General Information of the Protein
Protein ID
PT03555
Protein Name
Prostaglandin E2 receptor EP3 subtype
Secondarily
Protein Name
Prostanoid EP3 receptor
Gene Name
PTGER3
Sequence
MAGVWAPEHSVEAHSNQSSAADGCGSVSVAFPITMMVTGFVGNALAMLLVVRSYRRRESKRKKSFLLCIGWLALTDLVGQLLTSPVVILVYLSQRRWEQLDPSGRLCTFFGLTMTVFGLSSLLVASAMAVERALAIRAPHWYASHMKTRATPVLLGVWLSVLAFALLPVLGVGRYSVQWPGTWCFISTGPAGNETDSAREPGSVAFASAFACLGLLALVVTFACNLATIKALVSRCRAKAAASQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLIMMLKMIFNQMSVEQCKTQMGKEKECNSFLIAVRLASLNQILDPWVYLLLRKILLRKFCQIRDHTNYASSSTSLPCPGSSVLMWSDQLER
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Organism
Rattus norvegicus, Rat
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Small molecule receptor (family A GPCR)
>
Lipid-like ligand receptor (family A GPCR)
>
Prostanoid receptor
Function
Receptor for prostaglandin E2 (PGE2) (PubMed:8393672, PubMed:11006128). Required for normal development of fever in response to pyrinogens, including IL1B, prostaglandin E2 and bacterial lipopolysaccharide (LPS). Required for normal potentiation of platelet aggregation by prostaglandin E2, and thus plays a role in the regulation of blood coagulation. Required for increased HCO3(-) secretion in the duodenum in response to mucosal acidification, and thereby contributes to the protection of the mucosa against acid-induced ulceration. Not required for normal kidney function, normal urine volume and osmolality (By similarity).
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Uniprot ID
Primary ID:
P34980

Secondarily ID:
Q63194
Q64376
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Ensembl ID
ENSG00000050628
Subcellular Location
Cell membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000065 , HEK293-EBNA
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0452755
 Compound Info 
4-{1-[({2,5-Dimethyl-4-[4-(trifluoromethyl)benzyl]-3-thienyl}-carbonyl)amino]cyclopropyl}benzoic Acid
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C25H22F3NO3S
  1
1
Ki = 3300 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Cell Line ID: CL000043 , U2OS
 Cell Line Info 
Similar Protein(s) and Bioactivity Statistics
90% Identity
Protein ID Protein Name Protein Organism
PT02345 Prostaglandin E2 receptor EP3 subtype Mus musculus, Mouse
 Protein Info 
50% Identity
Protein ID Protein Name Protein Organism
PT01367 Prostaglandin E2 receptor EP3 subtype Homo sapiens, Human
 Protein Info