = 39 nM Bioactivity Info	TI LI LO TS
CP0955739 Compound Info	3-[1-(2-aminothiazol-5-yl)-2-methyl-propyl]-6-(8-fluoro-2-naphthyl)-1H-pyridin-2-one Show/Hide	C22H20FN3OS	2
1	IC50 = 39 nM Bioactivity Info	TI LI LO TS
2	Ki = 16 nM Bioactivity Info	TI LI LO TS
CP0956167 Compound Info	6-(8-fluoro-2-naphthyl)-3-[2-methyl-1-(2-oxo-1-piperidyl)propyl]-1H-pyridin-2-one Show/Hide	C24H25FN2O2	2
1	IC50 = 40 nM Bioactivity Info	TI LI LO TS
2	Ki = 6.4 nM Bioactivity Info	TI LI LO TS
CP0926335 Compound Info	2-[6-(8-fluoro-2-naphthyl)-2-oxo-1H-pyridin-3-yl]-N-[2-hydroxy-1-(hydroxymethyl)ethyl]-3-methyl-butanamide Show/Hide	C23H25FN2O4	2
1	IC50 = 41 nM Bioactivity Info	TI LI LO TS
2	Ki = 10 nM Bioactivity Info	TI LI LO TS
CP0947528 Compound Info	3-[1-[6-(8-fluoro-2-naphthyl)-2-oxo-1H-pyridin-3-yl]-2-methyl-propyl]-4H-1,2,4-oxadiazol-5-one Show/Hide	C21H18FN3O3	2
1	IC50 = 41 nM Bioactivity Info	TI LI LO TS
2	Ki = 15 nM Bioactivity Info	TI LI LO TS
CP0568404 Compound Info	(5Z)-5-[2-[6-(6,8-difluoronaphthalen-2-yl)-2-oxo-1H-pyridin-3-yl]-2-ethylbutylidene]-1,3-oxazolidine-2,4-dione Show/Hide	C24H20F2N2O4	1
1	IC50 = 45 nM Bioactivity Info	TI LI LO TS
CP0926292 Compound Info	3-[1-(4,5-dimethyl-1H-imidazol-2-yl)-2-methyl-propyl]-6-(8-fluoro-2-naphthyl)-1H-pyridin-2-one Show/Hide	C24H24FN3O	2
1	IC50 = 50 nM Bioactivity Info	TI LI LO TS
2	Ki = 7 nM Bioactivity Info	TI LI LO TS
CP0926327 Compound Info	3-[6-(8-fluoro-2-naphthyl)-2-oxo-1H-pyridin-3-yl]-4-methyl-pentanamide Show/Hide	C21H21FN2O2	2
1	IC50 = 53 nM Bioactivity Info	TI LI LO TS
2	Ki = 5 nM Bioactivity Info	TI LI LO TS
CP0563799 Compound Info	(5Z)-5-[[1-[6-(8-fluoronaphthalen-2-yl)-2-oxo-1H-pyridin-3-yl]cyclopropyl]methylidene]-1,3-oxazolidine-2,4-dione Show/Hide	C22H15FN2O4	1
1	IC50 = 55 nM Bioactivity Info	TI LI LO TS
CP0571745 Compound Info	(5Z)-5-[2-[6-(8-fluoronaphthalen-2-yl)-2-oxo-1H-pyridin-3-yl]-2-methylpropylidene]-1,3-oxazolidine-2,4-dione Show/Hide	C22H17FN2O4	1
1	IC50 = 57 nM Bioactivity Info	TI LI LO TS
CP0558212 Compound Info	(5Z)-5-[2-ethyl-2-[6-(8-fluoronaphthalen-2-yl)-2-oxo-1H-pyridin-3-yl]butylidene]-1,3-oxazolidine-2,4-dione Show/Hide	C24H21FN2O4	1
1	IC50 = 61 nM Bioactivity Info	TI LI LO TS
CP0563796 Compound Info	(5Z)-5-[1-[6-(8-fluoronaphthalen-2-yl)-2-oxo-1H-pyridin-3-yl]-2-methylpropylidene]-1,3-thiazolidine-2,4-dione Show/Hide	C22H17FN2O3S	1
1	IC50 = 63 nM Bioactivity Info	TI LI LO TS
CP0958893 Compound Info	6-(8-fluoro-2-naphthyl)-3-(2-methyl-1-oxazol-2-yl-propyl)-1H-pyridin-2-one Show/Hide	C22H19FN2O2	2
1	IC50 = 64 nM Bioactivity Info	TI LI LO TS
2	Ki = 24 nM Bioactivity Info	TI LI LO TS
CP0955090 Compound Info	5-(2-(6-(8-Fluoronaphthalen-2-yl)-2-oxo-1,2-dihydropyridin-3-yl)-3-methylbutyl)-1-methylimidazo-lidine-2,4-dione Show/Hide	C24H24FN3O3	1
1	IC50 = 65 nM Bioactivity Info	TI LI LO TS
CP0516972 Compound Info	(5Z)-5-[[1-[6-(8-fluoronaphthalen-2-yl)-2-oxo-1H-pyridin-3-yl]cyclopentyl]methylidene]-1,3-oxazolidine-2,4-dione Show/Hide	C24H19FN2O4	1
1	IC50 = 66 nM Bioactivity Info	TI LI LO TS
CP0911040 Compound Info	2-[6-(8-fluoro-2-naphthyl)-2-oxo-1H-pyridin-3-yl]-3-methyl-N-thiazol-2-yl-butanamide Show/Hide	C23H20FN3O2S	2
1	IC50 = 67 nM Bioactivity Info	TI LI LO TS
2	Ki = 28 nM Bioactivity Info	TI LI LO TS
CP0073581 Compound Info	5-(6-naphthalen-2-yl-2-oxo-1H-pyridin-3-yl)-5-propan-2-yl-1,3-oxazolidine-2,4-dione Show/Hide	C21H18N2O4	2
1	IC50 = 68 nM Bioactivity Info	TI LI LO TS
2	Ki = 10 nM Bioactivity Info	TI LI LO TS
CP0926329 Compound Info	3-[1-[(1,1-dioxo-1,4-thiazinan-4-yl)methyl]-2-methyl-propyl]-6-(8-fluoro-2-naphthyl)-1H-pyridin-2-one Show/Hide	C24H27FN2O3S	2
1	IC50 = 68 nM Bioactivity Info	TI LI LO TS
2	Ki = 8.8 nM Bioactivity Info	TI LI LO TS
CP0911032 Compound Info	3-[2-[6-(8-fluoro-2-naphthyl)-2-oxo-1H-pyridin-3-yl]-3-methyl-butyl]-4H-1,2,4-oxadiazol-5-one Show/Hide	C22H20FN3O3	2
1	IC50 = 70 nM Bioactivity Info	TI LI LO TS
2	Ki = 34 nM Bioactivity Info	TI LI LO TS
CP0960238 Compound Info	6-(8-fluoro-2-naphthyl)-3-[1-(1H-imidazol-2-ylmethyl)-2-methyl-propyl]-1H-pyridin-2-one Show/Hide	C23H22FN3O	2
1	IC50 = 76 nM Bioactivity Info	TI LI LO TS
2	Ki = 11 nM Bioactivity Info	TI LI LO TS
CP0957899 Compound Info	(Z)-5-(2-(6-(8-Fluoronaphthalen-2-yl)-2-oxo-1,2-dihydropyridin-3-yl)-3-methylbutylidene)imidazolidine-2,4-dione Show/Hide	C23H20FN3O3	1
1	IC50 = 87 nM Bioactivity Info	TI LI LO TS
