General Information of the Compound
Compound ID
CP0859497
Compound Name
2-[3-{(spiro[indane-1,4'-piperidin]-1'-yl)methyl}-3,4-dihydroisoquinolin-2(1H)-yl]acetamide
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Structure
Formula
C24H29N3O
Molecular Weight
375.516
Canonical SMILES
NC(=O)N1Cc2ccccc2CC1CN1CCC2(CCc3ccccc32)CC1
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InChI
InChI=1S/C24H29N3O/c25-23(28)27-16-20-7-2-1-6-19(20)15-21(27)17-26-13-11-24(12-14-26)10-9-18-5-3-4-8-22(18)24/h1-8,21H,9-17H2,(H2,25,28)
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InChIKey
ADEPJPWGRSNLTK-UHFFFAOYSA-N
Physicochemical Property
logP
3.472
Rotatable Bonds
2
Heavy Atom Count
28
Polar Areas
49.57
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
2
Complexity
28

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 127034554
ChEMBL ID
CHEMBL3785839
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01515, Mu-type opioid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000026 CHO-K1 Cricetulus griseus (Chinese hamster)  1
1
Ki = 108 nM
   TI
   LI
   LO
   TS
Protein ID: PT01360, Nociceptin receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 18.1 nM
   TI
   LI
   LO
   TS