| Compound ID |
Compound Name |
Compound Formula |
|
CP0041262
|
5-chloro-2-[(4-methylpiperazin-1-yl)carbonyl]-1H-indole
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|
C14H16ClN3O
|
3
|
| 1 |
EC50 = 2.57 nM
|
|
|
| 2 |
EC50 = 42.66 nM
|
|
|
| 3 |
Ki = 2.692 nM
|
|
|
|
CP0094765
|
14-fluoro-6-(piperazin-1-yl)-3,5-diazatricyclo[9.4.0.0^{2,7}]pentadeca-1(15),2(7),3,5,11,13-hexaen-4-amine
Show/Hide
|
C17H20FN5
|
2
|
| 1 |
EC50 = 6.026 nM
|
|
|
| 2 |
Ki = 1.445 nM
|
|
|
|
CP0173066
|
2,4-diamino-5,6-disubstituted pyrimidine, 11
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|
C18H23N5
|
2
|
| 1 |
EC50 = 6.607 nM
|
|
|
| 2 |
Ki = 5.129 nM
|
|
|
|
CP0173068
|
2,4-diamino-5,6-disubstituted pyrimidine, 12
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|
C17H21N5
|
2
|
| 1 |
EC50 = 9.333 nM
|
|
|
| 2 |
Ki = 3.631 nM
|
|
|
|
CP0205085
|
2,4-diamino-5,6-disubstituted pyrimidine, 10
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|
C17H21N5
|
2
|
| 1 |
EC50 = 10 nM
|
|
|
| 2 |
Ki = 3.802 nM
|
|
|
|
CP0198951
|
2,4-diamino-5,6-disubstituted pyrimidine, 9
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|
C17H21N5
|
2
|
| 1 |
EC50 = 14.79 nM
|
|
|
| 2 |
Ki = 7.586 nM
|
|
|
|
CP0921847
|
4-(2,6-difluoropyridin-3-yl)-6-(4-methylpiperazin-1-yl)pyrimidin-2-amine
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|
C14H16F2N6
|
1
|
| 1 |
EC50 = 15.49 nM
|
|
|
|
CP0247209
|
2,4-diamino-5,6-disubstituted pyrimidine, 6
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|
C17H21N5
|
2
|
| 1 |
EC50 = 15.49 nM
|
|
|
| 2 |
Ki = 5.37 nM
|
|
|
|
CP0926263
|
(R)-4-(3-(methylamino)pyrrolidin-1-yl)-5H-indeno[1,2-d]pyrimidin-2-amine
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|
C16H19N5
|
1
|
| 1 |
EC50 = 19.05 nM
|
|
|
|
CP0318899
|
2,4-diamino-5,6-disubstituted pyrimidine, 8
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|
C15H17N5
|
2
|
| 1 |
EC50 = 19.95 nM
|
|
|
| 2 |
Ki = 4.786 nM
|
|
|
|
CP0247208
|
2,4-diamino-5,6-disubstituted pyrimidine, 7
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|
C16H19N5
|
2
|
| 1 |
EC50 = 23.99 nM
|
|
|
| 2 |
Ki = 9.12 nM
|
|
|
|
CP0173069
|
5-chloro-2-(piperazin-1-ylcarbonyl)-1H-indole
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|
C13H14ClN3O
|
2
|
| 1 |
EC50 = 30.9 nM
|
|
|
| 2 |
Ki = 3.981 nM
|
|
|
|
CP0850029
|
4-(3-Chlorophenyl)-6-(4-methylpiperazin-1-yl)pyrimidin-2-ylamine
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|
C15H18ClN5
|
1
|
| 1 |
EC50 = 31.62 nM
|
|
|
|
CP0383812
|
4-(4-chlorophenyl)-6-(4-methylpiperazin-1-yl)pyrimidin-2-amine
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|
C15H18ClN5
|
1
|
| 1 |
EC50 = 37.15 nM
|
|
|
|
CP0259827
|
4-(4-methylpiperazin-1-yl)-6-phenylpyrimidin-2-amine
