| Compound ID |
Compound Name |
Compound Formula |
|
CP0168566
|
ethyl (3E)-3-[3-(6-methylpyridin-2-yl)prop-2-ynylidene]pyrrolidine-1-carboxylate
Show/Hide
|
C16H18N2O2
|
4
|
| 1 |
EC50 > 30000 nM
|
|
|
| 2 |
IC50 = 4.1 nM
|
|
|
| 3 |
IC50 > 20000 nM
|
|
|
| 4 |
Ki = 3.5 nM
|
|
|
|
CP0410820
|
3-nitro-2-[4-(3-pyridin-2-ylprop-2-ynylidene)piperidin-1-yl]pyridine
Show/Hide
|
C18H16N4O2
|
2
|
| 1 |
IC50 = 0.4 nM
|
|
|
| 2 |
Ki = 0.3 nM
|
|
|
|
CP0163635
|
2-methyl-6-[3-[1-(3-nitropyridin-2-yl)piperidin-4-ylidene]prop-1-ynyl]pyridine
Show/Hide
|
C19H18N4O2
|
2
|
| 1 |
IC50 = 0.8 nM
|
|
|
| 2 |
Ki = 0.5 nM
|
|
|
|
CP0410806
|
1-[4-(3-nitropyridin-2-yl)piperazin-1-yl]-3-phenylprop-2-yn-1-one
Show/Hide
|
C18H16N4O3
|
2
|
| 1 |
IC50 = 0.9 nM
|
|
|
| 2 |
Ki = 0.5 nM
|
|
|
|
CP0453226
|
6-[3-[1-(6-methyl-3-nitropyridin-2-yl)piperidin-4-ylidene]prop-1-ynyl]pyridine-3-carbonitrile
Show/Hide
|
C20H17N5O2
|
2
|
| 1 |
IC50 = 1.3 nM
|
|
|
| 2 |
Ki = 0.3 nM
|
|
|
|
CP0410803
|
2-[4-[3-(3-methylphenyl)prop-2-ynylidene]piperidin-1-yl]-3-nitropyridine
Show/Hide
|
C20H19N3O2
|
2
|
| 1 |
IC50 = 1.8 nM
|
|
|
| 2 |
Ki = 0.3 nM
|
|
|
|
CP0060762
|
ethyl 4-[3-(3-chlorophenyl)prop-2-ynylidene]piperidine-1-carboxylate
Show/Hide
|
C17H18ClNO2
|
2
|
| 1 |
IC50 = 2.5 nM
|
|
|
| 2 |
Ki = 0.7 nM
|
|
|
|
CP0400458
|
3-nitro-2-[4-(3-phenylprop-2-ynylidene)piperidin-1-yl]pyridine
Show/Hide
|
C19H17N3O2
|
2
|
| 1 |
IC50 = 2.8 nM
|
|
|
| 2 |
Ki = 0.4 nM
|
|
|
|
CP0098717
|
ethyl 4-[3-(6-methylpyridin-2-yl)prop-2-ynylidene]piperidine-1-carboxylate
Show/Hide
|
C17H20N2O2
|
2
|
| 1 |
IC50 = 3.3 nM
|
|
|
| 2 |
Ki = 2.5 nM
|
|
|
|
CP0381788
|
2-[4-[3-(3-chlorophenyl)prop-2-ynylidene]piperidin-1-yl]-3-nitropyridine
Show/Hide
|
C19H16ClN3O2
|
2
|
| 1 |
IC50 = 3.8 nM
|
|
|
| 2 |
Ki = 0.5 nM
|
|
|
|
CP0096634
|
ethyl 4-[3-(3-methylphenyl)prop-2-ynylidene]piperidine-1-carboxylate
Show/Hide
|
C18H21NO2
|
2
|
| 1 |
IC50 = 5.1 nM
|
|
|
| 2 |
Ki = 2 nM
|
|
|
|
CP0096631
|
methyl 4-[3-(6-methylpyridin-2-yl)prop-2-ynylidene]piperidine-1-carboxylate
Show/Hide
|
C16H18N2O2
|
2
|
| 1 |
IC50 = 6 nM
|
|
|
| 2 |
Ki = 4 nM
|
|
|
|
CP0374317
|
2-(Pyridin-3-yl)-5-(2-methylthiazol-4ylethynyl)pyridine
Show/Hide
|
C16H11N3S
|
2
|
| 1 |
IC50 = 6.1 nM
|
|
|
| 2 |
Ki = 4.7 nM
|
|
|
|
CP0558165
|
furan-2-yl-[(3E)-3-[3-(6-methylpyridin-2-yl)prop-2-ynylidene]pyrrolidin-1-yl]methanone
Show/Hide
|
C18H16N2O2