CP0543351 Compound Info	6-(1-ethyl-4-fluoroindazol-6-yl)-3-[3-(5-methyl-1H-1,2,4-triazol-3-yl)pentan-3-yl]-1H-pyridin-2-one Show/Hide	C22H25FN6O	2
1	IC50 = 90 nM Bioactivity Info	TI LI LO TS
2	Ki = 34 nM Bioactivity Info	TI LI LO TS
CP0556954 Compound Info	(5Z)-5-[2-ethyl-2-[6-(8-ethylnaphthalen-2-yl)-2-oxo-1H-pyridin-3-yl]butylidene]-1,3-oxazolidine-2,4-dione Show/Hide	C26H26N2O4	1
1	IC50 = 91 nM Bioactivity Info	TI LI LO TS
CP0966319 Compound Info	syn-(6-(8-Fluoronaphthalen-2-yl)-2-oxo-1,2-dihydropyridin-3-yl)-2-methylpropyl)oxazolidine-2,4-dione Show/Hide	C22H19FN2O4	1
1	IC50 = 92 nM Bioactivity Info	TI LI LO TS
CP0966325 Compound Info	(Z)-5-(2-(6-(8-Fluoronaphthalen-2-yl)-5-methyl-2-oxo-1,2-dihydropyridin-3-yl)-3-methylbutylidene)oxazolidine-2,4-dione Show/Hide	C24H21FN2O4	1
1	IC50 = 92 nM Bioactivity Info	TI LI LO TS
CP0548382 Compound Info	6-(1-ethyl-4-fluoroindazol-6-yl)-3-[3-(1-methyl-1,2,4-triazol-3-yl)pentan-3-yl]-1H-pyridin-2-one Show/Hide	C22H25FN6O	2
1	IC50 = 96 nM Bioactivity Info	TI LI LO TS
2	Ki = 39 nM Bioactivity Info	TI LI LO TS
CP0960241 Compound Info	2-[6-(8-fluoro-2-naphthyl)-2-oxo-1H-pyridin-3-yl]-N-[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]-3-methyl-butanamide Show/Hide	C24H27FN2O5	2
1	IC50 = 99 nM Bioactivity Info	TI LI LO TS
2	Ki = 25 nM Bioactivity Info	TI LI LO TS
CP0966322 Compound Info	5-(1-(6-(8-Fluoronaphthalen-2-yl)-2-oxo-1,2-dihydropyridin-3-yl)-2-methylpropyl)thiazolidine-2,4-dione Show/Hide	C22H19FN2O3S	1
1	IC50 = 110 nM Bioactivity Info	TI LI LO TS
CP0485538 Compound Info	6-(1-ethyl-4-fluoroindazol-6-yl)-3-[3-(4-methyl-1,2,4-triazol-3-yl)pentan-3-yl]-1H-pyridin-2-one Show/Hide	C22H25FN6O	2
1	IC50 = 120 nM Bioactivity Info	TI LI LO TS
2	Ki = 54 nM Bioactivity Info	TI LI LO TS
CP0911041 Compound Info	6-(8-fluoro-2-naphthyl)-3-[2-methyl-1-[(4-methylsulfonylpiperazin-1-yl)methyl]propyl]-1H-pyridin-2-one Show/Hide	C25H30FN3O3S	2
1	IC50 = 120 nM Bioactivity Info	TI LI LO TS
2	Ki = 15 nM Bioactivity Info	TI LI LO TS
CP0926336 Compound Info	3-[1-(1,1-dioxothiazinan-2-yl)-2-methyl-propyl]-6-(8-fluoro-2-naphthyl)-1H-pyridin-2-one Show/Hide	C23H25FN2O3S	2
1	IC50 = 122 nM Bioactivity Info	TI LI LO TS
2	Ki = 14 nM Bioactivity Info	TI LI LO TS
CP0953687 Compound Info	6-(8-fluoro-2-naphthyl)-3-[2-methyl-1-(1H-tetrazol-5-ylmethyl)propyl]-1H-pyridin-2-one Show/Hide	C21H20FN5O	2
1	IC50 = 134 nM Bioactivity Info	TI LI LO TS
2	Ki = 34 nM Bioactivity Info	TI LI LO TS
CP0966838 Compound Info	6-(8-fluoro-2-naphthyl)-3-[2-methyl-1-(4H-1,2,4-triazol-3-ylamino)propyl]-1H-pyridin-2-one Show/Hide	C21H20FN5O	2
1	IC50 = 185 nM Bioactivity Info	TI LI LO TS
2	Ki = 22 nM Bioactivity Info	TI LI LO TS
CP0955091 Compound Info	(Z)-5-(2-(6-(8-fluoronaphthalen-2-yl)-2-oxo-2,3-dihydropyridin-3-yl)-2-phenylethylidene)oxazolidine-2,4-dione Show/Hide	C26H17FN2O4	1
1	IC50 = 190 nM Bioactivity Info	TI LI LO TS
CP0957043 Compound Info	3-methyl-2-[6-(2-naphthyl)-2-oxo-1H-pyridin-3-yl]butanamide Show/Hide	C20H20N2O2	2
1	IC50 = 191 nM Bioactivity Info	TI LI LO TS
2	Ki = 18 nM Bioactivity Info	TI LI LO TS
CP0898410 Compound Info	(Z)-5-(2-(6-(8-fluoronaphthalen-2-yl)-2-oxo-1,2-dihydropyridin-3-yl)-3-phenylpropylidene)oxazolidine-2,4-dione Show/Hide	C27H19FN2O4	1
1	IC50 = 200 nM Bioactivity Info	TI LI LO TS
CP0561450 Compound Info	6-(4-ethyl-8-fluoro-2,3-dihydro-1,4-benzoxazin-6-yl)-3-[3-(1H-1,2,4-triazol-5-yl)pentan-3-yl]-1H-pyridin-2-one Show/Hide	C22H26FN5O2	2
1	IC50 = 200 nM Bioactivity Info	TI LI LO TS
2	Ki = 97 nM Bioactivity Info	TI LI LO TS
CP0558213 Compound Info	(5Z)-5-[2-ethyl-2-[6-(4-ethyl-2,3-dihydro-1,4-benzoxazin-6-yl)-2-oxo-1H-pyridin-3-yl]butylidene]-1,3-oxazolidine-2,4-dione Show/Hide	C24H27N3O5	1
1	IC50 = 220 nM Bioactivity Info	TI LI LO TS
CP0871082 Compound Info	5-(1-(6-(8-Fluoronaphthalen-2-yl)-2-oxo-1,2-dihydropyridin-3-yl)-2-methylpropyl)imidazolidine-2,4-dione Show/Hide	C22H20FN3O3	1
1	IC50 = 320 nM Bioactivity Info	TI LI LO TS
CP0966321 Compound Info	5-(1-(6-(8-Fluoronaphthalen-2-yl)-2-oxo-1,2-dihydropyridin-3-yl)-2-methylpropyl)-1-methylimidazolidine-2,4-dione Show/Hide	C23H22FN3O3	1
1	IC50 = 320 nM Bioactivity Info	TI LI LO TS
CP0095751 Compound Info	(5Z,13E,15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dien-1-oic acid Show/Hide	C20H34O5	1
1	IC50 = 322 nM Bioactivity Info	TI LI LO TS
