General Information of the Compound
Compound ID
CP0410850
Compound Name
(3-chloro-4-fluorophenyl)-[4-[[[6-(diethylamino)-5-methylpyridin-2-yl]methylamino]methyl]-4-fluoropiperidin-1-yl]methanone
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Structure
Formula
C24H31ClF2N4O
Molecular Weight
464.988
Canonical SMILES
CCN(CC)c1nc(CNCC2(F)CCN(CC2)C(=O)c2ccc(F)c(Cl)c2)ccc1C
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InChI
InChI=1S/C24H31ClF2N4O/c1-4-30(5-2)22-17(3)6-8-19(29-22)15-28-16-24(27)10-12-31(13-11-24)23(32)18-7-9-21(26)20(25)14-18/h6-9,14,28H,4-5,10-13,15-16H2,1-3H3
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InChIKey
ZXRDUXWLWTXVEO-UHFFFAOYSA-N
Physicochemical Property
logP
4.76282
Rotatable Bonds
8
Heavy Atom Count
32
Polar Areas
48.47
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
4
Complexity
32

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 10695466
SID: 15729455
ChEMBL ID
CHEMBL45048
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00819, 5-hydroxytryptamine receptor 1A
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000803 HA7 Homo sapiens (Human)  1
1
EC50 = 28.84 nM
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