|
2
|
| 1 |
IC50 = 6.4 nM
|
|
|
| 2 |
Ki = 7.9 nM
|
|
|
|
CP0096630
|
ethyl 4-(3-pyridin-2-ylprop-2-ynylidene)piperidine-1-carboxylate
Show/Hide
|
C16H18N2O2
|
2
|
| 1 |
IC50 = 6.5 nM
|
|
|
| 2 |
Ki = 2.6 nM
|
|
|
|
CP0534566
|
2-[4-[3-(6-methylpyridin-2-yl)prop-2-ynylidene]piperidin-1-yl]-5-phenylpyridine-3-carbonitrile
Show/Hide
|
C26H22N4
|
2
|
| 1 |
IC50 = 9.7 nM
|
|
|
| 2 |
Ki = 0.5 nM
|
|
|
|
CP0448934
|
2-methyl-6-[3-[1-(2-nitrophenyl)piperidin-4-ylidene]prop-1-ynyl]pyridine
Show/Hide
|
C20H19N3O2
|
2
|
| 1 |
IC50 = 10.4 nM
|
|
|
| 2 |
Ki = 0.3 nM
|
|
|
|
CP0191235
|
2-Methyl-6-(phenylethynyl)pyridine
Show/Hide
|
C14H11N
|
2
|
| 1 |
IC50 = 11.2 nM
|
|
|
| 2 |
Ki = 10.4 nM
|
|
|
|
CP0168550
|
(3E)-N-methyl-3-[3-(6-methylpyridin-2-yl)prop-2-ynylidene]-N-propan-2-ylpyrrolidine-1-carboxamide
Show/Hide
|
C18H23N3O
|
2
|
| 1 |
IC50 = 15.1 nM
|
|
|
| 2 |
Ki = 8.6 nM
|
|
|
|
CP0098731
|
ethyl 4-[3-(3-fluorophenyl)prop-2-ynylidene]piperidine-1-carboxylate
Show/Hide
|
C17H18FNO2
|
2
|
| 1 |
IC50 = 18.7 nM
|
|
|
| 2 |
Ki = 4 nM
|
|
|
|
CP0098733
|
ethyl 6-[3-(6-methylpyridin-2-yl)prop-2-ynylidene]-2-azaspiro[3.3]heptane-2-carboxylate
Show/Hide
|
C18H20N2O2
|
2
|
| 1 |
IC50 = 23.1 nM
|
|
|
| 2 |
Ki = 3.6 nM
|
|
|
|
CP0168578
|
(3-chlorophenyl)-[(3E)-3-[3-(6-methylpyridin-2-yl)prop-2-ynylidene]pyrrolidin-1-yl]methanone
Show/Hide
|
C20H17ClN2O
|
2
|
| 1 |
IC50 = 27 nM
|
|
|
| 2 |
Ki = 3.9 nM
|
|
|
|
CP0330115
|
(3E)-N-ethyl-3-[3-(6-methylpyridin-2-yl)prop-2-ynylidene]-N-propan-2-ylpyrrolidine-1-carboxamide
Show/Hide
|
C19H25N3O
|
2
|
| 1 |
IC50 = 29.1 nM
|
|
|
| 2 |
Ki = 5.8 nM
|
|
|
|
CP0402213
|
tert-butyl 4-[3-(6-methylpyridin-2-yl)prop-2-ynylidene]piperidine-1-carboxylate
Show/Hide
|
C19H24N2O2
|
2
|
| 1 |
IC50 = 34 nM
|
|
|
| 2 |
Ki = 11.9 nM
|
|
|
|
CP0140128
|
FENOBAM
Show/Hide
|
C11H11ClN4O2
|
2
|
| 1 |
IC50 = 36.3 nM
|
|
|
| 2 |
Ki = 162.2 nM
|
|
|
|
CP0545393
|
1-[4-(6-ethenyl-3-nitropyridin-2-yl)piperazin-1-yl]-3-phenylprop-2-yn-1-one
Show/Hide
|
C20H18N4O3
|
1
|
| 1 |
IC50 = 42 nM
|
|
|
|
CP0098720
|
2-methyl-6-[3-[1-(4-methylphenyl)sulfonylpiperidin-4-ylidene]prop-1-ynyl]pyridine
Show/Hide
|
C21H22N2O2S
|
2
|
| 1 |
IC50 = 43.8 nM
|
|
|
| 2 |
Ki = 2.7 nM
|
|
|
|
CP0098719
|
2-methyl-4-(pyridin-3-ylethynyl)thiazole
Show/Hide
|
C11H8N2S
|
2
|
| 1 |
IC50 = 47.3 nM
|
|
|
| 2 |
Ki = 32.7 nM
|
|
|
|
CP0168546
|
(3-chlorophenyl)-[4-[3-(6-methylpyridin-2-yl)prop-2-ynylidene]piperidin-1-yl]methanone
Show/Hide
|
C21H19ClN2O
|
2
|
| 1 |
IC50 = 49.2 nM
|
|
|
| 2 |
Ki = 0.7 nM
|
|
|
|
CP0421536
|
(3-fluorophenyl)-[4-[3-(6-methylpyridin-2-yl)prop-2-ynylidene]piperidin-1-yl]methanone
Show/Hide
|
C21H19FN2O
|
2
|
| 1 |
IC50 = 50.1 nM
|
|
|
| 2 |
Ki = 15.8 nM
|
|
|
|
CP0205249
|
2-phenylethyl 4-[3-(6-methylpyridin-2-yl)prop-2-ynylidene]piperidine-1-carboxylate
Show/Hide
|
C23H24N2O2
|
2
|
| 1 |
IC50 = 52.5 nM
|
|
|
| 2 |
Ki = 2.5 nM
|
|
|
|
CP0528788
|
2-methyl-6-[3-(1-phenylpiperidin-4-ylidene)prop-1-ynyl]pyridine
Show/Hide
|
C20H20N2
|
2
|
| 1 |
IC50 = 55 nM
|
|
|
| 2 |
Ki = 29.2 nM
|
|
|
|
CP0096665
|
[4-[3-(6-methylpyridin-2-yl)prop-2-ynylidene]piperidin-1-yl]-phenylmethanone
Show/Hide
|
C21H20N2O
|
2
|
| 1 |
IC50 = 67.3 nM
|
|
|
| 2 |
Ki = 18.4 nM
|
|
|
|
CP0234531
|
(3-methoxyphenyl)-[4-[3-(6-methylpyridin-2-yl)prop-2-ynylidene]piperidin-1-yl]methanone
Show/Hide
|
C22H22N2O2
|
2
|
| 1 |
IC50 = 88.4 nM
|
|
|
| 2 |
Ki = 18.5 nM
|
|
|
|
CP0168551
|
2-[3-[1-(3-bromophenyl)sulfonylpiperidin-4-ylidene]prop-1-ynyl]-6-methylpyridine
Show/Hide
|
C20H19BrN2O2S
|
2
|
| 1 |
IC50 = 89.9 nM
|
|
|
| 2 |
Ki = 18.2 nM
|
|
|
|
CP0410807
|
5-methyl-2-[(3E)-3-[3-(6-methylpyridin-2-yl)prop-2-ynylidene]piperidin-1-yl]-3-nitropyridine
Show/Hide
|
C20H20N4O2
|
2
|
| 1 |
IC50 = 91 nM
|
|
|
| 2 |
Ki = 41.8 nM
|
|
|
|
CP0096632
|
2-[3-[1-(4-methoxyphenyl)sulfonylpiperidin-4-ylidene]prop-1-ynyl]-6-methylpyridine
Show/Hide
|
C21H22N2O3S
|
2
|
| 1 |
IC50 = 95.2 nM
|
|
|
| 2 |
Ki = 2.9 nM
|
|
|
|
CP0474171
|
ethyl 3-[3-(6-methylpyridin-2-yl)prop-2-ynylidene]azetidine-1-carboxylate
Show/Hide
|
C15H16N2O2
|
2
|
| 1 |
IC50 = 117 nM
|
|
|
| 2 |
Ki = 38.3 nM
|
|
|
|
CP0098722
|
N-ethyl-4-[3-(6-methylpyridin-2-yl)prop-2-ynylidene]-N-propan-2-ylpiperidine-1-carboxamide
Show/Hide
|
C20H27N3O
|
2
|
| 1 |
IC50 = 133 nM
|
|
|
| 2 |
Ki = 2.9 nM
|
|
|
|
CP0063934
|
4-[4-[3-(6-methylpyridin-2-yl)prop-2-ynylidene]piperidin-1-yl]sulfonylbenzonitrile
Show/Hide
|
C21H19N3O2S
|
2
|
| 1 |
IC50 = 163 nM
|
|
|
| 2 |
Ki = 3.3 nM
|
|
|
|
CP0168548
|
benzyl 4-[3-(6-methylpyridin-2-yl)prop-2-ynylidene]piperidine-1-carboxylate
Show/Hide
|
C22H22N2O2
|
2
|
| 1 |
IC50 = 248 nM
|
|
|
| 2 |
Ki = 4.8 nM
|
|
|
|
CP0205248
|
(3-chlorophenyl)-[4-[3-(6-chloropyridin-2-yl)prop-2-ynylidene]piperidin-1-yl]methanone
Show/Hide
|
C20H16Cl2N2O
|
2
|
| 1 |
IC50 = 287 nM
|
|
|
| 2 |
Ki = 2.9 nM
|
|
|
|
CP0063927
|
(3-methylphenyl)-[4-[3-(6-methylpyridin-2-yl)prop-2-ynylidene]piperidin-1-yl]methanone
Show/Hide
|
C22H22N2O
|
2
|
| 1 |
IC50 = 1383 nM
|
|
|
| 2 |
Ki = 11.3 nM
|
|
|
|
CP0410805
|
1-[4-(2-nitrophenyl)piperazin-1-yl]-3-phenylprop-2-yn-1-one
Show/Hide
|
C19H17N3O3
|
1
|
| 1 |
Ki = 0.4 nM
|
|
|
|
CP0060764
|
ethyl 4-[3-(3-cyanophenyl)prop-2-ynylidene]piperidine-1-carboxylate
Show/Hide
|
C18H18N2O2
|
1
|
| 1 |
Ki = 0.98 nM
|
|
|
|
CP0234525
|
N-methyl-4-[3-(6-methylpyridin-2-yl)prop-2-ynylidene]-N-(1-phenylethyl)piperidine-1-carboxamide
Show/Hide
|
C24H27N3O
|
1
|
| 1 |
Ki = 4.3 nM
|
|
|
|
CP0205245
|
N-butyl-N-methyl-4-[3-(6-methylpyridin-2-yl)prop-2-ynylidene]piperidine-1-carboxamide
Show/Hide
|
C20H27N3O
|
1
|
| 1 |
Ki = 20.4 nM
|
|
|
|
CP0060761
|
1-[4-[3-(6-methylpyridin-2-yl)prop-2-ynylidene]piperidin-1-yl]butan-1-one
Show/Hide
|
C18H22N2O
|
1
|
| 1 |
Ki = 24 nM
|
|
|
|
CP0330107
|
(2-methoxyphenyl)-[4-[3-(6-methylpyridin-2-yl)prop-2-ynylidene]piperidin-1-yl]methanone
Show/Hide
|
C22H22N2O2
|
1
|
| 1 |
Ki = 40 nM
|
|
|
|
CP0440308
|
3,3-dimethyl-1-[4-[3-(6-methylpyridin-2-yl)prop-2-ynylidene]piperidin-1-yl]butan-1-one
Show/Hide
|
C20H26N2O
|
1
|
| 1 |
Ki = 48.2 nM
|
|
|
|
CP0456043
|
1-(3-nitropyridin-2-yl)-4-(3-phenylprop-2-ynyl)piperazine
Show/Hide
|
C18H18N4O2
|
1
|
| 1 |
Ki = 60.7 nM
|
|
|
|
CP0524574
|
2-[3-[1-(benzenesulfonyl)piperidin-4-ylidene]prop-1-ynyl]-6-methylpyridine
Show/Hide
|
C20H20N2O2S
|
1
|
| 1 |
Ki = 64.2 nM
|
|
|
|
CP0096669
|
2-[3-(1-ethylsulfonylpiperidin-4-ylidene)prop-1-ynyl]-6-methylpyridine
Show/Hide
|
C16H20N2O2S
|
1
|
| 1 |
Ki = 67.3 nM
|
|
|
|
CP0563387
|
1-[4-[3-(6-methylpyridin-2-yl)prop-2-ynylidene]piperidin-1-yl]-2-phenylethanone
Show/Hide
|
C22H22N2O
|
1
|
| 1 |
Ki = 83 nM
|
|
|
|
CP0459736
|
N-butyl-4-[3-(6-methylpyridin-2-yl)prop-2-ynylidene]piperidine-1-carboxamide
Show/Hide
|
C19H25N3O
|
1
|
| 1 |
Ki = 92 nM
|
|
|
|
CP0558164
|
(4-methoxyphenyl)-[4-[3-(6-methylpyridin-2-yl)prop-2-ynylidene]piperidin-1-yl]methanone
Show/Hide
|
C22H22N2O2
|
1
|
| 1 |
Ki = 122 nM
|
|
|
|
CP0474170
|
2-methoxy-1-[4-[3-(6-methylpyridin-2-yl)prop-2-ynylidene]piperidin-1-yl]ethanone
Show/Hide
|
C17H20N2O2
|
1
|
| 1 |
Ki = 178 nM
|
|
|
|
CP0474157
|
2-(3,5-difluorophenyl)-1-[4-[3-(6-methylpyridin-2-yl)prop-2-ynylidene]piperidin-1-yl]ethanone