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|
C15H19N5
|
2
|
| 1 |
EC50 = 39.81 nM
|
|
|
| 2 |
Ki = 14.13 nM
|
|
|
|
CP0845898
|
4-(4-Methylpiperazin-1-yl)pyrimidine-2,5-diamine
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|
C9H16N6
|
1
|
| 1 |
EC50 = 42.66 nM
|
|
|
|
CP0913525
|
4-(4-Methylpiperazin-1-yl)-6-m-tolylpyrimidin-2-ylamine
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|
C16H21N5
|
1
|
| 1 |
EC50 = 42.66 nM
|
|
|
|
CP0866966
|
4-(2-Methoxyphenyl)-6-(4-methylpiperazin-1-yl)pyrimidin-2-ylamine
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|
C16H21N5O
|
1
|
| 1 |
EC50 = 43.65 nM
|
|
|
|
CP0894476
|
4-(4-Methylpiperazin-1-yl)-6-piperidin-1-ylpyrimidin-2-ylamine
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|
C14H24N6
|
1
|
| 1 |
EC50 = 46.77 nM
|
|
|
|
CP0229853
|
2,4-diamino-5,6-disubstituted pyrimidine, 14
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|
C19H25N5
|
2
|
| 1 |
EC50 = 54.95 nM
|
|
|
| 2 |
Ki = 4.467 nM
|
|
|
|
CP0894471
|
4-(4-Methylpiperazin-1-yl)-6-p-tolylpyrimidin-2-ylamine
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|
C16H21N5
|
1
|
| 1 |
EC50 = 56.23 nM
|
|
|
|
CP0068173
|
2-Aminopyrimidine analog., 4
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|
C16H18N6
|
3
|
| 1 |
EC50 = 58.88 nM
|
|
|
| 2 |
EC50 = 4677.35 nM
|
|
|
| 3 |
Ki = 275.42 nM
|
|
|
|
CP0911631
|
4-[2-Amino-5-methyl-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]benzonitrile
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|
C17H20N6
|
1
|
| 1 |
EC50 = 58.88 nM
|
|
|
|
CP0919099
|
5-Methyl-4-(4-methylpiperazin-1-yl)pyrimidin-2-ylamine
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|
C10H17N5
|
1
|
| 1 |
EC50 = 66.07 nM
|
|
|
|
CP0896297
|
4-tert-butyl-6-(4-methylpiperazin-1-yl)pyrimidin-2-ylamine
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|
C13H23N5
|
1
|
| 1 |
EC50 = 67.61 nM
|
|
|
|
CP0171840
|
4-(4-Methylpiperazin-1-yl)-6-pyrrolidin-1-ylpyrimidin-2-ylamine
Show/Hide
|
C13H22N6
|
1
|
| 1 |
EC50 = 69.18 nM
|
|
|
|
CP0880836
|
4-(2-methoxypyridin-3-yl)-6-(4-methylpiperazin-1-yl)pyrimidin-2-amine
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|
C15H20N6O
|
1
|
| 1 |
EC50 = 93.33 nM
|
|
|
|
CP0850028
|
4-(3-Methoxyphenyl)-6-(4-methylpiperazin-1-yl)pyrimidin-2-ylamine
Show/Hide
|
C16H21N5O
|
1
|
| 1 |
EC50 = 102.33 nM
|
|
|
|
CP0850031
|
4-(1-Methyl-1H-imidazol-4-yl)-6-(4-methylpiperazin-1-yl)pyrimidin-2-ylamine
Show/Hide
|
C13H19N7
|
1
|
| 1 |
EC50 = 102.33 nM
|
|
|
|
CP0425035
|
4-(4-methylpiperazin-1-yl)pyrimidin-2-amine
Show/Hide
|
C9H15N5
|
1
|
| 1 |
EC50 = 114.82 nM
|
|
|
|
CP0845917
|
4-(4-methoxyphenyl)-6-(4-methylpiperazin-1-yl)pyrimidin-2-amine
