| Compound ID |
Compound Name |
Compound Formula |
|
CP0447774
|
4-[6,7-Bis-(2-methoxy-ethoxy)-quinazolin-4-yl]-piperazine-1-carboxylic acid [4-(isoquinolin-5-yloxy)-phenyl]-amide
Show/Hide
|
C34H36N6O6
|
2
|
| 1 |
IC50 = 0.4 nM
|
|
|
| 2 |
IC50 = 120 nM
|
|
|
|
CP0537131
|
4-[6,7-Bis-(2-methoxy-ethoxy)-quinazolin-4-yl]-piperazine-1-carboxylic acid [4-(naphthalen-2-yloxy)-phenyl]-amide
Show/Hide
|
C35H37N5O6
|
2
|
| 1 |
IC50 = 0.4 nM
|
|
|
| 2 |
IC50 = 150 nM
|
|
|
|
CP0380727
|
4-[6,7-Bis-(2-methoxy-ethoxy)-quinazolin-4-yl]-piperazine-1-carboxylic acid [4-(1H-indol-4-yloxy)-phenyl]-amide
Show/Hide
|
C33H36N6O6
|
2
|
| 1 |
IC50 = 1 nM
|
|
|
| 2 |
IC50 = 32 nM
|
|
|
|
CP0406303
|
4-[6,7-Bis-(2-methoxy-ethoxy)-quinazolin-4-yl]-piperazine-1-carboxylic acid (4-tert-butyl-phenyl)-amide
Show/Hide
|
C29H39N5O5
|
2
|
| 1 |
IC50 = 1.4 nM
|
|
|
| 2 |
IC50 = 80 nM
|
|
|
|
CP0406345
|
4-[6,7-Bis-(2-methoxy-ethoxy)-quinazolin-4-yl]-piperazine-1-carboxylic acid [4-(quinolin-5-yloxy)-phenyl]-amide
Show/Hide
|
C34H36N6O6
|
2
|
| 1 |
IC50 = 1.6 nM
|
|
|
| 2 |
IC50 = 500 nM
|
|
|
|
CP0425901
|
4-[7-(2-Methoxy-ethoxy)-quinazolin-4-yl]-piperazine-1-carboxylic acid [4-(1H-indol-5-yloxy)-phenyl]-amide
Show/Hide
|
C30H30N6O4
|
2
|
| 1 |
IC50 = 2 nM
|
|
|
| 2 |
IC50 = 180 nM
|
|
|
|
CP0404621
|
4-[6,7-Bis-(2-methoxy-ethoxy)-quinazolin-4-yl]-piperazine-1-carboxylic acid [4-(4-bromo-phenoxy)-phenyl]-amide
Show/Hide
|
C31H34BrN5O6
|
2
|
| 1 |
IC50 = 2.4 nM
|
|
|
| 2 |
IC50 = 190 nM
|
|
|
|
CP0485148
|
4-[3-Cyano-6-methoxy-7-(3-piperidin-1-yl-propoxy)-quinolin-4-yl]-piperazine-1-carbothioic acid (6-trifluoromethyl-pyridin-3-ylmethyl)-amide
Show/Hide
|
C31H36F3N7O2S
|
2
|
| 1 |
IC50 = 3 nM
|
|
|
| 2 |
IC50 = 10 nM
|
|
|
|
CP0374313
|
4-{6-Methoxy-7-[3-(4-methyl-piperidin-1-yl)-propoxy]-quinazolin-4-yl}-piperazine-1-carboxylic acid (4-isopropoxy-phenyl)-amide
Show/Hide
|
C32H44N6O4
|
2
|
| 1 |
IC50 < 4 nM
|
|
|
| 2 |
IC50 = 51 nM
|
|
|
|
CP0380972
|
4-{6-Methoxy-7-[3-(2-methyl-piperidin-1-yl)-propoxy]-quinazolin-4-yl}-piperazine-1-carboxylic acid (4-isopropoxy-phenyl)-amide
Show/Hide
|
C32H44N6O4
|
2
|
| 1 |
IC50 < 4 nM
|
|
|
| 2 |
IC50 = 35 nM
|
|
|
|
CP0430789
|
4-{6-Methoxy-7-[3-(2-methyl-piperidin-1-yl)-propoxy]-quinazolin-4-yl}-piperazine-1-carboxylic acid (4-cyano-phenyl)-amide
Show/Hide
|
C30H37N7O3
|
2
|
| 1 |
IC50 < 4 nM
|
|
|
| 2 |
IC50 = 29 nM
|
|
|
|
CP0448810
|
4-{6-Methoxy-7-[3-(4-methyl-piperidin-1-yl)-propoxy]-quinazolin-4-yl}-piperazine-1-carboxylic acid (4-cyano-phenyl)-amide
Show/Hide
|
C30H37N7O3
|
2
|
| 1 |
IC50 < 4 nM
|
|
|
| 2 |
IC50 = 22 nM
|
|
|
|
CP0420185
|
4-[3-Cyano-6-methoxy-7-(3-piperidin-1-yl-propoxy)-quinolin-4-yl]-piperazine-1-carbothioic acid (4-cyano-phenyl)-amide
Show/Hide
|
C31H35N7O2S
|
2
|
| 1 |
IC50 = 5 nM
|
|
|
| 2 |
IC50 = 120 nM
|
|
|
|
CP0441722
|
4-[6-Methoxy-7-(3-morpholin-4-yl-propoxy)-quinazolin-4-yl]-piperazine-1-carbothioic acid (6-trifluoromethyl-pyridin-3-ylmethyl)-amide
Show/Hide
|
C28H34F3N7O3S
|
2
|
| 1 |
IC50 = 5 nM
|
|
|
| 2 |
IC50 = 50 nM
|
|
|
|
CP0485475
|
4-[6-Methoxy-7-(2-pyrrolidin-1-yl-ethoxy)-quinazolin-4-yl]-piperazine-1-carbothioic acid (benzo[1,3]dioxol-5-ylmethyl)-amide
Show/Hide
|
C28H34N6O4S
|
2
|
| 1 |
IC50 = 5 nM
|
|
|
| 2 |
IC50 = 160 nM
|
|
|
|
CP0467139
|
4-[6-Methoxy-7-(2-methoxy-ethoxy)-quinazolin-4-yl]-piperazine-1-carboxylic acid [4-(1H-indol-5-yloxy)-phenyl]-amide
Show/Hide
|
C31H32N6O5
|
2
|
| 1 |
IC50 = 9 nM
|
|
|
| 2 |
IC50 = 167 nM
|
|
|
|
CP0404663
|
4-[6,7-Bis-(2-methoxy-ethoxy)-quinazolin-4-yl]-piperazine-1-carboxylic acid (4-phenoxy-phenyl)-amide
Show/Hide
|
C31H35N5O6
|
2
|
| 1 |
IC50 = 10 nM
|
|
|
| 2 |
IC50 = 183 nM
|
|
|
|
CP0442377
|
4-[3-Cyano-6-methoxy-7-(3-piperidin-1-yl-propoxy)-quinolin-4-yl]-piperazine-1-carbothioic acid (6-phenyl-pyridin-3-ylmethyl)-amide