CP0911029 Compound Info	N-(azetidin-3-yl)-2-[6-(8-fluoro-2-naphthyl)-2-oxo-1H-pyridin-3-yl]-3-methyl-butanamide Show/Hide	C23H24FN3O2	2
1	IC50 = 347 nM Bioactivity Info	TI LI LO TS
2	Ki = 14 nM Bioactivity Info	TI LI LO TS
CP0546226 Compound Info	(5Z)-5-[1-[6-(8-fluoronaphthalen-2-yl)-2-oxo-1H-pyridin-3-yl]-2-methylpropylidene]-1-methylimidazolidine-2,4-dione Show/Hide	C23H20FN3O3	1
1	IC50 = 350 nM Bioactivity Info	TI LI LO TS
CP0514831 Compound Info	6-(6,8-difluoronaphthalen-2-yl)-3-[3-(1H-1,2,4-triazol-5-yl)pentan-3-yl]-1H-pyridin-2-one Show/Hide	C22H20F2N4O	2
1	IC50 = 350 nM Bioactivity Info	TI LI LO TS
2	Ki = 89 nM Bioactivity Info	TI LI LO TS
CP0966324 Compound Info	(Z)-5-(2-(5-chloro-6-(8-fluoronaphthalen-2-yl)-2-oxo-1,2-dihydropyridin-3-yl)-3-methylbutylidene)oxazolidine-2,4-dione Show/Hide	C23H18ClFN2O4	1
1	IC50 = 360 nM Bioactivity Info	TI LI LO TS
CP0911035 Compound Info	2-fluoro-2-[6-(8-fluoro-2-naphthyl)-2-oxo-1H-pyridin-3-yl]-3-methyl-butanamide Show/Hide	C20H18F2N2O2	2
1	IC50 = 426 nM Bioactivity Info	TI LI LO TS
2	Ki = 26 nM Bioactivity Info	TI LI LO TS
CP0922698 Compound Info	N-(2-(dimethylamino)ethyl)-2-(6-(8-fluoronaphthalen-2-yl)-2-oxo-1,2-dihydropyridin-3-yl)-3-methylbutanamide Show/Hide	C24H28FN3O2	2
1	IC50 = 445 nM Bioactivity Info	TI LI LO TS
2	Ki = 33 nM Bioactivity Info	TI LI LO TS
CP0926293 Compound Info	2-hydroxy-3-methyl-2-[6-(2-naphthyl)-2-oxo-1H-pyridin-3-yl]butanamide Show/Hide	C20H20N2O3	2
1	IC50 = 509 nM Bioactivity Info	TI LI LO TS
2	Ki = 50 nM Bioactivity Info	TI LI LO TS
CP0966320 Compound Info	anti-(6-(8-fluoronaphthalen-2-yl)-2-oxo-1,2-dihydropyridin-3-yl)-2-methylpropyl)oxazolidine Show/Hide	C22H19FN2O4	1
1	IC50 = 610 nM Bioactivity Info	TI LI LO TS
CP0295469 Compound Info	(Z)-7-{(1R,2R,3R,5S)-2-[(E)-(R)-4-(3-Chloro-phenoxy)-3-hydroxy-but-1-enyl]-3,5-dihydroxy-cyclopentyl}-hept-5-enoic acid Show/Hide	C22H29ClO6	1
1	IC50 = 635 nM Bioactivity Info	TI LI LO TS
CP0572991 Compound Info	(4E)-4-[1-[6-(8-fluoronaphthalen-2-yl)-2-oxo-1H-pyridin-3-yl]-2-methylpropylidene]-1,3-oxazolidine-2,5-dione Show/Hide	C22H17FN2O4	1
1	IC50 = 680 nM Bioactivity Info	TI LI LO TS
CP0445340 Compound Info	7-{3,5-Dihydroxy-2-[3-hydroxy-4-(thiophen-2-ylsulfanyl)-butyl]-cyclopentyl}-heptanoic acid Show/Hide	C20H32O5S2	1
1	IC50 = 1000 nM Bioactivity Info	TI LI LO TS
CP0571744 Compound Info	(5Z)-5-[1-[6-(8-fluoronaphthalen-2-yl)-2-oxo-1H-pyridin-3-yl]-2-methylpropylidene]-1,3-oxazolidine-2,4-dione Show/Hide	C22H17FN2O4	1
1	IC50 = 1300 nM Bioactivity Info	TI LI LO TS
CP0922699 Compound Info	2-hydroxy-3-methyl-2-[6-(2-naphthyl)-2-oxo-1H-pyridin-3-yl]butanoic acid Show/Hide	C20H19NO4	2
1	IC50 = 1580 nM Bioactivity Info	TI LI LO TS
2	Ki = 544 nM Bioactivity Info	TI LI LO TS
CP0477510 Compound Info	4-[(1S)-1-[[5-prop-1-ynyl-3-[[4-(trifluoromethyl)phenyl]methyl]triazole-4-carbonyl]amino]ethyl]benzoic acid Show/Hide	C23H19F3N4O3	1
1	IC50 = 2292.3 nM Bioactivity Info	TI LI LO TS
CP0402541 Compound Info	7-{(1R,2R,3R,5S)-2-[(R)-4-(3-Chloro-phenoxy)-3-hydroxy-butyl]-3,5-dihydroxy-cyclopentyl}-heptanoic acid Show/Hide	C22H33ClO6	1
1	IC50 = 3100 nM Bioactivity Info	TI LI LO TS
CP0438269 Compound Info	7-[3,5-Dihydroxy-2-(3-hydroxy-4-phenoxy-butyl)-cyclopentyl]-heptanoic acid Show/Hide	C22H34O6	1
1	IC50 = 5900 nM Bioactivity Info	TI LI LO TS
CP0372737 Compound Info	7-[3,5-Dihydroxy-2-(3-hydroxy-4-m-tolylsulfanyl-butyl)-cyclopentyl]-heptanoic acid Show/Hide	C23H36O5S	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0374214 Compound Info	7-{2-[4-(3-Chloro-phenylsulfanyl)-3-hydroxy-butyl]-3,5-dihydroxy-cyclopentyl}-heptanoic acid Show/Hide	C22H33ClO5S	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0377752 Compound Info	7-[3,5-Dihydroxy-2-(3-hydroxy-4-phenylamino-butyl)-cyclopentyl]-heptanoic acid Show/Hide	C22H35NO5	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0395236 Compound Info	7-{2-[4-(3-Fluoro-phenylsulfanyl)-3-hydroxy-butyl]-3,5-dihydroxy-cyclopentyl}-heptanoic acid Show/Hide	C22H33FO5S	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0402565 Compound Info	7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-((R)-3-hydroxy-5-phenyl-pentyl)-cyclopentyl]-heptanoic acid Show/Hide	C23H36O5	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0432809 Compound Info	7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-((S)-3-hydroxy-octyl)-cyclopentyl]-heptanoic