General Information of the Compound
| Compound ID |
CP0011042
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| Compound Name |
4-(4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl)-N,N-dimethyl-2,2-diphenylbutanamide
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| Synonyms |
Apo-Loperamide
Diamide (TN)
Diarr-Eze
Dimor (TN)
Imodium (TN)
Imodium A-D Caplets
Ioperamide
Kaopectate II
Loperacap
Loperamida
Loperamida [INN-Spanish]
Loperamide
Loperamide (INN)
Loperamide Monohydrochloride
Loperamide [INN:BAN]
Loperamidum
Loperamidum [INN-Latin]
Lopex (TN)
Maalox Anti-Diarrheal
Nu-Loperamide
PMS-Loperamide
Pepto (TN)
Pepto Diarrhea Control
R-18553
Rho-Loperamide
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| Structure |
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| Formula |
C29H33ClN2O2
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| Molecular Weight |
477.048
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| Canonical SMILES |
CN(C)C(=O)C(CCN1CCC(O)(CC1)c1ccc(Cl)cc1)(c1ccccc1)c1ccccc1
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| InChI |
InChI=1S/C29H33ClN2O2/c1-31(2)27(33)29(24-9-5-3-6-10-24,25-11-7-4-8-12-25)19-22-32-20-17-28(34,18-21-32)23-13-15-26(30)16-14-23/h3-16,34H,17-22H2,1-2H3
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| InChIKey |
RDOIQAHITMMDAJ-UHFFFAOYSA-N
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| CAS |
53179-11-6
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| Physicochemical Property |
"RO5" indicates the cutoff set by lipinski's rule of five: (1) Molecular weight less than 500 Dalton; (2) xlogp less than 5; (3) No more than 5 hbonddonor (Hydrogen Bond Donor Count); (4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count); (5) No more than 10 rotbonds (Rotatable Bond Count). Show/Hide
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Map of Molecular Bioactivity Related to the Compound
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Map of Molecular Bioactivity Related to the Compound Compound Cell Line Protein Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity |
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Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00817, Cytochrome P450 2D6
Protein ID: PT01200, Delta-type opioid receptor
Protein ID: PT06109, Geminin
Protein ID: PT01352, Mu-type opioid receptor
Protein ID: PT01360, Nociceptin receptor
Protein ID: PT01065, Serine/threonine-protein kinase mTOR
Protein ID: PT03795, Solute carrier family 22 member 1
Clinical Information about the Compound
Drug 1 ( Loperamide )
| Drug Name | Loperamide | ||
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| Company | Janssen Pharmaceutica | ||
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