Show/Hide
|
C36H41N7O2S
|
2
|
| 1 |
IC50 = 10 nM
|
|
|
| 2 |
IC50 = 100 nM
|
|
|
|
CP0375017
|
4-[6,7-Bis-(2-methoxy-ethoxy)-quinazolin-4-yl]-piperazine-1-carboxylic acid [4-(4-tert-butyl-phenoxy)-phenyl]-amide
Show/Hide
|
C35H43N5O6
|
2
|
| 1 |
IC50 = 12 nM
|
|
|
| 2 |
IC50 = 634 nM
|
|
|
|
CP0115223
|
4-[6-Methoxy-7-(3-morpholin-4-yl-propoxy)-quinazolin-4-yl]-piperazine-1-carboxylic acid (4-isopropoxy-phenyl)-amide
Show/Hide
|
C30H40N6O5
|
2
|
| 1 |
IC50 = 20 nM
|
|
|
| 2 |
IC50 = 60 nM
|
|
|
|
CP0439303
|
4-[6,7-Bis-(2-methoxy-ethoxy)-quinazolin-4-yl]-piperazine-1-carboxylic acid [4-(2,3-dihydro-1H-indol-4-yloxy)-phenyl]-amide
Show/Hide
|
C33H38N6O6
|
2
|
| 1 |
IC50 = 20 nM
|
|
|
| 2 |
IC50 = 420 nM
|
|
|
|
CP0441712
|
4-[6-Methoxy-7-(2-piperidin-1-yl-ethoxy)-quinazolin-4-yl]-piperazine-1-carbothioic acid (benzo[1,3]dioxol-5-ylmethyl)-amide
Show/Hide
|
C29H36N6O4S
|
2
|
| 1 |
IC50 = 20 nM
|
|
|
| 2 |
IC50 = 120 nM
|
|
|
|
CP0485459
|
4-[6-Methoxy-7-(3-piperidin-1-yl-propoxy)-quinazolin-4-yl]-piperazine-1-carbothioic acid (6-phenyl-pyridin-3-ylmethyl)-amide
Show/Hide
|
C34H41N7O2S
|
2
|
| 1 |
IC50 = 20 nM
|
|
|
| 2 |
IC50 = 130 nM
|
|
|
|
CP0485710
|
4-[6-Methoxy-7-(3-piperidin-1-yl-propoxy)-quinazolin-4-yl]-piperazine-1-carbothioic acid (6-chloro-pyridin-3-ylmethyl)-amide
Show/Hide
|
C28H36ClN7O2S
|
2
|
| 1 |
IC50 = 20 nM
|
|
|
| 2 |
IC50 = 60 nM
|
|
|
|
CP0034949
|
4-[6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-yl]-N-(4-propan-2-yloxyphenyl)piperazine-1-carboxamide
Show/Hide
|
C31H42N6O4
|
2
|
| 1 |
IC50 = 26 nM
|
|
|
| 2 |
IC50 = 36 nM
|
|
|
|
CP0449649
|
4-[6,7-Bis-(2-methoxy-ethoxy)-quinazolin-4-yl]-piperazine-1-carboxylic acid (4-p-tolyloxy-phenyl)-amide
Show/Hide
|
C32H37N5O6
|
2
|
| 1 |
IC50 = 26 nM
|
|
|
| 2 |
IC50 = 206 nM
|
|
|
|
CP0404620
|
4-{7-[3-(3,3-Difluoro-piperidin-1-yl)-propoxy]-6-methoxy-quinazolin-4-yl}-piperazine-1-carboxylic acid (4-isopropoxy-phenyl)-amide
Show/Hide
|
C31H40F2N6O4
|
2
|
| 1 |
IC50 = 29 nM
|
|
|
| 2 |
IC50 = 150 nM
|
|
|
|
CP0497296
|
4-[6-Methoxy-7-(3-piperidin-1-yl-propoxy)-quinazolin-4-yl]-piperazine-1-carbothioic acid (6-trifluoromethyl-pyridin-3-ylmethyl)-amide
Show/Hide
|
C29H36F3N7O2S
|
2
|
| 1 |
IC50 = 30 nM
|
|
|
| 2 |
IC50 = 60 nM
|
|
|
|
CP0430790
|
4-{6-Methoxy-7-[3-(2-methyl-propane-1-sulfonyl)-propoxy]-quinazolin-4-yl}-piperazine-1-carboxylic acid (4-isopropoxy-phenyl)-amide
Show/Hide
|
C30H41N5O6S
|
2
|
| 1 |
IC50 = 36 nM
|
|
|
| 2 |
IC50 = 121 nM
|
|
|
|
CP0405138
|
4-{7-[3-(4,4-Difluoro-piperidin-1-yl)-propoxy]-6-methoxy-quinazolin-4-yl}-piperazine-1-carboxylic acid (4-isopropoxy-phenyl)-amide
Show/Hide
|
C31H40F2N6O4
|
2
|
| 1 |
IC50 = 40 nM
|
|
|
| 2 |
IC50 = 90 nM
|
|
|
|
CP0479999
|
4-[6-Methoxy-7-(2-methoxy-ethoxy)-quinazolin-4-yl]-piperazine-1-carboxylic acid (4-phenoxy-phenyl)-amide
Show/Hide
|
C29H31N5O5
|
2
|
| 1 |
IC50 = 40 nM
|
|
|
| 2 |
IC50 = 525 nM
|
|
|
|
CP0515067
|
4-[7-(2-Methoxy-ethoxy)-quinazolin-4-yl]-piperazine-1-carboxylic acid (4-phenoxy-phenyl)-amide
Show/Hide
|
C28H29N5O4
|
2
|
| 1 |
IC50 = 40 nM
|
|
|
| 2 |
IC50 = 920 nM
|
|
|
|
CP0453322
|
4-{6-Methoxy-7-[3-(3-methyl-butane-1-sulfonyl)-propoxy]-quinazolin-4-yl}-piperazine-1-carboxylic acid (4-isopropoxy-phenyl)-amide
Show/Hide
|
C31H43N5O6S
|
2
|
| 1 |
IC50 = 50 nM
|
|
|
| 2 |
IC50 = 240 nM
|
|
|
|
CP0536770
|
4-[6,7-Bis-(2-methoxy-ethoxy)-quinazolin-4-yl]-piperazine-1-carboxylic acid (4-isopropoxy-phenyl)-amide
Show/Hide
|
C28H37N5O6
|
2
|
| 1 |
IC50 = 50 nM
|
|
|
| 2 |
IC50 = 300 nM
|
|
|
|
CP0485458
|
4-[6-Methoxy-7-(3-piperidin-1-yl-propoxy)-quinazolin-4-yl]-piperazine-1-carbothioic acid (pyridin-3-ylmethyl)-amide
Show/Hide
|
C28H37N7O2S
|
2
|
| 1 |
IC50 = 50 nM
|
|
|
| 2 |
IC50 = 320 nM
|
|
|
|
