Brief Information of the Compound and Protein
Compound Name
4-{7-[3-(3,3-Difluoro-piperidin-1-yl)-propoxy]-6-methoxy-quinazolin-4-yl}-piperazine-1-carboxylic acid (4-isopropoxy-phenyl)-amide
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PubChem ID
CID: 10963044
SID: 16018028
Canonical SMILES
COc1cc2c(ncnc2cc1OCCCN1CCCC(F)(F)C1)N1CCN(CC1)C(=O)Nc1ccc(OC(C)C)cc1
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Compound Formula C31H40F2N6O4
Compound Structure
Protein Name
Platelet-derived growth factor receptor beta
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TK protein kinase group
>
Tyrosine protein kinase PDGFR family
Uniprot ID
P09619
Gene Name
PDGFRB
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000197 MG-63 Homo sapiens (Human)  2
1
IC50 = 29 nM
   TI
   LI
   LO
   TS
2
IC50 = 150 nM
   TI
   LI
   LO
   TS