Brief Information of the Cell Line and Protein
Cell Line ID: CL000803 , HA7
Category Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_1241
Protein ID: PT00819 , 5-hydroxytryptamine receptor 1A
Gene Name HTR1A
Organism Homo sapiens, Human
Protein Classification Membrane receptor
Uniprot ID P08908
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000803  Protein ID: PT00819
 
Compound ID Compound Name Compound Formula
CP0449809
(3-chloro-4-fluorophenyl)-[4-fluoro-4-[[[6-(1H-pyrazol-5-yl)pyridin-2-yl]methylamino]methyl]piperidin-1-yl]methanone
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C22H22ClF2N5O
 1
1
EC50 = 0.7244 nM
   TI
   LI
   LO
   TS
CP0405393
(3,4-dichlorophenyl)-[4-fluoro-4-[[[6-(1H-pyrazol-5-yl)pyridin-2-yl]methylamino]methyl]piperidin-1-yl]methanone
   Show/Hide
C22H22Cl2FN5O
 1
1
EC50 = 1.122 nM
   TI
   LI
   LO
   TS
CP0493968
(3,4-dichlorophenyl)-[4-[[[6-(1,3-oxazol-5-yl)pyridin-2-yl]methylamino]methyl]piperidin-1-yl]methanone
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C22H22Cl2N4O2
 1
1
EC50 = 1.995 nM
   TI
   LI
   LO
   TS
CP0479975
(3-chloro-4-fluorophenyl)-[4-fluoro-4-[[[5-methyl-6-(methylamino)pyridin-2-yl]methylamino]methyl]piperidin-1-yl]methanone
   Show/Hide
C21H25ClF2N4O
 1
1
EC50 = 2.138 nM
   TI
   LI
   LO
   TS
CP0538311
(3,4-dichlorophenyl)-[4-fluoro-4-[[[6-(furan-2-yl)pyridin-2-yl]methylamino]methyl]piperidin-1-yl]methanone
   Show/Hide
C23H22Cl2FN3O2
 1
1
EC50 = 2.63 nM
   TI
   LI
   LO
   TS
CP0529634
(3-chloro-4-fluorophenyl)-[4-fluoro-4-[[[5-methyl-6-(1H-pyrazol-5-yl)pyridin-2-yl]methylamino]methyl]piperidin-1-yl]methanone
   Show/Hide
C23H24ClF2N5O
 1
1
EC50 = 2.754 nM
   TI
   LI
   LO
   TS
CP0497708
(3,4-dichlorophenyl)-[4-[[[6-(dimethylamino)pyridin-2-yl]methylamino]methyl]-4-fluoropiperidin-1-yl]methanone
   Show/Hide
C21H25Cl2FN4O
 1
1
EC50 = 2.951 nM
   TI
   LI
   LO
   TS
CP0486075
(3,4-dichlorophenyl)-[4-[[[6-(1H-pyrazol-5-yl)pyridin-2-yl]methylamino]methyl]piperidin-1-yl]methanone
   Show/Hide
C22H23Cl2N5O
 1
1
EC50 = 3.02 nM
   TI
   LI
   LO
   TS
CP0487376
(3-chloro-4-fluorophenyl)-[4-fluoro-4-[[[6-(furan-2-yl)pyridin-2-yl]methylamino]methyl]piperidin-1-yl]methanone
   Show/Hide
C23H22ClF2N3O2
 1
1
EC50 = 3.467 nM
   TI
   LI
   LO
   TS
CP0373260
(3-chloro-4-fluorophenyl)-[4-[[[6-(dimethylamino)pyridin-2-yl]methylamino]methyl]-4-fluoropiperidin-1-yl]methanone
   Show/Hide
C21H25ClF2N4O
 1
1
EC50 = 3.631 nM
   TI
   LI
   LO
   TS
CP0442717
(3-chloro-4-fluorophenyl)-[4-[[[6-(dimethylamino)-5-methylpyridin-2-yl]methylamino]methyl]-4-fluoropiperidin-1-yl]methanone
   Show/Hide
C22H27ClF2N4O
 1
1
EC50 = 3.715 nM
