| Compound ID |
Compound Name |
Compound Formula |
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CP0430838
|
(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S,3R)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-1-hydroxy-3-phenylpropylidene]amino]-1-hydroxyethylidene]amino]-1-hydroxyethylidene]amino]-1-hydroxy-3-phenylpropylidene]amino]-1,3-dihydroxybutylidene]amino]-1-hydroxyethylidene]amino]-1-hydroxybutylidene]amino]-5-carbamimidamido-1-hydroxypentylidene]amino]-1-hydroxyhexylidene]amino]-1,3-dihydroxypropylidene]amino]-1-hydroxypropylidene]amino]-5-carbamimidamido-1-hydroxypentylidene]amino]-1-hydroxyhexylidene]amino]-1-hydroxy-4-methylpentylidene]amino]-1-hydroxypropylidene]amino]-1,4-dihydroxy-4-iminobutylidene]amino]pentanediimidic acid
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C80H132N28O21
|
2
|
| 1 |
EC50 = 0.06 nM
|
|
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| 2 |
Ki = 0.05 nM
|
|
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CP0462751
|
(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S,3R)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-1-hydroxy-3-phenylpropylidene]amino]-1-hydroxyethylidene]amino]-1-hydroxyethylidene]amino]-1-hydroxy-3-phenylpropylidene]amino]-1,3-dihydroxybutylidene]amino]-1-hydroxyethylidene]amino]-1-hydroxybutylidene]amino]-5-carbamimidamido-1-hydroxypentylidene]amino]-1-hydroxyhexylidene]amino]-1,3-dihydroxypropylidene]amino]-1-hydroxybutylidene]amino]-5-carbamimidamido-1-hydroxypentylidene]amino]-1-hydroxyhexylidene]amino]-1-hydroxy-4-methylpentylidene]amino]-1-hydroxypropylidene]amino]-1,4-dihydroxy-4-iminobutylidene]amino]pentanediimidic acid
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C81H134N28O21
|
2
|
| 1 |
EC50 = 0.08 nM
|
|
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| 2 |
Ki = 0.05 nM
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|
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CP0424703
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(2S)-6-amino-2-[[(2S)-6-amino-2-[[(2S)-6-amino-2-[[(2S)-6-amino-2-[[(2S)-6-amino-2-[[(2S)-6-amino-2-[4-[3-[(2R)-3-amino-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S,3R)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-phenylpropanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]propanoyl]amino]-5-carbamimidamidopentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]-5-carbamimidamidopentanoyl]amino]hexanoyl]amino]-3-oxopropyl]sulfanyl-2,5-dioxopyrrolidin-1-yl]butanoylamino]hexanoyl]amino]hexanoyl]amino]hexanoyl]amino]hexanoyl]amino]hexanoyl]amino]hexanamide
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C108H187N37O25S
|
2
|
| 1 |
EC50 = 0.0871 nM
|
|
|
| 2 |
EC50 = 6.026 nM
|
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CP0677646
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3,4-dichloro-N-[(1S,5R,13R,14R,17S)-4-(cyclopropylmethyl)-10,17-dihydroxy-12-oxa-4-azapentacyclo[9.6.1.0^{1,13}.0^{5,17}.0^{7,18}]octadeca-7(18),8,10-trien-14-yl]benzamide oxalic acid
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C29H30Cl2N2O8
|
2
|
| 1 |
EC50 = 0.1 nM
|
|
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| 2 |
EC50 > 10000 nM
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|
|
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CP0404622
|
(2S)-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S,3R)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-phenylpropanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]propanoyl]amino]-5-carbamimidamidopentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]butanoyl]amino]-5-carbamimidamidopentanoyl]amino]hexanoyl]amino]-4-methylpentanoyl]amino]propanoyl]amino]-4-oxobutanoyl]amino]pentanediamide
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C80H132N28O21
|
2
|
| 1 |
EC50 = 0.14 nM
|
|
|
| 2 |
Ki = 0.08 nM
|
|
|
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CP0460054
|
(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S,3R)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-1-hydroxy-3-phenylpropylidene]amino]-1-hydroxyethylidene]amino]-1-hydroxyethylidene]amino]-1-hydroxy-3-phenylpropylidene]amino]-1,3-dihydroxybutylidene]amino]-1-hydroxyethylidene]amino]-1-hydroxypropylidene]amino]-5-carbamimidamido-1-hydroxypentylidene]amino]-1-hydroxyhexylidene]amino]-1,3-dihydroxypropylidene]amino]-1-hydroxypropylidene]amino]-5-carbamimidamido-1-hydroxypentylidene]amino]-1-hydroxyhexylidene]amino]-1-hydroxy-4-methylpentylidene]amino]-1-hydroxybutylidene]amino]-1,4-dihydroxy-4-iminobutylidene]amino]pentanediimidic acid
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C80H132N28O21
|
2
|
| 1 |
EC50 = 0.2 nM
|
|
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| 2 |
Ki = 0.02 nM
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CP0038350
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(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-6-amino-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-6-amino-2-[(2S)-2-[(2S)-2-{2-[(2S,3R)-2-[(2S)-2-(2-{2-[(2S)-2-amino-3-phenylpropanamido]acetamido}acetamido)-3-phenylpropanamido]-3-hydroxybutanamido]acetamido}propanamido]-5-carbamimidamidopentanamido]hexanamido]-3-hydroxypropanamido]propanamido]-5-carbamimidamidopentanamido]hexanamido]-4-methylpentanamido]propanamido]butanediamido]-4-carbamoylbutanoic acid
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C79H129N27O22
|
7
|
| 1 |
EC50 = 0.23 nM
|
|
|
| 2 |
EC50 = 0.45 nM
|
|
|
| 3 |
EC50 = 1.5 nM
|
|
|
| 4 |
IC50 = 1.3 nM
|
|
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| 5 |
Ki = 0.13 nM
|
|
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| 6 |
Ki = 0.3 nM
|
|
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| 7 |
Ki = 0.39 nM
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|
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CP0509420
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(2S)-5-amino-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S,3R)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-phenylpropanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]butanoyl]amino]-5-carbamimidamidopentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]-5-carbamimidamidopentanoyl]amino]hexanoyl]amino]-4-methylpentanoyl]amino]propanoyl]amino]-4-oxobutanoyl]amino]-5-oxopentanoic acid
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C80H131N27O22
|
2
|
| 1 |
EC50 = 0.27 nM
|
|
|
| 2 |
Ki = 0.1 nM
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CP0469116
|
N-[3-[3-[(2R)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S,3R)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-phenylpropanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-3-[[(2S)-1-[[(2S)-5-(diaminomethylideneamino)-1-[[(2S)-1,6-diamino-1-oxohexan-2-yl]amino]-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-oxopropyl]sulfanyl-2,5-dioxopyrrolidin-1-yl]propyl]hexadecanamide
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C84H140N24O17S
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2
|
| 1 |
EC50 = 0.2884 nM
|
|
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| 2 |
EC50 = 19.05 nM
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|
|
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CP0556269
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N-[3-[3-[(2R)-3-amino-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S,3R)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-phenylpropanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-3-oxopropyl]sulfanyl-2,5-dioxopyrrolidin-1-yl]propyl]tetradecanamide
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C85H141N25O19S
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2
|
| 1 |
EC50 = 0.2884 nM
|
|
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| 2 |
EC50 = 24.55 nM
|
|
|
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CP0386129
|
1-[1-(1-Methylcyclooctyl)-4-piperidinyl]-2-[(3R)-3-piperidinyl]-1H-benzimidazole
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C26H40N4
|
2
|
| 1 |
EC50 = 0.39 nM
|
|
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| 2 |
Ki = 0.0858 nM
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|
|
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CP0469115
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N-[3-[3-[(2R)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S,3R)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-phenylpropanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]-3-[[(2S)-5-(diaminomethylideneamino)-1-[[(2S)-1,6-diamino-1-oxohexan-2-yl]amino]-1-oxopentan-2-yl]amino]-3-oxopropyl]sulfanyl-2,5-dioxopyrrolidin-1-yl]propyl]hexadecanamide
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C84H140N24O18S
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2
|
| 1 |
EC50 = 0.4365 nM
|
|
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| 2 |
EC50 = 34.67 nM
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CP0469109
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(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S,3R)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-(4-fluorophenyl)propanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanamide
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C61H99FN22O15
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2
|
| 1 |
EC50 = 0.4571 nM
|
|
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| 2 |
EC50 = 3.981 nM
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CP0535065
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(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S,3R)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-1-hydroxy-3-phenylpropylidene]amino]-1-hydroxyethylidene]amino]-1-hydroxyethylidene]amino]-1-hydroxy-3-phenylpropylidene]amino]-1,3-dihydroxybutylidene]amino]-1-hydroxyethylidene]amino]-1-hydroxypropylidene]amino]-5-carbamimidamido-1-hydroxypentylidene]amino]-1-hydroxyhexylidene]amino]-1,3-dihydroxypropylidene]amino]-1-hydroxypropylidene]amino]-5-carbamimidamido-1-hydroxypentylidene]amino]-1-hydroxyhexylidene]amino]-1-hydroxy-4-methylpentylidene]amino]-1-hydroxybutylidene]amino]-1,4-dihydroxy-4-iminobutylidene]amino]-5-hydroxy-5-iminopentanoic acid
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C80H131N27O22
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2
|
| 1 |
EC50 = 0.47 nM
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|
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| 2 |
Ki = 0.15 nM
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CP0401390
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1-[1-(1-Methylcyclooctyl)-4-piperidinyl]-2-[(3S)-3-piperidinyl]-1H-benzimidazole
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C26H40N4
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2
|
| 1 |
EC50 = 0.5 nM
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|
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| 2 |
Ki = 0.1 nM
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CP0512527
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N-[3-[3-[(2R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S,3R)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-phenylpropanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]-3-[[(2S)-1,6-diamino-1-oxohexan-2-yl]amino]-3-oxopropyl]sulfanyl-2,5-dioxopyrrolidin-1-yl]propyl]hexadecanamide
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|
C81H133N21O18S
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2
|
| 1 |
EC50 = 0.5248 nM
|
|
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| 2 |
EC50 = 22.39 nM
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CP0477720
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N-[3-[3-[(2R)-3-amino-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S,3R)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-phenylpropanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-3-oxopropyl]sulfanyl-2,5-dioxopyrrolidin-1-yl]propyl]hexadecanamide
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C87H145N25O19S
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2
|
| 1 |
EC50 = 0.537 nM
|
|
|
| 2 |
EC50 = 54.95 nM
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CP0424705
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(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S,3R)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-phenylpropanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]propanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanamide
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C61H100N22O14
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2
|
| 1 |
EC50 = 0.5623 nM
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|
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| 2 |
EC50 = 3.715 nM
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CP0424539
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(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S,3R)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-1-hydroxy-3-phenylpropylidene]amino]-1-hydroxyethylidene]amino]-1-hydroxyethylidene]amino]-1-hydroxy-3-phenylpropylidene]amino]-1,3-dihydroxybutylidene]amino]-1-hydroxyethylidene]amino]-1-hydroxypropylidene]amino]-5-carbamimidamido-1-hydroxypentylidene]amino]-1-hydroxyhexylidene]amino]-1,3-dihydroxypropylidene]amino]-1-hydroxypropylidene]amino]-5-carbamimidamido-1-hydroxypentylidene]amino]-1-hydroxyhexylidene]amino]-4-methylpentanoyl]-methylamino]-1-hydroxypropylidene]amino]-1,4-dihydroxy-4-iminobutylidene]amino]pentanediimidic acid
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C80H132N28O21
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2
|
| 1 |
EC50 = 0.73 nM
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| 2 |
Ki = 0.06 nM
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CP0487405
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(2S)-6-amino-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[4-[3-[(2R)-3-amino-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S,3R)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-phenylpropanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]propanoyl]amino]-5-carbamimidamidopentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]-5-carbamimidamidopentanoyl]amino]hexanoyl]amino]-3-oxopropyl]sulfanyl-2,5-dioxopyrrolidin-1-yl]butanoylamino]propanoyl]amino]hexanoyl]amino]propanoyl]amino]hexanoyl]amino]propanoyl]amino]hexanoyl]amino]propanoyl]amino]hexanoyl]amino]propanoyl]amino]hexanoyl]amino]propanoyl]amino]hexanamide
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C126H217N43O31S
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2
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| 1 |
EC50 = 0.7943 nM
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| 2 |
EC50 = 17.38 nM
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CP0466534
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(2S)-5-amino-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S,3R)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-phenylpropanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]butanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-4-methylpentanoyl]amino]propanoyl]amino]-4-oxobutanoyl]amino]-5-oxopentanoic acid
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C80H131N27O22
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2
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| 1 |
EC50 = 1 nM
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| 2 |
Ki = 0.48 nM
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CP0421426
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(2S)-6-amino-2-[[2-[[(2S)-6-amino-2-[[2-[[(2S)-6-amino-2-[[2-[[(2S)-6-amino-2-[[2-[[(2S)-6-amino-2-[[2-[[(2S)-6-amino-2-[[2-[4-[3-[(2R)-3-amino-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S,3R)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-phenylpropanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]propanoyl]amino]-5-carbamimidamidopentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]-5-carbamimidamidopentanoyl]amino]hexanoyl]amino]-3-oxopropyl]sulfanyl-2,5-dioxopyrrolidin-1-yl]butanoylamino]acetyl]amino]hexanoyl]amino]acetyl]amino]hexanoyl]amino]acetyl]amino]hexanoyl]amino]acetyl]amino]hexanoyl]amino]acetyl]amino]hexanoyl]amino]acetyl]amino]hexanamide
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C120H205N43O31S
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2
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| 1 |
EC50 = 1.096 nM
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|
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| 2 |
EC50 = 14.45 nM
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|
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CP0181125
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Demethyl-AMPA
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C61H100N22O15
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4
|
| 1 |
EC50 = 1.12 nM
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|
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| 2 |
EC50 = 8.318 nM
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|
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| 3 |
EC50 = 10 nM
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| 4 |
IC50 = 0.353 nM
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CP0424684
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(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S,3R)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-cyclohexylpropanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanamide
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C61H106N22O15
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2
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| 1 |
EC50 = 1.175 nM
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|
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| 2 |
EC50 = 5.248 nM
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CP0539177
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(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[2-[[2-[[(2S,3R)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-phenylpropanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]-2-methylpropanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanamide
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C62H102N22O15
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2
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| 1 |
EC50 = 1.202 nM
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|
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| 2 |
EC50 = 3.981 nM
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|
|
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CP0424701
|
N-[3-[3-[(2R)-3-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S,3R)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-phenylpropanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-oxopropyl]sulfanyl-2,5-dioxopyrrolidin-1-yl]propyl]hexadecanamide
Show/Hide
|
C81H133N23O18S
|
2
|
| 1 |
EC50 = 1.259 nM
|
|
|
| 2 |
EC50 = 54.95 nM
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|
|
|
CP0372876
|
1-(3-{1-[1-(1-Methylcyclooctyl)piperidin-4-yl]-1H-benzimidazol-2-yl}phenyl)methanamine
Show/Hide
|
C28H38N4
|
2
|
| 1 |
EC50 = 1.3 nM
|
|
|
| 2 |
Ki = 0.18 nM
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|
|
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CP0386132
|
1-[1-(1-Methylcyclooctyl)-4-piperidinyl]-2-[(3R)-1-methyl-3-piperidinyl]-1H-benzimidazole
Show/Hide
|
C27H42N4
|
2
|
| 1 |
EC50 = 1.4 nM
|
|
|
| 2 |
Ki = 0.2 nM
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|
|
|
CP0424683
|
N-[3-[3-[(2R)-3-amino-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S,3R)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-phenylpropanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-3-oxopropyl]sulfanyl-2,5-dioxopyrrolidin-1-yl]propyl]octadecanamide
Show/Hide
|
C89H149N25O19S
|
2
|
| 1 |
EC50 = 1.585 nM
|
|
|
| 2 |
EC50 = 60.26 nM
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|
|
|
CP0372874
|
1-[1-(1-Methylcyclooctyl)piperidin-4-yl]-2-[3-(methylsulfonyl)phenyl]-1H-benzimidazole
Show/Hide
|
C28H37N3O2S
|
2
|
| 1 |
EC50 = 1.6 nM
|
|
|
| 2 |
Ki = 0.15 nM
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|
|
|
CP0386131
|
2-(3-Chloro-4-fluorophenyl)-1-[1-(1-methylcyclooctyl)piperidin-4-yl]-1H-benzimidazole
Show/Hide
|
C27H33ClFN3
|
2
|
| 1 |
EC50 = 1.6 nM
|
|
|
| 2 |
Ki = 0.22 nM
|
|
|
|
CP0401391
|
1-[1-(1-Methylcyclooctyl)-4-piperidinyl]-2-[(3S)-1-methyl-3-piperidinyl]-1H-benzimidazole
Show/Hide
|
C27H42N4
|
2
|
| 1 |
EC50 = 1.6 nM
|
|
|
| 2 |
Ki = 0.24 nM
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|
|
|
CP0405523
|
(4S)-5-amino-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S,3R)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-phenylpropanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-4-methylpentanoyl]amino]propanoyl]amino]-3-carboxypropanoyl]amino]-5-oxopentanoic acid
Show/Hide
|
C79H128N26O23
|
2
|
| 1 |
EC50 = 1.93 nM
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|
|
| 2 |
IC50 = 0.286 nM
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|
|
|
CP0374048
|
(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S,3R)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-phenylpropanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-N-[(2S)-1-amino-4-methyl-1-oxopentan-2-yl]hexanamide
Show/Hide
|
C67H111N23O16
|
2
|
| 1 |
EC50 = 1.97 nM
|
|
|
| 2 |
IC50 = 0.52 nM
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|
|
|
CP0469117
|
1-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S,3R)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-phenylpropanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]-N-[(2S)-5-(diaminomethylideneamino)-1-[[(2S)-1,6-diamino-1-oxohexan-2-yl]amino]-1-oxopentan-2-yl]cyclopentane-1-carboxamide
Show/Hide
|
C64H104N22O15
|
2
|
| 1 |
EC50 = 2.455 nM
|
|
|
| 2 |
EC50 = 6.026 nM
|
|
|
|
CP0386133
|
2-(3-{1-[1-(1-Methylcyclooctyl)piperidin-4-yl]-1H-benzimidazol-2-yl}phenoxy)ethanol
Show/Hide
|
C29H39N3O2
|
2
|
| 1 |
EC50 = 2.6 nM
|
|
|
| 2 |
Ki = 0.3 nM
|
|
|
|
CP0443386
|
2-(1-Benzofuran-2-yl)-1-[1-(1-methylcyclooctyl)piperidin-4-yl]-1H-benzimidazole
Show/Hide
|
C29H35N3O
|
2
|
| 1 |
EC50 = 3.1 nM
|
|
|
| 2 |
Ki = 0.53 nM
|
|
|
|
CP0668278
|
17-Cyclopropylmethyl-3,14beta-dihydroxy-4,5alpha-epoxy-6beta-[(4'-iodo)benzamido]morphinan-oxalate
Show/Hide
|
C29H31IN2O8
|
3
|
| 1 |
EC50 = 3.6 nM
|
|
|
| 2 |
EC50 > 10000 nM
|
|
|
| 3 |
Ki > 10000 nM
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|
|
|
CP0409873
|
(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S,3R)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-phenylpropanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-3-sulfanylpropanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-N-[(2R)-1-amino-1-oxo-3-sulfanylpropan-2-yl]hexanamide
