General Information of the Compound
Compound ID
CP0402184
Compound Name
[4-[[[6-(azetidin-1-yl)pyridin-2-yl]methylamino]methyl]piperidin-1-yl]-(3,4-dichlorophenyl)methanone
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Structure
Formula
C22H26Cl2N4O
Molecular Weight
433.383
Canonical SMILES
Clc1ccc(cc1Cl)C(=O)N1CCC(CNCc2cccc(n2)N2CCC2)CC1
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InChI
InChI=1S/C22H26Cl2N4O/c23-19-6-5-17(13-20(19)24)22(29)28-11-7-16(8-12-28)14-25-15-18-3-1-4-21(26-18)27-9-2-10-27/h1,3-6,13,16,25H,2,7-12,14-15H2
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InChIKey
LNIQZQYUYOSMFT-UHFFFAOYSA-N
Physicochemical Property
logP
4.2405
Rotatable Bonds
6
Heavy Atom Count
29
Polar Areas
48.47
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
4
Complexity
29

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 10025854
SID: 15007427
ChEMBL ID
CHEMBL298260
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00819, 5-hydroxytryptamine receptor 1A
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000803 HA7 Homo sapiens (Human)  1
1
EC50 = 7.079 nM
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