CP0509627
|
4-[6-Methoxy-7-(2-piperidin-1-yl-ethoxy)-quinazolin-4-yl]-piperazine-1-carbothioic acid (5-methyl-pyrazin-2-ylmethyl)-amide
Show/Hide
|
C27H36N8O2S
|
2
|
| 1 |
IC50 = 50 nM
|
|
|
| 2 |
IC50 = 60 nM
|
|
|
|
CP0441721
|
4-[6-Methoxy-7-(3-piperidin-1-yl-propoxy)-quinazolin-4-yl]-piperazine-1-carbothioic acid (5-methyl-pyrazin-2-ylmethyl)-amide
Show/Hide
|
C28H38N8O2S
|
2
|
| 1 |
IC50 = 50 nM
|
|
|
| 2 |
IC50 = 140 nM
|
|
|
|
CP0431634
|
4-[6-Methoxy-7-(3-piperidin-1-yl-propoxy)-quinazolin-4-yl]-piperazine-1-carboxylic acid (4-cyano-phenyl)-amide
Show/Hide
|
C29H35N7O3
|
2
|
| 1 |
IC50 = 53 nM
|
|
|
| 2 |
IC50 = 60 nM
|
|
|
|
CP0116958
|
2-N-(3,5-dimorpholin-4-ylphenyl)-4-N-(1H-indazol-4-yl)-4-N-methylpyrimidine-2,4-diamine
Show/Hide
|
C26H30N8O2
|
1
|
| 1 |
IC50 = 58 nM
|
|
|
|
CP0435399
|
4-[6-Methoxy-7-(3-piperidin-1-yl-propoxy)-quinazolin-4-yl]-piperazine-1-carbothioic acid pyridin-4-ylamide
Show/Hide
|
C27H35N7O2S
|
2
|
| 1 |
IC50 = 60 nM
|
|
|
| 2 |
IC50 = 220 nM
|
|
|
|
CP0435407
|
4-[6-Methoxy-7-(3-piperidin-1-yl-propoxy)-quinazolin-4-yl]-piperazine-1-carbothioic acid (4-isopropoxy-phenyl)-amide
Show/Hide
|
C31H42N6O3S
|
2
|
| 1 |
IC50 = 70 nM
|
|
|
| 2 |
IC50 = 550 nM
|
|
|
|
CP0402821
|
4-[7-(3-Dimethylamino-propoxy)-6-methoxy-quinazolin-4-yl]-piperazine-1-carboxylic acid (4-isopropoxy-phenyl)-amide
Show/Hide
|
C28H38N6O4
|
2
|
| 1 |
IC50 = 76 nM
|
|
|
| 2 |
IC50 = 123 nM
|
|
|
|
CP0431601
|
4-[6-Methoxy-7-(3-pyrrolidin-1-yl-propoxy)-quinazolin-4-yl]-piperazine-1-carboxylic acid (4-isopropoxy-phenyl)-amide
Show/Hide
|
C30H40N6O4
|
2
|
| 1 |
IC50 = 77 nM
|
|
|
| 2 |
IC50 = 100 nM
|
|
|
|
CP0453479
|
4-[6-(2-Methoxy-ethoxy)-7-(2-piperidin-1-yl-ethoxy)-quinazolin-4-yl]-piperazine-1-carboxylic acid (4-cyano-phenyl)-amide
Show/Hide
|
C30H37N7O4
|
2
|
| 1 |
IC50 = 79 nM
|
|
|
| 2 |
IC50 = 90 nM
|
|
|
|
CP0425154
|
4-[6-Methoxy-7-(3-piperidin-1-yl-propoxy)-quinazolin-4-yl]-piperazine-1-carbothioic acid (5-methyl-furan-2-ylmethyl)-amide
Show/Hide
|
C28H38N6O3S
|
2
|
| 1 |
IC50 = 80 nM
|
|
|
| 2 |
IC50 = 90 nM
|
|
|
|
CP0497321
|
4-[6-Methoxy-7-(2-piperidin-1-yl-ethoxy)-quinazolin-4-yl]-piperazine-1-carbothioic acid (6-chloro-pyridin-3-ylmethyl)-amide
Show/Hide
|
C27H34ClN7O2S
|
2
|
| 1 |
IC50 = 80 nM
|
|
|
| 2 |
IC50 = 1010 nM
|
|
|
|
CP0403328
|
4-{6-Methoxy-7-[3-(propane-1-sulfonyl)-propoxy]-quinazolin-4-yl}-piperazine-1-carboxylic acid (4-isopropoxy-phenyl)-amide
Show/Hide
|
C29H39N5O6S
|
2
|
| 1 |
IC50 = 87 nM
|
|
|
| 2 |
IC50 = 265 nM
|
|
|
|
CP0534163
|
4-[6-(2-Methoxy-ethoxy)-7-(2-piperidin-1-yl-ethoxy)-quinazolin-4-yl]-piperazine-1-carboxylic acid (4-isopropoxy-phenyl)-amide
Show/Hide
|
C32H44N6O5
|
2
|
| 1 |
IC50 = 90 nM
|
|
|
| 2 |
IC50 = 99 nM
|
|
|
|
CP0435329
|
4-[6-Methoxy-7-(2-piperidin-1-yl-ethoxy)-quinazolin-4-yl]-piperazine-1-carbothioic acid (6-trifluoromethyl-pyridin-3-ylmethyl)-amide
Show/Hide
|
C28H34F3N7O2S
|
2
|
| 1 |
IC50 = 90 nM
|
|
|
| 2 |
IC50 = 1030 nM
|
|
|
|
CP0495108
|
4-[6-Methoxy-7-(3-piperidin-1-yl-propoxy)-quinazolin-4-yl]-piperazine-1-carbothioic acid (6-methyl-pyridin-3-ylmethyl)-amide
Show/Hide
|
C29H39N7O2S
|
2
|
| 1 |
IC50 = 90 nM
|
|
|
| 2 |
IC50 = 140 nM
|
|
|
|
CP0406306
|
4-[6-Methoxy-7-(2-piperidin-1-yl-ethoxy)-quinazolin-4-yl]-piperazine-1-carboxylic acid (4-cyano-phenyl)-amide
Show/Hide
|
C28H33N7O3
|
2
|
| 1 |
IC50 = 97 nM
|
|
|
| 2 |
IC50 = 424 nM
|
|
|
|
CP0442379
|
4-[6-Methoxy-7-(2-morpholin-4-yl-ethoxy)-quinazolin-4-yl]-piperazine-1-carbothioic acid (benzo[1,3]dioxol-5-ylmethyl)-amide
Show/Hide
|
C28H34N6O5S
|
2
|
| 1 |
IC50 = 100 nM
|
|
|
| 2 |
IC50 = 260 nM
|
|
|
|
CP0502831
|
4-[6-Methoxy-7-(2-piperidin-1-yl-ethoxy)-quinazolin-4-yl]-piperazine-1-carbothioic acid thiophen-3-ylamide
Show/Hide
|
C25H32N6O2S2
|
2
|
| 1 |