acid Show/Hide	C20H38O5	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0432810 Compound Info	7-{3,5-Dihydroxy-2-[3-hydroxy-4-(thiazol-2-ylsulfanyl)-butyl]-cyclopentyl}-heptanoic acid Show/Hide	C19H31NO5S2	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0433187 Compound Info	7-[3,5-Dihydroxy-2-(3-hydroxy-4-phenylsulfanyl-butyl)-cyclopentyl]-heptanoic acid Show/Hide	C22H34O5S	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0448266 Compound Info	7-{3,5-Dihydroxy-2-[3-hydroxy-4-(3-trifluoromethyl-phenylsulfanyl)-butyl]-cyclopentyl}-heptanoic acid Show/Hide	C23H33F3O5S	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0427396 Compound Info	4-[(1S)-1-[[5-phenyl-3-[[4-(trifluoromethyl)phenyl]methyl]triazole-4-carbonyl]amino]ethyl]benzoic acid Show/Hide	C26H21F3N4O3	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0427397 Compound Info	4-[(1S)-1-[[5-(cyclopenten-1-yl)-3-[[4-(trifluoromethyl)phenyl]methyl]triazole-4-carbonyl]amino]ethyl]benzoic acid Show/Hide	C25H23F3N4O3	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0435681 Compound Info	US8686018, 107 Show/Hide	C22H18F5N3O4	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0438577 Compound Info	4-[(1S)-1-[[5-phenyl-3-[2-[3-(trifluoromethyl)phenoxy]ethyl]triazole-4-carbonyl]amino]ethyl]benzoic acid Show/Hide	C27H23F3N4O4	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0438580 Compound Info	4-[(1S)-1-[[5-(furan-3-yl)-3-[[4-(trifluoromethyl)phenyl]methyl]triazole-4-carbonyl]amino]ethyl]benzoic acid Show/Hide	C24H19F3N4O4	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0473341 Compound Info	4-[(1S)-1-[[5-(5-methylthiophen-2-yl)-3-[[4-(trifluoromethyl)phenyl]methyl]triazole-4-carbonyl]amino]ethyl]benzoic acid Show/Hide	C25H21F3N4O3S	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0473342 Compound Info	4-[(1S)-1-[[5-thiophen-3-yl-3-[[4-(trifluoromethyl)phenyl]methyl]triazole-4-carbonyl]amino]ethyl]benzoic acid Show/Hide	C24H19F3N4O3S	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0473344 Compound Info	4-[(1S)-1-[[5-[(E)-prop-1-enyl]-3-[[4-(trifluoromethyl)phenyl]methyl]triazole-4-carbonyl]amino]ethyl]benzoic acid Show/Hide	C23H21F3N4O3	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0477511 Compound Info	4-[(1S)-1-[[3-[2-(4-fluorophenoxy)ethyl]-5-phenyltriazole-4-carbonyl]amino]ethyl]benzoic acid Show/Hide	C26H23FN4O4	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0571749 Compound Info	(5Z)-5-[2-ethyl-2-[6-(1-ethyl-3-methylindazol-6-yl)-2-oxo-1H-pyridin-3-yl]butylidene]-1,3-oxazolidine-2,4-dione Show/Hide	C24H26N4O4	1
1	IC50 = 18000 nM Bioactivity Info	TI LI LO TS
CP0556956 Compound Info	(5Z)-5-[2-ethyl-2-[6-(2-ethyl-4-fluoroindazol-5-yl)-2-oxo-1H-pyridin-3-yl]butylidene]-1,3-oxazolidine-2,4-dione Show/Hide	C23H23FN4O4	1
1	IC50 > 20000 nM Bioactivity Info	TI LI LO TS
CP0571750 Compound Info	(5Z)-5-[2-ethyl-2-[6-(1-ethyl-4-fluoroindazol-5-yl)-2-oxo-1H-pyridin-3-yl]butylidene]-1,3-oxazolidine-2,4-dione Show/Hide	C23H23FN4O4	1
1	IC50 > 20000 nM Bioactivity Info	TI LI LO TS
CP0572992 Compound Info	(5Z)-5-[2-[6-(2,2-dimethyl-3,4-dihydrochromen-7-yl)-2-oxo-1H-pyridin-3-yl]-2-ethylbutylidene]-1,3-oxazolidine-2,4-dione Show/Hide	C25H28N2O5	1
1	IC50 > 20000 nM Bioactivity Info	TI LI LO TS
CP0578917 Compound Info	(5Z)-5-[2-ethyl-2-[6-(1-ethyl-5-methylindazol-6-yl)-2-oxo-1H-pyridin-3-yl]butylidene]-1,3-oxazolidine-2,4-dione Show/Hide	C24H26N4O4	1
1	IC50 > 20000 nM Bioactivity Info	TI LI LO TS
CP0966018 Compound Info	(R)-6-(1-ethyl-4-methyl-1H-indazol-6-yl)-3-(3-methyl-2-oxopyrrolidin-3-yl)pyridin-2(1H)-one Show/Hide	C20H22N4O2	1
1	Ki = 5 nM Bioactivity Info	TI LI LO TS
CP0520913 Compound Info	5-(5-methyl-6-naphthalen-2-yl-2-oxo-1H-pyridin-3-yl)-5-propan-2-yl-1,3-oxazolidine-2,4-dione Show/Hide	C22H20N2O4	1
1	Ki = 6.31 nM Bioactivity Info	TI LI LO TS
CP0911043 Compound Info	6-(8-fluoro-2-naphthyl)-3-[(1R)-2-methyl-1-[[(3S)-2-oxopyrrolidin-3-yl]methyl]propyl]-1H-pyridin-2-one Show/Hide	C24H25FN2O2	1
1	Ki = 7.1 nM Bioactivity Info	TI LI LO TS
CP0495383 Compound Info	(5S)-5-(6-naphthalen-2-yl-2-oxo-1H-pyridin-3-yl)-5-propan-2-yl-1,3-oxazolidine-2,4-dione Show/Hide	C21H18N2O4	1
1	Ki = 7.943 nM Bioactivity Info	TI LI LO TS
CP0498674 Compound Info	5-cyclopentyl-5-(6-naphthalen-2-yl-2-oxo-1H-pyridin-3-yl)-1,3-oxazolidine-2,4-dione Show/Hide	C23H20N2O4	1