   TI
   LI
   LO
   TS
CP0538313
(3,4-dichlorophenyl)-[4-[[[6-(1,3-thiazol-2-yl)pyridin-2-yl]methylamino]methyl]piperidin-1-yl]methanone
   Show/Hide
C22H22Cl2N4OS
 1
1
EC50 = 5.012 nM
   TI
   LI
   LO
   TS
CP0405964
(3,4-dichlorophenyl)-[4-[[[6-(furan-2-yl)pyridin-2-yl]methylamino]methyl]piperidin-1-yl]methanone
   Show/Hide
C23H23Cl2N3O2
 1
1
EC50 = 5.248 nM
   TI
   LI
   LO
   TS
CP0381008
(3-chloro-4-methylphenyl)-[4-[[[6-(dimethylamino)pyridin-2-yl]methylamino]methyl]-4-fluoropiperidin-1-yl]methanone
   Show/Hide
C22H28ClFN4O
 1
1
EC50 = 5.754 nM
   TI
   LI
   LO
   TS
CP0392753
(3,4-dichlorophenyl)-[4-[[(6-thiophen-2-ylpyridin-2-yl)methylamino]methyl]piperidin-1-yl]methanone
   Show/Hide
C23H23Cl2N3OS
 1
1
EC50 = 5.754 nM
   TI
   LI
   LO
   TS
CP0538477
(3,4-dichlorophenyl)-[4-fluoro-4-[[[6-(methylamino)pyridin-2-yl]methylamino]methyl]piperidin-1-yl]methanone
   Show/Hide
C20H23Cl2FN4O
 1
1
EC50 = 6.607 nM
   TI
   LI
   LO
   TS
CP0402184
[4-[[[6-(azetidin-1-yl)pyridin-2-yl]methylamino]methyl]piperidin-1-yl]-(3,4-dichlorophenyl)methanone
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C22H26Cl2N4O
 1
1
EC50 = 7.079 nM
   TI
   LI
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   TS
CP0437357
(3-chloro-4-fluorophenyl)-[4-[[[6-(ethylamino)-5-methylpyridin-2-yl]methylamino]methyl]-4-fluoropiperidin-1-yl]methanone
   Show/Hide
C22H27ClF2N4O
 1
1
EC50 = 8.318 nM
   TI
   LI
   LO
   TS
CP0380714
(3,4-dichlorophenyl)-[4-fluoro-4-[[[6-(1,3-oxazol-5-yl)pyridin-2-yl]methylamino]methyl]piperidin-1-yl]methanone
   Show/Hide
C22H21Cl2FN4O2
 1
1
EC50 = 8.913 nM
   TI
   LI
   LO
   TS
CP0455329
(3-chlorophenyl)-[4-[[[6-(dimethylamino)pyridin-2-yl]methylamino]methyl]-4-fluoropiperidin-1-yl]methanone
   Show/Hide
C21H26ClFN4O
 1
1
EC50 = 10 nM
   TI
   LI
   LO
   TS
CP0480538
[4-[[[6-(azetidin-1-yl)pyridin-2-yl]methylamino]methyl]-4-fluoropiperidin-1-yl]-(3,4-dichlorophenyl)methanone
   Show/Hide
C22H25Cl2FN4O
 1
1
EC50 = 10.72 nM
   TI
   LI
   LO
   TS
CP0538038
(3,4-dichlorophenyl)-[4-fluoro-4-[[(6-thiophen-2-ylpyridin-2-yl)methylamino]methyl]piperidin-1-yl]methanone
   Show/Hide
C23H22Cl2FN3OS
 1
1
EC50 = 12.02 nM
   TI
   LI
   LO
   TS
CP0496257
(3-chloro-4-fluorophenyl)-[4-fluoro-4-[[(6-pyrazol-1-ylpyridin-2-yl)methylamino]methyl]piperidin-1-yl]methanone
   Show/Hide
C22H22ClF2N5O
 1
1
EC50 = 12.3 nM
   TI
   LI
   LO
   TS
CP0408549
(3-chloro-4-fluorophenyl)-[4-fluoro-4-[[[6-(methylamino)pyridin-2-yl]methylamino]methyl]piperidin-1-yl]methanone
   Show/Hide
C20H23ClF2N4O
 1
1
EC50 = 12.59 nM
   TI
   LI
   LO
   TS
CP0538240