Show/Hide
|
C16H21N5O
|
1
|
| 1 |
EC50 = 114.82 nM
|
|
|
|
CP0894475
|
6-(4-Methylpiperazin-1-yl)-N4-phenylpyrimidine-2,4-diamine
Show/Hide
|
C15H20N6
|
1
|
| 1 |
EC50 = 117.49 nM
|
|
|
|
CP0913526
|
4-(4-methylpiperazin-1-yl)-6-(naphthalen-2-yl)pyrimidin-2-amine
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|
C19H21N5
|
1
|
| 1 |
EC50 = 173.78 nM
|
|
|
|
CP0851269
|
4-(4-Methylpiperazin-1-yl)-6-o-tolylpyrimidin-2-ylamine
Show/Hide
|
C16H21N5
|
1
|
| 1 |
EC50 = 177.83 nM
|
|
|
|
CP0915568
|
4-(2,6-Dimethoxyphenyl)-6-(4-methylpiperazin-1-yl)pyrimidin-2-ylamine
Show/Hide
|
C17H23N5O2
|
1
|
| 1 |
EC50 = 194.98 nM
|
|
|
|
CP0921848
|
4-(4-Methylpiperazin-1-yl)-6-pyridin-3-ylpyrimidin-2-ylamine
Show/Hide
|
C14H18N6
|
1
|
| 1 |
EC50 = 208.93 nM
|
|
|
|
CP0387512
|
6-(4-Methylpiperazin-1-yl)pyrimidine-2,4-diamine
Show/Hide
|
C9H16N6
|
1
|
| 1 |
EC50 = 218.78 nM
|
|
|
|
CP0894604
|
4-(4-Methylpiperazin-1-yl)-6-(1-methyl-1H-pyrazol-4-yl)pyrimidin-2-ylamine
Show/Hide
|
C13H19N7
|
1
|
| 1 |
EC50 = 218.78 nM
|
|
|
|
CP0880854
|
4-(4-methylpiperazin-1-yl)-6-(pyridin-4-yl)pyrimidin-2-amine
Show/Hide
|
C14H18N6
|
1
|
| 1 |
EC50 = 229.09 nM
|
|
|
|
CP0915555
|
3-[2-Amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]benzonitrile
Show/Hide
|
C16H18N6
|
1
|
| 1 |
EC50 = 234.42 nM
|
|
|
|
CP0915556
|
4-(4-Methoxypyridin-3-yl)-6-(4-methylpiperazin-1-yl)pyrimidin-2-ylamine
Show/Hide
|
C15H20N6O
|
1
|
| 1 |
EC50 = 234.42 nM
|
|
|
|
CP0286034
|
2-Aminopyrimidine analog., 25
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|
C15H16N6
|
2
|
| 1 |
EC50 = 245.47 nM
|
|
|
| 2 |
Ki = 338.84 nM
|
|
|
|
CP0858872
|
4-tert-Butyl-6-(4-ethylpiperazin-1-yl)pyrimidin-2-ylamine
Show/Hide
|
C14H25N5
|
1
|
| 1 |
EC50 = 245.47 nM
|
|
|
|
CP0462563
|
4-tert-butyl-6-(4-methylpiperazin-1-yl)-1,3,5-triazin-2-amine
Show/Hide
|
C12H22N6
|
1
|
| 1 |
EC50 = 251.19 nM
|
|
|
|
CP0896072
|
4-(4-Iodophenyl)-6-(4-methylpiperazin-1-yl)pyrimidin-2-ylamine
Show/Hide
|
C15H18IN5
|
1
|
| 1 |
EC50 = 275.42 nM
|
|
|
|
CP0867841
|
4-tert-Butyl-6-(2-dimethylamino-ethoxy)-pyrimidin-2-ylamine
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|
C12H22N4O
|
1
|
| 1 |
EC50 = 302 nM
|
|
|
|
CP0894606
|
4-Adamantan-1-yl-6-(4-methylpiperazin-1-yl)pyrimidin-2-ylamine
Show/Hide
|
C19H29N5
|
1
|
| 1 |
EC50 = 316.23 nM
|
|
|
|
CP0896349
|
4-(4-Methylpiperazin-1-yl)-6-morpholin-4-ylpyrimidin-2-ylamine
Show/Hide
|
C13H22N6O
|
1
|
| 1 |
EC50 = 338.84 nM
|
|
|
|
CP0896308
|
N4,N4-Diethyl-6-(4-methylpiperazin-1-yl)pyrimidine-2,4-diamine
Show/Hide
|
C13H24N6
|
1
|
| 1 |
EC50 = 354.81 nM
|
|
|
|
CP0870498
|
4-Methyl-6-(4-methylpiperazin-1-yl)pyrimidin-2-ylamine
Show/Hide
|
C10H17N5
|
1
|
| 1 |
EC50 = 363.08 nM
|
|
|
|
CP0850150
