General Information of the Compound
Compound ID
CP0380714
Compound Name
(3,4-dichlorophenyl)-[4-fluoro-4-[[[6-(1,3-oxazol-5-yl)pyridin-2-yl]methylamino]methyl]piperidin-1-yl]methanone
    Show/Hide
Structure
Formula
C22H21Cl2FN4O2
Molecular Weight
463.34
Canonical SMILES
FC1(CNCc2cccc(n2)-c2cnco2)CCN(CC1)C(=O)c1ccc(Cl)c(Cl)c1
    Show/Hide
InChI
InChI=1S/C22H21Cl2FN4O2/c23-17-5-4-15(10-18(17)24)21(30)29-8-6-22(25,7-9-29)13-26-11-16-2-1-3-19(28-16)20-12-27-14-31-20/h1-5,10,12,14,26H,6-9,11,13H2
    Show/Hide
InChIKey
IWSQYCLFGIYRMU-UHFFFAOYSA-N
Physicochemical Property
logP
4.7775
Rotatable Bonds
6
Heavy Atom Count
31
Polar Areas
71.26
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
5
Complexity
31

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 10695395
SID: 15729384
ChEMBL ID
CHEMBL44659
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00819, 5-hydroxytryptamine receptor 1A
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000803 HA7 Homo sapiens (Human)  1
1
EC50 = 8.913 nM
   TI
   LI
   LO
   TS