General Information of the Compound
Compound ID
CP0551467
Compound Name
1-[(2Z)-2-[1-[(2,4-dichlorophenyl)methyl]-5,6-dihydro-4H-indazol-7-ylidene]-2-fluoroethyl]-3-(4,5-dichlorothiophen-2-yl)sulfonylurea
    Show/Hide
Structure
Formula
C21H17Cl4FN4O3S2
Molecular Weight
598.336
Canonical SMILES
F\C(CNC(=O)NS(=O)(=O)c1cc(Cl)c(Cl)s1)=C1\CCCc2cnn(Cc3ccc(Cl)cc3Cl)c12
    Show/Hide
InChI
InChI=1S/C21H17Cl4FN4O3S2/c22-13-5-4-12(15(23)6-13)10-30-19-11(8-28-30)2-1-3-14(19)17(26)9-27-21(31)29-35(32,33)18-7-16(24)20(25)34-18/h4-8H,1-3,9-10H2,(H2,27,29,31)/b17-14-
    Show/Hide
InChIKey
CBVZXYPCVKQUFI-VKAVYKQESA-N
Physicochemical Property
logP
6.3115
Rotatable Bonds
6
Heavy Atom Count
35
Polar Areas
93.09
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
6
Complexity
35

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 146291544
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01367, Prostaglandin E2 receptor EP3 subtype
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000026 CHO-K1 Cricetulus griseus (Chinese hamster)  1
1
IC50 = 1 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Ki = 1 nM