|
4-(1H-Imidazol-4-yl)-6-(4-methylpiperazin-1-yl)pyrimidin-2-ylamine
Show/Hide
|
C12H17N7
|
1
|
| 1 |
EC50 = 389.05 nM
|
|
|
|
CP0171842
|
4-N-benzyl-6-(4-methylpiperazin-1-yl)pyrimidine-2,4-diamine
Show/Hide
|
C16H22N6
|
1
|
| 1 |
EC50 = 489.78 nM
|
|
|
|
CP0845342
|
N4-Methyl-6-(4-methylpiperazin-1-yl)pyrimidine-2,4-diamine
Show/Hide
|
C10H18N6
|
1
|
| 1 |
EC50 = 489.78 nM
|
|
|
|
CP0913421
|
5-Methoxy-4-(4-methylpiperazin-1-yl)pyrimidin-2-ylamine
Show/Hide
|
C10H17N5O
|
1
|
| 1 |
EC50 = 630.96 nM
|
|
|
|
CP0939133
|
4-(3-Iodophenyl)-6-(4-methylpiperazin-1-yl)pyrimidin-2-ylamine
Show/Hide
|
C15H18IN5
|
1
|
| 1 |
EC50 = 891.25 nM
|
|
|
|
CP0913756
|
4-tert-Butyl-6-(4-methylpiperazin-1-yl)pyrimidine
Show/Hide
|
C13H22N4
|
1
|
| 1 |
EC50 = 933.25 nM
|
|
|
|
CP0896300
|
6-tert-Butyl-N4-(2-dimethylaminoethyl)-N4-methyl-pyrimidine-2,4-diamine
Show/Hide
|
C13H25N5
|
1
|
| 1 |
EC50 = 1122.02 nM
|
|
|
|
CP0850030
|
2-[2-Amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]benzonitrile
Show/Hide
|
C16H18N6
|
1
|
| 1 |
EC50 = 1202.26 nM
|
|
|
|
CP0866962
|
4,6-Bis-(4-methylpiperazin-1-yl)pyrimidin-2-ylamine
Show/Hide
|
C14H25N7
|
1
|
| 1 |
EC50 = 1348.96 nM
|
|
|
|
CP0896311
|
2-Amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-ol
Show/Hide
|
C9H15N5O
|
1
|
| 1 |
EC50 = 1479.11 nM
|
|
|
|
CP0896302
|
6-tert-Butyl-N4-(2-dimethylaminoethyl)pyrimidine-2,4-diamine
Show/Hide
|
C12H23N5
|
1
|
| 1 |
EC50 = 1778.28 nM
|
|
|
|
CP0880855
|
4-(4-Methylpiperazin-1-yl)-6-(1H-pyrazol-4-yl)pyrimidin-2-ylamine
Show/Hide
|
C12H17N7
|
1
|
| 1 |
EC50 = 1819.7 nM
|
|
|
|
CP0915588
|
4-[6-Amino-4-(4-methylpiperazin-1-yl)pyridin-2-yl]benzonitrile
Show/Hide
|
C17H19N5
|
1
|
| 1 |
EC50 = 1862.09 nM
|
|
|
|
CP0866965
|
4-Iodo-6-(4-methylpiperazin-1-yl)pyrimidin-2-ylamine
Show/Hide
|
C9H14IN5
|
1
|
| 1 |
EC50 = 2041.74 nM
|
|
|
|
CP0919449
|
4-tert-butyl-6-(piperazin-1-yl)-2-(1H-pyrrol-1-yl)pyrimidine
Show/Hide
|
C16H23N5
|
1
|
| 1 |
EC50 = 2290.87 nM
|
|
|
|
CP0926568
|
4-tert-Butyl-6-[4-(2-dimethylaminoethyl)piperazin-1-yl]pyrimidin-2-ylamine
Show/Hide
|
C16H30N6
|
1
|
| 1 |
EC50 = 2398.83 nM
|
|
|
|
CP0896347
|
N4,N4-Dimethyl-6-(4-methylpiperazin-1-yl)pyrimidine-2,4-diamine
Show/Hide
|
C11H20N6
|
1
|
| 1 |
EC50 = 3019.95 nM
|
|
|
|
CP0911632
|
2'-Methoxy-6-(4-methylpiperazin-1-yl)-[4,5']bipyrimidinyl-2-ylamine
Show/Hide
|
C14H19N7O
|
1
|
| 1 |
EC50 = 3235.94 nM
|
|
|
|
CP0896070
|
4-tert-Butyl-6-(1-methylpiperidin-4-yl)pyrimidin-2-ylamine
Show/Hide
|
C14H24N4
|
1
|
| 1 |
EC50 = 3630.78 nM
|
|
|
|
CP0918790
|
4-(3-Dimethylaminopyrrolidin-1-yl)-6-(4-methylpiperazin-1-yl)pyrimidin-2-ylamine
Show/Hide
|
C15H27N7
|
1
|
| 1 |
EC50 = 3630.78 nM
|
|
|
|
CP0858873
|