(3-chloro-4-fluorophenyl)-[4-[[[6-(ethylamino)pyridin-2-yl]methylamino]methyl]-4-fluoropiperidin-1-yl]methanone
   Show/Hide
C21H25ClF2N4O
 1
1
EC50 = 13.18 nM
   TI
   LI
   LO
   TS
CP0517892
(3-chloro-4-fluorophenyl)-[4-fluoro-4-[[(5-methyl-6-pyrazol-1-ylpyridin-2-yl)methylamino]methyl]piperidin-1-yl]methanone
   Show/Hide
C23H24ClF2N5O
 1
1
EC50 = 14.79 nM
   TI
   LI
   LO
   TS
CP0537916
4-[(2R,3R,4R,5R)-3,4-bis(phenylmethoxy)-5-(phenylmethoxymethyl)oxolan-2-yl]-1H-1,2,4-triazole-5-thione
   Show/Hide
C28H29N3O4S
 1
1
EC50 = 14.79 nM
   TI
   LI
   LO
   TS
CP0402356
(3,4-dichlorophenyl)-[4-[[[6-(dimethylamino)pyridin-2-yl]methylamino]methyl]piperidin-1-yl]methanone
   Show/Hide
C21H26Cl2N4O
 1
1
EC50 = 20.42 nM
   TI
   LI
   LO
   TS
CP0515086
(3,4-dichlorophenyl)-[4-fluoro-4-[[(5-methylpyridin-2-yl)methylamino]methyl]piperidin-1-yl]methanone
   Show/Hide
C20H22Cl2FN3O
 1
1
EC50 = 20.89 nM
   TI
   LI
   LO
   TS
CP0393459
(3,4-dichlorophenyl)-[4-[[[6-(methylamino)pyridin-2-yl]methylamino]methyl]piperidin-1-yl]methanone
   Show/Hide
C20H24Cl2N4O
 1
1
EC50 = 21.88 nM
   TI
   LI
   LO
   TS
CP0535311
(3,4-dichlorophenyl)-[4-fluoro-4-[[[6-(1,3-thiazol-2-yl)pyridin-2-yl]methylamino]methyl]piperidin-1-yl]methanone
   Show/Hide
C22H21Cl2FN4OS
 1
1
EC50 = 22.91 nM
   TI
   LI
   LO
   TS
CP0071669
(3-Chloro-4-fluoro-phenyl)-(4-fluoro-4-{[(5-methyl-pyridin-2-ylmethyl)-amino]-methyl}-piperidin-1-yl)-methanone
   Show/Hide
C20H22ClF2N3O
 1
1
EC50 = 25.7 nM
   TI
   LI
   LO
   TS
CP0535303
(3,4-dichlorophenyl)-[4-fluoro-4-[[(6-pyrazol-1-ylpyridin-2-yl)methylamino]methyl]piperidin-1-yl]methanone
   Show/Hide
C22H22Cl2FN5O
 1
1
EC50 = 28.18 nM
   TI
   LI
   LO
   TS
CP0410850
(3-chloro-4-fluorophenyl)-[4-[[[6-(diethylamino)-5-methylpyridin-2-yl]methylamino]methyl]-4-fluoropiperidin-1-yl]methanone
   Show/Hide
C24H31ClF2N4O
 1
1
EC50 = 28.84 nM
   TI
   LI
   LO
   TS
CP0380681
(3,4-dichlorophenyl)-[4-[[(6-pyrazol-1-ylpyridin-2-yl)methylamino]methyl]piperidin-1-yl]methanone
   Show/Hide
C22H23Cl2N5O
 1
1
EC50 = 30.9 nM
   TI
   LI
   LO
   TS
CP0496225
(3-chloro-4-fluorophenyl)-[4-[[[6-(dimethylamino)-4-methylpyridin-2-yl]methylamino]methyl]-4-fluoropiperidin-1-yl]methanone
   Show/Hide
C22H27ClF2N4O
 1
1
EC50 = 33.11 nM
   TI
   LI
   LO
   TS
CP0392985
(3,4-dichlorophenyl)-[4-hydroxy-4-[[(6-pyrazol-1-ylpyridin-2-yl)methylamino]methyl]piperidin-1-yl]methanone
   Show/Hide
C22H23Cl2N5O2
 1
1
EC50 = 39.81 nM
   TI
   LI
   LO
   TS
CP0432245
(3-chloro-4-fluorophenyl)-[4-[[[6-(dimethylamino)-3-methylpyridin-2-yl]methylamino]methyl]-4-fluoropiperidin-1-yl]methanone
   Show/Hide
C22H27ClF2N4O
 1
1
EC50 = 47.86 nM
   TI
   LI
   LO
   TS