1	Ki = 7.943 nM Bioactivity Info	TI LI LO TS
CP0528861 Compound Info	5-cyclohexyl-5-(6-naphthalen-2-yl-2-oxo-1H-pyridin-3-yl)-1,3-oxazolidine-2,4-dione Show/Hide	C24H22N2O4	1
1	Ki = 7.943 nM Bioactivity Info	TI LI LO TS
CP0437974 Compound Info	5-benzyl-5-(6-naphthalen-2-yl-2-oxo-1H-pyridin-3-yl)-1,3-oxazolidine-2,4-dione Show/Hide	C25H18N2O4	1
1	Ki = 15.85 nM Bioactivity Info	TI LI LO TS
CP0488369 Compound Info	5-methyl-5-(6-naphthalen-2-yl-2-oxo-1H-pyridin-3-yl)-1,3-oxazolidine-2,4-dione Show/Hide	C19H14N2O4	1
1	Ki = 19.95 nM Bioactivity Info	TI LI LO TS
CP0520924 Compound Info	(5R)-5-(6-naphthalen-2-yl-2-oxo-1H-pyridin-3-yl)-5-propan-2-yl-1,3-oxazolidine-2,4-dione Show/Hide	C21H18N2O4	1
1	Ki = 19.95 nM Bioactivity Info	TI LI LO TS
CP0500008 Compound Info	5-(6-naphthalen-2-yl-2-oxo-1H-pyridin-3-yl)-5-phenyl-1,3-oxazolidine-2,4-dione Show/Hide	C24H16N2O4	1
1	Ki = 31.62 nM Bioactivity Info	TI LI LO TS
CP0422124 Compound Info	5-(5-bromo-6-naphthalen-2-yl-2-oxo-1H-pyridin-3-yl)-5-propan-2-yl-1,3-oxazolidine-2,4-dione Show/Hide	C21H17BrN2O4	1
1	Ki = 39.81 nM Bioactivity Info	TI LI LO TS
CP0501496 Compound Info	3-(4-methyl-2-oxoimidazolidin-4-yl)-6-naphthalen-2-yl-1H-pyridin-2-one Show/Hide	C19H17N3O2	1
1	Ki = 39.81 nM Bioactivity Info	TI LI LO TS
CP0425897 Compound Info	5-cyclopropyl-5-(6-naphthalen-2-yl-2-oxo-1H-pyridin-3-yl)-1,3-oxazolidine-2,4-dione Show/Hide	C21H16N2O4	1
1	Ki = 50.12 nM Bioactivity Info	TI LI LO TS
CP0528843 Compound Info	5-(5-chloro-6-naphthalen-2-yl-2-oxo-1H-pyridin-3-yl)-5-propan-2-yl-1,3-oxazolidine-2,4-dione Show/Hide	C21H17ClN2O4	1
1	Ki = 50.12 nM Bioactivity Info	TI LI LO TS
CP0437977 Compound Info	5-methyl-5-(6-naphthalen-2-yl-2-oxo-1H-pyridin-3-yl)-1,3-oxazolidin-2-one Show/Hide	C19H16N2O3	1
1	Ki = 79.43 nM Bioactivity Info	TI LI LO TS
CP0503174 Compound Info	5-(6-naphthalen-2-yl-2-oxo-1H-pyridin-3-yl)-5-(trifluoromethyl)-1,3-oxazolidine-2,4-dione Show/Hide	C19H11F3N2O4	1
1	Ki = 125.89 nM Bioactivity Info	TI LI LO TS
CP0437976 Compound Info	5-(6-naphthalen-2-yl-2-oxo-1H-pyridin-3-yl)-5-(oxan-4-yl)-1,3-oxazolidine-2,4-dione Show/Hide	C23H20N2O5	1
1	Ki = 199.53 nM Bioactivity Info	TI LI LO TS
CP0513984 Compound Info	5-methyl-5-(6-naphthalen-2-yl-2-oxo-1H-pyridin-3-yl)imidazolidine-2,4-dione Show/Hide	C19H15N3O3	1
1	Ki = 316.23 nM Bioactivity Info	TI LI LO TS
CP0383448 Compound Info	5-[2-[5-chloro-2-[(4-fluorophenyl)methoxy]phenyl]-5-methylpyrrol-1-yl]-2-methylbenzoic acid Show/Hide	C26H21ClFNO3	1
1	Ki = 501.19 nM Bioactivity Info	TI LI LO TS
CP0209434 Compound Info	3-acetamido-5-[2-[5-bromo-2-[(2,4-difluorophenyl)methoxy]phenyl]-5-methylpyrrol-1-yl]benzoic acid Show/Hide	C27H21BrF2N2O4	1
1	Ki = 501.19 nM Bioactivity Info	TI LI LO TS
CP0377854 Compound Info	3,5-dimethyl-5-(6-naphthalen-2-yl-2-oxo-1H-pyridin-3-yl)-1,3-oxazolidine-2,4-dione Show/Hide	C20H16N2O4	1
1	Ki = 501.19 nM Bioactivity Info	TI LI LO TS
CP0377857 Compound Info	5-[6-naphthalen-2-yl-2-oxo-5-(trifluoromethyl)-1H-pyridin-3-yl]-5-propan-2-yl-1,3-oxazolidine-2,4-dione Show/Hide	C22H17F3N2O4	1
1	Ki = 630.96 nM Bioactivity Info	TI LI LO TS
CP0531249 Compound Info	5-(6-naphthalen-2-yl-4-oxo-1H-pyridin-3-yl)-5-propan-2-yl-1,3-oxazolidine-2,4-dione Show/Hide	C21H18N2O4	1
1	Ki = 794.33 nM Bioactivity Info	TI LI LO TS
CP0501497 Compound Info	5-(2-hydroxy-4-naphthalen-2-ylphenyl)-5-methyl-1,3-oxazolidine-2,4-dione Show/Hide	C20H15NO4	1
1	Ki = 1258.93 nM Bioactivity Info	TI LI LO TS
CP0555218 Compound Info	5-methyl-5-(6-naphthalen-2-yl-2-oxo-1H-pyridin-3-yl)-3-propan-2-yl-1,3-oxazolidine-2,4-dione Show/Hide	C22H20N2O4	1
1	Ki = 1584.89 nM Bioactivity Info	TI LI LO TS
CP0555219 Compound Info	5-(6-naphthalen-2-yl-2-oxo-5-phenyl-1H-pyridin-3-yl)-5-propan-2-yl-1,3-oxazolidine-2,4-dione Show/Hide	C27H22N2O4	1
1	Ki = 2511.89 nM Bioactivity Info	TI LI LO TS
CP0460683 Compound Info	5-(2-methoxy-4-naphthalen-2-ylphenyl)-5-methyl-1,3-oxazolidine-2,4-dione Show/Hide	C21H17NO4	1
1	Ki = 3162.28 nM Bioactivity Info	TI LI LO TS
CP0377855 Compound Info	5-methyl-5-(1-methyl-6-naphthalen-2-yl-2-oxopyridin-3-yl)-1,3-oxazolidine-2,4-dione Show/Hide	C20H16N2O4	1
1	Ki > 25118.86 nM Bioactivity Info	TI LI LO TS
CP0504278 Compound Info	5-(6-naphthalen-2-ylpyridin-3-yl)-5-propan-2-yl-1,3-oxazolidine-2,4-dione Show/Hide	C21H18N2O3	1
1	Ki > 25118.86 nM Bioactivity Info	TI LI LO TS