IC50 = 100 nM
|
|
|
| 2 |
IC50 = 740 nM
|
|
|
|
CP0375745
|
4-[6-Methoxy-7-(3-piperidin-1-yl-propoxy)-quinazolin-4-yl]-piperazine-1-carbothioic acid (4-pyridin-2-yl-phenyl)-amide
Show/Hide
|
C33H39N7O2S
|
2
|
| 1 |
IC50 = 100 nM
|
|
|
| 2 |
IC50 = 220 nM
|
|
|
|
CP0439258
|
4-[7-(2-Methoxy-ethoxy)-6-(2-piperidin-1-yl-ethoxy)-quinazolin-4-yl]-piperazine-1-carboxylic acid (4-isopropoxy-phenyl)-amide
Show/Hide
|
C32H44N6O5
|
2
|
| 1 |
IC50 = 110 nM
|
|
|
| 2 |
IC50 = 198 nM
|
|
|
|
CP0505344
|
4-{7-[3-(4,4-Difluoro-piperidin-1-yl)-propoxy]-6-methoxy-quinazolin-4-yl}-piperazine-1-carboxylic acid (4-cyano-phenyl)-amide
Show/Hide
|
C29H33F2N7O3
|
2
|
| 1 |
IC50 = 110 nM
|
|
|
| 2 |
IC50 = 165 nM
|
|
|
|
CP0510394
|
4-{7-[3-(Butane-1-sulfonyl)-propoxy]-6-methoxy-quinazolin-4-yl}-piperazine-1-carboxylic acid (4-isopropoxy-phenyl)-amide
Show/Hide
|
C30H41N5O6S
|
2
|
| 1 |
IC50 = 112 nM
|
|
|
| 2 |
IC50 = 292 nM
|
|
|
|
CP0420184
|
4-[3-Cyano-6-methoxy-7-(3-piperidin-1-yl-propoxy)-quinolin-4-yl]-piperazine-1-carbothioic acid pyridin-4-ylamide
Show/Hide
|
C29H35N7O2S
|
2
|
| 1 |
IC50 = 130 nM
|
|
|
| 2 |
IC50 = 240 nM
|
|
|
|
CP0441713
|
4-[3-Cyano-6-methoxy-7-(3-piperidin-1-yl-propoxy)-quinolin-4-yl]-piperazine-1-carbothioic acid (4-pyridin-2-yl-phenyl)-amide
Show/Hide
|
C35H39N7O2S
|
2
|
| 1 |
IC50 = 130 nM
|
|
|
| 2 |
IC50 = 220 nM
|
|
|
|
CP0457104
|
4-[6-Methoxy-7-(3-morpholin-4-yl-propoxy)-quinazolin-4-yl]-piperazine-1-carboxylic acid (4-cyano-phenyl)-amide
Show/Hide
|
C28H33N7O4
|
2
|
| 1 |
IC50 = 140 nM
|
|
|
| 2 |
IC50 = 145 nM
|
|
|
|
CP0527691
|
4-[6-(2-Methoxy-ethoxy)-7-(2-pyrrolidin-1-yl-ethoxy)-quinazolin-4-yl]-piperazine-1-carboxylic acid (4-isopropoxy-phenyl)-amide
Show/Hide
|
C31H42N6O5
|
2
|
| 1 |
IC50 = 145 nM
|
|
|
| 2 |
IC50 = 175 nM
|
|
|
|
CP0419238
|
4-[6-Methoxy-7-(2-pyrrolidin-1-yl-ethoxy)-quinazolin-4-yl]-piperazine-1-carboxylic acid (4-cyano-phenyl)-amide
Show/Hide
|
C27H31N7O3
|
2
|
| 1 |
IC50 = 150 nM
|
|
|
| 2 |
IC50 = 206 nM
|
|
|
|
CP0500793
|
4-[3-Cyano-6-methoxy-7-(3-piperidin-1-yl-propoxy)-quinolin-4-yl]-piperazine-1-carbothioic acid (6-phenyl-pyridin-3-yl)-amide
Show/Hide
|
C35H39N7O2S
|
2
|
| 1 |
IC50 = 150 nM
|
|
|
| 2 |
IC50 = 280 nM
|
|
|
|
CP0464610
|
4-[6-Methoxy-7-(2-piperidin-1-yl-ethoxy)-quinazolin-4-yl]-piperazine-1-carbothioic acid (4-pyridin-2-yl-phenyl)-amide
Show/Hide
|
C32H37N7O2S
|
2
|
| 1 |
IC50 = 150 nM
|
|
|
| 2 |
IC50 = 180 nM
|
|
|
|
CP0449697
|
4-[6,7-Bis-(2-methoxy-ethoxy)-quinazolin-4-yl]-piperazine-1-carboxylic acid (4-cyano-phenyl)-amide
Show/Hide
|
C26H30N6O5
|
2
|
| 1 |
IC50 = 160 nM
|
|
|
| 2 |
IC50 = 610 nM
|
|
|
|
CP0509435
|
4-[6-Methoxy-7-(2-pyrrolidin-1-yl-ethoxy)-quinazolin-4-yl]-piperazine-1-carbothioic acid (furan-2-ylmethyl)-amide
Show/Hide
|
C25H32N6O3S
|
2
|
| 1 |
IC50 = 160 nM
|
|
|
| 2 |
IC50 = 310 nM
|
|
|
|
CP0409676
|
4-[6-(2-Methoxy-ethoxy)-7-(2-pyrrolidin-1-yl-ethoxy)-quinazolin-4-yl]-piperazine-1-carboxylic acid (4-cyano-phenyl)-amide
Show/Hide
|
C29H35N7O4
|
2
|
| 1 |
IC50 = 168 nM
|
|
|
| 2 |
IC50 = 200 nM
|
|
|
|
CP0406454
|
4-[6-Methoxy-7-(2-piperidin-1-yl-ethoxy)-quinazolin-4-yl]-piperazine-1-carboxylic acid (4-isopropoxy-phenyl)-amide
Show/Hide
|
C30H40N6O4
|
2
|
| 1 |
IC50 = 170 nM
|
|
|
| 2 |
IC50 = 1250 nM
|
|
|
|
CP0380566
|
4-[6-Methoxy-7-(2-morpholin-4-yl-ethoxy)-quinazolin-4-yl]-piperazine-1-carboxylic acid (4-isopropoxy-phenyl)-amide
Show/Hide
|
C29H38N6O5
|
2
|
| 1 |
IC50 = 177 nM
|
|
|
| 2 |
IC50 = 198 nM
|
|
|
|
CP0442305
|
4-[6-Methoxy-7-(3-pyrrolidin-1-yl-propoxy)-quinazolin-4-yl]-piperazine-1-carboxylic acid (4-cyano-phenyl)-amide
Show/Hide
|
C28H33N7O3
|
2
|
| 1 |
IC50 = 178 nM
|
|
|
| 2 |
IC50 = 210 nM
|
|
|
|
CP0494618
|
4-[6-Methoxy-7-(2-morpholin-4-yl-ethoxy)-quinazolin-4-yl]-piperazine-1-carbothioic acid (4-bromo-phenyl)-amide
