Brief Information of the Compound and Protein
Compound Name
4-{6-Methoxy-7-[2-(4-methyl-piperazin-1-yl)-ethoxy]-quinazolin-4-yl}-piperazine-1-carboxylic acid (4-cyano-phenyl)-amide
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PubChem ID
CID: 10918469
SID: 15968360
Canonical SMILES
COc1cc2c(ncnc2cc1OCCN1CCN(C)CC1)N1CCN(CC1)C(=O)Nc1ccc(cc1)C#N
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Compound Formula C28H34N8O3
Compound Structure
Protein Name
Platelet-derived growth factor receptor beta
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TK protein kinase group
>
Tyrosine protein kinase PDGFR family
Uniprot ID
P09619
Gene Name
PDGFRB
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000197 MG-63 Homo sapiens (Human)  2
1
IC50 = 662 nM
   TI
   LI
   LO
   TS
2
IC50 = 750 nM
   TI
   LI
   LO
   TS