Brief Information of the Compound and Protein
Compound Name
(3-Chloro-4-fluoro-phenyl)-(4-fluoro-4-{[(5-methyl-pyridin-2-ylmethyl)-amino]-methyl}-piperidin-1-yl)-methanone
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PubChem ID
CID: 9865384
SID: 14830131
Canonical SMILES
Cc1ccc(CNCC2(F)CCN(CC2)C(=O)c2ccc(F)c(Cl)c2)nc1
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Compound Formula C20H22ClF2N3O
Compound Structure
Protein Name
5-hydroxytryptamine receptor 1A
Protein Classification
Membrane receptor
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Family A G protein-coupled receptor
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Small molecule receptor (family A GPCR)
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Monoamine receptor
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Serotonin receptor
Uniprot ID
P08908
Gene Name
HTR1A
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000049 C6 Rattus norvegicus (Rat)  1
1
EC50 = 23.44 nM
   TI
   LI
   LO
   TS
CL000803 HA7 Homo sapiens (Human)  1
1
EC50 = 25.7 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Ki = 1 nM