Show/Hide
|
C26H31BrN6O3S
|
2
|
| 1 |
IC50 = 180 nM
|
|
|
| 2 |
IC50 = 540 nM
|
|
|
|
CP0377709
|
4-[6-Methoxy-7-(2-methoxy-ethoxy)-quinazolin-4-yl]-piperazine-1-carboxylic acid (4-isopropoxy-phenyl)-amide
Show/Hide
|
C26H33N5O5
|
2
|
| 1 |
IC50 = 216 nM
|
|
|
| 2 |
IC50 = 420 nM
|
|
|
|
CP0401200
|
4-[6-Methoxy-7-(2-tetrazol-2-yl-ethoxy)-quinazolin-4-yl]-piperazine-1-carboxylic acid (4-isopropoxy-phenyl)-amide
Show/Hide
|
C26H31N9O4
|
2
|
| 1 |
IC50 = 216 nM
|
|
|
| 2 |
IC50 = 350 nM
|
|
|
|
CP0528787
|
4-{7-[2-(1,4-Dioxa-8-aza-spiro[4.5]dec-8-yl)-ethoxy]-6-methoxy-quinazolin-4-yl}-piperazine-1-carboxylic acid (4-cyano-phenyl)-amide
Show/Hide
|
C30H35N7O5
|
2
|
| 1 |
IC50 = 222 nM
|
|
|
| 2 |
IC50 = 336 nM
|
|
|
|
CP0494617
|
4-[6-Methoxy-7-(2-morpholin-4-yl-ethoxy)-quinazolin-4-yl]-piperazine-1-carbothioic acid (5-methyl-pyrazin-2-ylmethyl)-amide
Show/Hide
|
C26H34N8O3S
|
2
|
| 1 |
IC50 = 230 nM
|
|
|
| 2 |
IC50 = 1360 nM
|
|
|
|
CP0451878
|
4-[6-Methoxy-7-(2-piperidin-1-yl-ethoxy)-quinazolin-4-yl]-piperazine-1-carbothioic acid pyridin-4-ylamide
Show/Hide
|
C26H33N7O2S
|
2
|
| 1 |
IC50 = 240 nM
|
|
|
| 2 |
IC50 = 400 nM
|
|
|
|
CP0435401
|
4-[6-Methoxy-7-(3-piperidin-1-yl-propoxy)-quinazolin-4-yl]-piperazine-1-carbothioic acid (6-phenyl-pyridin-3-yl)-amide
Show/Hide
|
C33H39N7O2S
|
2
|
| 1 |
IC50 = 270 nM
|
|
|
| 2 |
IC50 = 360 nM
|
|
|
|
CP0405597
|
4-[6-Methoxy-7-(2-thiomorpholin-4-yl-ethoxy)-quinazolin-4-yl]-piperazine-1-carboxylic acid (4-cyano-phenyl)-amide
Show/Hide
|
C27H31N7O3S
|
2
|
| 1 |
IC50 = 305 nM
|
|
|
| 2 |
IC50 = 450 nM
|
|
|
|
CP0502832
|
4-[4-(N-Substituted-thio-carbamoyl)-1-piperazinyl]-6-methoxy-7-alkoxyamino-quinazoline derivative
Show/Hide
|
C31H38N8O4
|
2
|
| 1 |
IC50 = 320 nM
|
|
|
| 2 |
IC50 = 590 nM
|
|
|
|
CP0414896
|
4-[7-(2-Methoxy-ethoxy)-6-(2-piperidin-1-yl-ethoxy)-quinazolin-4-yl]-piperazine-1-carboxylic acid (4-cyano-phenyl)-amide
Show/Hide
|
C30H37N7O4
|
2
|
| 1 |
IC50 = 335 nM
|
|
|
| 2 |
IC50 = 501 nM
|
|
|
|
CP0464369
|
4-[6-Methoxy-7-(2-[1,2,3]triazol-1-yl-ethoxy)-quinazolin-4-yl]-piperazine-1-carboxylic acid (4-isopropoxy-phenyl)-amide
Show/Hide
|
C27H32N8O4
|
2
|
| 1 |
IC50 = 335 nM
|
|
|
| 2 |
IC50 = 380 nM
|
|
|
|
CP0451877
|
4-[6-Methoxy-7-(2-pyrrolidin-1-yl-ethoxy)-quinazolin-4-yl]-piperazine-1-carbothioic acid (4-bromo-phenyl)-amide
Show/Hide
|
C26H31BrN6O2S
|
2
|
| 1 |
IC50 = 350 nM
|
|
|
| 2 |
IC50 = 470 nM
|
|
|
|
CP0451817
|
4-[6-Methoxy-7-(2-piperidin-1-yl-ethoxy)-quinazolin-4-yl]-piperazine-1-carbothioic acid (2-chloro-6-methyl-pyridin-3-ylmethyl)-amide
Show/Hide
|
C28H36ClN7O2S
|
2
|
| 1 |
IC50 = 350 nM
|
|
|
| 2 |
IC50 = 1150 nM
|
|
|
|
CP0486388
|
4-[4-(N-Substituted-thio-carbamoyl)-1-piperazinyl]-6-methoxy-7-alkoxyamino-quinazoline derivative
Show/Hide
|
C34H39N9O2
|
2
|
| 1 |
IC50 = 370 nM
|
|
|
| 2 |
IC50 = 420 nM
|
|
|
|
CP0420131
|
4-[6-Methoxy-7-(2-piperidin-1-yl-ethoxy)-quinazolin-4-yl]-piperazine-1-carbothioic acid (4-bromo-phenyl)-amide
Show/Hide
|
C27H33BrN6O2S
|
2
|
| 1 |
IC50 = 390 nM
|
|
|
| 2 |
IC50 = 1010 nM
|
|
|
|
CP0510393
|
4-[6-Methoxy-7-(3-[1,2,3]triazol-2-yl-propoxy)-quinazolin-4-yl]-piperazine-1-carboxylic acid (4-isopropoxy-phenyl)-amide
Show/Hide
|
C28H34N8O4
|
2
|
| 1 |
IC50 = 400 nM
|
|
|
| 2 |
IC50 = 800 nM
|
|
|
|
CP0447771
|
4-[7-(3-Ethanesulfonyl-propoxy)-6-methoxy-quinazolin-4-yl]-piperazine-1-carboxylic acid (4-isopropoxy-phenyl)-amide
Show/Hide
|
C28H37N5O6S
|
2
|
| 1 |
IC50 = 409 nM
|
|
|
| 2 |
IC50 = 530 nM
|
|
|
|
CP0440086
|
4-[6-Methoxy-7-(2-piperidin-1-yl-ethoxy)-quinazolin-4-yl]-piperazine-1-carbothioic acid (6-chloro-pyridazin-3-yl)-amide
Show/Hide
|
C25H31ClN8O2S
|
2
|
| 1 |
IC50 = 420 nM
|
|
|
| 2 |
IC50 = 1330 nM
|
|
|
|
CP0440241
|
