General Information of the Compound
Compound ID
CP0375017
Compound Name
4-[6,7-Bis-(2-methoxy-ethoxy)-quinazolin-4-yl]-piperazine-1-carboxylic acid [4-(4-tert-butyl-phenoxy)-phenyl]-amide
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Structure
Formula
C35H43N5O6
Molecular Weight
629.758
Canonical SMILES
COCCOc1cc2ncnc(N3CCN(CC3)C(=O)Nc3ccc(Oc4ccc(cc4)C(C)(C)C)cc3)c2cc1OCCOC
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InChI
InChI=1S/C35H43N5O6/c1-35(2,3)25-6-10-27(11-7-25)46-28-12-8-26(9-13-28)38-34(41)40-16-14-39(15-17-40)33-29-22-31(44-20-18-42-4)32(45-21-19-43-5)23-30(29)36-24-37-33/h6-13,22-24H,14-21H2,1-5H3,(H,38,41)
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InChIKey
QYQSABYRKQKCSG-UHFFFAOYSA-N
Physicochemical Property
logP
6.1241
Rotatable Bonds
12
Heavy Atom Count
46
Polar Areas
107.51
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
9
Complexity
46

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 11734851
SID: 16840750
ChEMBL ID
CHEMBL125721
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00844, Platelet-derived growth factor receptor beta
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000197 MG-63 Homo sapiens (Human)  2
1
IC50 = 12 nM
   TI
   LI
   LO
   TS
2
IC50 = 634 nM
   TI
   LI
   LO
   TS