General Information of the Compound
Compound ID
CP0538038
Compound Name
(3,4-dichlorophenyl)-[4-fluoro-4-[[(6-thiophen-2-ylpyridin-2-yl)methylamino]methyl]piperidin-1-yl]methanone
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Structure
Formula
C23H22Cl2FN3OS
Molecular Weight
478.42
Canonical SMILES
FC1(CNCc2cccc(n2)-c2cccs2)CCN(CC1)C(=O)c1ccc(Cl)c(Cl)c1
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InChI
InChI=1S/C23H22Cl2FN3OS/c24-18-7-6-16(13-19(18)25)22(30)29-10-8-23(26,9-11-29)15-27-14-17-3-1-4-20(28-17)21-5-2-12-31-21/h1-7,12-13,27H,8-11,14-15H2
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InChIKey
ADGCARVTPQCUGH-UHFFFAOYSA-N
Physicochemical Property
logP
5.851
Rotatable Bonds
6
Heavy Atom Count
31
Polar Areas
45.23
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
4
Complexity
31

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 10719425
SID: 15754615
ChEMBL ID
CHEMBL288244
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00819, 5-hydroxytryptamine receptor 1A
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000803 HA7 Homo sapiens (Human)  1
1
EC50 = 12.02 nM
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