4-[6-Methoxy-7-(2-piperidin-1-yl-ethoxy)-quinazolin-4-yl]-piperazine-1-carbothioic acid [4-(1-oxy-pyridin-2-yl)-phenyl]-amide
Show/Hide
|
C32H37N7O3S
|
2
|
| 1 |
IC50 = 430 nM
|
|
|
| 2 |
IC50 = 800 nM
|
|
|
|
CP0485457
|
4-[6-Methoxy-7-(2-piperidin-1-yl-ethoxy)-quinazolin-4-yl]-piperazine-1-carbothioic acid (4-cyano-phenyl)-amide
Show/Hide
|
C28H33N7O2S
|
2
|
| 1 |
IC50 = 450 nM
|
|
|
| 2 |
IC50 = 470 nM
|
|
|
|
CP0446053
|
4-[6-Methoxy-7-(3-piperidin-1-yl-propoxy)-quinazolin-4-yl]-piperazine-1-carbothioic acid (2-methyl-thiazol-4-ylmethyl)-amide
Show/Hide
|
C27H37N7O2S2
|
2
|
| 1 |
IC50 = 450 nM
|
|
|
| 2 |
IC50 = 630 nM
|
|
|
|
CP0440084
|
4-[6-Methoxy-7-(2-pyrrolidin-1-yl-ethoxy)-quinazolin-4-yl]-piperazine-1-carbothioic acid (4-cyano-phenyl)-amide
Show/Hide
|
C27H31N7O2S
|
2
|
| 1 |
IC50 = 460 nM
|
|
|
| 2 |
IC50 = 21580 nM
|
|
|
|
CP0453423
|
4-{7-[2-(1,1-Dioxo-1lambda*6*-thiomorpholin-4-yl)-ethoxy]-6-methoxy-quinazolin-4-yl}-piperazine-1-carboxylic acid (4-isopropoxy-phenyl)-amide
Show/Hide
|
C29H38N6O6S
|
2
|
| 1 |
IC50 = 494 nM
|
|
|
| 2 |
IC50 = 680 nM
|
|
|
|
CP0406292
|
4-[6-Methoxy-7-(2-tetrazol-1-yl-ethoxy)-quinazolin-4-yl]-piperazine-1-carboxylic acid (4-isopropoxy-phenyl)-amide
Show/Hide
|
C26H31N9O4
|
2
|
| 1 |
IC50 = 507 nM
|
|
|
| 2 |
IC50 = 1430 nM
|
|
|
|
CP0394705
|
4-[6-Methoxy-7-(2-piperidin-1-yl-ethoxy)-quinazolin-4-yl]-piperazine-1-carbothioic acid (6-chloro-pyridin-3-yl)-amide
Show/Hide
|
C26H32ClN7O2S
|
2
|
| 1 |
IC50 = 510 nM
|
|
|
| 2 |
IC50 = 890 nM
|
|
|
|
CP0439326
|
4-[6-Methoxy-7-(2-[1,2,3]triazol-2-yl-ethoxy)-quinazolin-4-yl]-piperazine-1-carboxylic acid (4-isopropoxy-phenyl)-amide
Show/Hide
|
C27H32N8O4
|
2
|
| 1 |
IC50 = 520 nM
|
|
|
| 2 |
IC50 = 526 nM
|
|
|
|
CP0500774
|
4-[6-Methoxy-7-(3-piperidin-1-yl-propoxy)-quinazolin-4-yl]-piperazine-1-carbothioic acid (5-phenyl-pyridin-2-yl)-amide
Show/Hide
|
C33H39N7O2S
|
2
|
| 1 |
IC50 = 550 nM
|
|
|
| 2 |
IC50 = 1980 nM
|
|
|
|
CP0380567
|
4-{6-Methoxy-7-[3-(2,2,2-trifluoro-ethanesulfonyl)-propoxy]-quinazolin-4-yl}-piperazine-1-carboxylic acid (4-isopropoxy-phenyl)-amide
Show/Hide
|
C28H34F3N5O6S
|
2
|
| 1 |
IC50 = 564 nM
|
|
|
| 2 |
IC50 = 1230 nM
|
|
|
|
CP0449641
|
4-[7-(2-Methoxy-ethoxy)-6-(2-morpholin-4-yl-ethoxy)-quinazolin-4-yl]-piperazine-1-carboxylic acid (4-cyano-phenyl)-amide
Show/Hide
|
C29H35N7O5
|
2
|
| 1 |
IC50 = 582 nM
|
|
|
| 2 |
IC50 = 1100 nM
|
|
|
|
CP0442051
|
4-{6-Methoxy-7-[2-(4-oxo-piperidin-1-yl)-ethoxy]-quinazolin-4-yl}-piperazine-1-carboxylic acid (4-cyano-phenyl)-amide
Show/Hide
|
C28H31N7O4
|
2
|
| 1 |
IC50 = 601 nM
|
|
|
| 2 |
IC50 = 1370 nM
|
|
|
|
CP0453189
|
4-{6-Methoxy-7-[2-(4-methyl-piperazin-1-yl)-ethoxy]-quinazolin-4-yl}-piperazine-1-carboxylic acid (4-cyano-phenyl)-amide
Show/Hide
|
C28H34N8O3
|
2
|
| 1 |
IC50 = 662 nM
|
|
|
| 2 |
IC50 = 750 nM
|
|
|
|
CP0497431
|
4-[6-Methoxy-7-(2-piperidin-1-yl-ethoxy)-quinazolin-4-yl]-piperazine-1-carbothioic acid (pyridin-3-ylmethyl)-amide
Show/Hide
|
C27H35N7O2S
|
2
|
| 1 |
IC50 = 710 nM
|
|
|
| 2 |
IC50 = 2110 nM
|
|
|
|
CP0494158
|
4-[6-Methoxy-7-(2-pyrrol-1-yl-ethoxy)-quinazolin-4-yl]-piperazine-1-carboxylic acid (4-cyano-phenyl)-amide
Show/Hide
|
C27H27N7O3
|
2
|
| 1 |
IC50 = 715 nM
|
|
|
| 2 |
IC50 = 2490 nM
|
|
|
|
CP0398494
|
4-[6-Methoxy-7-(3-[1,2,3]triazol-1-yl-propoxy)-quinazolin-4-yl]-piperazine-1-carboxylic acid (4-isopropoxy-phenyl)-amide
Show/Hide
|
C28H34N8O4
|
2
|
| 1 |
IC50 = 720 nM
|
|
|
| 2 |
IC50 = 1450 nM
|
|
|
|
CP0509841
|
4-[6-Methoxy-7-(2-piperidin-1-yl-ethoxy)-quinazolin-4-yl]-piperazine-1-carbothioic acid (2-chloro-pyridin-4-ylmethyl)-amide
Show/Hide
|
C27H34ClN7O2S
|
2
|
| 1 |
IC50 = 770 nM
|
|
|
| 2 |
IC50 = 1790 nM
|
|
|
|
CP0506576
|
4-[6-Methoxy-7-(2-methoxy-ethoxy)-quinazolin-4-yl]-piperazine-1-carboxylic acid (4-cyano-phenyl)-amide
