General Information of the Compound
Compound ID
CP0392753
Compound Name
(3,4-dichlorophenyl)-[4-[[(6-thiophen-2-ylpyridin-2-yl)methylamino]methyl]piperidin-1-yl]methanone
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Structure
Formula
C23H23Cl2N3OS
Molecular Weight
460.43
Canonical SMILES
Clc1ccc(cc1Cl)C(=O)N1CCC(CNCc2cccc(n2)-c2cccs2)CC1
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InChI
InChI=1S/C23H23Cl2N3OS/c24-19-7-6-17(13-20(19)25)23(29)28-10-8-16(9-11-28)14-26-15-18-3-1-4-21(27-18)22-5-2-12-30-22/h1-7,12-13,16,26H,8-11,14-15H2
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InChIKey
CKSMNIPCJNWJND-UHFFFAOYSA-N
Physicochemical Property
logP
5.7589
Rotatable Bonds
6
Heavy Atom Count
30
Polar Areas
45.23
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
4
Complexity
30

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 10575934
SID: 15604080
ChEMBL ID
CHEMBL42618
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00819, 5-hydroxytryptamine receptor 1A
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000803 HA7 Homo sapiens (Human)  1
1
EC50 = 5.754 nM
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