CP0497713
1-(3,4-dichlorobenzoyl)-4-[[(6-pyrazol-1-ylpyridin-2-yl)methylamino]methyl]piperidine-4-carbonitrile
   Show/Hide
C23H22Cl2N6O
 1
1
EC50 = 162.18 nM
   TI
   LI
   LO
   TS
CP0537104
(3,4-dichlorophenyl)-[4-[[(6-pyrazol-1-ylpyridin-2-yl)methylamino]methyl]-3,6-dihydro-2H-pyridin-1-yl]methanone
   Show/Hide
C22H21Cl2N5O
 1
1
EC50 = 269.15 nM
   TI
   LI
   LO
   TS
CP0461350
(3,4-dichlorophenyl)-[4-(fluoromethyl)-4-[[(6-pyrazol-1-ylpyridin-2-yl)methylamino]methyl]piperidin-1-yl]methanone
   Show/Hide
C23H24Cl2FN5O
 1
1
EC50 = 309.03 nM
   TI
   LI
   LO
   TS
CP0514845
(3-chloro-4-fluorophenyl)-[4-[[(5-ethylpyridin-2-yl)methylamino]methyl]-4-fluoropiperidin-1-yl]methanone
   Show/Hide
C21H24ClF2N3O
 1
1
EC50 = 407.38 nM
   TI
   LI
   LO
   TS
CP0150505
N'-(6-chloropyridazin-3-yl)-N-(3,4-dihydro-2H-chromen-2-ylmethyl)propane-1,3-diamine
   Show/Hide
C17H21ClN4O
 1
1
IC50 = 0.3981 nM
   TI
   LI
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   TS
CP0141595
N-(3,4-dihydro-2H-chromen-2-ylmethyl)-N'-pyridin-2-ylpropane-1,3-diamine
   Show/Hide
C18H23N3O
 1
1
IC50 = 1.259 nM
   TI
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   TS
CP0138007
N-(3,4-dihydro-2H-chromen-2-ylmethyl)-N'-(1,3-thiazol-2-yl)propane-1,3-diamine
   Show/Hide
C16H21N3OS
 1
1
IC50 = 1.585 nM
   TI
   LI
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   TS
CP0215236
2-[3-(3,4-dihydro-2H-chromen-2-ylmethylamino)propylamino]-1,4,5,6-tetrahydro-1,3-diazepin-7-one
   Show/Hide
C18H26N4O2
 1
1
IC50 = 1.995 nM
   TI
   LI
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   TS
CP0287041
N-(3,4-dihydro-2H-chromen-2-ylmethyl)-N'-pyrimidin-2-ylpropane-1,3-diamine
   Show/Hide
C17H22N4O
 1
1
IC50 = 1.995 nM
   TI
   LI
   LO
   TS
CP0366657
N-(3,4-dihydro-2H-chromen-2-ylmethyl)-N'-pyrazin-2-ylpropane-1,3-diamine
   Show/Hide
C17H22N4O
 1
1
IC50 = 3.981 nM
   TI
   LI
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   TS
CP0256088
N-[(7-ethyl-3,4-dihydro-2H-chromen-2-yl)methyl]-N'-(1,4,5,6-tetrahydropyrimidin-2-yl)propane-1,3-diamine
   Show/Hide
C19H30N4O
 1
1
IC50 = 3.981 nM
   TI
   LI
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CP0252853
ALNIDITAN
   Show/Hide
C17H26N4O
 1
1
IC50 = 5.012 nM
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CP0297947
N-(3,4-dihydro-2H-chromen-2-ylmethyl)-N'-pyrimidin-4-ylpropane-1,3-diamine
   Show/Hide
C17H22N4O
 1
1
IC50 = 5.012 nM
   TI
   LI
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   TS
CP0154130
N-[(8-methoxy-3,4-dihydro-2H-chromen-2-yl)methyl]-N'-(1,4,5,6-tetrahydropyrimidin-2-yl)propane-1,3-diamine
   Show/Hide
C18H28N4O2
 1
1