Show/Hide
|
C64H105N23O15S2
|
2
|
| 1 |
EC50 = 3.9 nM
|
|
|
| 2 |
IC50 = 0.471 nM
|
|
|
|
CP0050068
|
(1S,2S,13R,21R)-22-(cyclopropylmethyl)-14-oxa-11,22-diazaheptacyclo[13.9.1.01,13.02,21.04,12.05,10.019,25]pentacosa-4(12),5,7,9,15,17,19(25)-heptaene-2,16-diol
Show/Hide
|
C26H26N2O3
|
1
|
| 1 |
EC50 = 3.9 nM
|
|
|
|
CP0469110
|
(2S)-6-amino-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2R)-1-amino-3-[1-[4-(cyclooctylamino)-4-oxobutyl]-2,5-dioxopyrrolidin-3-yl]sulfanyl-1-oxopropan-2-yl]amino]-1-oxohexan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S,3R)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-phenylpropanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanamide
Show/Hide
|
C80H129N25O19S
|
2
|
| 1 |
EC50 = 3.981 nM
|
|
|
| 2 |
EC50 = 27.54 nM
|
|
|
|
CP0902705
|
(2S)-6-amino-2-((2S,5S,8S,11S,14S,17S,23S,26S,35S)-35-amino-11-(4-aminobutyl)-26-benzyl-2,14-bis(3-guanidinopropyl)-23-((R)-1-hydroxyethyl)-8-(hydroxymethyl)-5,17-dimethyl-4,7,10,13,16,19,22,25,28,31,34-undecaoxo-36-phenyl-3,6,9,12,15,18,21,24,27,30,33-undecaazahexatriacontanamido)-N-((2R)-1-amino-3-(1-((2S,8S,14S,20S,26S,32S)-2,8,14,20,26,32-hexakis((1H-imidazol-5-yl)methyl)-1-amino-1,4,7,10,13,16,19,22,25,28,31,34,37-tridecaoxo-3,6,9,12,15,18,21,24,27,30,33,36-dodecaazatetracontan-40-yl)-2,5-dioxopyrrolidin-3-ylthio)-1-oxopropan-2-yl)hexanamide
Show/Hide
|
C120H175N49O31S
|
2
|
| 1 |
EC50 = 4.266 nM
|
|
|
| 2 |
EC50 = 12.59 nM
|
|
|
|
CP0404817
|
(4R,7S,10S,13S,16R)-16-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S,3R)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-phenylpropanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-7-(4-aminobutyl)-10-[3-(diaminomethylideneamino)propyl]-13-methyl-6,9,12,15-tetraoxo-1,2-dithia-5,8,11,14-tetrazacycloheptadecane-4-carboxamide
Show/Hide
|
C64H103N23O15S2
|
2
|
| 1 |
EC50 = 4.37 nM
|
|
|
| 2 |
IC50 = 0.122 nM
|
|
|
|
CP0424702
|
(2S)-6-amino-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S,3R)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-phenylpropanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]-2-methylpropanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanamide
Show/Hide
|
C62H102N22O15
|
2
|
| 1 |
EC50 = 4.467 nM
|
|
|
| 2 |
EC50 = 6.166 nM
|
|
|
|
CP0480032
|
(2R)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S,3R)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-phenylpropanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanamide
Show/Hide
|
C61H100N22O15
|
2
|
| 1 |
EC50 = 4.571 nM
|
|
|
| 2 |
EC50 = 5.888 nM
|
|
|
|
CP0512528
|
11-[11-[4-[3-[(2R)-3-amino-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S,3R)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-phenylpropanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]propanoyl]amino]-5-carbamimidamidopentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]-5-carbamimidamidopentanoyl]amino]hexanoyl]amino]-3-oxopropyl]sulfanyl-2,5-dioxopyrrolidin-1-yl]butanoylamino]undecanoylamino]undecanamide
Show/Hide
|
C94H157N27O21S
|
2
|
| 1 |
EC50 = 5.129 nM
|
|
|
| 2 |
EC50 = 46.77 nM
|
|
|
|
CP0493875
|
(2S)-5-amino-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S,3R)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-phenylpropanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]propanoyl]amino]-5-carbamimidamidopentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]-5-carbamimidamidopentanoyl]amino]hexanoyl]amino]-4-methylpentanoyl]-methylamino]propanoyl]amino]-4-oxobutanoyl]amino]-5-oxopentanoic acid
Show/Hide
|
C80H131N27O22
|
2
|
| 1 |
EC50 = 5.3 nM
|
|
|
| 2 |
Ki = 1.1 nM
|
|
|
|
CP0386130
|
1-[1-(1-Methylcyclooctyl)piperidin-4-yl]-2-[3-(trifluoromethyl)phenyl]-1H-benzimidazole
Show/Hide
|
C28H34F3N3
|
2
|
| 1 |
EC50 = 5.7 nM
|
|
|
| 2 |
Ki = 0.63 nM
|
|
|
|
CP0372877
|
2-(3,5-dimethylpiperazin-1-yl)-1-[1-(1-methylcyclooctyl)piperidin-4-yl]-1H-benzimidazole
Show/Hide
|
C27H43N5
|
2
|
| 1 |
EC50 = 6 nM
|
|
|
| 2 |
Ki = 2.1 nM
|
|
|
|
CP0424698
|
(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S,3R)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-4-methylpentanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanamide
Show/Hide
|
C58H102N22O15
|
2
|
| 1 |
EC50 = 6.457 nM
|
|
|
| 2 |
EC50 = 13.49 nM
|
|
|
|
CP0480028
|
11-[11-[11-[4-[3-[(2R)-3-amino-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S,3R)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-phenylpropanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]propanoyl]amino]-5-carbamimidamidopentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]-5-carbamimidamidopentanoyl]amino]hexanoyl]amino]-3-oxopropyl]sulfanyl-2,5-dioxopyrrolidin-1-yl]butanoylamino]undecanoylamino]undecanoylamino]undecanamide
Show/Hide
|
C105H178N28O22S
|
2
|
| 1 |
EC50 = 6.457 nM
|
|
|
| 2 |
EC50 = 58.88 nM
|
|
|
|
CP0469108
|
(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S,3R)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-phenylpropanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]propanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanamide
Show/Hide
|
C58H93N21O15
|
2
|
| 1 |
EC50 = 7.244 nM
|
|
|
| 2 |
EC50 = 16.98 nM
|
|
|
|
CP0380831
|
(1R,2S,6R,14R,15R,19R)-5-(cyclopropylmethyl)-19-[(R)-(4-fluorophenyl)-hydroxymethyl]-15-methoxy-19-methyl-13-oxa-5-azahexacyclo[13.2.2.12,8.01,6.02,14.012,20]icosa-8(20),9,11,16-tetraen-11-ol
Show/Hide
|
C31H34FNO4
|
2
|
| 1 |
EC50 = 7.3 nM
|
|
|
| 2 |
Ki = 34 nM
|
|
|
|
CP0512526
|
N-[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-5-(diaminomethylideneamino)-1-[[(2S)-1,6-diamino-1-oxohexan-2-yl]amino]-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-1-oxohexan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-1-[[2-[[(2S,3R)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-phenylpropanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]cyclopentane-1-carboxamide
Show/Hide
|
C64H104N22O15
|
1
|
| 1 |
EC50 = 7.943 nM
|
|
|
|
CP0943860
|
(2S)-6-amino-2-((2S,5S,8S,11S,14S,17S,23S,26S,35S)-35-amino-11-(4-aminobutyl)-26-benzyl-2,14-bis(3-guanidinopropyl)-23-((R)-1-hydroxyethyl)-8-(hydroxymethyl)-5,17-dimethyl-4,7,10,13,16,19,22,25,28,31,34-undecaoxo-36-phenyl-3,6,9,12,15,18,21,24,27,30,33-undecaazahexatriacontanamido)-N-((2R)-1-amino-3-(1-((2S,5S,8S,11S,14S,17S,20S,23S,26S,29S,32S,35S)-2,8,14,20,26,32-hexakis((1H-imidazol-5-yl)methyl)-1-amino-5,11,17,23,29,35-hexamethyl-1,4,7,10,13,16,19,22,25,28,31,34,37-tridecaoxo-3,6,9,12,15,18,21,24,27,30,33,36-dodecaazatetracontan-40-yl)-2,5-dioxopyrrolidin-3-ylthio)-1-oxopropan-2-yl)hexanamide
Show/Hide
|
C126H187N49O31S
|
2
|
| 1 |
EC50 = 7.943 nM
|
|
|
| 2 |
EC50 = 9.333 nM
|
|
|
|
CP0376885
|
(1-{4-[2-(3-Chloro-4-fluorophenyl)-1H-benzimidazol-1-yl]piperidin-1-yl}cyclooctyl)methanol
Show/Hide
|
C27H33ClFN3O
|
2
|
| 1 |
EC50 = 8.9 nM
|
|
|
| 2 |
Ki = 0.73 nM
|
|
|
|
CP0194278
|
(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S,3R)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-phenylpropyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanamide
Show/Hide
|
C61H102N22O14
|
3
|
| 1 |
EC50 = 8.913 nM
|
|
|
| 2 |
Kd = 5.888 nM
|
|
|
| 3 |
Kd = 14.79 nM
|
|
|
|
CP0377809
|
(1-{4-[2-(4-Chlorophenyl)-1H-benzimidazol-1-yl]piperidin-1-yl}cyclooctyl)methanol
Show/Hide
|
C27H34ClN3O
|
2
|
| 1 |
EC50 = 9.1 nM
|
|
|
| 2 |
Ki = 0.15 nM
|
|
|
|
CP0469113
|
(2S)-N-[2-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-5-(diaminomethylideneamino)-1-[[(2S)-1,6-diamino-1-oxohexan-2-yl]amino]-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-1-oxohexan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-2-oxoethyl]-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-phenylpropanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]butanediamide
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C61H99N23O15
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2
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| 1 |
EC50 = 9.333 nM
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| 2 |
EC50 = 27.54 nM
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CP0406297
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(2S)-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S,3R)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-phenylpropanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]-methylamino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-4-methylpentanoyl]amino]propanoyl]amino]-4-oxobutanoyl]amino]pentanediamide
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C80H132N28O21
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2
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| 1 |
EC50 = 10.5 nM
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| 2 |
Ki = 2.2 nM
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CP0538489
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(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-phenylpropanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-methylbutanoyl]amino]acetyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanamide
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C62H102N22O14
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2
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| 1 |
EC50 = 11.48 nM
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| 2 |
EC50 = 41.69 nM
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CP0145209
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[1-[4-[2-(2,3,3a,4,6,6a-hexahydro-1H-pyrrolo[3,4-c]pyrrol-5-yl)benzimidazol-1-yl]piperidin-1-yl]cyclooctyl]methanol
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C27H41N5O
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2
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| 1 |
EC50 = 12 nM
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| 2 |
Ki = 1.438 nM
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CP0424700
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(2S)-6-amino-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-1-oxopropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S,3R)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-phenylpropanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanamide
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C58H93N21O15
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2
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| 1 |
EC50 = 12.3 nM
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| 2 |
EC50 = 13.18 nM
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CP0469114
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(2S)-6-amino-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2R)-1-amino-3-[1-[4-[2-[2-[2-[2-[2-[2-[2-[2-(2-amino-2-oxoethoxy)ethoxy]ethylamino]-2-oxoethoxy]ethoxy]ethylamino]-2-oxoethoxy]ethoxy]ethylamino]-4-oxobutyl]-2,5-dioxopyrrolidin-3-yl]sulfanyl-1-oxopropan-2-yl]amino]-1-oxohexan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S,3R)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-phenylpropanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]propanoyl]amino]-5-carbamimidamidopentanoyl]amino]hexanamide
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C90H148N28O28S
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2
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| 1 |
EC50 = 12.59 nM
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| 2 |
EC50 = 15.14 nM
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CP0443423
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2-(1H-Indol-6-yl)-1-[1-(1-methylcyclooctyl)piperidin-4-yl]-1Hbenzimidazole
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C29H36N4
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2
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| 1 |
EC50 = 13 nM
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| 2 |
Ki = 1.7 nM
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CP0514958
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(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-amino-3-phenylpropanoyl]amino]acetyl]amino]propanoyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanamide
Show/Hide
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C62H102N22O15
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2
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| 1 |
EC50 = 13.18 nM
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| 2 |
EC50 = 28.84 nM
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CP0848722
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(1'R,5alpha,6R,7R,14alpha)-1'-(3-methylphenyl)-1'-(4,5-epoxy-7,8-dihydro-3-hydroxy-6-methoxy-7beta-methyl 17-cyclopropylmethyl-6,14-etheno-morphinan-7-yl)-methan-1'-ol
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C32H37NO4
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2
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| 1 |
EC50 = 14 nM
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| 2 |
Ki = 79 nM
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CP0677647
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17-Cyclopropylmethyl-3,14beta-dihydroxy-4,5alpha-epoxy-6beta-[(4'-t-butyl)benzamido]morphinan-oxalate
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C33H40N2O8
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3
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| 1 |
EC50 = 15 nM
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| 2 |
EC50 > 10000 nM
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| 3 |
Ki > 10000 nM
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CP0537538
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(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S,3R)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-phenylpropanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanamide
Show/Hide
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C61H100N22O15
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2
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| 1 |
EC50 = 15.85 nM
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| 2 |
EC50 = 22.39 nM
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CP0376884
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(1-{4-[2-(4-Methylpiperazin-1-yl)-1H-benzimidazol-1-yl]piperidin-1-yl}cyclooctyl)methanol
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C26H41N5O
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2
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| 1 |
EC50 = 17 nM
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| 2 |
Ki = 4.29 nM
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CP0477719
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(3S)-4-amino-3-[[2-[[(2S)-2-[[2-[[(2S)-2-[[2-[[(2S)-2-[[2-[[(2S)-2-[[2-[[(2S)-2-[[2-[4-[3-[(2R)-3-amino-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S,3R)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-phenylpropanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]propanoyl]amino]-5-carbamimidamidopentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]-5-carbamimidamidopentanoyl]amino]hexanoyl]amino]-3-oxopropyl]sulfanyl-2,5-dioxopyrrolidin-1-yl]butanoylamino]acetyl]amino]-3-carboxypropanoyl]amino]acetyl]amino]-3-carboxypropanoyl]amino]acetyl]amino]-3-carboxypropanoyl]amino]acetyl]amino]-3-carboxypropanoyl]amino]acetyl]amino]-3-carboxypropanoyl]amino]acetyl]amino]-4-oxobutanoic acid
Show/Hide
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C108H163N37O43S
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2
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| 1 |
EC50 = 17.78 nM
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| 2 |
EC50 = 48.98 nM
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CP0676041
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17-Cyclopropylmethyl-3,14beta-dihydroxy-4,5alpha-epoxy-6beta-[(4'-trimethylfluoro)benzamido]morphinan-oxalate
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C30H31F3N2O8
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3
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| 1 |
EC50 = 20 nM
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| 2 |
EC50 > 10000 nM
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| 3 |
Ki = 4.2 nM
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CP0471171
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N-[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-5-(diaminomethylideneamino)-1-[[(2S)-1,6-diamino-1-oxohexan-2-yl]amino]-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-1-oxohexan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-1-[[2-[[(2S,3R)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-phenylpropanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]cyclopropane-1-carboxamide
Show/Hide
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C62H100N22O15
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2
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| 1 |
EC50 = 21.38 nM
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| 2 |
EC50 = 27.54 nM
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CP0486115
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(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-phenylpropanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]propanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanamide
Show/Hide
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C62H102N22O15
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2
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| 1 |
EC50 = 21.88 nM
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| 2 |
EC50 = 79.43 nM
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CP0462034
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(2S)-6-amino-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2R)-1-amino-1-oxo-3-sulfanylpropan-2-yl]amino]-1-oxohexan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]-2-[[(2S)-2-[[(2R)-2-[[2-[[(2S,3R)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-phenylpropanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]-3-sulfanylpropanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanamide
Show/Hide
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C64H105N23O16S2
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2
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| 1 |
EC50 = 22.3 nM
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| 2 |
IC50 = 37.2 nM
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CP0377807
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(1-{4-[2-(3,3-Dimethylpiperazin-1-yl)-1H-benzimidazol-1-yl]piperidin-1-yl}cyclooctyl)methanol
Show/Hide
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C27H43N5O
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2
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| 1 |
EC50 = 23 nM
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| 2 |
Ki = 4.54 nM
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CP0512522
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(2S)-6-amino-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S,3R)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-phenylpropanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanamide
Show/Hide
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C61H100N22O15
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2
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| 1 |
EC50 = 23.44 nM
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| 2 |
EC50 = 40.74 nM
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CP0956183
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(S)-2-((2S,5S,11S,14S,23S)-14-((1H-indol-3-yl)methyl)-23-amino-2-(3-guanidinopropyl)-11-((R)-1-hydroxyethyl)-5-methyl-4,7,10,13,16,19,22-heptaoxo-24-phenyl-3,6,9,12,15,18,21-heptaazatetracosanamido)-6-amino-N-((S)-1-((S)-1-((S)-1-((S)-1,6-diamino-1-oxohexan-2-ylamino)-5-guanidino-1-oxopentan-2-ylamino)-1-oxopropan-2-ylamino)-3-hydroxy-1-oxopropan-2-yl)hexanamide
Show/Hide
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C63H101N23O15
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2
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| 1 |
EC50 = 23.44 nM
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| 2 |
EC50 = 67.61 nM
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CP0469120
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(3S)-4-amino-3-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[4-[3-[(2R)-3-amino-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S,3R)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-phenylpropanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]propanoyl]amino]-5-carbamimidamidopentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]-5-carbamimidamidopentanoyl]amino]hexanoyl]amino]-3-oxopropyl]sulfanyl-2,5-dioxopyrrolidin-1-yl]butanoylamino]propanoyl]amino]-3-carboxypropanoyl]amino]propanoyl]amino]-3-carboxypropanoyl]amino]propanoyl]amino]-3-carboxypropanoyl]amino]propanoyl]amino]-3-carboxypropanoyl]amino]propanoyl]amino]-3-carboxypropanoyl]amino]propanoyl]amino]-4-oxobutanoic acid
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C114H175N37O43S
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2
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| 1 |
EC50 = 23.99 nM
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| 2 |
EC50 = 93.33 nM
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CP0399796
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(4R,7S,10S,13S,16S,19S,22S,25R)-7,19-bis(4-aminobutyl)-25-[[2-[[(2S,3R)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-phenylpropanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]-10,22-bis[3-(diaminomethylideneamino)propyl]-16-(hydroxymethyl)-13-methyl-6,9,12,15,18,21,24-heptaoxo-1,2-dithia-5,8,11,14,17,20,23-heptazacyclohexacosane-4-carboxamide
Show/Hide
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C64H103N23O16S2
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2
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| 1 |
EC50 = 25 nM
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| 2 |
IC50 = 4.97 nM
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CP0409259
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(2S)-6-amino-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2R)-2-[[2-[[(2S,3R)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-phenylpropanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]-3-sulfanylpropanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]-3-sulfanylpropanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanamide
Show/Hide
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C61H100N22O15S2
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2
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| 1 |
EC50 = 26.3 nM
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| 2 |
IC50 = 8.7 nM
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CP0537533