Show/Hide
|
C22H20F2N2O
|
1
|
| 1 |
Ki = 194 nM
|
|
|
|
CP0437675
|
ethyl (3Z)-3-[3-(6-methylpyridin-2-yl)prop-2-ynylidene]pyrrolidine-1-carboxylate
Show/Hide
|
C16H18N2O2
|
1
|
| 1 |
Ki = 243 nM
|
|
|
|
CP0384226
|
N-tert-butyl-N-methyl-4-[3-(6-methylpyridin-2-yl)prop-2-ynylidene]piperidine-1-carboxamide
Show/Hide
|
C20H27N3O
|
1
|
| 1 |
Ki = 258 nM
|
|
|
|
CP0488095
|
6-methyl-2-[(3Z)-3-[3-(6-methylpyridin-2-yl)prop-2-ynylidene]piperidin-1-yl]-3-nitropyridine
Show/Hide
|
C20H20N4O2
|
1
|
| 1 |
Ki = 264.3 nM
|
|
|
|
CP0567454
|
4-[3-(6-methylpyridin-2-yl)prop-2-ynylidene]-N-(1-phenylethyl)piperidine-1-carboxamide
Show/Hide
|
C23H25N3O
|
1
|
| 1 |
Ki = 276 nM
|
|
|
|
CP0498981
|
3-chloro-5-[3-[1-(3-nitropyridin-2-yl)piperidin-4-ylidene]prop-1-ynyl]benzonitrile
Show/Hide
|
C20H15ClN4O2
|
1
|
| 1 |
Ki = 283.1 nM
|
|
|
|
CP0459744
|
N-tert-butyl-4-[3-(6-methylpyridin-2-yl)prop-2-ynylidene]piperidine-1-carboxamide
Show/Hide
|
C19H25N3O
|
1
|
| 1 |
Ki = 399 nM
|
|
|
|
CP0474156
|
2-[3-(1-benzylsulfonylpiperidin-4-ylidene)prop-1-ynyl]-6-methylpyridine
Show/Hide
|
C21H22N2O2S
|
1
|
| 1 |
Ki = 415 nM
|
|
|
|
CP0412986
|
2-[3-[1-(cyclohexylmethylsulfonyl)piperidin-4-ylidene]prop-1-ynyl]-6-methylpyridine
Show/Hide
|
C21H28N2O2S
|
1
|
| 1 |
Ki = 456 nM
|
|
|
|
CP0380629
|
[4-(6-methyl-3-nitropyridin-2-yl)piperazin-1-yl]-(3-phenylphenyl)methanone
Show/Hide
|
C23H22N4O3
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0448929
|
[4-(3-nitropyridin-2-yl)piperazin-1-yl]-quinoxalin-2-ylmethanone
Show/Hide
|
C18H16N6O3
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0494741
|
[4-(3-nitropyridin-2-yl)piperazin-1-yl]-(4-phenylphenyl)methanone
Show/Hide
|
C22H20N4O3
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0528789
|
[4-(3-nitropyridin-2-yl)piperazin-1-yl]-(2-phenylphenyl)methanone
Show/Hide
|
C22H20N4O3
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0381786
|
3,3-dimethyl-1-[4-[3-[1-(3-nitropyridin-2-yl)piperidin-4-ylidene]prop-1-ynyl]phenyl]azetidin-2-one
Show/Hide
|
C24H24N4O3
|
1
|
| 1 |
Ki > 1000 nM
|
|
|
|
CP0459743
|
1-[4-[3-(6-methylpyridin-2-yl)prop-2-ynylidene]piperidin-1-yl]-2-pyrrolidin-1-ylethanone
Show/Hide
|
C20H25N3O
|
1
|
| 1 |
Ki > 1000 nM
|
|
|
|
CP0553743
|
cyclobutylmethyl 4-[3-(6-methylpyridin-2-yl)prop-2-ynylidene]piperidine-1-carboxylate
Show/Hide
|
C20H24N2O2
|
1
|
| 1 |
Ki > 1000 nM
|
|
|
