Brief Information of the Compound and Protein
Compound Name
2-(Pyridin-3-yl)-5-(2-methylthiazol-4ylethynyl)pyridine
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PubChem ID
CID: 10039170
SID: 15021835
Canonical SMILES
Cc1nc(cs1)C#Cc1ccc(nc1)-c1cccnc1
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Compound Formula C16H11N3S
Compound Structure
Protein Name
Metabotropic glutamate receptor 5
Protein Classification
Membrane receptor
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Family C G protein-coupled receptor
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Small molecule receptor (family C GPCR)
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Neurotransmitter receptor (family C GPCR)
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Metabotropic glutamate receptor
Uniprot ID
P41594
Gene Name
GRM5
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000025 HEK-293T Homo sapiens (Human)  1
1
Ki = 5.65 nM
   TI
   LI
   LO
   TS
CL000308 T-REx-CHO Cricetulus griseus (Chinese hamster)  2
1
IC50 = 6.1 nM
   TI
   LI
   LO
   TS
2
Ki = 4.7 nM
   TI
   LI
   LO
   TS