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(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S,3R)-2-[[(2S)-2-[[2-[[(2R)-2-[[(2S)-2-amino-3-phenylpropanoyl]amino]propanoyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanamide
Show/Hide
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C62H102N22O15
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2
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| 1 |
EC50 = 26.92 nM
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| 2 |
EC50 = 69.18 nM
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CP0204782
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(2S)-2-[[(2R,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-acetamido-5-(diaminomethylideneamino)pentanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-methylpentanoyl]amino]-6-aminohexanamide
Show/Hide
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C44H70N14O9
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2
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| 1 |
EC50 = 29 nM
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| 2 |
Ki = 0.53 nM
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CP0404429
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(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S,3R)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-phenylpropanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]-3-sulfanylpropanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-3-sulfanylpropanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanamide
Show/Hide
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C62H102N22O14S2
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2
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| 1 |
EC50 = 29.7 nM
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| 2 |
IC50 = 3.03 nM
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CP0151872
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(4R,7S,10S,13S,16R)-7-(4-aminobutyl)-16-[[(2S,3R)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-phenylpropanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]-N-[(2S)-1-[[(2S)-5-(diaminomethylideneamino)-1-[[(2S)-1,6-diamino-1-oxohexan-2-yl]amino]-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]-10-[3-(diaminomethylideneamino)propyl]-13-methyl-6,9,12,15-tetraoxo-1,2-dithia-5,8,11,14-tetrazacycloheptadecane-4-carboxamide
Show/Hide
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C62H100N22O14S2
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2
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| 1 |
EC50 = 31.3 nM
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| 2 |
IC50 = 0.833 nM
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CP0427455
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1-{1-[1-(Hydroxymethyl)cyclooctyl]piperidin-4-yl}-1Hbenzimidazol-2(3H)-one
Show/Hide
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C21H31N3O2
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2
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| 1 |
EC50 = 37 nM
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| 2 |
Ki = 4.29 nM
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CP0377808
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(1-{4-[2-(3-Methylpiperazin-1-yl)-1H-benzimidazol-1-yl]piperidin-1-yl}cyclooctyl)methanol
Show/Hide
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C26H41N5O
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2
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| 1 |
EC50 = 38 nM
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| 2 |
Ki = 0.96 nM
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CP0471503
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(2S)-6-amino-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S,3R)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-phenylpropanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanamide
Show/Hide
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C61H100N22O15
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2
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| 1 |
EC50 = 39.81 nM
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| 2 |
EC50 = 72.44 nM
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CP0424704
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(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S,3R)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-phenylpropanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]propanoyl]amino]hexanamide
Show/Hide
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C58H93N19O15
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2
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| 1 |
EC50 = 48.98 nM
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| 2 |
EC50 = 141.25 nM
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CP0380699
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(2S)-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S,3R)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-phenylpropanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]-methylamino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-4-methylpentanoyl]amino]propanoyl]amino]-4-oxobutanoyl]amino]pentanediamide
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C80H132N28O21
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2
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| 1 |
EC50 = 52 nM
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| 2 |
Ki = 6.7 nM
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CP0376886
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(1-{4-[2-(3-Chloro-4-fluorophenyl)-1H-benzimidazol-1-yl]piperidin-1-yl}cyclohexyl)methanol
Show/Hide
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C25H29ClFN3O
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2
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| 1 |
EC50 = 53 nM
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| 2 |
Ki = 4.29 nM
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CP0537605
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(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2R)-2-[[2-[[(2S,3R)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-phenylpropanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanamide
Show/Hide
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C61H100N22O15
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2
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| 1 |
EC50 = 54.95 nM
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| 2 |
EC50 = 173.78 nM
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CP0469112
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(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-phenylpropanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]propanoyl]amino]acetyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanamide
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C60H98N22O14
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2
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| 1 |
EC50 = 75.86 nM
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| 2 |
EC50 = 741.31 nM
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CP0845402
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4-chloro-N-[(1S,5R,13R,14R,17S)-4-(cyclopropylmethyl)-10,17-dihydroxy-12-oxa-4-azapentacyclo[9.6.1.0^{1,13}.0^{5,17}.0^{7,18}]octadeca-7(18),8,10-trien-14-yl]benzamide oxalic acid
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C29H31ClN2O8
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2
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| 1 |
EC50 = 88 nM
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| 2 |
EC50 > 10000 nM
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CP0512523
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(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2R)-2-[[(2S)-2-[[2-[[(2S,3R)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-phenylpropanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanamide
Show/Hide
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C61H100N22O15
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2
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| 1 |
EC50 = 93.33 nM
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| 2 |
EC50 = 281.84 nM
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CP0660496
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17-Cyclopropylmethyl-3,14beta-dihydroxy-4,5alpha-epoxy-6beta-[(4'-bromo)benzamido]morphinan-oxalate
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C29H31BrN2O8
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3
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| 1 |
EC50 = 94 nM
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| 2 |
EC50 > 10000 nM
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| 3 |
Ki > 10000 nM
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CP0430774
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(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S,3R)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-1-hydroxy-3-phenylpropylidene]amino]-1-hydroxyethylidene]amino]-1-hydroxyethylidene]amino]-1-hydroxy-3-phenylpropylidene]amino]-1,3-dihydroxybutylidene]amino]acetyl]-methylamino]-1-hydroxypropylidene]amino]-5-carbamimidamido-1-hydroxypentylidene]amino]-1-hydroxyhexylidene]amino]-1,3-dihydroxypropylidene]amino]-1-hydroxypropylidene]amino]-5-carbamimidamido-1-hydroxypentylidene]amino]-1-hydroxyhexylidene]amino]-1-hydroxy-4-methylpentylidene]amino]-1-hydroxypropylidene]amino]-1,4-dihydroxy-4-iminobutylidene]amino]-5-hydroxy-5-iminopentanoic acid
Show/Hide
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C80H131N27O22
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2
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| 1 |
EC50 = 96 nM
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| 2 |
Ki = 15 nM
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CP0547696
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(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2R)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S,3R)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-phenylpropanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanamide
Show/Hide
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C61H100N22O15
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2
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| 1 |
EC50 = 97.72 nM
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| 2 |
EC50 = 489.78 nM
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CP0668279
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17-Cyclopropylmethyl-3,14beta-dihydroxy-4,5alpha-epoxy-6beta-[(4'-methyl)benzamido]morphinan-oxalate
Show/Hide
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C30H34N2O8
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3
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| 1 |
EC50 = 135 nM
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| 2 |
EC50 > 10000 nM
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| 3 |
Ki > 10000 nM
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CP0380849
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(1S,2S,6R,14R,15R,16R)-5-(cyclopropylmethyl)-16-[(R)-hydroxy(phenyl)methyl]-15-methoxy-16-methyl-13-oxa-5-azahexacyclo[13.2.2.12,8.01,6.02,14.012,20]icosa-8(20),9,11-trien-11-ol
Show/Hide
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C31H37NO4
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2
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| 1 |
EC50 = 147 nM
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| 2 |
Ki = 80 nM
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CP0392427
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(4R,7S,10S,13S,16R)-10-(4-aminobutyl)-16-[[2-[[(2S,3R)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-phenylpropanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]-N-[(2S)-5-(diaminomethylideneamino)-1-[[(2S)-1,6-diamino-1-oxohexan-2-yl]amino]-1-oxopentan-2-yl]-13-[3-(diaminomethylideneamino)propyl]-7-(hydroxymethyl)-6,9,12,15-tetraoxo-1,2-dithia-5,8,11,14-tetrazacycloheptadecane-4-carboxamide
Show/Hide
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C61H98N22O15S2
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2
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| 1 |
EC50 = 156 nM
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| 2 |
IC50 = 3.04 nM
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CP0385505
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(1S,2S,6R,14R,15R,16R)-5-(cyclopropylmethyl)-16-[(R)-(3-fluorophenyl)-hydroxymethyl]-15-methoxy-16-methyl-13-oxa-5-azahexacyclo[13.2.2.12,8.01,6.02,14.012,20]icosa-8(20),9,11-trien-11-ol
Show/Hide
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C31H36FNO4
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2
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| 1 |
EC50 = 160 nM
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| 2 |
Ki = 62.2 nM
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CP0380850
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(1S,2S,6R,14R,15R,16R)-5-(cyclopropylmethyl)-16-[(R)-furan-3-yl(hydroxy)methyl]-15-methoxy-16-methyl-13-oxa-5-azahexacyclo[13.2.2.12,8.01,6.02,14.012,20]icosa-8(20),9,11-trien-11-ol
Show/Hide
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C29H35NO5
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2
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| 1 |
EC50 = 230 nM
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| 2 |
Ki = 1455 nM
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CP0385503
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(1S,2S,6R,14R,15R,16R)-16-[(R)-(3-chlorophenyl)-hydroxymethyl]-5-(cyclopropylmethyl)-15-methoxy-16-methyl-13-oxa-5-azahexacyclo[13.2.2.12,8.01,6.02,14.012,20]icosa-8(20),9,11-trien-11-ol
Show/Hide
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C31H36ClNO4
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2
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| 1 |
EC50 = 230 nM
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| 2 |
Ki = 47.8 nM
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CP0376705
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CFGGFTGARKCARK
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C64H105N23O15S2
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2
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| 1 |
EC50 = 286 nM
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| 2 |
IC50 = 1290 nM
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CP0385500
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(1S,2S,6R,14R,15R,16R)-5-(cyclopropylmethyl)-16-[(R)-hydroxy-(3-methylphenyl)methyl]-15-methoxy-16-methyl-13-oxa-5-azahexacyclo[13.2.2.12,8.01,6.02,14.012,20]icosa-8(20),9,11-trien-11-ol
Show/Hide
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C32H39NO4
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2
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| 1 |
EC50 = 331 nM
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| 2 |
Ki = 240 nM
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CP0502552
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(2S)-5-amino-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S,3R)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-phenylpropanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]-methylamino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-4-methylpentanoyl]amino]propanoyl]amino]-4-oxobutanoyl]amino]-5-oxopentanoic acid
Show/Hide
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C80H131N27O22
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2
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| 1 |
EC50 = 407 nM
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| 2 |
Ki = 20 nM
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CP0850661
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(1'R,5alpha,6R,7R,14alpha)-1'-phenyl-1'-(4,5-epoxy-7,8-dihydro-3-hydroxy-6-methoxy-7beta-methyl 17-cyclopropylmethyl-6,14-ethenomorphinan-7-yl)-methan-1'-ol
Show/Hide
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C31H35NO4
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2
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| 1 |
EC50 = 416 nM
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| 2 |
Ki = 97 nM
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CP0533256
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(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S,3R)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-amino-3-phenylpropanoyl]amino]propanoyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanamide
Show/Hide
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C62H102N22O15
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1
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| 1 |
EC50 = 436.52 nM
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CP0404488
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CFGGFTGARKCARK
Show/Hide
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C64H103N23O15S2
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2
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| 1 |
EC50 = 439 nM
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| 2 |
IC50 = 387 nM
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CP0514957
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H-PHE-(R)-GLY-GLY-PHE-THR-GLY-ALA-ARG-LYS-SER-ALA-ARG-LYS-NH2
Show/Hide
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C61H100N22O15
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1
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| 1 |
EC50 = 954.99 nM
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CP0556696
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(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S,3R)-2-[[(2R)-2-[[2-[[2-[[(2S)-2-amino-3-phenylpropanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanamide
Show/Hide
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C61H100N22O15
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1
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| 1 |
EC50 = 1023.29 nM
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CP0072627
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BUPRENORPHINE
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C29H41NO4
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2
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| 1 |
EC50 = 1480 nM
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| 2 |
Ki = 212 nM
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CP0446331
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3-(1-(1,2-dihydroacenaphthylen-1-yl)piperidin-4-yl)-1H-pyrrolo[2,3-b]pyridine
Show/Hide
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C24H23N3
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2
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| 1 |
EC50 = 4200 nM
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| 2 |
Ki = 4 nM
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CP0375952
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CFGGFTCARKSARK
Show/Hide
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C65H107N23O16S2
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2
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| 1 |
EC50 > 10000 nM
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| 2 |
IC50 = 2710 nM
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CP0522630
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CFGGFTCARKSARK
Show/Hide
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C65H105N23O16S2
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2
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| 1 |
EC50 > 10000 nM
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| 2 |
IC50 = 874 nM
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CP0380599
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(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[3-[(4S)-4-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-oxo-4,5-dihydro-1H-2-benzazepin-2-yl]propanoylamino]-5-carbamimidamidopentanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-(4-fluorophenyl)propanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-5-carbamimidamidopentanamide
Show/Hide
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C77H105FN24O12
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3
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| 1 |
EC50 > 10000 nM
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| 2 |
Kd = 1000 nM
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| 3 |
Ki = 27 nM
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CP0386503
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(2S)-6-amino-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[3-[(4S)-4-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-oxo-4,5-dihydro-1H-2-benzazepin-2-yl]propanoylamino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-methylpentanoyl]amino]hexanamide
Show/Hide
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C72H107N21O13
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3
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| 1 |
EC50 > 10000 nM
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| 2 |
Kd = 4073.8 nM
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| 3 |
Ki = 42 nM
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CP0401976
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(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[3-[(4S)-4-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-oxo-4,5-dihydro-1H-2-benzazepin-2-yl]propanoylamino]-5-carbamimidamidopentanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-5-carbamimidamidopentanamide
Show/Hide
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C77H106N24O13
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3
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| 1 |
EC50 > 10000 nM
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| 2 |
Kd = 977.24 nM
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| 3 |
Ki = 47 nM
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CP0558145
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(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[3-[(4S)-4-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-oxo-4,5-dihydro-1H-2-benzazepin-2-yl]propanoylamino]-5-carbamimidamidopentanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-5-carbamimidamidopentanamide
Show/Hide
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C79H110N24O13
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3
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| 1 |