IC50 = 5.012 nM
   TI
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CP0280987
N-(3,4-dihydro-2H-chromen-2-ylmethyl)-N'-(1,4,5,6-tetrahydropyrimidin-2-yl)pentane-1,5-diamine
   Show/Hide
C19H30N4O
 1
1
IC50 = 5.012 nM
   TI
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CP0291828
N-(3,4-dihydro-2H-chromen-2-ylmethyl)-N'-(2,3,4,5-tetrahydropyridin-6-yl)propane-1,3-diamine
   Show/Hide
C18H27N3O
 1
1
IC50 = 6.31 nM
   TI
   LI
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   TS
CP0258467
N-(3,4-dihydro-2H-chromen-2-ylmethyl)-N'-(1,4,5,6-tetrahydropyrimidin-2-yl)butane-1,4-diamine
   Show/Hide
C18H28N4O
 1
1
IC50 = 7.943 nM
   TI
   LI
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   TS
CP0309198
1-[3-(3,4-dihydro-2H-chromen-2-ylmethylamino)propylamino]-2-propan-2-ylguanidine
   Show/Hide
C17H29N5O
 1
1
IC50 = 7.943 nM
   TI
   LI
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   TS
CP0276798
N-(3,4-dihydro-2H-chromen-2-ylmethyl)-N'-(4,5-dihydro-1H-imidazol-2-yl)propane-1,3-diamine
   Show/Hide
C16H24N4O
 1
1
IC50 = 12.59 nM
   TI
   LI
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   TS
CP0138336
N-[(7-methoxy-3,4-dihydro-2H-chromen-2-yl)methyl]-N'-(1,4,5,6-tetrahydropyrimidin-2-yl)propane-1,3-diamine
   Show/Hide
C18H28N4O2
 1
1
IC50 = 12.59 nM
   TI
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   TS
CP0730229
N-Chroman-2-ylmethyl-N'-(1,4,5,6-tetrahydro-pyrimidin-2-yl)-propane-1,3-diamine
   Show/Hide
C17H26N4O
 1
1
IC50 = 12.59 nM
   TI
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   TS
CP0277860
1-cyano-2-[3-(3,4-dihydro-2H-chromen-2-ylmethylamino)propyl]-3-propan-2-ylguanidine
   Show/Hide
C18H27N5O
 1
1
IC50 = 15.85 nM
   TI
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   TS
CP0287002
N-(3,4-dihydro-2H-chromen-2-ylmethyl)-N'-(1,4,5,6-tetrahydropyrimidin-2-yl)ethane-1,2-diamine
   Show/Hide
C16H24N4O
 1
1
IC50 = 15.85 nM
   TI
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   TS
CP0154131
N-(2,3-dihydro-1,4-benzodioxin-3-ylmethyl)-N'-(1,4,5,6-tetrahydropyrimidin-2-yl)propane-1,3-diamine
   Show/Hide
C16H24N4O2
 1
1
IC50 = 19.95 nM
   TI
   LI
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   TS
CP0310880
N-[(6-fluoro-3,4-dihydro-2H-chromen-2-yl)methyl]-N'-(1,4,5,6-tetrahydropyrimidin-2-yl)propane-1,3-diamine
   Show/Hide
C17H25FN4O
 1
1
IC50 = 25.12 nM
   TI
   LI
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   TS
CP0166054
N-(3,4-dihydro-2H-chromen-2-ylmethyl)-N'-pyrimidin-2-ylethane-1,2-diamine
   Show/Hide
C16H20N4O
 1
1
IC50 = 31.62 nM
   TI
   LI
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   TS