Cell Line ID: CL000064 , Chem-1

Cell Line Info

Cell Line ID: CL000026 , CHO-K1

Cell Line Info

Cell Line ID: CL000076 , CHO/Galpha16

Cell Line Info

Cell Line ID: CL000516 , ECV-304

Cell Line Info

Cell Line ID: CL000006 , HEK293

Cell Line Info

Cell Line ID: CL000065 , HEK293-EBNA

Cell Line Info

Cell Line ID: CL000043 , U2OS

Cell Line Info

Biochemical Assays

Compound ID	Compound Name	Compound Formula
CP0182637 Compound Info	2-[2-[(4S)-4-[(E,3R)-3-[1-(4-fluorobutyl)cyclobutyl]-3-hydroxyprop-1-enyl]-2-oxo-1,3-oxazolidin-3-yl]ethylsulfanyl]-1,3-thiazole-4-carboxylic acid Show/Hide	C20H27FN2O5S2	1
1	EC50 = 10 nM
CP0055947 Compound Info	(15S)-prostaglandin E2 Show/Hide	C20H32O5	3
1	IC50 = 0.94 nM
2	Ki = 0.33 nM
3	Ki = 5 nM
CP0281482 Compound Info	3-(1-(2,3-dichlorobenzyl)-3a-methyl-2-oxo-2,3,3a,4,5,6-hexahydro-1H-indol-7-yl)-N-(3,4-difluorophenylsulfonyl)acrylamide Show/Hide	C25H22Cl2F2N2O4S	1
1	IC50 = 3.4 nM
CP0302572 Compound Info	(E)-N-(4,5-dichlorothiophen-2-yl)sulfonyl-3-[1-[(3,4-difluorophenyl)methyl]-3a-methyl-2-oxo-3,4,5,6-tetrahydroindol-7-yl]prop-2-enamide Show/Hide	C23H20Cl2F2N2O4S2	1
1	IC50 = 3.5 nM
CP0144171 Compound Info	3-(1-(2,3-dichlorobenzyl)-3a-methyl-2-oxo-2,3,3a,4,5,6-hexahydro-1H-indol-7-yl)-N-(2,4,5-trifluorophenylsulfonyl)acrylamide Show/Hide	C25H21Cl2F3N2O4S	1
1	IC50 = 4.3 nM
CP0274965 Compound Info	3-(1-(2,3-dichlorobenzyl)-3a-methyl-2-oxo-2,3,3a,4,5,6-hexahydro-1H-indol-7-yl)-N-(4,5-dichlorothiophen-2-ylsulfonyl)acrylamide Show/Hide	C23H20Cl4N2O4S2	1
1	IC50 = 4.4 nM
CP0178380 Compound Info	(E)-N-(3,5-dichlorophenyl)sulfonyl-3-[1-[(3,4-difluorophenyl)methyl]-3a-methyl-2-oxo-3,4,5,6-tetrahydroindol-7-yl]prop-2-enamide Show/Hide	C25H22Cl2F2N2O4S	1
1	IC50 = 5.6 nM
CP0197388 Compound Info	(E)-N-(4,5-dichlorothiophen-2-yl)sulfonyl-3-[1-[(3-methoxyphenyl)methyl]-3a-methyl-2-oxo-3,4,5,6-tetrahydroindol-7-yl]prop-2-enamide Show/Hide	C24H24Cl2N2O5S2	1
1	IC50 = 6.4 nM
CP0254209 Compound Info	3-(1-(3,4-difluorobenzyl)-3a-methyl-2-oxo-2,3,3a,4,5,6-hexahydro-1H-indol-7-yl)-N-(2,4,5-trifluorophenylsulfonyl)acrylamide Show/Hide	C25H21F5N2O4S	1
1	IC50 = 7.7 nM
CP0070748 Compound Info	3-(4-(2,4-dichlorophenoxy)-1-methyl-1H-indol-3-yl)-N-(3,4-difluorophenylsulfonyl)acrylamide Show/Hide	C24H16Cl2F2N2O4S	2
1	IC50 = 11.8 nM
2	IC50 = 23.7 nM
CP0189115 Compound Info	(E)-3-(1-benzylindol-7-yl)-N-thiophen-2-ylsulfonylprop-2-enamide Show/Hide	C22H18N2O3S2	2
1	IC50 = 98 nM
2	IC50 = 6129 nM
CP0095751 Compound Info	(5Z,13E,15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dien-1-oic acid Show/Hide	C20H34O5	1
1	IC50 = 110 nM
CP0254532 Compound Info	(E)-3-[1-(naphthalen-2-ylmethyl)indol-7-yl]-N-thiophen-2-ylsulfonylprop-2-enamide Show/Hide	C26H20N2O3S2	1
1	IC50 = 378 nM
CP0070143 Compound Info	2-(2-benzoyl-3,4-dihydro-1H-pyrido[4,3-b]indol-5-yl)acetic acid Show/Hide	C20H18N2O3	1
1	IC50 > 10000 nM
CP0663915 Compound Info	4-((S)-1-((R)-1-(2-phenoxyethyl)piperidine-2-carboxamido)ethyl)benzoic acid hydrochloride Show/Hide	C23H29ClN2O4	2
1	IC50 > 25000 nM
2	Ki > 12700 nM
CP0572038 Compound Info	1-(4,5-dichlorothiophen-2-yl)sulfonyl-3-[(2E)-2-[1-[4-(trifluoromethyl)phenyl]-5,6-dihydro-4H-indazol-7-ylidene]ethyl]urea Show/Hide	C21H17Cl2F3N4O3S2	1
1	Ki = 0.4 nM
CP0574263 Compound Info	1-[(2E)-2-[1-[(2,4-dichlorophenyl)methyl]-5,6-dihydro-4H-indazol-7-ylidene]ethyl]-3-(4,5-dichlorothiophen-2-yl)sulfonylurea Show/Hide	C21H18Cl4N4O3S2	1
1	Ki = 0.5 nM