EC50 > 10000 nM
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| 2 |
Kd = 562.34 nM
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| 3 |
Ki = 38 nM
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CP0421467
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(2S)-2-[3-[(4S)-4-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-oxo-4,5-dihydro-1H-2-benzazepin-2-yl]propanoylamino]-N-[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]-5-(diaminomethylideneamino)pentanamide
Show/Hide
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C45H63N13O7
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1
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| 1 |
EC50 > 10000 nM
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CP0453003
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3-(1-(1,2-dihydroacenaphthylen-1-yl)piperidin-4-yl)-5-fluoro-1H-indole
Show/Hide
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C25H23FN2
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2
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| 1 |
EC50 = 27200 nM
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| 2 |
Ki = 18 nM
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CP0441682
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5-chloro-3-(1-(1,2-dihydroacenaphthylen-1-yl)piperidin-4-yl)-2-methyl-1H-indole
Show/Hide
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C26H25ClN2
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2
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| 1 |
EC50 = 54600 nM
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| 2 |
Ki = 10 nM
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CP0436265
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7-chloro-3-(1-(1,2-dihydroacenaphthylen-1-yl)piperidin-4-yl)-1H-indole
Show/Hide
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C25H23ClN2
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2
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| 1 |
EC50 > 80000 nM
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| 2 |
Ki = 57 nM
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CP0433515
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Ac-RYYRIK-GGG-K-(NH2)-YAFGYPS-GG
Show/Hide
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C100H144N28O25
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1
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| 1 |
IC50 = 0.0464 nM
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CP0456418
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Ac-RYYRIK-GGG-K-(NH2)-YRFB-GGGGG
Show/Hide
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C85H130N28O19
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1
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| 1 |
IC50 = 0.0803 nM
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CP0393854
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Ac-RYYRIK-NH2
Show/Hide
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C44H70N14O9
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1
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| 1 |
IC50 = 0.767 nM
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CP0433514
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Ac-RYYRIK-K-(NH2)-YRFB
Show/Hide
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C77H117N23O15
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1
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| 1 |
IC50 = 0.789 nM
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CP0394547
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(2S)-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S,3R)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-phenylpropanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-4-methylpentanoyl]amino]propanoyl]amino]-4-oxobutanoyl]amino]pentanediamide
Show/Hide
|
C79H130N28O21
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1
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| 1 |
IC50 = 1.3 nM
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CP0554715
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3-[(2R)-3-[2-(3,4-dimethoxyphenyl)ethylamino]-2-hydroxypropyl]-1-phenyl-8-[2-(2-thiophen-2-ylphenyl)ethyl]-1,3,8-triazaspiro[4.5]decan-4-one
Show/Hide
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C38H46N4O4S
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1
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| 1 |
IC50 = 3.9 nM
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CP0379377
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3-[(2R)-2-hydroxy-3-[(4-methoxyphenyl)methylamino]propyl]-1-phenyl-8-[2-(2-thiophen-2-ylphenyl)ethyl]-1,3,8-triazaspiro[4.5]decan-4-one
Show/Hide
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C36H42N4O3S
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1
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| 1 |
IC50 = 4.2 nM
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CP0272526
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8-[(1R,3aR)-2,3,3a,4,5,6-hexahydro-1H-phenalen-1-yl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
Show/Hide
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C26H31N3O
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2
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| 1 |
IC50 = 4.4 nM
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| 2 |
Ki = 0.39 nM
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CP0530025
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3-(9-(dimethylamino)nonyl)-8-(4-isopropylcyclohexyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
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C33H56N4O
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1
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| 1 |
IC50 = 5.5 nM
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CP0419221
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3-[(2R)-2-hydroxy-3-(thiophen-2-ylmethylamino)propyl]-1-phenyl-8-[2-(2-thiophen-2-ylphenyl)ethyl]-1,3,8-triazaspiro[4.5]decan-4-one
Show/Hide
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C33H38N4O2S2
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1
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| 1 |
IC50 = 8 nM
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CP0397806
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8-(cyclooctylmethyl)-3-[(2S)-3-[2-(3,4-dimethoxyphenyl)ethylamino]-2-hydroxypropyl]-1-(4-fluorophenyl)-1,3,8-triazaspiro[4.5]decan-4-one
Show/Hide
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C35H51FN4O4
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1
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| 1 |
IC50 = 8.8 nM
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CP0442084
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Ac-RYYRIK-K-(NH2)-YAFGYPS
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C90H129N23O20
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1
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| 1 |
IC50 = 11.6 nM
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CP0502924
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(2S)-1-[3-[4-(2,6-dimethylphenyl)piperidin-1-yl]propanoyl]-N,N-dimethyl-2,3-dihydroindole-2-carboxamide
Show/Hide
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C27H35N3O2
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2
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| 1 |
IC50 = 12 nM
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| 2 |
Ki = 0.96 nM
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CP0397801
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3-[(2S)-2-hydroxy-3-[(2-methylphenyl)methylamino]propyl]-1-phenyl-8-[2-(2-thiophen-2-ylphenyl)ethyl]-1,3,8-triazaspiro[4.5]decan-4-one
Show/Hide
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C36H42N4O2S
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1
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| 1 |
IC50 = 14 nM
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CP0331627
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1-phenyl-8-(1-phenyl-cyclohexyl)-1,3,8-triaza-spiro[4.5]decan-4-one
Show/Hide
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C25H31N3O
|
1
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| 1 |
IC50 = 15 nM
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CP0444789
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(2R)-2-amino-N-[(2S)-3-[8-(cyclooctylmethyl)-1-(4-fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]decan-3-yl]-2-hydroxypropyl]-3-methyl-N-[(4-methylphenyl)methyl]butanamide
Show/Hide
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C38H56FN5O3
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1
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| 1 |
IC50 = 18 nM
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CP0380262
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5-chloro-3-(spiro[1,2-dihydroindene-3,4'-piperidine]-1'-ylmethyl)-1,2,3,4-tetrahydroisoquinolin-8-ol
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C23H27ClN2O
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2
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| 1 |
IC50 = 21.3 nM
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| 2 |
Ki = 2.2 nM
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CP0431276
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1'-cyclooctylmethyl-5-fluoro-1-methylspiro[2,3-dihydro-1H-indole-3,4'-(hexahydropyridine)]-2-one
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C22H31FN2O
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1
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| 1 |
IC50 = 23 nM
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CP0499950
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3-[9-[4-oxo-1-phenyl-8-(4-propan-2-ylcyclohexyl)-1,3,8-triazaspiro[4.5]decan-3-yl]nonyl]-1-phenyl-8-(4-propan-2-ylcyclohexyl)-1,3,8-triazaspiro[4.5]decan-4-one
Show/Hide
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C53H82N6O2
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1
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| 1 |
IC50 = 25.2 nM
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CP0444808
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3-[(2R)-2-hydroxy-3-[(2-methylphenyl)methylamino]propyl]-1-phenyl-8-[2-(2-thiophen-2-ylphenyl)ethyl]-1,3,8-triazaspiro[4.5]decan-4-one
Show/Hide
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C36H42N4O2S
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1
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| 1 |
IC50 = 26 nM
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CP0438200
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N-(4-amino-2-methylquinolin-6-yl)-2-[[4-[[9-[[4-[[2-[(4-amino-2-methylquinolin-6-yl)carbamoyl]phenyl]methoxy]phenyl]methylamino]nonylamino]methyl]phenoxy]methyl]benzamide
Show/Hide
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C59H64N8O4
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1
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| 1 |
IC50 = 28.1 nM
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CP0385701
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5-chloro-3-[[4-(4-fluoro-2-methylphenyl)piperidin-1-yl]methyl]-1,2,3,4-tetrahydroisoquinolin-8-ol
Show/Hide
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C22H26ClFN2O
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2
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| 1 |
IC50 = 28.7 nM
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| 2 |
Ki = 3.13 nM
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CP0124715
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N-(4-amino-2-methylquinolin-6-yl)-2-[(4-ethylphenoxy)methyl]benzamide
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C26H25N3O2
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1
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| 1 |
IC50 = 30 nM
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CP0473197
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N-(4-amino-2-methylquinolin-6-yl)-2-[[4-[[7-[[4-[[2-[(4-amino-2-methylquinolin-6-yl)carbamoyl]phenyl]methoxy]phenyl]methylamino]heptylamino]methyl]phenoxy]methyl]benzamide
Show/Hide
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C57H60N8O4
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1
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| 1 |
IC50 = 30.1 nM
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CP0464762
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N-(4-amino-2-methylquinolin-6-yl)-2-[[4-[[8-[[4-[[2-[(4-amino-2-methylquinolin-6-yl)carbamoyl]phenyl]methoxy]phenyl]methylamino]octylamino]methyl]phenoxy]methyl]benzamide
Show/Hide
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C58H62N8O4
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1
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| 1 |
IC50 = 31.6 nM
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CP0378193
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1'-cyclooctylmethyl-1-methylspiro[2,3-dihydro-1H-indole-3,4'-(hexahydropyridine)]-2-one
Show/Hide
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C22H32N2O
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1
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| 1 |
IC50 = 32 nM
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CP0467715
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N-(4-amino-2-methylquinolin-6-yl)-2-[[4-[[10-[[4-[[2-[(4-amino-2-methylquinolin-6-yl)carbamoyl]phenyl]methoxy]phenyl]methylamino]decylamino]methyl]phenoxy]methyl]benzamide
Show/Hide
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C60H66N8O4
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1
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| 1 |
IC50 = 32.7 nM
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CP0397802
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3-[(2S)-3-[benzyl(butyl)amino]-2-hydroxypropyl]-8-(cyclooctylmethyl)-1-(4-fluorophenyl)-1,3,8-triazaspiro[4.5]decan-4-one
Show/Hide
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C36H53FN4O2
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1
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| 1 |
IC50 = 34 nM
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CP0866727
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5-bromo-3-{(2,3-dihydro-1'H-spiro[indene-1,4'-piperidin]-1'-yl)methyl}-1,2,3,4-tetrahydroisoquinolin-8-ol
Show/Hide
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C23H27BrN2O
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2
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| 1 |
IC50 = 35.1 nM
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| 2 |
Ki = 1.74 nM
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CP0505246
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(E,E)-N,N'-bis[[4-[[2-[[(4-amino-2-methylquinolin-6-yl)amino]carbonyl]phenyl]methoxy]phenyl]methylene]-1,4-butanediamine
Show/Hide
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C54H50N8O4
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1
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| 1 |
IC50 = 35.6 nM
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CP0431274
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1'-cyclooctylmethyl-1,4-dimethylspiro[2,3-dihydro-1H-indole-3,4'-(hexahydropyridine)]-2-one
Show/Hide
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C23H34N2O
|
1
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| 1 |
IC50 = 37 nM
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CP0419220
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8-(cyclooctylmethyl)-1-(4-fluorophenyl)-3-[(2R)-2-hydroxy-3-(3-methylphenyl)sulfanylpropyl]-1,3,8-triazaspiro[4.5]decan-4-one
Show/Hide
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C32H44FN3O2S
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1
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| 1 |
IC50 = 37 nM
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CP0388933
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3-[(2R)-3-(tert-butylamino)-2-hydroxypropyl]-1-phenyl-8-[2-(2-thiophen-2-ylphenyl)ethyl]-1,3,8-triazaspiro[4.5]decan-4-one
Show/Hide
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C32H42N4O2S
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1
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| 1 |
IC50 = 40.9 nM
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CP0441036
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(2S)-1-[3-[4-(4-fluoro-2-methylphenyl)piperidin-1-yl]propanoyl]-N,N-dimethyl-2,3-dihydroindole-2-carboxamide
Show/Hide
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C26H32FN3O2
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2
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| 1 |
IC50 = 42 nM
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| 2 |
Ki = 3.79 nM
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CP0481420
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(2S)-N,N-dimethyl-1-[3-[4-(2-methylphenyl)piperidin-1-yl]propanoyl]-2,3-dihydroindole-2-carboxamide
Show/Hide
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C26H33N3O2
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2
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| 1 |
IC50 = 44 nM
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| 2 |
Ki = 3.03 nM
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CP0441168
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(E,E)-N,N'-bis[[4-[[2-[[(4-amino-2-methylquinolin-6-yl)amino]carbonyl]phenyl]methoxy]phenyl]methylene]-1,3-propanediamine
Show/Hide
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C53H48N8O4
|
1
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| 1 |
IC50 = 48 nM
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CP0458894
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(E,E)-N,N'-bis[[4-[[2-[[(4-amino-2-methylquinolin-6-yl)amino]carbonyl]phenyl]methoxy]phenyl]methylene]-1,5-pentanediamine
Show/Hide
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C55H52N8O4
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1
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| 1 |
IC50 = 50.9 nM
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CP0852726
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3-{(2,3-dihydro-1'H-spiro[indene-1,4'-piperidin]-1'-yl)methyl}-1,2,3,4-tetrahydroisoquinolin-8-ol
Show/Hide
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C23H28N2O
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2
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| 1 |
IC50 = 53.9 nM
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| 2 |
Ki = 2.4 nM
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CP0458879
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N-(4-amino-2-methylquinolin-6-yl)-2-[[4-[[4-[[4-[[2-[(4-amino-2-methylquinolin-6-yl)carbamoyl]phenyl]methoxy]phenyl]methylamino]butylamino]methyl]phenoxy]methyl]benzamide
Show/Hide
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C54H54N8O4
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1
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| 1 |
IC50 = 56.6 nM
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CP0504915
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3-[[4-(4-fluoro-2-methylphenyl)piperidin-1-yl]methyl]-1,2,3,4-tetrahydroisoquinoline
Show/Hide
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C22H27FN2
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2
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| 1 |
IC50 = 58.8 nM
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| 2 |
Ki = 3.56 nM
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CP0397803
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3-[(2S)-2-hydroxy-3-[(4-methoxyphenyl)methylamino]propyl]-1-phenyl-8-[2-(2-thiophen-2-ylphenyl)ethyl]-1,3,8-triazaspiro[4.5]decan-4-one
Show/Hide
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C36H42N4O3S
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1
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| 1 |
IC50 = 61 nM
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CP0494103
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(E,E)-N,N'-bis[[4-[[2-[[(4-amino-2-methylquinolin-6-yl)amino]carbonyl]phenyl]methoxy]phenyl]methylene]-1,7-heptanediamine
Show/Hide
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C57H56N8O4
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1
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| 1 |
IC50 = 63.1 nM
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CP0460591
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N-(4-amino-2-methylquinolin-6-yl)-2-[[4-[[6-[[4-[[2-[(4-amino-2-methylquinolin-6-yl)carbamoyl]phenyl]methoxy]phenyl]methylamino]hexylamino]methyl]phenoxy]methyl]benzamide
Show/Hide
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C56H58N8O4
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1
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| 1 |
IC50 = 71.7 nM
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CP0477972
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N-(4-amino-2-methylquinolin-6-yl)-2-[[4-[[5-[[4-[[2-[(4-amino-2-methylquinolin-6-yl)carbamoyl]phenyl]methoxy]phenyl]methylamino]pentylamino]methyl]phenoxy]methyl]benzamide
Show/Hide
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C55H56N8O4
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1
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| 1 |
IC50 = 76.2 nM
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CP0460590
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N-(4-amino-2-methylquinolin-6-yl)-2-[[4-[[3-[[4-[[2-[(4-amino-2-methylquinolin-6-yl)carbamoyl]phenyl]methoxy]phenyl]methylamino]propylamino]methyl]phenoxy]methyl]benzamide
Show/Hide
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C53H52N8O4
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1
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| 1 |
IC50 = 76.5 nM
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CP0449171
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8-(cyclooctylmethyl)-3-[(2R)-3-[2-(3,4-dimethoxyphenyl)ethoxy]-2-hydroxypropyl]-1-(4-fluorophenyl)-1,3,8-triazaspiro[4.5]decan-4-one
Show/Hide
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C35H50FN3O5
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1
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| 1 |
IC50 = 82 nM
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CP0464765
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(E,E)-N,N'-bis[[4-[[2-[[(4-amino-2-methylquinolin-6-yl)amino]carbonyl]phenyl]methoxy]phenyl]methylene]-1,10-decanediamine
Show/Hide
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C60H62N8O4
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1
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| 1 |
IC50 = 82.1 nM
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CP0473997
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(E,E)-N,N'-bis[[4-[[2-[[(4-amino-2-methylquinolin-6-yl)amino]carbonyl]phenyl]methoxy]phenyl]methylene]-1,9-nonanediamine
Show/Hide
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C59H60N8O4
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1
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| 1 |
IC50 = 82.7 nM
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CP0378189
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1'-cyclooctylmethyl-1-(2-oxiranylmethyl)spiro[2,3-dihydro-1H-indole-3,4'-(hexahydropyridine)]-2-one
Show/Hide
|
C24H34N2O2
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1
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| 1 |
IC50 = 83 nM
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CP0458880
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N-(4-amino-2-methylquinolin-6-yl)-2-[[4-(propylaminomethyl)phenoxy]methyl]benzamide
Show/Hide
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C28H30N4O2
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1
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| 1 |
IC50 = 83 nM
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CP0505247
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(E,E)-N,N'-bis[[4-[[2-[[(4-amino-2-methylquinolin-6-yl)amino]carbonyl]phenyl]methoxy]phenyl]methylene]-1,6-hexanediamine
Show/Hide
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C56H54N8O4
|
1
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| 1 |
IC50 = 83.3 nM
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CP0471447
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(E)-N-(4-amino-2-methylquinolin-6-yl)-2-[4-(propyliminomethyl)phenoxymethyl]benzamide
Show/Hide
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C28H28N4O2
|
1
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| 1 |
IC50 = 98.9 nM
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CP0487919
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3-[(2S)-3-[benzyl(butyl)amino]-2-hydroxypropyl]-1-phenyl-8-[2-(2-thiophen-2-ylphenyl)ethyl]-1,3,8-triazaspiro[4.5]decan-4-one
Show/Hide
|
C39H48N4O2S
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1
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| 1 |
IC50 = 99.7 nM
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CP0442122
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methyl 2-[1'-(cyclooctylmethyl)-2-oxospiro[indole-3,4'-piperidine]-1-yl]acetate
Show/Hide
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C24H34N2O3
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1
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| 1 |
IC50 = 100 nM
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CP0485755
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methyl 2-[1'-[(4-tert-butylcyclohexyl)methyl]-2-oxospiro[indole-3,4'-piperidine]-1-yl]acetate
Show/Hide
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C26H38N2O3
|
1
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| 1 |
IC50 = 100 nM
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CP0526255
|
(2S)-1-[3-[4-(4-fluorophenyl)piperidin-1-yl]propanoyl]-N,N-dimethyl-2,3-dihydroindole-2-carboxamide
Show/Hide
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C25H30FN3O2
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2
|
| 1 |
IC50 = 107 nM
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| 2 |
Ki = 9.84 nM
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CP0499156
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(E,E)-N,N'-bis[[4-[[2-[[(4-amino-2-methylquinolin-6-yl)amino]carbonyl]phenyl]methoxy]phenyl]methylene]-1,8-octanediamine
Show/Hide
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C58H58N8O4
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1
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| 1 |
IC50 = 113.6 nM
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CP0470259
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2-[[4-(aminomethyl)phenoxy]methyl]-N-(4-amino-2-methylquinolin-6-yl)benzamide
Show/Hide
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C25H24N4O2
|
1
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| 1 |
IC50 = 115.7 nM
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CP0920426
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N,N-Dimethyl-1-[3-(4-o-tolylpiperidin-1-yl)propanoyl]indoline-(2RS)-2-carboxamide
Show/Hide
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C26H33N3O2
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2
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| 1 |
IC50 = 116 nM
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| 2 |
Ki = 5.55 nM
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CP0378938
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1'-cyclooctylmethyl-1-{2-hydroxy-3-[2-(1,4-oxazinan-4-yl)ethylamino]propyl}spiro[2,3-dihydro-1H-indole-3,4'-(hexahydropyridine)]-2-one
Show/Hide
|
C30H48N4O3
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1
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| 1 |
IC50 = 120 nM
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CP0442124
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1-benzyl-1'-cyclooctylmethylspiro[2,3-dihydro-1H-indole-3,4'-(hexahydropyridine)]-2-one
Show/Hide
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C28H36N2O
|
1
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| 1 |
IC50 = 120 nM
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CP0921140
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1'-{(3,4-dihydro-2H-chromen-3-yl)methyl}-2,3-dihydro-1'H-spiro[indene-1,4'-piperidine]
Show/Hide
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C23H27NO
|
2
|
| 1 |
IC50 = 122 nM
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| 2 |
Ki = 5.65 nM
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CP0046134
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8-((trans, rac)-2-hydroxy-2-phenyl-cyclohexyl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one
Show/Hide
|
C25H31N3O2
|
1
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| 1 |
IC50 = 130 nM
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CP0452286
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(2S)-N,N-dimethyl-1-[3-(4-phenylpiperidin-1-yl)propanoyl]-2,3-dihydroindole-2-carboxamide
Show/Hide
|
C25H31N3O2
|
2
|
| 1 |
IC50 = 138 nM
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| 2 |
Ki = 13.6 nM
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CP0518120
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methyl 2-[2-oxo-1'-[[3-(trifluoromethyl)phenyl]methyl]spiro[indole-3,4'-piperidine]-1-yl]acetate
Show/Hide
|
C23H23F3N2O3
|
1
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| 1 |
IC50 = 140 nM
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CP0464759
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(E)-N-(4-amino-2-methylquinolin-6-yl)-2-[4-(heptyliminomethyl)phenoxymethyl]benzamide
Show/Hide
|
C32H36N4O2
|
1
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| 1 |
IC50 = 141.9 nM
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CP0458883
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N-(4-amino-2-methylquinolin-6-yl)-2-[[4-[(8-aminooctylamino)methyl]phenoxy]methyl]benzamide
Show/Hide
|
C33H41N5O2
|
1
|
| 1 |
IC50 = 144 nM
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CP0473198
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(E)-N-(4-amino-2-methylquinolin-6-yl)-2-[4-(octyliminomethyl)phenoxymethyl]benzamide
Show/Hide
|
C33H38N4O2
|
1
|
| 1 |
IC50 = 146.5 nM
|
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CP0431273
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1'-cyclooctylmethyl-1,6-dimethylspiro[2,3-dihydro-1H-indole-3,4'-(hexahydropyridine)]-2-one
Show/Hide
|
C23H34N2O
|
1
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| 1 |
IC50 = 150 nM
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CP0464763
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2-[[4-[(10-aminodecylamino)methyl]phenoxy]methyl]-N-(4-amino-2-methylquinolin-6-yl)benzamide
Show/Hide
|
C35H45N5O2
|
1
|
| 1 |
IC50 = 152.9 nM
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CP0460587
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(E)-N-(4-amino-2-methylquinolin-6-yl)-2-[4-(nonyliminomethyl)phenoxymethyl]benzamide
Show/Hide
|
C34H40N4O2
|
1
|
| 1 |
IC50 = 154.5 nM
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CP0458881
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N-(4-amino-2-methylquinolin-6-yl)-2-[[4-[(3-aminopropylamino)methyl]phenoxy]methyl]benzamide
Show/Hide
|
C28H31N5O2
|
1
|
| 1 |
IC50 = 159.6 nM
|
|
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CP0456005
|
3-[(2S)-2-hydroxy-3-(thiophen-2-ylmethylamino)propyl]-1-phenyl-8-[2-(2-thiophen-2-ylphenyl)ethyl]-1,3,8-triazaspiro[4.5]decan-4-one
Show/Hide
|
C33H38N4O2S2
|
1
|
| 1 |
IC50 = 160 nM
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|
|
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CP0397804
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3-[(2R)-3-[benzyl(butyl)amino]-2-hydroxypropyl]-1-phenyl-8-[2-(2-thiophen-2-ylphenyl)ethyl]-1,3,8-triazaspiro[4.5]decan-4-one
Show/Hide
|
C39H48N4O2S
|
1
|
| 1 |
IC50 = 166 nM
|
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CP0431272
|
2-[1'-cyclooctylmethyl-2-oxospiro[2,3-dihydro-1H-indole-3,4'-(hexahydropyridine)]-1-yl]ethyl acetate
Show/Hide
|
C25H36N2O3
|
1
|
| 1 |
IC50 = 180 nM
|
|
|
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CP0436410
|
(E)-N-(4-amino-2-methylquinolin-6-yl)-2-[4-(decyliminomethyl)phenoxymethyl]benzamide
Show/Hide
|
C35H42N4O2
|
1
|
| 1 |
IC50 = 184.5 nM
|
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CP0458895
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(E)-N-(4-amino-2-methylquinolin-6-yl)-2-[4-(pentyliminomethyl)phenoxymethyl]benzamide
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C30H32N4O2
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1
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| 1 |
IC50 = 186.2 nM
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CP0530026
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N-(4-amino-2-methylquinolin-6-yl)-2-[[4-[(5-aminopentylamino)methyl]phenoxy]methyl]benzamide
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C30H35N5O2
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1
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| 1 |
IC50 = 206.9 nM
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CP0470261
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4-amino-6-[[2-(4-formylphenoxymethyl)benzoyl]amino]-2-methylquinoline
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C25H21N3O3
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1
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| 1 |
IC50 = 207.3 nM
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CP0464758
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(E)-N-(4-amino-2-methylquinolin-6-yl)-2-[4-(hexyliminomethyl)phenoxymethyl]benzamide
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C31H34N4O2
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1
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| 1 |
IC50 = 208.6 nM
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CP0505803
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N-(4-amino-2-methylquinolin-6-yl)-2-[[4-[(9-aminononylamino)methyl]phenoxy]methyl]benzamide
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C34H43N5O2
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1
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| 1 |
IC50 = 211.6 nM
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CP0848412
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3-{(2,3-Dihydro-1'H-spiro[indene-1,4'-piperidin]-1'-yl)methyl}-1,2,3,4-tetrahydroisoquinolin-6-ol
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C23H28N2O
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2
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| 1 |
IC50 = 227 nM
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| 2 |
Ki = 10.2 nM
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CP0467675
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2-[[4-[(7-aminoheptylamino)methyl]phenoxy]methyl]-N-(4-amino-2-methylquinolin-6-yl)benzamide
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C32H39N5O2
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1
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| 1 |
IC50 = 246.4 nM
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CP0386093
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1'-(1,2,3,4-tetrahydroisoquinolin-3-ylmethyl)spiro[1,2-dihydroindene-3,4'-piperidine]
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C23H28N2
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2
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| 1 |
IC50 = 248 nM
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| 2 |
Ki = 8.5 nM
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CP0446411
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methyl 2-[1'-(naphthalen-2-ylmethyl)-2-oxospiro[indole-3,4'-piperidine]-1-yl]acetate
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C26H26N2O3
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1
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| 1 |
IC50 = 250 nM
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CP0467158
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1'-cyclooctylmethyl-1-(2-hydroxyethyl)spiro[2,3-dihydro-1H-indole-3,4'-(hexahydropyridine)]-2-one
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C23H34N2O2
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1
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| 1 |
IC50 = 290 nM
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CP0146215
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1-phenyl-8-((trans, rac)-2-phenyl-cyclohexyl)-1,3,8-triaza-spiro[4.5]decan-4-one
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C25H31N3O
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2
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| 1 |
IC50 = 300 nM
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| 2 |
IC50 = 310 nM
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CP0467714
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N-(4-amino-2-methylquinolin-6-yl)-2-[[4-[(nonylamino)methyl]phenoxy]methyl]benzamide
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C34H42N4O2
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1
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| 1 |
IC50 = 304.6 nM
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CP0460584
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(E)-N-(4-amino-2-methylquinolin-6-yl)-2-[4-(butyliminomethyl)phenoxymethyl]benzamide
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C29H30N4O2
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1
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| 1 |
IC50 = 308.9 nM
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CP0378190
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1'-cyclooctylmethyl-1-[3-ethyl(4-methylbenzyl)amino-2-hydroxypropyl]spiro[2,3-dihydro-1H-indole-3,4'-(hexahydropyridine)]-2-one
Show/Hide
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C34H49N3O2
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1
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| 1 |
IC50 = 320 nM
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CP0501956
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methyl 2-[1'-(1,2-dihydroacenaphthylen-5-yl)-2-oxospiro[indole-3,4'-piperidine]-1-yl]acetate
Show/Hide
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C27H26N2O3
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1
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| 1 |
IC50 = 350 nM
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CP0446480
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1'-cyclooctylmethylspiro[2,3-dihydro-1H-indole-3,4'-(hexahydropyridine)]-2-one
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C21H30N2O
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1
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| 1 |
IC50 = 380 nM
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CP0464761
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N-(4-amino-2-methylquinolin-6-yl)-2-[[4-[(decylamino)methyl]phenoxy]methyl]benzamide
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C35H44N4O2
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1
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| 1 |
IC50 = 404.7 nM
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CP0448592
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1'-cyclooctylmethyl-1,5-dimethylspiro[2,3-dihydro-1H-indole-3,4'-(hexahydropyridine)]-2-one
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C23H34N2O
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1
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| 1 |
IC50 = 450 nM
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CP0431269
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methyl 2-[1'-(naphthalen-1-ylmethyl)-2-oxospiro[indole-3,4'-piperidine]-1-yl]acetate
Show/Hide
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C26H26N2O3
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1
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| 1 |
IC50 = 470 nM
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CP0464760
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N-(4-amino-2-methylquinolin-6-yl)-2-[[4-[(octylamino)methyl]phenoxy]methyl]benzamide
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C33H40N4O2
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1
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| 1 |
IC50 = 482.9 nM
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CP0495945
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methyl 2-[1'-(cycloheptylmethyl)-2-oxospiro[indole-3,4'-piperidine]-1-yl]acetate
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C23H32N2O3
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1
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| 1 |
IC50 = 510 nM
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CP0431275
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1'-cyclooctylmethyl-1-methyl-5-trifluoromethylspiro[2,3-dihydro-1H-indole-3,4'-(hexahydropyridine)]-2-one
Show/Hide
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C23H31F3N2O
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1
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| 1 |
IC50 = 600 nM
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CP0464766
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N-(4-amino-2-methylquinolin-6-yl)-2-[[4-[(heptylamino)methyl]phenoxy]methyl]benzamide
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C32H38N4O2
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1
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| 1 |
IC50 = 667.5 nM
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CP0428062
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1-cyclohexylmethyl-1'-cyclooctylmethylspiro[2,3-dihydro-1H-indole-3,4'-(hexahydropyridine)]-2-one
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C28H42N2O
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1
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| 1 |
IC50 = 680 nM
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CP0851049
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1'-[(1,2,3,4-tetrahydronaphthalen-2-yl)methyl]-2,3-dihydro-1'H-spiro[indene-1,4'-piperidine]
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C24H29N
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2
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| 1 |
IC50 = 683 nM
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| 2 |
Ki = 5.55 nM
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CP0486646
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methyl 2-[1'-[(4-chlorophenyl)methyl]-2-oxospiro[indole-3,4'-piperidine]-1-yl]acetate
Show/Hide
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C22H23ClN2O3
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1
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| 1 |
IC50 = 710 nM
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CP0460589
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N-(4-amino-2-methylquinolin-6-yl)-2-[[4-[(pentylamino)methyl]phenoxy]methyl]benzamide
Show/Hide
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C30H34N4O2
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1
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| 1 |
IC50 = 731.6 nM
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CP0458882
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2-[[4-[(4-aminobutylamino)methyl]phenoxy]methyl]-N-(4-amino-2-methylquinolin-6-yl)benzamide
Show/Hide
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C29H33N5O2
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1
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| 1 |
IC50 = 799.8 nM
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CP0436203
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methyl 2-[1'-(cyclohexylmethyl)-2-oxospiro[indole-3,4'-piperidine]-1-yl]acetate
Show/Hide
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C22H30N2O3
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1
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| 1 |
IC50 = 800 nM
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CP0485754
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methyl 2-(1'-hexyl-2-oxospiro[indole-3,4'-piperidine]-1-yl)acetate
Show/Hide
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C21H30N2O3
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1
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| 1 |
IC50 = 820 nM
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CP0518119
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methyl 2-[2-oxo-1'-[[4-(trifluoromethyl)phenyl]methyl]spiro[indole-3,4'-piperidine]-1-yl]acetate
Show/Hide
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C23H23F3N2O3
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1
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| 1 |
IC50 = 880 nM
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CP0431271
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methyl 2-[1'-(1,2,3,4,4a,5,6,7,8,8a-decahydronaphthalen-2-yl)-2-oxospiro[indole-3,4'-piperidine]-1-yl]acetate
Show/Hide
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C25H34N2O3
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1
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| 1 |
IC50 = 900 nM
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CP0075650
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8-[(cis, rac)-2-(4-chloro-phenyl)-2-hydroxy-cyclohexyl]-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one
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C25H30ClN3O2
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1
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| 1 |
IC50 = 1000 nM
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CP0103598
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8-((cis, rac)-2-hydroxy-2-o-tolyl-cyclohexyl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one
Show/Hide
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C26H33N3O2
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1
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| 1 |
IC50 = 1000 nM
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CP0302926
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8-[(cis, rac)-2-(4-fluoro-phenyl)-2-hydroxy-cyclohexyl]-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one
Show/Hide
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C25H30FN3O2
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1
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| 1 |
IC50 = 1000 nM
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CP0486647
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methyl 2-[2-oxo-1'-(1,2,3,4-tetrahydronaphthalen-2-yl)spiro[indole-3,4'-piperidine]-1-yl]acetate
Show/Hide
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C25H28N2O3
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1
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| 1 |
IC50 = 1080 nM
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CP0436411
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2-[[4-[(6-aminohexylamino)methyl]phenoxy]methyl]-N-(4-amino-2-methylquinolin-6-yl)benzamide
Show/Hide
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C31H37N5O2
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1
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| 1 |
IC50 = 1106.7 nM
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CP0471448
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N-(4-amino-2-methylquinolin-6-yl)-2-[[4-(butylaminomethyl)phenoxy]methyl]benzamide
Show/Hide
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C29H32N4O2
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1
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| 1 |
IC50 = 1115.9 nM
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CP0501964
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methyl 2-[1'-(cyclododecylmethyl)-2-oxospiro[indole-3,4'-piperidine]-1-yl]acetate
Show/Hide
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C28H42N2O3
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1
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| 1 |
IC50 = 1120 nM
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CP0441164
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N-(4-amino-2-methylquinolin-6-yl)-2-[[4-[(hexylamino)methyl]phenoxy]methyl]benzamide
Show/Hide
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C31H36N4O2
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1
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| 1 |
IC50 = 1217.8 nM
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CP0485757
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1'-cyclooctylmethyl-1-(4-methoxybenzyl)spiro[2,3-dihydro-1H-indole-3,4'-(hexahydropyridine)]-2-one
Show/Hide
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C29H38N2O2
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1
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| 1 |
IC50 = 1310 nM
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CP0489089
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N,N-dimethyl-1-[3-(4-phenylpiperidin-1-yl)propanoyl]-2,3-dihydroindole-2-carboxamide
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C25H31N3O2
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2
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| 1 |
IC50 = 2296 nM
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| 2 |
Ki = 26.2 nM
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CP0404849
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1'-cyclooctylmethyl-6-methoxy-1-methylspiro[2,3-dihydro-1H-indole-3,4'-(hexahydropyridine)]-2-one
Show/Hide
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C23H34N2O2
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1
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| 1 |
IC50 = 2400 nM
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CP0378192
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1'-cyclooctylmethyl-6-hydroxy-1-methylspiro[2,3-dihydro-1H-indole-3,4'-(hexahydropyridine)]-2-one
Show/Hide
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C22H32N2O2
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1
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| 1 |
IC50 = 2680 nM
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CP0378191
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1'-cyclooctylmethyl-1-ethyl-6-methoxyspiro[2,3-dihydro-1H-indole-3,4'-(hexahydropyridine)]-2-one
Show/Hide
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C24H36N2O2
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1
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| 1 |
IC50 = 2750 nM
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CP0436183
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methyl 2-[1'-(cyclopropylmethyl)-2-oxospiro[indole-3,4'-piperidine]-1-yl]acetate
Show/Hide
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C19H24N2O3
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1
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| 1 |
IC50 = 3600 nM
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CP0453139
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1-phenyl-8-((cis,1R,2R)-2-phenyl-cyclohexyl)-1,3,8-triaza-spiro[4.5]decan-4-one
Show/Hide
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C25H31N3O
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1
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| 1 |
IC50 = 3700 nM
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CP0078022
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8-[(cis, rac)-2-(3-chloro-phenyl)-2-hydroxy-cyclohexyl]-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one
Show/Hide
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C25H30ClN3O2
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1
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| 1 |
IC50 = 3850 nM
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CP0441519
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1-(4-chloro-phenyl)-8-((1S,2S)-2-phenyl-cyclohexyl)-1,3,8-triaza-spiro[4.5]decan-4-one
Show/Hide
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C25H30ClN3O
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1
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| 1 |
IC50 = 4000 nM
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CP0297177
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8-[(cis, rac)-2-hydroxy-2-(3-methoxy-phenyl)-cyclohexyl]-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one
Show/Hide
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C26H33N3O3
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1
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| 1 |
IC50 = 5800 nM
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CP0077854
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1-Phenyl-8-((cis,1S,2S)-2-phenyl-cyclohexyl)-1,3,8-triaza-spiro[4.5]decan-4-one
Show/Hide
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C25H31N3O
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1
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| 1 |
IC50 = 6000 nM
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CP0135238
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8-[(cis, rac)-2-hydroxy-2-(4-methoxy-phenyl)-cyclohexyl]-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one
Show/Hide
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C26H33N3O3
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1
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| 1 |
IC50 = 7000 nM
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CP0431277
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1'-cyclooctylmethyl-5-isopropyl-1-methylspiro[2,3-dihydro-1H-indole-3,4'-(hexahydropyridine)]-2-one
Show/Hide
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C25H38N2O
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1
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| 1 |
IC50 = 7400 nM
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CP0058985
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(S)-4-(4-fluoro-phenyl)-8-[(1R,2R)-2-(4-fluoro-phenyl)-cyclohexyl]-2,8-diaza-spiro[4.5]decan-1-one
Show/Hide
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C26H30F2N2O
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1
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| 1 |
IC50 > 10000 nM
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CP0058987
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4-phenyl-8-(2-phenyl-cyclohexyl)-2,8-diaza-spiro[4.5]decan-1-one
Show/Hide
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C26H32N2O
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1
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| 1 |
IC50 > 10000 nM
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CP0081536
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(R)-4-(4-fluoro-phenyl)-8-[(1R,2R)-2-(4-fluoro-phenyl)-cyclohexyl]-2,8-diaza-spiro[4.5]decan-1-one
Show/Hide
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C26H30F2N2O
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1
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| 1 |
IC50 > 10000 nM
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CP0081540
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(R)-4-phenyl-8-((1S,2S)-2-phenyl-cyclohexyl)-2,8-diaza-spiro[4.5]decan-1-one
Show/Hide
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C26H32N2O
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1
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| 1 |
IC50 > 10000 nM
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CP0134842
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(S)-4-phenyl-8-((1S,2S)-2-phenyl-cyclohexyl)-2,8-diaza-spiro[4.5]decan-1-one
Show/Hide
|
C26H32N2O
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1
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| 1 |
IC50 > 10000 nM
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CP0378194
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1'-cyclooctylmethyl-5-isopropyl-1-propylspiro[2,3-dihydro-1H-indole-3,4'-(hexahydropyridine)]-2-one
Show/Hide
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C27H42N2O
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1
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| 1 |
IC50 > 10000 nM
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CP0378939
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1'-cyclooctylmethyl-1-cyclopropylmethyl-6-methoxyspiro[2,3-dihydro-1H-indole-3,4'-(hexahydropyridine)]-2-one
Show/Hide
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C26H38N2O2
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1
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| 1 |
IC50 > 10000 nM
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CP0431270
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methyl 2-[2-oxo-1'-[(4-phenylphenyl)methyl]spiro[indole-3,4'-piperidine]-1-yl]acetate
Show/Hide
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C28H28N2O3
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1
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| 1 |
IC50 = 10000 nM
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CP0446476
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methyl 2-[2-oxo-1'-(4-oxo-4-phenylbutanoyl)spiro[indole-3,4'-piperidine]-1-yl]acetate
Show/Hide
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C25H26N2O5
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1
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| 1 |
IC50 > 10000 nM
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CP0448617
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methyl 2-[2-oxo-1'-[(2-thiophen-3-ylphenyl)methyl]spiro[indole-3,4'-piperidine]-1-yl]acetate
Show/Hide
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C26H26N2O3S
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1
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| 1 |
IC50 = 10000 nM
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CP0502586
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methyl 2-[2-oxo-1'-(1-phenylethyl)spiro[indole-3,4'-piperidine]-1-yl]acetate
Show/Hide
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C23H26N2O3
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1
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| 1 |
IC50 = 10000 nM
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CP0505628
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methyl 2-[1'-(2-butyloctyl)-2-oxospiro[indole-3,4'-piperidine]-1-yl]acetate
Show/Hide
|
C27H42N2O3
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1
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| 1 |
IC50 = 10000 nM
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CP0515574
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methyl 2-[1'-(4-methoxycyclohexanecarbonyl)-2-oxospiro[indole-3,4'-piperidine]-1-yl]acetate
Show/Hide
|
C23H30N2O5
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1
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| 1 |
IC50 > 10000 nM
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CP0058966
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8-[1-(4-chloro-phenyl)-cyclohexyl]-4-phenyl-2,8-diaza-spiro[4.5]decan-1-one
Show/Hide
|
C26H31ClN2O
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1
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| 1 |
IC50 > 10000 nM
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CP0058967
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4-(4-fluoro-phenyl)-8-(1-m-tolyl-cyclohexyl)-2,8-diaza-spiro[4.5]decan-1-one
Show/Hide
|
C27H33FN2O
|
1
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| 1 |
IC50 > 10000 nM
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CP0081578
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4-(4-fluoro-phenyl)-8-[1-(4-fluoro-phenyl)-cyclohexyl]-2,8-diaza-spiro[4.5]decan-1-one
Show/Hide
|
C26H30F2N2O
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1
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| 1 |
IC50 > 10000 nM
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CP0108222
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4-phenyl-8-(1-p-tolyl-cyclohexyl)-2,8-diaza-spiro[4.5]decan-1-one
Show/Hide
|
C27H34N2O
|
1
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| 1 |
IC50 > 10000 nM
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CP0108223
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4-(4-fluorophenyl)-8-[1-(2-methylphenyl)cyclohexyl]-2,8-diazaspiro[4.5]decan-1-one
Show/Hide
|
C27H33FN2O
|
1
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| 1 |
IC50 > 10000 nM
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CP0108225
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8-[1-(3-fluoro-phenyl)-cyclohexyl]-4-phenyl-2,8-diaza-spiro[4.5]decan-1-one
Show/Hide
|
C26H31FN2O
|
1
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| 1 |
IC50 > 10000 nM
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CP0180148
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4-(4-fluorophenyl)-8-[1-(3-fluorophenyl)cyclohexyl]-2,8-diazaspiro[4.5]decan-1-one
Show/Hide
|
C26H30F2N2O
|
1
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| 1 |
IC50 > 10000 nM
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CP0659598
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4-(4-fluoro-phenyl)-8-[1-(4-fluoro-phenyl)-cyclohexyl]-2,8-diaza-spiro[4.5]decan-1-one
Show/Hide
|
C26H31F3N2O
|
1
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| 1 |
IC50 > 10000 nM
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CP0046108
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8-((cis, rac)-2-hydroxy-2-p-tolyl-cyclohexyl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one
Show/Hide
|
C26H33N3O2
|
1
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| 1 |
IC50 > 10000 nM
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CP0046120
|
1-(4-fluoro-phenyl)-8-[(cis, rac)-2-(4-fluoro-phenyl)-2-hydroxy-cyclohexyl]-1,3,8-triaza-spiro[4.5]decan-4-one
Show/Hide
|
C25H29F2N3O2
|
1
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| 1 |
IC50 = 10000 nM
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CP0103401
|
8-[(cis, rac)-2-(4-chloro-phenyl)-2-hydroxy-cyclohexyl]-1-(4-methoxy-phenyl)-1,3,8-triaza-spiro[4.5]decan-4-one
Show/Hide
|
C26H32ClN3O3
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0167089
|
1-(4-chloro-phenyl)-8-[(cis, rac)-2-(4-fluoro-phenyl)-2-hydroxy-cyclohexyl]-1,3,8-triaza-spiro[4.5]decan-4-one
Show/Hide
|
C25H29ClFN3O2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0255149
|
8-((cis, rac)-3-hydroxy-3-phenyl-tetrahydro-pyran-4-yl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one
Show/Hide
|
C24H29N3O3
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0272339
|
8-[(cis, rac)-2-(3,4-dichloro-phenyl)-2-hydroxy-cyclohexyl]-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one
Show/Hide
|
C25H29Cl2N3O2
|
1
|
| 1 |
IC50 = 10000 nM
|
|
|
|
CP0277722
|
8-((cis, rac)-2-hydroxy-2-pyridin-4-yl-cyclohexyl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one
Show/Hide
|
C24H30N4O2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0297132
|
8-((cis, rac)-4-hydroxy-4-phenyl-tetrahydro-pyran-3-yl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one
Show/Hide
|
C24H29N3O3
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0432525
|
1-phenethyl-8-((1S,2S)-2-phenyl-cyclohexyl)-1,3,8-triaza-spiro[4.5]decan-4-one
Show/Hide
|
C27H35N3O
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0432526
|
1-pentyl-8-((1S,2S)-2-phenyl-cyclohexyl)-1,3,8-triaza-spiro[4.5]decan-4-one
Show/Hide
|
C24H37N3O
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0146697
|
(S)-1-[(S)-2-[2-((S)-2-{(R)-2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-propionylamino}-3-phenyl-propionylamino)-acetylamino]-3-(4-hydroxy-phenyl)-propionyl]-pyrrolidine-2-carboxylic acid ((S)-1-carbamoyl-2-hydroxy-ethyl)-amide
Show/Hide
|
C40H50N8O10
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0390475
|
3-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-phenylpropanoyl]amino]propanoic acid
Show/Hide
|
C27H37N7O6
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0795225
|
1-(3-Thiophen-2-yl-phenyl)-ethanone, O-(phenylaminocarbonyl)oxime
Show/Hide
|
C19H16N2O2S
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0277721
|
8-[(cis, rac)-2-(4-chloro-phenyl)-2-hydroxy-cyclohexyl]-1-(4-fluoro-phenyl)-1,3,8-triaza-spiro[4.5]decan-4-one
Show/Hide
|
C25H29ClFN3O2
|
1
|
| 1 |
IC50 = 10400 nM
|
|
|
|
CP0135237
|
8-((cis, rac)-2-hydroxy-2-pyridin-3-yl-cyclohexyl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one
Show/Hide
|
C24H30N4O2
|
1
|
| 1 |
IC50 = 13400 nM
|
|
|
|
CP0103402
|
8-((cis, rac)-2-hydroxy-2-pyridin-2-yl-cyclohexyl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one
Show/Hide
|
C24H30N4O2
|
1
|
| 1 |
IC50 = 15000 nM
|
|
|
|
CP0182472
|
8-((cis, rac)-2-hydroxy-2-phenyl-cyclohexyl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one
Show/Hide
|
C25H31N3O2
|
1
|
| 1 |
IC50 = 15000 nM
|
|
|
|
CP0443601
|
N,N-dimethyl-1-[3-(4-phenylpiperazin-1-yl)propanoyl]-2,3-dihydroindole-2-carboxamide
Show/Hide
|
C24H30N4O2
|
2
|
| 1 |
IC50 = 48000 nM
|
|
|
| 2 |
Ki > 250 nM
|
|
|
|
CP0483671
|
2-[1'-cyclooctylmethyl-2-oxospiro[2,3-dihydro-1H-indole-3,4'-(hexahydropyridine)]-1-yl]acetic acid
Show/Hide
|
C23H32N2O3
|
1
|
| 1 |
IC50 < 10000 nM
|
|
|
|
CP0946659
|
(S)-6-amino-2-((2S,5S,11S,14S,25S)-14-benzyl-2-(3-guanidinopropyl)-11-((R)-1-hydroxyethyl)-5-methyl-4,7,10,13,16,19,22-heptaoxo-25-phenyl-3,6,9,12,15,18,21,24-octaazahexacosanamido)-N-((S)-1-((S)-1-((S)-1-((S)-1,6-diamino-1-oxohexan-2-ylamino)-5-guanidino-1-oxopentan-2-ylamino)-1-oxopropan-2-ylamino)-3-hydroxy-1-oxopropan-2-yl)hexanamide
Show/Hide
|
C62H102N22O15
|
2
|
| 1 |
Kd = 13.8 nM
|
|
|
| 2 |
Kd = 21.38 nM
|
|
|
|
CP0487408
|
(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S,3R)-2-[[(2S)-2-[[2-[[2-[[2-(benzylamino)acetyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanamide
Show/Hide
|
C61H100N22O15
|
2
|
| 1 |
Kd = 30.9 nM
|
|
|
| 2 |
Kd = 74.13 nM
|
|
|
|
CP0870987
|
(S)-6-amino-2-((2S,5S,11S,14S,23S)-23-amino-14-benzyl-2-(3-guanidinopropyl)-11-((R)-1-hydroxyethyl)-5-methyl-4,7,10,13,16,19-hexaoxo-24-phenyl-21-thia-3,6,9,12,15,18-hexaazatetracosanamido)-N-((S)-1-((S)-1-((S)-1-((S)-1,6-diamino-1-oxohexan-2-ylamino)-5-guanidino-1-oxopentan-2-ylamino)-1-oxopropan-2-ylamino)-3-hydroxy-1-oxopropan-2-yl)hexanamide
Show/Hide
|
C61H101N21O14S
|
2
|
| 1 |
Kd = 102.33 nM
|
|
|
| 2 |
Kd = 131.83 nM
|
|
|
|
CP0274703
|
8-Acenaphthen-1-yl-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one
Show/Hide
|
C25H25N3O
|
1
|
| 1 |
Ki = 0.52 nM
|
|
|
|
CP0427873
|
8-indan-1-yl-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one
Show/Hide
|
C22H25N3O
|
1
|
| 1 |
Ki = 0.7 nM
|
|
|
|
CP0419034
|
8-(5-Methyl-1,2,3,4-tetrahydro-naphthalen-1-yl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one
Show/Hide
|
C24H29N3O
|
1
|
| 1 |
Ki = 1.4 nM
|
|
|
|
CP0446495
|
1-(1,2-dihydroacenaphthylen-1-yl)-4-(1-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)piperidin-3-ol
Show/Hide
|
C25H25N3O
|
1
|
| 1 |
Ki = 2 nM
|
|
|
|
CP0384913
|
1-Phenyl-8-(1,2,3,4-tetrahydro-naphthalen-1-yl)-1,3,8-triaza-spiro[4.5]decan-4-one
Show/Hide
|
C23H27N3O
|
1
|
| 1 |
Ki = 2.1 nM
|
|
|
|
CP0371873
|
1-((3R,4R)-1-Cyclooctylmethyl-3-hydroxymethyl-piperidin-4-yl)-3-ethyl-1,3-dihydro-benzoimidazol-2-one
Show/Hide
|
C24H37N3O2
|
1
|
| 1 |
Ki = 2.3 nM
|
|
|
|
CP0289733
|
8-Indan-2-yl-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one
Show/Hide
|
C22H25N3O
|
1
|
| 1 |
Ki = 2.5 nM
|
|
|
|
CP0506573
|
1-Phenyl-8-(1,2,3,4-tetrahydro-naphthalen-1-yl)-1,3,8-triaza-spiro[4.5]decan-4-one
Show/Hide
|
C23H27N3O
|
1
|
| 1 |
Ki = 2.5 nM
|
|
|
|
CP0386134
|
1-[1-(1-methylcyclooctyl)piperidin-4-yl]-1H-benzimidazole
Show/Hide
|
C21H31N3
|
1
|
| 1 |
Ki = 2.5 nM
|
|
|
|
CP0441775
|
8-(5,8-Dichloro-1,2,3,4-tetrahydro-naphthalen-2-yl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one
Show/Hide
|
C23H25Cl2N3O
|
1
|
| 1 |
Ki = 2.8 nM
|
|
|
|
CP0393640
|
8-(5-Chloro-1,2,3,4-tetrahydro-naphthalen-2-yl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one
Show/Hide
|
C23H26ClN3O
|
1
|
| 1 |
Ki = 2.9 nM
|
|
|
|
CP0437154
|
2-methyl-1'-[4-(propan-2-yl)cyclohexyl]-2,3-dihydro-1H-spiro[isoquinoline-4,4'-piperidine]-3-one
Show/Hide
|
C23H34N2O
|
1
|
| 1 |
Ki = 3.1 nM
|
|
|
|
CP0501250
|
8-(5,8-Dichloro-1,2,3,4-tetrahydro-naphthalen-2-yl)-3-methyl-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one
Show/Hide
|
C24H27Cl2N3O
|
1
|
| 1 |
Ki = 3.3 nM
|
|
|
|
CP0524499
|
US8637502, 56
Show/Hide
|
C24H33N3O2
|
1
|
| 1 |
Ki = 4 nM
|
|
|
|
CP0437156
|
1'-[4-(propan-2-yl)cyclohexyl]-2,3-dihydro-1H-spiro[isoquinoline-4,4'-piperidine]-3-one
Show/Hide
|
C22H32N2O
|
1
|
| 1 |
Ki = 4.7 nM
|
|
|
|
CP0448645
|
8-(5,8-Dichloro-1,2,3,4-tetrahydro-naphthalen-2-yl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one
Show/Hide
|
C23H25Cl2N3O
|
1
|
| 1 |
Ki = 5.6 nM
|
|
|
|
CP0526528
|
US8637502, 60
Show/Hide
|
C23H27N3O2
|
1
|
| 1 |
Ki = 5.6 nM
|
|
|
|
CP0404575
|
8-(7-Chloro-1,2,3,4-tetrahydro-naphthalen-2-yl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one
Show/Hide
|
C23H26ClN3O
|
1
|
| 1 |
Ki = 5.8 nM
|
|
|
|
CP0504159
|
1-Phenyl-8-(1,2,3,4-tetrahydro-naphthalen-2-yl)-1,3,8-triaza-spiro[4.5]decan-4-one
Show/Hide
|
C23H27N3O
|
1
|
| 1 |
Ki = 6.3 nM
|
|
|
|
CP0377805
|
[1-[4-[2-(2-benzyl-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl)benzimidazol-1-yl]piperidin-1-yl]cyclooctyl]methanol
Show/Hide
|
C34H47N5O
|
1
|
| 1 |
Ki = 6.56 nM
|
|
|
|
CP0372979
|
2-benzyl-1'-[4-(propan-2-yl)cyclohexyl]-2,3-dihydro-1H-spiro[isoquinoline-4,4'-piperidine]-3-one
Show/Hide
|
C29H38N2O
|
1
|
| 1 |
Ki = 6.6 nM
|
|
|
|
CP0414922
|
3-Allyl-8-(5,8-dichloro-1,2,3,4-tetrahydro-naphthalen-2-yl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one
Show/Hide
|
C26H29Cl2N3O
|
1
|
| 1 |
Ki = 6.8 nM
|
|
|
|
CP0392868
|
8-(8-Chloro-1,2,3,4-tetrahydro-naphthalen-2-yl)-3-(2-hydroxy-ethyl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one
Show/Hide
|
C25H30ClN3O2
|
1
|
| 1 |
Ki = 7.2 nM
|
|
|
|
CP0498221
|
8-(8-Chloro-1,2,3,4-tetrahydro-naphthalen-2-yl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one
Show/Hide
|
C23H26ClN3O
|
1
|
| 1 |
Ki = 7.3 nM
|
|
|
|
CP0492825
|
8-(8-Chloro-1,2,3,4-tetrahydro-naphthalen-2-yl)-3-methoxymethyl-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one
Show/Hide
|
C25H30ClN3O2
|
1
|
| 1 |
Ki = 8.5 nM
|
|
|
|
CP0405144
|
7-fluoro-2-methyl-1'-[4-(propan-2-yl)cyclohexyl]-2,3-dihydro-1H-spiro[isoquinoline-4,4'-piperidine]-3-one
Show/Hide
|
C23H33FN2O
|
1
|
| 1 |
Ki = 8.9 nM
|
|
|
|
CP0418230
|
US8637502, 12
Show/Hide
|
C25H23N3O2
|
1
|
| 1 |
Ki = 8.9 nM
|
|
|
|
CP0537913
|
1-Phenyl-8-(1,2,3,4-tetrahydro-naphthalen-1-yl)-1,3,8-triaza-spiro[4.5]decan-4-one
Show/Hide
|
C23H27N3O
|
1
|
| 1 |
Ki = 10.2 nM
|
|
|
|
CP0448201
|
(3aR,7aR)-1-(1-Cyclooctylmethyl-piperidin-4-yl)-3-ethyl-octahydro-benzoimidazol-2-one
Show/Hide
|
C23H41N3O
|
1
|
| 1 |
Ki = 11 nM
|
|
|
|
CP0551650
|
US8637502, 17
Show/Hide
|
C21H28FN3O2
|
1
|
| 1 |
Ki = 11.5 nM
|
|
|
|
CP0526254
|
N,N-dimethyl-1-[3-[4-(2-methylphenyl)piperazin-1-yl]propanoyl]-2,3-dihydroindole-2-carboxamide
Show/Hide
|
C25H32N4O2
|
1
|
| 1 |
Ki = 11.6 nM
|
|
|
|
CP0437155
|
2-benzyl-5-fluoro-1'-[4-(propan-2-yl)cyclohexyl]-2,3-dihydro-1H-spiro[isoquinoline-4,4'-piperidine]-3-one
Show/Hide
|
C29H37FN2O
|
1
|
| 1 |
Ki = 12 nM
|
|
|
|
CP0551328
|
US8637502, 57
Show/Hide
|
C24H33N3O2
|
1
|
| 1 |
Ki = 13 nM
|
|
|
|
CP0431678
|
8-(8-Chloro-1,2,3,4-tetrahydro-naphthalen-2-yl)-3-(2-oxo-2-phenyl-ethyl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one
Show/Hide
|
C31H32ClN3O2
|
1
|
| 1 |
Ki = 15 nM
|
|
|
|
CP0493037
|
3-Benzyl-8-(5,8-dichloro-1,2,3,4-tetrahydro-naphthalen-2-yl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one
Show/Hide
|
C30H31Cl2N3O
|
1
|
| 1 |
Ki = 15.3 nM
|
|
|
|
CP0373072
|
(3aR,7aR)-1-(1-Cyclooctylmethyl-piperidin-4-yl)-octahydro-benzoimidazol-2-one
Show/Hide
|
C21H37N3O
|
1
|
| 1 |
Ki = 16 nM
|
|
|
|
CP0859497
|
2-[3-{(spiro[indane-1,4'-piperidin]-1'-yl)methyl}-3,4-dihydroisoquinolin-2(1H)-yl]acetamide
Show/Hide
|
C24H29N3O
|
1
|
| 1 |
Ki = 18.1 nM
|
|
|
|
CP0389454
|
1'-[(2-methyl-3,4-dihydro-1H-isoquinolin-3-yl)methyl]spiro[1,2-dihydroindene-3,4'-piperidine]
Show/Hide
|
C24H30N2
|
1
|
| 1 |
Ki = 18.9 nM
|
|
|
|
CP0460113
|
8-(5,8-Dichloro-1,2,3,4-tetrahydro-naphthalen-2-yl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one
Show/Hide
|
C23H25Cl2N3O
|
1
|
| 1 |
Ki = 20.7 nM
|
|
|
|
CP0500714
|
1'-(4-tert-butylcyclohexyl)-2-methyl-2,3-dihydro-1H-spiro[isoquinoline-4,4'-piperidine]-3-one
Show/Hide
|
C24H36N2O
|
1
|
| 1 |
Ki = 21 nM
|
|
|
|
CP0524500
|
US8637502, 9
Show/Hide
|
C22H31N3O2
|
1
|
| 1 |
Ki = 22.8 nM
|
|
|
|
CP0405147
|
7-fluoro-1'-[4-(propan-2-yl)cyclohexyl]-2,3-dihydro-1H-spiro[isoquinoline-4,4'-piperidine]-3-one
Show/Hide
|
C22H31FN2O
|
1
|
| 1 |
Ki = 23 nM
|
|
|
|
CP0462059
|
3-Methyl-1-phenethyl-4-(phenyl-propionyl-amino)-piperidine-4-carboxylic acid methyl ester
Show/Hide
|
C25H32N2O3
|
1
|
| 1 |
Ki = 24 nM
|
|
|
|
CP0372978
|
2-benzyl-7-fluoro-1'-[4-(propan-2-yl)cyclohexyl]-2,3-dihydro-1H-spiro[isoquinoline-4,4'-piperidine]-3-one
Show/Hide
|
C29H37FN2O
|
1
|
| 1 |
Ki = 26 nM
|
|
|
|
CP0431745
|
(1S,2S,6R,14R,15R,16R)-5-(cyclopropylmethyl)-16-[(R)-hydroxy-(4-methoxyphenyl)methyl]-15-methoxy-16-methyl-13-oxa-5-azahexacyclo[13.2.2.12,8.01,6.02,14.012,20]icosa-8(20),9,11-trien-11-ol
Show/Hide
|
C32H39NO5
|
1
|
| 1 |
Ki = 26 nM
|
|
|
|
CP0461966
|
1-[3-[4-(2-fluorophenyl)piperidin-1-yl]propanoyl]-N,N-dimethyl-2,3-dihydroindole-2-carboxamide
Show/Hide
|
C25H30FN3O2
|
1
|
| 1 |
Ki = 26.5 nM
|
|
|
|
CP0486900
|
1-[3-(spiro[1,2-dihydroindene-3,4'-piperidine]-1'-ylmethyl)-3,4-dihydro-1H-isoquinolin-2-yl]ethanone
Show/Hide
|
C25H30N2O
|
1
|
| 1 |
Ki = 29.8 nM
|
|
|
|
CP0470565
|
N,N-dimethyl-1-[3-[4-[2-(trifluoromethyl)phenyl]piperidin-1-yl]propanoyl]-2,3-dihydroindole-2-carboxamide
Show/Hide
|
C26H30F3N3O2
|
1
|
| 1 |
Ki = 31.5 nM
|
|
|
|
CP0550160
|
US8637502, 16
Show/Hide
|
C22H30FN3O2
|
1
|
| 1 |
Ki = 32.6 nM
|
|
|
|
CP0472344
|
US8637502, 5
Show/Hide
|
C22H31N3O2
|
1
|
| 1 |
Ki = 35.5 nM
|
|
|
|
CP0453622
|
(3aR,7aR)-1-[1-(4-Isopropyl-cyclohexyl)-piperidin-4-yl]-octahydro-benzoimidazol-2-one
Show/Hide
|
C21H37N3O
|
1
|
| 1 |
Ki = 39 nM
|
|
|
|
CP0098923
|
(2S)-6-amino-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-methylpentanoyl]amino]hexanamide
Show/Hide
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C42H68N14O8
|
1
|
| 1 |
Ki = 39 nM
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CP0405145
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1'-(4-tert-butylcyclohexyl)-2,3-dihydro-1H-spiro[isoquinoline-4,4'-piperidine]-3-one
Show/Hide
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C23H34N2O
|
1
|
| 1 |
Ki = 42 nM
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CP0395432
|
(1S,2S,6R,14R,15R,16R)-5-(cyclopropylmethyl)-16-[(1S)-1-hydroxy-1-phenylethyl]-15-methoxy-13-oxa-5-azahexacyclo[13.2.2.12,8.01,6.02,14.012,20]icosa-8(20),9,11-trien-11-ol
Show/Hide
|
C31H37NO4
|
1
|
| 1 |
Ki = 43.2 nM
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CP0385502
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(1S,2S,6R,14R,15R,16R)-16-[(S)-(5-chlorothiophen-2-yl)-hydroxymethyl]-5-(cyclopropylmethyl)-15-methoxy-16-methyl-13-oxa-5-azahexacyclo[13.2.2.12,8.01,6.02,14.012,20]icosa-8(20),9,11-trien-11-ol
Show/Hide
|
C29H34ClNO4S
|
1
|
| 1 |
Ki = 44 nM
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CP0405142
|
2-benzyl-1'-(4-tert-butylcyclohexyl)-2,3-dihydro-1H-spiro[isoquinoline-4,4'-piperidine]-3-one
Show/Hide
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C30H40N2O
|
1
|
| 1 |
Ki = 51 nM
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CP0383805
|
(3aR,7aR)-3-[1-(1,2,3,4,4a,5,6,7,8,8a-decahydronaphthalen-2-yl)piperidin-4-yl]-3a,4,5,6,7,7a-hexahydro-1H-benzimidazol-2-one
Show/Hide
|
C22H37N3O
|
1
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| 1 |
Ki = 51 nM
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CP0517899
|
US8637502, 67
Show/Hide
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C21H30N4O2
|
1
|
| 1 |
Ki = 51 nM
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CP0394000
|
3-(1-(1,2-dihydroacenaphthylen-1-yl)piperidin-4-yl)-6-fluoro-1H-indole
Show/Hide
|
C25H23FN2
|
1
|
| 1 |
Ki = 52 nM
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CP0551327
|
US8637502, 44
Show/Hide
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C23H30N4O2
|
1
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| 1 |
Ki = 52 nM
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CP0414678
|
(1S,2S,6R,14R,15R,16R)-5-(cyclopropylmethyl)-16-[(R)-(4-fluorophenyl)-hydroxymethyl]-15-methoxy-16-methyl-13-oxa-5-azahexacyclo[13.2.2.12,8.01,6.02,14.012,20]icosa-8(20),9,11-trien-11-ol
Show/Hide
|
C31H36FNO4
|
1
|
| 1 |
Ki = 56 nM
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CP0415110
|
(1S,2S,6R,14R,15R,16R)-5-(cyclopropylmethyl)-16-[(R)-hydroxy-(4-methylphenyl)methyl]-15-methoxy-16-methyl-13-oxa-5-azahexacyclo[13.2.2.12,8.01,6.02,14.012,20]icosa-8(20),9,11-trien-11-ol
Show/Hide
|
C32H39NO4
|
1
|
| 1 |
Ki = 56 nM
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CP0450748
|
US8637502, 61
Show/Hide
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C23H27N3O2
|
1
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| 1 |
Ki = 56 nM
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CP0511035
|
(2R)-1-(3-(1-(1,2-dihydroacenaphthylen-1-yl)piperidin-4-yl)-6-fluoro-1H-indol-1-yl)-3-(dimethylamino)propan-2-ol
Show/Hide
|
C30H34FN3O
|
1
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| 1 |
Ki = 62 nM
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CP0557831
|
US8637502, 18
Show/Hide
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C21H28FN3O2
|
1
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| 1 |
Ki = 63.2 nM
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CP0500712
|
N-benzyl-4-phenyl-1-[4-(propan-2-yl)cyclohexyl]piperidine-4-carboxamide
Show/Hide
|
C28H38N2O
|
1
|
| 1 |
Ki = 65 nM
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CP0517947
|
US8637502, 6
Show/Hide
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C21H29N3O2
|
1
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| 1 |
Ki = 65 nM
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CP0551329
|
US8637502, 87
Show/Hide
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C24H32FN3O4
|
1
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| 1 |
Ki = 68 nM
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CP0413167
|
(1S,2S,6R,14R,15R,16R)-5-(cyclopropylmethyl)-16-[(1S)-1-hydroxy-1-thiophen-2-ylethyl]-15-methoxy-13-oxa-5-azahexacyclo[13.2.2.12,8.01,6.02,14.012,20]icosa-8(20),9,11-trien-11-ol
Show/Hide
|
C29H35NO4S
|
1
|
| 1 |
Ki = 75 nM
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CP0168848
|
4-[4-Hydroxy-4-(3-trifluoromethyl-phenyl)-piperidin-1-yl]-2,2-diphenyl-butyric acid methyl ester
Show/Hide
|
C29H30F3NO3
|
1
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| 1 |
Ki = 78 nM
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CP0376883
|
methyl 1-[4-[2-(4-methylpiperazin-1-yl)benzimidazol-1-yl]piperidin-1-yl]cyclooctane-1-carboxylate
Show/Hide
|
C27H41N5O2
|
1
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| 1 |
Ki = 80.5 nM
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CP0446330
|
3-(1-(1,2-dihydroacenaphthylen-1-yl)piperidin-4-yl)-1-methyl-1H-pyrrolo[2,3-b]pyridine
Show/Hide
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C25H25N3
|
1
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| 1 |
Ki = 81 nM
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CP0437142
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2-benzyl-1'-(4-tert-butylcyclohexyl)-5-fluoro-2,3-dihydro-1H-spiro[isoquinoline-4,4'-piperidine]-3-one
Show/Hide
|
C30H39FN2O
|
1
|
| 1 |
Ki = 81 nM
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CP0377993
|
(3aR,7aR)-1-Ethyl-3-[1-(4-isopropyl-cyclohexyl)-piperidin-4-yl]-octahydro-benzoimidazol-2-one
Show/Hide
|
C23H41N3O
|
1
|
| 1 |
Ki = 89 nM
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CP0517946
|
US8637502, 66
Show/Hide
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C20H28N4O2
|
1
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| 1 |
Ki = 89 nM
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CP0500713
|
1'-(4-tert-butylcyclohexyl)-7-fluoro-2,3-dihydro-1H-spiro[isoquinoline-4,4'-piperidine]-3-one
Show/Hide
|
C23H33FN2O
|
1
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| 1 |
Ki = 90 nM
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CP0405140
|
4-phenyl-1-[4-(propan-2-yl)cyclohexyl]piperidine-4-carboxamide
Show/Hide
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C21H32N2O
|
1
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| 1 |
Ki = 92 nM
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CP0436267
|
2-(3-(1-(1,2-dihydroacenaphthylen-1-yl)piperidin-4-yl)-1H-pyrrolo[2,3-b]pyridin-1-yl)ethanol
Show/Hide
|
C26H27N3O
|
1
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| 1 |
Ki = 94 nM
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CP0917991
|
cis-1-(4-tert-butylcyclohexyl)-4-(2-fluorophenyl)piperidine-4-carboxamide
Show/Hide
|
C22H33FN2O
|
1
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| 1 |
Ki = 100 nM
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CP0121280
|
7-[2-[2-(3-chlorophenyl)ethylamino]ethyl]quinolin-2-amine
Show/Hide
|
C19H20ClN3
|
1
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| 1 |
Ki < 100 nM
|
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CP0489871
|
N,N-dimethyl-1-[3-(4-pentan-3-ylpiperazin-1-yl)propanoyl]-2,3-dihydroindole-2-carboxamide
Show/Hide
|
C23H36N4O2
|
1
|
| 1 |
Ki = 101 nM
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CP0918462
|
cis-N-benzyl-1-(4-tert-butylcyclohexyl)-4-phenylpiperidine-4-carboxamide
Show/Hide
|
C29H40N2O
|
1
|
| 1 |
Ki = 104 nM
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CP0377987
|
(3aR,7aR)-1-(1-Cyclooctyl-piperidin-4-yl)-3-ethyl-octahydro-benzoimidazol-2-one
Show/Hide
|
C22H39N3O
|
1
|
| 1 |
Ki = 111 nM
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CP0254642
|
1-(3,3-Diphenyl-propyl)-4-(3-trifluoromethyl-phenyl)-piperidin-4-ol
Show/Hide
|
C27H28F3NO
|
1
|
| 1 |
Ki = 116 nM
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CP0406755
|
(3aR,7aR)-1-(1-Cyclooctyl-piperidin-4-yl)-octahydro-benzoimidazol-2-one
Show/Hide
|
C20H35N3O
|
1
|
| 1 |
Ki = 125 nM
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CP0481417
|
1-[3-[4-(2-ethoxyphenyl)piperazin-1-yl]propanoyl]-N,N-dimethyl-2,3-dihydroindole-2-carboxamide
Show/Hide
|
C26H34N4O3
|
1
|
| 1 |
Ki = 128 nM
|
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CP0431782
|
N-methyl-4-phenyl-1-[4-(propan-2-yl)cyclohexyl]piperidine-4-carboxamide
Show/Hide
|
C22H34N2O
|
1
|
| 1 |
Ki = 130 nM
|
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CP0405141
|
2-benzyl-1'-(4-tert-butylcyclohexyl)-7-fluoro-2,3-dihydro-1H-spiro[isoquinoline-4,4'-piperidine]-3-one
Show/Hide
|
C30H39FN2O
|
1
|
| 1 |
Ki = 136 nM
|
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CP0405143
|
1'-(4-tert-butylcyclohexyl)-7-fluoro-2-methyl-2,3-dihydro-1H-spiro[isoquinoline-4,4'-piperidine]-3-one
Show/Hide
|
C24H35FN2O
|
1
|
| 1 |
Ki = 147 nM
|
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CP0102498
|
4-[4-(4-Chloro-3-trifluoromethyl-phenyl)-4-hydroxy-piperidin-1-yl]-2,2-diphenyl-butyric acid methyl ester
Show/Hide
|
C29H29ClF3NO3
|
1
|
| 1 |
Ki = 149 nM
|
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CP0383290
|
4-(4-Chloro-phenyl)-1-naphthalen-2-ylmethyl-piperidin-4-ol
Show/Hide
|
C22H22ClNO
|
1
|
| 1 |
Ki = 153 nM
|
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CP0453006
|
3-(1-(1,2-dihydroacenaphthylen-1-yl)-1,2,3,6-tetrahydropyridin-4-yl)-6-fluoro-1H-indole
Show/Hide
|
C25H21FN2
|
1
|
| 1 |
Ki = 160 nM
|
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CP0565701
|
US8637502, 58
Show/Hide
|
C25H35N3O2
|
1
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| 1 |
Ki = 173 nM
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CP0938261
|
cis-N-benzyl-4-(2-fluorophenyl)-1-(4-isopropylcyclohexyl)piperidine-4-carboxamide
Show/Hide
|
C28H37FN2O
|
1
|
| 1 |
Ki = 180 nM
|
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CP0410672
|
(3aR,7aR)-1-[1-(1,2,3,4,4a,5,6,7,8,8a-decahydronaphthalen-2-yl)piperidin-4-yl]-3-ethyl-3a,4,5,6,7,7a-hexahydrobenzimidazol-2-one
Show/Hide
|
C24H41N3O
|
1
|
| 1 |
Ki = 184 nM
|
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CP0405146
|
5-fluoro-2-methyl-1'-[4-(propan-2-yl)cyclohexyl]-2,3-dihydro-1H-spiro[isoquinoline-4,4'-piperidine]-3-one
Show/Hide
|
C23H33FN2O
|
1
|
| 1 |
Ki = 186 nM
|
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CP0875435
|
cis-4-(2-fluorophenyl)-1-(4-isopropylcyclohexyl)piperidine-4-carboxamide
Show/Hide
|
C21H31FN2O
|
1
|
| 1 |
Ki = 186 nM
|
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CP0374654
|
8-(6-Chloro-1,2,3,4-tetrahydro-naphthalen-2-yl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one
Show/Hide
|
C23H26ClN3O
|
1
|
| 1 |
Ki = 218 nM
|
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CP0149646
|
4-(4-Chloro-3-trifluoromethyl-phenyl)-1-(3,3-diphenyl-propyl)-piperidin-4-ol
Show/Hide
|
C27H27ClF3NO
|
1
|
| 1 |
Ki = 225 nM
|
|
|
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CP0443653
|
US8637502, 20
Show/Hide
|
C22H30FN3O2
|
1
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| 1 |
Ki = 229 nM
|
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CP0442764
|
4-(4-Chloro-3-trifluoromethyl-phenyl)-1-(4-fluoro-benzyl)-piperidin-4-ol
Show/Hide
|
C19H18ClF4NO
|
1
|
| 1 |
Ki = 234 nM
|
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CP0942320
|
cis-N-benzyl-1-(4-tert-butylcyclohexyl)-4-(2-fluorophenyl)piperidine-4-carboxamide
Show/Hide
|
C29H39FN2O
|
1
|
| 1 |
Ki = 260 nM
|
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CP0441050
|
1-[3-(4-cyclohexylpiperidin-1-yl)propanoyl]-N,N-dimethyl-2,3-dihydroindole-2-carboxamide
Show/Hide
|
C25H37N3O2
|
1
|
| 1 |
Ki = 286 nM
|
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CP0441681
|
3-(1-(cyclooctylmethyl)piperidin-4-yl)-5-fluoro-1H-indole
Show/Hide
|
C22H31FN2
|
1
|
| 1 |
Ki = 290 nM
|
|
|
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CP0450747
|
US8637502, 43
Show/Hide
|
C23H33N3O2
|
1
|
| 1 |
Ki = 291 nM
|
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CP0524586
|
4-(4-Chloro-phenyl)-1-(4-trifluoromethyl-benzyl)-piperidin-4-ol
Show/Hide
|
C19H19ClF3NO
|
1
|
| 1 |
Ki = 307 nM
|
|
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CP0252007
|
4-(4-Chloro-phenyl)-1-(3,3-diphenyl-propyl)-piperidin-4-ol
Show/Hide
|
C26H28ClNO
|
1
|
| 1 |
Ki = 372 nM
|
|
|
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CP0372980
|
1'-(4-tert-butylcyclohexyl)-5-fluoro-2-methyl-2,3-dihydro-1H-spiro[isoquinoline-4,4'-piperidine]-3-one
Show/Hide
|
C24H35FN2O
|
1
|
| 1 |
Ki = 395 nM
|
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CP0448762
|
(3aR,7aR)-1-[1-(1,4-Dimethyl-pentyl)-piperidin-4-yl]-3-ethyl-octahydro-benzoimidazol-2-one
Show/Hide
|
C21H39N3O
|
1
|
| 1 |
Ki = 410 nM
|
|
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CP0409503
|
(3aR,7aR)-1-[1-(1,4-Dimethyl-pentyl)-piperidin-4-yl]-octahydro-benzoimidazol-2-one
Show/Hide
|
C19H35N3O
|
1
|
| 1 |
Ki = 414 nM
|
|
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CP0397818
|
(3aR,7aR)-1-[1-(3,3-Diphenyl-propyl)-piperidin-4-yl]-octahydro-benzoimidazol-2-one
Show/Hide
|
C27H35N3O
|
1
|
| 1 |
Ki = 437 nM
|
|
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CP0462642
|
US8637502, 24
Show/Hide
|
C27H26N4O3
|
1
|
| 1 |
Ki = 453 nM
|
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CP0277834
|
4-[4-Hydroxy-4-(3-trifluoromethyl-phenyl)-piperidin-1-yl]-N,N-dimethyl-2,2-diphenyl-butyramide
Show/Hide
|
C30H33F3N2O2
|
1
|
| 1 |
Ki = 505 nM
|
|
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CP0917992
|
cis-N-benzyl-4-(4-fluorophenyl)-1-(4-isopropylcyclohexyl)piperidine-4-carboxamide
Show/Hide
|
C28H37FN2O
|
1
|
| 1 |
Ki = 545 nM
|
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CP0442845
|
3-(1-(cyclooctylmethyl)piperidin-4-yl)-1H-pyrrolo[2,3-b]pyridine
Show/Hide
|
C21H31N3
|
1
|
| 1 |
Ki = 550 nM
|
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|
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CP0415111
|
(1S,2S,6R,14R,15R,16R)-5-(cyclopropylmethyl)-16-[(S)-hydroxy(thiophen-2-yl)methyl]-15-methoxy-16-methyl-13-oxa-5-azahexacyclo[13.2.2.12,8.01,6.02,14.012,20]icosa-8(20),9,11-trien-11-ol
Show/Hide
|
C29H35NO4S
|
1
|
| 1 |
Ki = 571 nM
|
|
|
|
CP0550161
|
US8637502, 47
Show/Hide
|
C25H36N4O3
|
1
|
| 1 |
Ki = 584 nM
|
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CP0078630
|
4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-2,2-diphenyl-butyric acid methyl ester
Show/Hide
|
C28H30ClNO3
|
1
|
| 1 |
Ki = 590 nM
|
|
|
|
CP0476964
|
US8637502, 10
Show/Hide
|
C23H33N3O2
|
1
|
| 1 |
Ki = 610 nM
|
|
|
|
CP0551330
|
US8637502, 7
Show/Hide
|
C26H39N3O2
|
1
|
| 1 |
Ki = 620 nM
|
|
|
|
CP0409504
|
(3aR,7aR)-1-[1-(4-Propyl-cyclohexyl)-piperidin-4-yl]-octahydro-benzoimidazol-2-one
Show/Hide
|
C21H37N3O
|
1
|
| 1 |
Ki = 634 nM
|
|
|
|
CP0446496
|
7-chloro-3-(1-(cyclooctylmethyl)piperidin-4-yl)-1H-indole
Show/Hide
|
C22H31ClN2
|
1
|
| 1 |
Ki = 660 nM
|
|
|
|
CP0439695
|
1-(4-Fluoro-benzyl)-4-(3-trifluoromethyl-phenyl)-piperidin-4-ol
Show/Hide
|
C19H19F4NO
|
1
|
| 1 |
Ki = 692 nM
|
|
|
|
CP0404305
|
(3aR,7aR)-1-(1-Benzyl-piperidin-4-yl)-3-ethyl-octahydro-benzoimidazol-2-one
Show/Hide
|
C21H31N3O
|
1
|
| 1 |
Ki = 692 nM
|
|
|
|
CP0449437
|
5-chloro-3-(1-(cyclooctylmethyl)piperidin-4-yl)-2-methyl-1H-indole
Show/Hide
|
C23H33ClN2
|
1
|
| 1 |
Ki = 710 nM
|
|
|
|
CP0437760
|
1-Naphthalen-2-ylmethyl-4-(3-trifluoromethyl-phenyl)-piperidin-4-ol
Show/Hide
|
C23H22F3NO
|
1
|
| 1 |
Ki = 715 nM
|
|
|
|
CP0960913
|
cis-N-benzyl-1-(4-tert-butylcyclohexyl)-4-(4-fluorophenyl)piperidine-4-carboxamide
Show/Hide
|
C29H39FN2O
|
1
|
| 1 |
Ki = 740 nM
|
|
|
|
CP0425428
|
5-fluoro-3-(1-(naphthalen-1-ylmethyl)piperidin-4-yl)-1H-indole
Show/Hide
|
C24H23FN2
|
1
|
| 1 |
Ki = 800 nM
|
|
|
|
CP0428064
|
3-(1-(naphthalen-1-ylmethyl)piperidin-4-yl)-1H-pyrrolo[2,3-b]pyridine
Show/Hide
|
C23H23N3
|
1
|
| 1 |
Ki = 820 nM
|
|
|
|
CP0415112
|
(1S,2S,6R,14R,15R,16R)-5-(cyclopropylmethyl)-16-[(R)-hydroxy-(2-methylphenyl)methyl]-15-methoxy-16-methyl-13-oxa-5-azahexacyclo[13.2.2.12,8.01,6.02,14.012,20]icosa-8(20),9,11-trien-11-ol
Show/Hide
|
C32H39NO4
|
1
|
| 1 |
Ki = 820 nM
|
|
|
|
CP0373095
|
(3aR,7aR)-1-Ethyl-3-(1-naphthalen-2-ylmethyl-piperidin-4-yl)-octahydro-benzoimidazol-2-one
Show/Hide
|
C25H33N3O
|
1
|
| 1 |
Ki = 824 nM
|
|
|
|
CP0515920
|