Show/Hide
|
C24H26N6O4
|
2
|
| 1 |
IC50 = 800 nM
|
|
|
| 2 |
IC50 = 1300 nM
|
|
|
|
CP0467273
|
4-[4-(N-Substituted-thio-carbamoyl)-1-piperazinyl]-6-methoxy-7-alkoxyamino-quinazoline derivative
Show/Hide
|
C33H44N8O2
|
2
|
| 1 |
IC50 = 800 nM
|
|
|
| 2 |
IC50 = 1550 nM
|
|
|
|
CP0436702
|
4-[7-(3-Cyclohexyl-propoxy)-6-methoxy-quinazolin-4-yl]-piperazine-1-carboxylic acid (4-isopropoxy-phenyl)-amide
Show/Hide
|
C32H43N5O4
|
2
|
| 1 |
IC50 = 813 nM
|
|
|
| 2 |
IC50 = 19460 nM
|
|
|
|
CP0456727
|
4-[7-(3-Carbamimidoyl-propoxy)-6-methoxy-quinazolin-4-yl]-piperazine-1-carboxylic acid (4-isopropoxy-phenyl)-amide
Show/Hide
|
C27H35N7O4
|
2
|
| 1 |
IC50 = 871 nM
|
|
|
| 2 |
IC50 = 9100 nM
|
|
|
|
CP0435408
|
4-[6-Methoxy-7-(2-morpholin-4-yl-ethoxy)-quinazolin-4-yl]-piperazine-1-carbothioic acid (4-cyano-phenyl)-amide
Show/Hide
|
C27H31N7O3S
|
2
|
| 1 |
IC50 = 920 nM
|
|
|
| 2 |
IC50 = 1180 nM
|
|
|
|
CP0485147
|
4-[4-(N-Substituted-thio-carbamoyl)-1-piperazinyl]-6-methoxy-7-alkoxyamino-quinazoline derivative
Show/Hide
|
C33H44N8O2
|
2
|
| 1 |
IC50 = 920 nM
|
|
|
| 2 |
IC50 = 970 nM
|
|
|
|
CP0455018
|
4-[6-Methoxy-7-(3-[1,2,3]triazol-2-yl-propoxy)-quinazolin-4-yl]-piperazine-1-carboxylic acid (4-cyano-phenyl)-amide
Show/Hide
|
C26H27N9O3
|
2
|
| 1 |
IC50 = 943 nM
|
|
|
| 2 |
IC50 = 1660 nM
|
|
|
|
CP0394708
|
4-[6-Methoxy-7-(2-piperidin-1-yl-ethoxy)-quinazolin-4-yl]-piperazine-1-carbothioic acid (6-trifluoromethyl-pyridin-3-yl)-amide
Show/Hide
|
C27H32F3N7O2S
|
2
|
| 1 |
IC50 = 1060 nM
|
|
|
| 2 |
IC50 = 4100 nM
|
|
|
|
CP0486378
|
4-[6-Methoxy-7-(2-piperidin-1-yl-ethoxy)-quinazolin-4-yl]-piperazine-1-carbothioic acid (2-chloro-6-trifluoromethyl-pyridin-3-ylmethyl)-amide
Show/Hide
|
C28H33ClF3N7O2S
|
2
|
| 1 |
IC50 = 1130 nM
|
|
|
| 2 |
IC50 = 1400 nM
|
|
|
|
CP0455022
|
4-[6-Methoxy-7-(2-[1,2,3]triazol-2-yl-ethoxy)-quinazolin-4-yl]-piperazine-1-carboxylic acid (4-cyano-phenyl)-amide
Show/Hide
|
C25H25N9O3
|
2
|
| 1 |
IC50 = 1200 nM
|
|
|
| 2 |
IC50 = 2210 nM
|
|
|
|
CP0497169
|
4-[7-(2-Methoxy-ethoxy)-quinazolin-4-yl]-piperazine-1-carboxylic acid (4-cyano-phenyl)-amide
Show/Hide
|
C23H24N6O3
|
2
|
| 1 |
IC50 = 1250 nM
|
|
|
| 2 |
IC50 = 3560 nM
|
|
|
|
CP0448937
|
4-[6-Methoxy-7-(2-morpholin-4-yl-ethoxy)-quinazolin-4-yl]-piperazine-1-carboxylic acid (4-cyano-phenyl)-amide
Show/Hide
|
C27H31N7O4
|
2
|
| 1 |
IC50 = 1260 nM
|
|
|
| 2 |
IC50 = 1410 nM
|
|
|
|
CP0485476
|
4-[6-Methoxy-7-(2-piperidin-1-yl-ethoxy)-quinazolin-4-yl]-piperazine-1-carbothioic acid 4-pyridin-2-yl-benzylamide
Show/Hide
|
C33H39N7O2S
|
2
|
| 1 |
IC50 = 1490 nM
|
|
|
| 2 |
IC50 = 2130 nM
|
|
|
|
CP0445850
|
4-[6-Methoxy-7-(2-piperidin-1-yl-ethoxy)-quinazolin-4-yl]-piperazine-1-carbothioic acid (2-cyano-pyridin-4-yl)-amide
Show/Hide
|
C27H32N8O2S
|
2
|
| 1 |
IC50 = 1540 nM
|
|
|
| 2 |
IC50 = 1790 nM
|
|
|
|
CP0451823
|
4-[6-Methoxy-7-(2-piperidin-1-yl-ethoxy)-quinazolin-4-yl]-piperazine-1-carbothioic acid thiazol-2-ylamide
Show/Hide
|
C24H31N7O2S2
|
2
|
| 1 |
IC50 = 2000 nM
|
|
|
| 2 |
IC50 = 5040 nM
|
|
|
|
CP0502112
|
4-{7-[2-(1,1-Dioxo-1lambda*6*-thiomorpholin-4-yl)-ethoxy]-6-methoxy-quinazolin-4-yl}-piperazine-1-carboxylic acid (4-cyano-phenyl)-amide
Show/Hide
|
C27H31N7O5S
|
2
|
| 1 |
IC50 = 2130 nM
|
|
|
| 2 |
IC50 = 2970 nM
|
|
|
|
CP0494621
|
4-[4-(N-Substituted-thio-carbamoyl)-1-piperazinyl]-6-methoxy-7-alkoxyamino-quinazoline derivative
Show/Hide
|
C30H36F3N9O2
|
2
|
| 1 |
IC50 = 2180 nM
|
|
|
| 2 |
IC50 = 3420 nM
|
|
|
|
CP0455021
|
4-[6-Methoxy-7-(2-[1,2,3]triazol-1-yl-ethoxy)-quinazolin-4-yl]-piperazine-1-carboxylic acid (4-cyano-phenyl)-amide
Show/Hide
|
C25H25N9O3
|
2
|
| 1 |
IC50 = 2240 nM
|
|
|
| 2 |
IC50 = 4690 nM
|
|
|
|
CP0451841
|
4-[4-(N-Substituted-thio-carbamoyl)-1-piperazinyl]-6-methoxy-7-alkoxyamino-quinazoline derivative
