General Information of the Compound
Compound ID
CP0517892
Compound Name
(3-chloro-4-fluorophenyl)-[4-fluoro-4-[[(5-methyl-6-pyrazol-1-ylpyridin-2-yl)methylamino]methyl]piperidin-1-yl]methanone
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Structure
Formula
C23H24ClF2N5O
Molecular Weight
459.928
Canonical SMILES
Cc1ccc(CNCC2(F)CCN(CC2)C(=O)c2ccc(F)c(Cl)c2)nc1-n1cccn1
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InChI
InChI=1S/C23H24ClF2N5O/c1-16-3-5-18(29-21(16)31-10-2-9-28-31)14-27-15-23(26)7-11-30(12-8-23)22(32)17-4-6-20(25)19(24)13-17/h2-6,9-10,13,27H,7-8,11-12,14-15H2,1H3
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InChIKey
VTOWCNHGZNRYSU-UHFFFAOYSA-N
Physicochemical Property
logP
4.10232
Rotatable Bonds
6
Heavy Atom Count
32
Polar Areas
63.05
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
5
Complexity
32

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 10647621
SID: 15679235
ChEMBL ID
CHEMBL42042
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00819, 5-hydroxytryptamine receptor 1A
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000803 HA7 Homo sapiens (Human)  1
1
EC50 = 14.79 nM
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