CP0286533
N-(2,3-dihydro-1-benzofuran-2-ylmethyl)-N'-(1,4,5,6-tetrahydropyrimidin-2-yl)propane-1,3-diamine
   Show/Hide
C16H24N4O
 1
1
IC50 = 50.12 nM
   TI
   LI
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   TS
CP0297969
N-[[(2S)-3,4-dihydro-2H-chromen-2-yl]methyl]-N'-(1,4,5,6-tetrahydropyrimidin-2-yl)propane-1,3-diamine
   Show/Hide
C17H26N4O
 1
1
IC50 = 50.12 nM
   TI
   LI
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   TS
CP0520912
N-(1,2,3,4-tetrahydronaphthalen-2-ylmethyl)-N'-(1,4,5,6-tetrahydropyrimidin-2-yl)propane-1,3-diamine
   Show/Hide
C18H28N4
 1
1
IC50 = 125.89 nM
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CP0005653
(3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methylmethanesulfonamide
   Show/Hide
C14H21N3O2S
 1
1
IC50 = 398.11 nM
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CP0541608
N'-(1H-benzimidazol-2-yl)-N-(3,4-dihydro-2H-chromen-2-ylmethyl)propane-1,3-diamine
   Show/Hide
C20H24N4O
 1
1
IC50 > 100 nM
   TI
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   TS
CP0076350
N-[(1-methyl-3,4-dihydro-2H-quinolin-2-yl)methyl]-N'-(1,4,5,6-tetrahydropyrimidin-2-yl)propane-1,3-diamine
   Show/Hide
C18H29N5
 1
1
IC50 > 1000 nM
   TI
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CP0161440
N-[(2-methyl-3,4-dihydrochromen-2-yl)methyl]-N'-(1,4,5,6-tetrahydropyrimidin-2-yl)propane-1,3-diamine
   Show/Hide
C18H28N4O
 1
1
IC50 > 1000 nM
   TI
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   TS
CP0220677
N-(3,4-dihydro-2H-chromen-3-ylmethyl)-N'-(1,4,5,6-tetrahydropyrimidin-2-yl)propane-1,3-diamine
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C17H26N4O
 1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0255335
N-(3,4-dihydro-2H-1,4-benzoxazin-2-ylmethyl)-N'-(1,4,5,6-tetrahydropyrimidin-2-yl)propane-1,3-diamine
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C16H25N5O
 1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0510863
N-(2,3,4,5-tetrahydro-1-benzoxepin-2-ylmethyl)-N'-(1,4,5,6-tetrahydropyrimidin-2-yl)propane-1,3-diamine
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C18H28N4O
 1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0134406
N-[(5-methoxy-3,4-dihydro-2H-chromen-2-yl)methyl]-N'-(1,4,5,6-tetrahydropyrimidin-2-yl)propane-1,3-diamine
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C18H28N4O2
 1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0366766
N-[(6-methoxy-3,4-dihydro-2H-chromen-2-yl)methyl]-N'-(1,4,5,6-tetrahydropyrimidin-2-yl)propane-1,3-diamine
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C18H28N4O2
 1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS