General Information of the Compound
Compound ID
CP0486900
Compound Name
1-[3-(spiro[1,2-dihydroindene-3,4'-piperidine]-1'-ylmethyl)-3,4-dihydro-1H-isoquinolin-2-yl]ethanone
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Structure
Formula
C25H30N2O
Molecular Weight
374.528
Canonical SMILES
CC(=O)N1Cc2ccccc2CC1CN1CCC2(CCc3ccccc23)CC1
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InChI
InChI=1S/C25H30N2O/c1-19(28)27-17-22-8-3-2-7-21(22)16-23(27)18-26-14-12-25(13-15-26)11-10-20-6-4-5-9-24(20)25/h2-9,23H,10-18H2,1H3
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InChIKey
XSRIHAZBRFZRIH-UHFFFAOYSA-N
Physicochemical Property
logP
3.9398
Rotatable Bonds
2
Heavy Atom Count
28
Polar Areas
23.55
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
2
Complexity
28

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 11624970
SID: 16728000
ChEMBL ID
CHEMBL3787051
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01515, Mu-type opioid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000026 CHO-K1 Cricetulus griseus (Chinese hamster)  1
1
Ki = 74.4 nM
   TI
   LI
   LO
   TS
Protein ID: PT01360, Nociceptin receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 29.8 nM
   TI
   LI
   LO
   TS
Protein ID: PT00897, Potassium voltage-gated channel subfamily H member 2
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 500 nM
   TI
   LI
   LO
   TS