General Information of the Compound
Compound ID
CP0437357
Compound Name
(3-chloro-4-fluorophenyl)-[4-[[[6-(ethylamino)-5-methylpyridin-2-yl]methylamino]methyl]-4-fluoropiperidin-1-yl]methanone
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Structure
Formula
C22H27ClF2N4O
Molecular Weight
436.934
Canonical SMILES
CCNc1nc(CNCC2(F)CCN(CC2)C(=O)c2ccc(F)c(Cl)c2)ccc1C
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InChI
InChI=1S/C22H27ClF2N4O/c1-3-27-20-15(2)4-6-17(28-20)13-26-14-22(25)8-10-29(11-9-22)21(30)16-5-7-19(24)18(23)12-16/h4-7,12,26H,3,8-11,13-14H2,1-2H3,(H,27,28)
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InChIKey
NLOCMEFFQDIVKA-UHFFFAOYSA-N
Physicochemical Property
logP
4.34842
Rotatable Bonds
7
Heavy Atom Count
30
Polar Areas
57.26
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
4
Complexity
30

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 10550911
SID: 15577970
ChEMBL ID
CHEMBL46984
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00819, 5-hydroxytryptamine receptor 1A
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000803 HA7 Homo sapiens (Human)  1
1
EC50 = 8.318 nM
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