Show/Hide
|
C28H37N9O3
|
2
|
| 1 |
IC50 = 2370 nM
|
|
|
| 2 |
IC50 = 10450 nM
|
|
|
|
CP0442304
|
4-[6-Methoxy-7-(3-piperidin-1-yl-propoxy)-quinazolin-4-yl]-piperazine-1-carbothioic acid (pyridin-4-ylmethyl)-amide
Show/Hide
|
C28H37N7O2S
|
2
|
| 1 |
IC50 = 2450 nM
|
|
|
| 2 |
IC50 = 13400 nM
|
|
|
|
CP0441566
|
4-[7-(2-Methoxy-ethoxy)-6-(2-morpholin-4-yl-ethoxy)-quinazolin-4-yl]-piperazine-1-carboxylic acid (4-isopropoxy-phenyl)-amide
Show/Hide
|
C31H42N6O6
|
2
|
| 1 |
IC50 = 2670 nM
|
|
|
| 2 |
IC50 = 5000 nM
|
|
|
|
CP0449048
|
4-[6-Methoxy-7-(3-[1,2,3]triazol-1-yl-propoxy)-quinazolin-4-yl]-piperazine-1-carboxylic acid (4-cyano-phenyl)-amide
Show/Hide
|
C26H27N9O3
|
2
|
| 1 |
IC50 = 2810 nM
|
|
|
| 2 |
IC50 = 5920 nM
|
|
|
|
CP0451819
|
4-[6-Methoxy-7-(2-piperidin-1-yl-ethoxy)-quinazolin-4-yl]-piperazine-1-carbothioic acid (6-amino-pyridin-3-ylmethyl)-amide
Show/Hide
|
C27H36N8O2S
|
2
|
| 1 |
IC50 = 2930 nM
|
|
|
| 2 |
IC50 = 5810 nM
|
|
|
|
CP0494616
|
4-[6-Methoxy-7-(3-piperidin-1-yl-propoxy)-quinazolin-4-yl]-piperazine-1-carbothioic acid [2-(4-trifluoromethyl-phenyl)-thiazol-4-ylmethyl]-amide
Show/Hide
|
C33H38F3N7O2S2
|
2
|
| 1 |
IC50 = 3090 nM
|
|
|
| 2 |
IC50 = 4470 nM
|
|
|
|
CP0414962
|
4-[7-(3-Amino-propoxy)-6-methoxy-quinazolin-4-yl]-piperazine-1-carboxylic acid (4-isopropoxy-phenyl)-amide
Show/Hide
|
C26H34N6O4
|
2
|
| 1 |
IC50 = 3110 nM
|
|
|
| 2 |
IC50 = 15420 nM
|
|
|
|
CP0536910
|
4-{7-[2-(4-Hydroxy-piperidin-1-yl)-ethoxy]-6-methoxy-quinazolin-4-yl}-piperazine-1-carboxylic acid (4-cyano-phenyl)-amide
Show/Hide
|
C28H33N7O4
|
2
|
| 1 |
IC50 = 3230 nM
|
|
|
| 2 |
IC50 = 6150 nM
|
|
|
|
CP0486379
|
4-[6-Methoxy-7-(2-piperidin-1-yl-ethoxy)-quinazolin-4-yl]-piperazine-1-carbothioic acid (pyridin-4-ylmethyl)-amide
Show/Hide
|
C27H35N7O2S
|
2
|
| 1 |
IC50 = 3590 nM
|
|
|
| 2 |
IC50 = 12100 nM
|
|
|
|
CP0487153
|
4-[6-Methoxy-7-(2-piperidin-1-yl-ethoxy)-quinazolin-4-yl]-piperazine-1-carbothioic acid pyridin-3-ylamide
Show/Hide
|
C26H33N7O2S
|
2
|
| 1 |
IC50 = 3760 nM
|
|
|
| 2 |
IC50 = 4980 nM
|
|
|
|
CP0509840
|
4-[6-Methoxy-7-(2-piperidin-1-yl-ethoxy)-quinazolin-4-yl]-piperazine-1-carbothioic acid (pyridin-2-ylmethyl)-amide
Show/Hide
|
C27H35N7O2S
|
1
|
| 1 |
IC50 = 4090 nM
|
|
|
|
CP0442223
|
4-[6-Methoxy-7-(2-piperidin-1-yl-ethoxy)-quinazolin-4-yl]-piperazine-1-carbothioic acid 4-pyridin-4-yl-benzylamide
Show/Hide
|
C33H39N7O2S
|
2
|
| 1 |
IC50 = 5040 nM
|
|
|
| 2 |
IC50 = 9530 nM
|
|
|
|
CP0380726
|
4-[7-(2-Imidazol-1-yl-ethoxy)-6-methoxy-quinazolin-4-yl]-piperazine-1-carboxylic acid (4-cyano-phenyl)-amide
Show/Hide
|
C26H26N8O3
|
2
|
| 1 |
IC50 = 5170 nM
|
|
|
| 2 |
IC50 = 8180 nM
|
|
|
|
CP0491816
|
4-[6-Methoxy-7-(2-piperidin-1-yl-ethoxy)-quinazolin-4-yl]-piperazine-1-carbothioic acid 4-pyridin-3-yl-benzylamide
Show/Hide
|
C33H39N7O2S
|
2
|
| 1 |
IC50 = 5190 nM
|
|
|
| 2 |
IC50 = 14800 nM
|
|
|
|
CP0465117
|
4-[7-(3-Hydroxy-propoxy)-6-methoxy-quinazolin-4-yl]-piperazine-1-carboxylic acid (4-isopropoxy-phenyl)-amide
Show/Hide
|
C26H33N5O5
|
2
|
| 1 |
IC50 = 5590 nM
|
|
|
| 2 |
IC50 = 13970 nM
|
|
|
|
CP0415027
|
4-[6-Methoxy-7-(2-piperazin-1-yl-ethoxy)-quinazolin-4-yl]-piperazine-1-carboxylic acid (4-cyano-phenyl)-amide
Show/Hide
|
C27H32N8O3
|
2
|
| 1 |
IC50 = 6500 nM
|
|
|
| 2 |
IC50 = 7790 nM
|
|
|
|
CP0394283
|
4-{6-Methoxy-7-[3-(1-methyl-4,5-dihydro-1H-imidazol-2-yl)-propoxy]-quinazolin-4-yl}-piperazine-1-carboxylic acid (4-isopropoxy-phenyl)-amide
Show/Hide
|
C30H39N7O4
|
2
|
| 1 |
IC50 = 6750 nM
|
|
|
| 2 |
IC50 = 12250 nM
|
|
|
|
CP0451825
|
4-[4-(N-Substituted-thio-carbamoyl)-1-piperazinyl]-6-methoxy-7-alkoxyamino-quinazoline derivative
Show/Hide
|
C28H35N9O2
|
2
|
| 1 |
IC50 = 17100 nM
|
|
|
| 2 |
IC50 = 31700 nM
|
|
|