1-Naphthalen-1-ylmethyl-4-phenyl-piperidine-4-carbonitrile
Show/Hide
|
C23H22N2
|
1
|
| 1 |
Ki = 827 nM
|
|
|
|
CP0168501
|
4-(4-Chloro-3-trifluoromethyl-phenyl)-1-naphthalen-2-ylmethyl-piperidin-4-ol
Show/Hide
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C23H21ClF3NO
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1
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| 1 |
Ki = 879 nM
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CP0458107
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(R)-1-(3-(1-(cyclooctylmethyl)piperidin-4-yl)-5-fluoro-1H-indol-1-yl)-3-(dimethylamino)propan-2-ol
Show/Hide
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C27H42FN3O
|
1
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| 1 |
Ki = 970 nM
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CP0392380
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(3aR,7aR)-1-(1-Benzyl-piperidin-4-yl)-octahydro-benzoimidazol-2-one
Show/Hide
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C19H27N3O
|
1
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| 1 |
Ki = 1054 nM
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CP0437657
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1-Naphthalen-2-ylmethyl-4-phenyl-piperidine-4-carbonitrile
Show/Hide
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C23H22N2
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1
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| 1 |
Ki = 1106 nM
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CP0403752
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3-(1-benzylpiperidin-4-yl)-5-chloro-1H-indole
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C20H21ClN2
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1
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| 1 |
Ki = 1140 nM
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CP0383265
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4-(4-Chloro-3-trifluoromethyl-phenyl)-1-(4-trifluoromethyl-benzyl)-piperidin-4-ol
Show/Hide
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C20H18ClF6NO
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1
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| 1 |
Ki = 1194 nM
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CP0448246
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(3aR,7aR)-1-Ethyl-3-[1-(4-propyl-cyclohexyl)-piperidin-4-yl]-octahydro-benzoimidazol-2-one
Show/Hide
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C23H41N3O
|
1
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| 1 |
Ki = 1239 nM
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CP0404259
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(3aR,7aR)-1-(1-Naphthalen-2-ylmethyl-piperidin-4-yl)-octahydro-benzoimidazol-2-one
Show/Hide
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C23H29N3O
|
1
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| 1 |
Ki = 1259 nM
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CP0419385
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1-(3,4-Dichloro-benzyl)-4-phenyl-piperidine-4-carbonitrile
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C19H18Cl2N2
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1
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| 1 |
Ki = 1270 nM
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CP0431744
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(1R,2S,6R,14R,15R,19R)-5-(cyclopropylmethyl)-19-[(R)-hydroxy-(2-methylphenyl)methyl]-15-methoxy-19-methyl-13-oxa-5-azahexacyclo[13.2.2.12,8.01,6.02,14.012,20]icosa-8(20),9,11,16-tetraen-11-ol
Show/Hide
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C32H37NO4
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1
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| 1 |
Ki = 1270 nM
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CP0550623
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US8637502, 29
Show/Hide
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C23H33N3O2
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1
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| 1 |
Ki = 1526 nM
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CP0517898
|
US8637502, 11
Show/Hide
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C27H41N3O2
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1
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| 1 |
Ki = 1550 nM
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CP0395364
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1-((R)-3-amino-2-hydroxypropyl)-3-(1-(1,2-dihydroacenaphthylen-1-yl)-1,2,3,6-tetrahydropyridin-4-yl)-1H-indole-5-carbonitrile
Show/Hide
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C29H28N4O
|
1
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| 1 |
Ki = 1650 nM
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CP0544762
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US8637502, 78
Show/Hide
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C27H36N4O3
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1
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| 1 |
Ki = 1762 nM
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CP0544763
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US8637502, 80
Show/Hide
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C29H34N4O3
|
1
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| 1 |
Ki = 1777 nM
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CP0565710
|
US8637502, 79
Show/Hide
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C26H34N4O4
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1
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| 1 |
Ki = 1965 nM
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CP0184336
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4-[4-(4-Chloro-3-trifluoromethyl-phenyl)-4-hydroxy-piperidin-1-yl]-N,N-dimethyl-2,2-diphenyl-butyramide
Show/Hide
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C30H32ClF3N2O2
|
1
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| 1 |
Ki = 2151 nM
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CP0428067
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3-(1-(cyclohexylmethyl)piperidin-4-yl)-1H-pyrrolo[2,3-b]pyridine
Show/Hide
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C19H27N3
|
1
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| 1 |
Ki = 3500 nM
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CP0395295
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(3aR,7aR)-1-[1-(3,3-Diphenyl-propyl)-piperidin-4-yl]-3-ethyl-octahydro-benzoimidazol-2-one
Show/Hide
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C29H39N3O
|
1
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| 1 |
Ki = 4358 nM
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CP0382350
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(1S,2S,6R,14R,15R,16R)-5-(cyclopropylmethyl)-16-[(1R)-1-hydroxy-1-pyridin-4-ylethyl]-15-methoxy-13-oxa-5-azahexacyclo[13.2.2.12,8.01,6.02,14.012,20]icosa-8(20),9,11-trien-11-ol
Show/Hide
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C30H36N2O4
|
1
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| 1 |
Ki = 4630 nM
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CP0564030
|
US8637502, 83
Show/Hide
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C22H30N4O3
|
1
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| 1 |
Ki = 6010 nM
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CP0492609
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1-(4-Trifluoromethyl-benzyl)-4-(3-trifluoromethyl-phenyl)-piperidin-4-ol
Show/Hide
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C20H19F6NO
|
1
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| 1 |
Ki = 6520 nM
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CP0184335
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4-[4-(4-Chloro-3-trifluoromethyl-phenyl)-4-hydroxy-piperidin-1-ylmethyl]-benzonitrile
Show/Hide
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C20H18ClF3N2O
|
1
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| 1 |
Ki > 10000 nM
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CP0405024
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1-(2-Methyl-naphthalen-1-ylmethyl)-4-phenyl-piperidine-4-carbonitrile
Show/Hide
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C24H24N2
|
1
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| 1 |
Ki > 10000 nM
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CP0437584
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4-(4-Chloro-3-trifluoromethyl-phenyl)-1-(5-nitro-furan-2-ylmethyl)-piperidin-4-ol
Show/Hide
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C17H16ClF3N2O4
|
1
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| 1 |
Ki > 10000 nM
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CP0496139
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1-(4-Fluoro-benzyl)-4-phenyl-piperidine-4-carbonitrile
Show/Hide
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C19H19FN2
|
1
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| 1 |
Ki > 10000 nM
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CP0509088
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2-Benzyloxy-1-[4-(4-bromo-phenyl)-4-hydroxy-piperidin-1-yl]-ethanone
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C20H22BrNO3
|
1
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| 1 |
Ki > 10000 nM
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CP0011042
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4-(4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl)-N,N-dimethyl-2,2-diphenylbutanamide
Show/Hide
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C29H33ClN2O2
|
1
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| 1 |
Ki > 10000 nM
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CP0156379
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4-[4-Hydroxy-4-(3-trifluoromethyl-phenyl)-piperidin-1-yl]-2,2-diphenyl-butyric acid
Show/Hide
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C28H28F3NO3
|
1
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| 1 |
Ki > 10000 nM
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CP0156492
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4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-2,2-diphenyl-butyric acid
Show/Hide
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C27H28ClNO3
|
1
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| 1 |
Ki > 10000 nM
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CP0156494
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4-(4-Chloro-3-trifluoromethyl-phenyl)-1-naphthalen-2-ylmethyl-1-oxy-piperidin-4-ol
Show/Hide
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C23H21ClF3NO2
|
1
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| 1 |
Ki > 10000 nM
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CP0168732
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4-(4-Chloro-3-trifluoromethyl-phenyl)-1-(3,3-diphenyl-propyl)-1-oxy-piperidin-4-ol
Show/Hide
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C27H27ClF3NO2
|
1
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| 1 |
Ki > 10000 nM
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CP0176748
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4-[4-(4-Chloro-3-trifluoromethyl-phenyl)-4-hydroxy-piperidin-1-yl]-2,2-diphenyl-butyric acid
Show/Hide
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C28H27ClF3NO3
|
1
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| 1 |
Ki > 10000 nM
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CP0273047
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1-(3,3-Diphenyl-propyl)-1-oxy-4-(3-trifluoromethyl-phenyl)-piperidin-4-ol
Show/Hide
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C27H28F3NO2
|
1
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| 1 |
Ki > 10000 nM
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CP0048724
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(4R,4aS,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-bis(oxidanyl)-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7-one;hydrochloride
Show/Hide
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C20H23NO4
|
1
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| 1 |
Ki > 10000 nM
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CP0403123
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(2R)-2-[[(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl]amino]-N-[(4S)-2-(3-amino-3-oxopropyl)-3-oxo-4,5-dihydro-1H-2-benzazepin-4-yl]-5-(diaminomethylideneamino)pentanamide
Show/Hide
|
C30H42N8O5
|
1
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| 1 |
Ki > 10000 nM
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CP0563344
|
US8637502, 81
Show/Hide
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C22H30N4O3
|
1
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| 1 |
Ki = 16500 nM
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CP0492234
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(2R)-N-[(1R)-2-amino-2-oxo-1-phenylethyl]-5-(diaminomethylideneamino)-2-[(2,2-diphenylacetyl)amino]pentanamide
Show/Hide
|
C28H32N6O3
|
1
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| 1 |
Ki > 30000 nM
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CP0563345
|
US8637502, 85
Show/Hide
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C24H33N3O4
|
1
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| 1 |
Ki = 39930 nM
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CP0528734
|
(2R)-N-(2-amino-2-oxoethyl)-5-(diaminomethylideneamino)-2-(3,3-diphenylprop-2-enoylamino)pentanamide
Show/Hide
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C23H28N6O3
|
1
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| 1 |
Ki > 50000 nM
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CP0557832
|
US8637502, 86
Show/Hide
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C23H31N3O4
|
1
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| 1 |
Ki > 106 nM
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CP0393713
|
1-{4-[2-(4-Methylpiperazin-1-yl)-1H-benzimidazol-1-yl]-piperidin-1-yl}cyclooctanecarboxylic acid
Show/Hide
|
C26H39N5O2
|
1
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| 1 |
Ki > 250 nM
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CP0441033
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1-[3-[4-(2,4-dimethylphenyl)piperazin-1-yl]propanoyl]-N,N-dimethyl-2,3-dihydroindole-2-carboxamide
Show/Hide
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C26H34N4O2
|
1
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| 1 |
Ki > 250 nM
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CP0441034
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N,N-dimethyl-1-[3-[4-(1-phenylethyl)piperazin-1-yl]propanoyl]-2,3-dihydroindole-2-carboxamide
Show/Hide
|
C26H34N4O2
|
1
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| 1 |
Ki > 250 nM
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CP0441035
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1-[3-(4-cyclohexylpiperazin-1-yl)propanoyl]-N,N-dimethyl-2,3-dihydroindole-2-carboxamide
Show/Hide
|
C24H36N4O2
|
1
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| 1 |
Ki > 250 nM
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CP0441045
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N,N-dimethyl-1-[3-(4-pentan-2-ylpiperazin-1-yl)propanoyl]-2,3-dihydroindole-2-carboxamide
Show/Hide
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C23H36N4O2
|
1
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| 1 |
Ki > 250 nM
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CP0441046
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1-[3-[(4aS,10bS)-2,4,4a,5,6,10b-hexahydro-1H-benzo[f]isoquinolin-3-yl]propanoyl]-N,N-dimethyl-2,3-dihydroindole-2-carboxamide
Show/Hide
|
C27H33N3O2
|
1
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| 1 |
Ki > 250 nM
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CP0441047
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(2S)-N,N-dimethyl-1-[3-(8-phenyl-3-azabicyclo[3.2.1]octan-3-yl)propanoyl]-2,3-dihydroindole-2-carboxamide
Show/Hide
|
C27H33N3O2
|
1
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| 1 |
Ki > 250 nM
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CP0441048
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1-[3-(4-cycloheptylpiperazin-1-yl)propanoyl]-N,N-dimethyl-2,3-dihydroindole-2-carboxamide
Show/Hide
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C25H38N4O2
|
1
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| 1 |
Ki > 250 nM
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CP0441049
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1-[3-(4-cyclooctylpiperazin-1-yl)propanoyl]-N,N-dimethyl-2,3-dihydroindole-2-carboxamide
Show/Hide
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C26H40N4O2
|
1
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| 1 |
Ki > 250 nM
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CP0441051
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N,N-dimethyl-1-[3-[4-(3-methylphenyl)piperazin-1-yl]propanoyl]-2,3-dihydroindole-2-carboxamide
Show/Hide
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C25H32N4O2
|
1
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| 1 |
Ki > 250 nM
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CP0443595
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N,N-dimethyl-1-[3-(4-piperidin-1-ylpiperidin-1-yl)propanoyl]-2,3-dihydroindole-2-carboxamide
Show/Hide
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C24H36N4O2
|
1
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| 1 |
Ki > 250 nM
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CP0443597
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1-[3-(1,3-dihydroisoindol-2-yl)propanoyl]-N,N-dimethyl-2,3-dihydroindole-2-carboxamide
Show/Hide
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C22H25N3O2
|
1
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| 1 |
Ki > 250 nM
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CP0443598
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1-[3-(3,4-dihydro-1H-isoquinolin-2-yl)propanoyl]-N,N-dimethyl-2,3-dihydroindole-2-carboxamide
Show/Hide
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C23H27N3O2
|
1
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| 1 |
Ki > 250 nM
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CP0443603
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N,N-dimethyl-1-[3-(4-pyrazin-2-ylpiperazin-1-yl)propanoyl]-2,3-dihydroindole-2-carboxamide
Show/Hide
|
C22H28N6O2
|
1
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| 1 |
Ki > 250 nM
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CP0443606
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N,N-dimethyl-1-[3-(4-phenylazepan-1-yl)propanoyl]-2,3-dihydroindole-2-carboxamide
Show/Hide
|
C26H33N3O2
|
1
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| 1 |
Ki > 250 nM
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CP0458245
|
1-[3-(4-benzylpiperazin-1-yl)propanoyl]-N,N-dimethyl-2,3-dihydroindole-2-carboxamide
Show/Hide
|
C25H32N4O2
|
1
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| 1 |
Ki > 250 nM
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CP0461815
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1-[3-(4-cyclopentylpiperazin-1-yl)propanoyl]-N,N-dimethyl-2,3-dihydroindole-2-carboxamide
Show/Hide
|
C23H34N4O2
|
1
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| 1 |
Ki > 250 nM
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CP0461816
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N,N-dimethyl-1-[3-(4-pyridin-2-ylpiperidin-1-yl)propanoyl]-2,3-dihydroindole-2-carboxamide
Show/Hide
|
C24H30N4O2
|
1
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| 1 |
Ki > 250 nM
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CP0913384
|
1-(3-{1H-Benzo[de]isoquinolin-2(3H)-yl}propanoyl)-N,N-dimethylindoline-(2RS)-2-carboxamide formate
Show/Hide
|
C27H29N3O4
|
1
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| 1 |
Ki > 250 nM
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CP0386094
|
spiro[1,2-dihydroindene-3,4'-piperidine]-1'-yl(1,2,3,4-tetrahydroisoquinolin-3-yl)methanone
Show/Hide
|
C23H26N2O
|
1
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| 1 |
Ki > 250 nM
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CP0401625
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2-methyl-3-(spiro[1,2-dihydroindene-3,4'-piperidine]-1'-ylmethyl)-3,4-dihydroisoquinolin-1-one
Show/Hide
|
C24H28N2O
|
1
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| 1 |
Ki > 250 nM
|
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CP0496330
|
(2R)-N-[(2R)-1-amino-1-oxo-3-phenylpropan-2-yl]-5-(diaminomethylideneamino)-2-(3,3-diphenylprop-2-enoylamino)pentanamide
Show/Hide
|
C30H34N6O3
|
1
|
| 1 |
Ki > 1000 nM
|
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CP0395365
|
3-(1-(1,2-dihydroacenaphthylen-1-yl)-1,2,3,6-tetrahydropyridin-4-yl)-1H-indole-5-carbonitrile
Show/Hide
|
C26H21N3
|
1
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| 1 |
Ki > 5000 nM
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CP0403753
|
3-(1-benzyl-1,2,3,6-tetrahydropyridin-4-yl)-5-chloro-1H-indole
Show/Hide
|
C20H19ClN2
|
1
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| 1 |
Ki > 5000 nM
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CP0428049
|
1-(1,2-dihydroacenaphthylen-1-yl)-4-(1-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)piperidin-3-yl acetate
Show/Hide
|
C27H27N3O2
|
1
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| 1 |
Ki > 5000 nM
|
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CP0446332
|
3-(1-(4-phenoxybenzyl)piperidin-4-yl)-1H-pyrrolo[2,3-b]pyridine
Show/Hide
|
C25H25N3O
|
1
|
| 1 |
Ki > 5000 nM
|
|
|
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CP0453004
|
5-chloro-2-methyl-3-(1-(naphthalen-1-ylmethyl)piperidin-4-yl)-1H-indole
Show/Hide
|
C25H25ClN2
|
1
|
| 1 |
Ki > 5000 nM
|
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CP0458106
|
1-benzyl-6-chloro-3-(1-(1,2-dihydroacenaphthylen-1-yl)piperidin-4-yl)-1H-indole
Show/Hide
|
C32H29ClN2
|
1
|
| 1 |
Ki > 5000 nM
|
|
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CP0464515
|
(4-(1H-pyrrolo[2,3-b]pyridin-3-yl)piperidin-1-yl)(4-tert-butylcyclohexyl)methanone
Show/Hide
|
C23H33N3O
|
1
|
| 1 |
Ki > 5000 nM
|
|
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CP0496761
|
3-(1-hexylpiperidin-4-yl)-1H-pyrrolo[2,3-b]pyridine
Show/Hide
|
C18H27N3
|
1
|
| 1 |
Ki > 5000 nM
|
|
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CP0528735
|
(2S)-2-[[(2R)-5-(diaminomethylideneamino)-2-(3,3-diphenylprop-2-enoylamino)pentanoyl]amino]-4-methylpentanamide
Show/Hide
|
C27H36N6O3
|
1
|
| 1 |
Ki > 5000 nM
|
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