CP0549886 Compound Info	1-(4,5-dichlorothiophen-2-yl)sulfonyl-3-[(2E)-2-[1-[1-(4-fluorophenyl)piperidin-4-yl]-5,6-dihydro-4H-indazol-7-ylidene]ethyl]urea Show/Hide	C25H26Cl2FN5O3S2	1
1	Ki = 1 nM
CP0551467 Compound Info	1-[(2Z)-2-[1-[(2,4-dichlorophenyl)methyl]-5,6-dihydro-4H-indazol-7-ylidene]-2-fluoroethyl]-3-(4,5-dichlorothiophen-2-yl)sulfonylurea Show/Hide	C21H17Cl4FN4O3S2	1
1	Ki = 1 nM
CP0578038 Compound Info	1-(4,5-dichlorothiophen-2-yl)sulfonyl-3-[(2E)-2-[1-(4-methylsulfonylphenyl)-5,6-dihydro-4H-indazol-7-ylidene]ethyl]urea Show/Hide	C21H20Cl2N4O5S3	1
1	Ki = 1 nM
CP0579397 Compound Info	[(2E)-2-[1-[(2,4-dichlorophenyl)methyl]-5,6-dihydro-4H-indazol-7-ylidene]ethyl] N-(4,5-dichlorothiophen-2-yl)sulfonylcarbamate Show/Hide	C21H17Cl4N3O4S2	1
1	Ki = 1 nM
CP0567972 Compound Info	1-(5-chloro-4-methylthiophen-2-yl)sulfonyl-3-[(2Z)-2-[1-[(2,4-dichlorophenyl)methyl]-5,6-dihydro-4H-indazol-7-ylidene]-2-fluoroethyl]urea Show/Hide	C22H20Cl3FN4O3S2	1
1	Ki = 2 nM
CP0574267 Compound Info	1-[(2E)-2-[1-[(2,4-dichlorophenyl)methyl]-5,6-dihydro-4H-indazol-7-ylidene]ethyl]-3-[(2,4-dimethyl-1,3-thiazol-5-yl)sulfonyl]urea Show/Hide	C22H23Cl2N5O3S2	1
1	Ki = 2 nM
CP0574268 Compound Info	1-(4,5-dichlorothiophen-2-yl)sulfonyl-3-[(2E)-2-[1-(6-methoxypyridin-3-yl)-5,6-dihydro-4H-indazol-7-ylidene]ethyl]urea Show/Hide	C20H19Cl2N5O4S2	1
1	Ki = 2 nM
CP0562245 Compound Info	1-(3-chloro-4-methoxyphenyl)sulfonyl-3-[(2Z)-2-[1-[(2,4-dichlorophenyl)methyl]-5,6-dihydro-4H-indazol-7-ylidene]-2-fluoroethyl]urea Show/Hide	C24H22Cl3FN4O4S	1
1	Ki = 3 nM
CP0573454 Compound Info	1-(4,5-dichlorothiophen-2-yl)sulfonyl-3-[(2Z)-2-fluoro-2-[1-[4-(trifluoromethyl)phenyl]-5,6-dihydro-4H-indazol-7-ylidene]ethyl]urea Show/Hide	C21H16Cl2F4N4O3S2	1
1	Ki = 3 nM
CP0574265 Compound Info	1-(5-chloro-2-methoxyphenyl)sulfonyl-3-[(2E)-2-[1-[(2,4-dichlorophenyl)methyl]-5,6-dihydro-4H-indazol-7-ylidene]ethyl]urea Show/Hide	C24H23Cl3N4O4S	1
1	Ki = 3 nM
CP0551466 Compound Info	1-(4-chlorophenyl)sulfonyl-3-[(2E)-2-[1-[(2,4-dichlorophenyl)methyl]-5,6-dihydro-4H-indazol-7-ylidene]ethyl]urea Show/Hide	C23H21Cl3N4O3S	1
1	Ki = 4 nM
CP0574266 Compound Info	1-(1-benzothiophen-2-ylsulfonyl)-3-[(2E)-2-[1-[(2,4-dichlorophenyl)methyl]-5,6-dihydro-4H-indazol-7-ylidene]ethyl]urea Show/Hide	C25H22Cl2N4O3S2	1
1	Ki = 5 nM
CP0073581 Compound Info	5-(6-naphthalen-2-yl-2-oxo-1H-pyridin-3-yl)-5-propan-2-yl-1,3-oxazolidine-2,4-dione Show/Hide	C21H18N2O4	1
1	Ki = 5.012 nM
CP0277044 Compound Info	(E)-3-{2-[(E)-3-(2-Benzyloxy-3-methyl-phenyl)-allyl]-phenyl}-acrylic acid Show/Hide	C26H24O3	1
1	Ki = 7 nM
CP0567973 Compound Info	1-(4,5-dichlorothiophen-2-yl)sulfonyl-3-[(2Z)-2-fluoro-2-[1-[[4-(trifluoromethyl)phenyl]methyl]-5,6-dihydro-4H-indazol-7-ylidene]ethyl]urea Show/Hide	C22H18Cl2F4N4O3S2	1
1	Ki = 7 nM
CP0578037 Compound Info	1-[(2E)-2-[1-[(2,4-dichlorophenyl)methyl]-5,6-dihydro-4H-indazol-7-ylidene]ethyl]-3-[(2-methyl-1,3-thiazol-5-yl)sulfonyl]urea Show/Hide	C21H21Cl2N5O3S2	1
1	Ki = 7 nM
CP0562242 Compound Info	1-[(2E)-2-[1-[(2,4-dichlorophenyl)methyl]-5,6-dihydro-4H-indazol-7-ylidene]ethyl]-3-(1-methylpyrazol-4-yl)sulfonylurea Show/Hide	C21H22Cl2N6O3S	1
1	Ki = 9 nM
CP0559192 Compound Info	1-[(2E)-2-[1-[(2,4-dichlorophenyl)methyl]-5,6-dihydro-4H-indazol-7-ylidene]ethyl]-3-(4-methoxyphenyl)sulfonylurea Show/Hide	C24H24Cl2N4O4S	1
1	Ki = 10 nM
CP0578036 Compound Info	[(2E)-2-[1-[(2,4-dichlorophenyl)methyl]-5,6-dihydro-4H-indazol-7-ylidene]ethyl] N-(4-chlorophenyl)sulfonylcarbamate Show/Hide	C23H20Cl3N3O4S	1
1	Ki = 11 nM
CP0573452 Compound Info	1-[(2E)-2-[1-[(2,4-dichlorophenyl)methyl]-5,6-dihydro-4H-indazol-7-ylidene]ethyl]-3-thiophen-2-ylsulfonylurea Show/Hide	C21H20Cl2N4O3S2	1
1	Ki = 15 nM
CP0578283 Compound Info	1-(1-benzothiophen-2-ylsulfonyl)-3-[(2Z)-2-[1-[(2,4-dichlorophenyl)methyl]-5,6-dihydro-4H-indazol-7-ylidene]-2-fluoroethyl]urea Show/Hide	C25H21Cl2FN4O3S2	1
1	Ki = 17 nM
CP0567971 Compound Info	1-(3-chlorophenyl)sulfonyl-3-[(2Z)-2-[1-[(2,4-dichlorophenyl)methyl]-5,6-dihydro-4H-indazol-7-ylidene]-2-fluoroethyl]urea Show/Hide	C23H20Cl3FN4O3S	1
1	Ki = 18 nM
CP0160939 Compound Info	(E)-3-[2-(3,4-dichlorophenyl)phenyl]-N-thiophen-2-ylsulfonylprop-2-enamide Show/Hide	C19H13Cl2NO3S2	1
1	Ki = 25 nM
CP0572037 Compound Info	1-(5-chloro-2-methoxyphenyl)sulfonyl-3-[(2Z)-2-[1-[(2,4-dichlorophenyl)methyl]-5,6-dihydro-4H-indazol-7-ylidene]-2-fluoroethyl]urea Show/Hide	C24H22Cl3FN4O4S	1
1	Ki = 26 nM
CP0573453 Compound Info	1-(4-chlorophenyl)sulfonyl-3-[(2Z)-2-[1-[(2,4-dichlorophenyl)methyl]-5,6-dihydro-4H-indazol-7-ylidene]-2-fluoroethyl]urea Show/Hide	C23H20Cl3FN4O3S	1
1	Ki = 28 nM
CP0966018 Compound Info	(R)-6-(1-ethyl-4-methyl-1H-indazol-6-yl)-3-(3-methyl-2-oxopyrrolidin-3-yl)pyridin-2(1H)-one Show/Hide	C20H22N4O2	1
1	Ki = 31.6 nM
CP0574264 Compound Info	1-[(2E)-2-[1-[(2,4-dichlorophenyl)methyl]-5,6-dihydro-4H-indazol-7-ylidene]ethyl]-3-(2-methoxyphenyl)sulfonylurea Show/Hide	C24H24Cl2N4O4S	1
1	Ki = 62 nM
CP0174264 Compound Info	7-[(1R,2S)-2-[4-(1-hydroxyhexyl)phenyl]-5-oxocyclopentyl]heptanoic acid Show/Hide	C24H36O4	1
1	Ki = 82 nM
CP0144553 Compound Info	7-[(R)-2-((E)-(S)-3-Hydroxy-oct-1-enyl)-5-oxo-pyrrolidin-1-yl]-heptanoic acid Show/Hide	C19H33NO4	1
1	Ki = 3000 nM
CP0084755 Compound Info	7-{(R)-2-[(E)-3-Hydroxy-3-(1-phenyl-cyclopropyl)-propenyl]-5-oxo-pyrrolidin-1-yl}-heptanoic acid Show/Hide	C23H31NO4	1
1	Ki = 20000 nM
CP0257412 Compound Info	7-[(R)-2-((E)-3-Hydroxy-4-phenyl-but-1-enyl)-5-oxo-pyrrolidin-1-yl]-heptanoic acid Show/Hide	C21H29NO4	1
1	Ki = 100000 nM
CP0045193 Compound Info	US8933098, 1 Show/Hide	C21H25N3O4	1
1	Ki > 14000 nM
CP0041889 Compound Info	2-((R)-4-(4-chlorobenzyl)-5-(1-hydroxyethyl)-7-(methylsulfonyl)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid Show/Hide	C23H24ClNO5S	1
1	Ki > 20000 nM
CP0108218 Compound Info	(R)-2-(4-(4-chlorobenzyl)-5-acetyl-7-(methylsulfonyl)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid Show/Hide	C23H22ClNO5S	1
1	Ki > 20000 nM

Clinical Information about the Protein

Target 1 ( Prostaglandin E2 receptor EP3 (PTGER3) )

Target Type	Clinical trial Target
Disease	3 Target-related Diseases				3
1	Stem cell engraftment [ICD-11: QB63.8]
2	Solid tumour/cancer [ICD-11: 2A00-2F9Z]
3	Peripheral vascular disease [ICD-11: BD4Z]
Clinical Trial Drug(s)	2 Clinical Trial Drugs				2
1	16,16-dimethyl-PGE2	Drug Info	Phase 2	Stem cell engraftment
2	PGF2alpha	Drug Info	Clinical trial	Solid tumour/cancer
Discontinued Drug(s)	1 Discontinued Drug				1
1	DG041	Drug Info	Discontinued in Phase 2	Peripheral vascular disease

Similar Protein(s) and Bioactivity Statistics

50% Identity

Protein ID	Protein Name	Protein Organism
PT02345	Prostaglandin E2 receptor EP3 subtype	Mus musculus, Mouse	Protein Info
PT03555	Prostaglandin E2 receptor EP3 subtype	Rattus norvegicus, Rat	Protein Info

Cite

About MolBiC

Correspondence

Prof. Feng ZHU

Prof. Leo, Lianyi Han