4-tert-Butyl-2-methoxy-6-(4-methylpiperazin-1-yl)pyrimidine
Show/Hide
|
C14H24N4O
|
1
|
| 1 |
EC50 = 4677.35 nM
|
|
|
|
CP0896299
|
2-tert-Butyl-6-(4-methylpiperazin-1-yl)pyrimidin-4-ylamine
Show/Hide
|
C13H23N5
|
1
|
| 1 |
EC50 = 4677.35 nM
|
|
|
|
CP0913757
|
[4-tert-Butyl-6-(4-methylpiperazin-1-yl)pyrimidin-2-yl]methylamine
Show/Hide
|
C14H25N5
|
1
|
| 1 |
EC50 = 5128.61 nM
|
|
|
|
CP0915587
|
4-[2-Amino-5-methoxy-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]benzonitrile
Show/Hide
|
C17H20N6O
|
1
|
| 1 |
EC50 = 5128.61 nM
|
|
|
|
CP0851286
|
4-Imidazol-1-yl-6-(4-methylpiperazin-1-yl)pyrimidin-2-ylamine
Show/Hide
|
C12H17N7
|
1
|
| 1 |
EC50 = 7943.28 nM
|
|
|
|
CP0867842
|
6-tert-Butyl-2-(4-methylpiperazin-1-yl)pyrimidin-4-ylamine
Show/Hide
|
C13H23N5
|
1
|
| 1 |
EC50 = 7943.28 nM
|
|
|
|
CP0896073
|
6-(4-Methylpiperazin-1-yl)-[4,5']bipyrimidinyl-2-ylamine
Show/Hide
|
C13H17N7
|
1
|
| 1 |
EC50 = 7943.28 nM
|
|
|
|
CP0845344
|
4-(4-Methylpiperazin-1-yl)-5-phenylpyrimidin-2-ylamine
Show/Hide
|
C15H19N5
|
1
|
| 1 |
EC50 = 8317.64 nM
|
|
|
|
CP0916702
|
4-tert-butyl-2-chloro-6-(4-methylpiperazin-1-yl)pyrimidine
Show/Hide
|
C13H21ClN4
|
1
|
| 1 |
EC50 = 8709.64 nM
|
|
|
|
CP0851271
|
4-(4-Methylpiperazin-1-yl)-6-phenylsulfanylpyrimidin-2-ylamine
Show/Hide
|
C15H19N5S
|
1
|
| 1 |
EC50 = 8912.51 nM
|
|
|
|
CP0894474
|
6-tert-Butyl-N4-(3-dimethylamino-propyl)-N4-methyl-pyrimidine-2,4-diamine
Show/Hide
|
C14H27N5
|
1
|
| 1 |
EC50 = 9772.37 nM
|
|
|
|
CP0866961
|
4-Methoxy-6-(4-methylpiperazin-1-yl)pyrimidin-2-ylamine
Show/Hide
|
C10H17N5O
|
1
|
| 1 |
EC50 = 10471.29 nM
|
|
|
|
CP0850149
|
1-[2-Amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]imidazolidin-2-one
Show/Hide
|
C12H19N7O
|
1
|
| 1 |
EC50 = 12302.69 nM
|
|
|
|
CP0851247
|
1-[2-Amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]-1H-pyridin-2-one
Show/Hide
|
C14H18N6O
|
1
|
| 1 |
EC50 = 14125.38 nM
|
|
|
|
CP0896558
|
4-Chloro-6-(4-methylpiperazin-1-yl)pyrimidin-2-ylamine
Show/Hide
|
C9H14ClN5
|
1
|
| 1 |
EC50 = 16982.44 nM
|
|
|
|
CP0896307
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[4-tert-Butyl-6-(4-methylpiperazin-1-yl)pyrimidin-2-yl]dimethylamine
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C15H27N5
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1
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| 1 |
EC50 = 18197.01 nM
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CP0896306
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4-tert-Butyl-6-(4-methylpiperazin-1-yl)pyrimidin-2-ol
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C13H22N4O
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1
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| 1 |
EC50 = 22908.68 nM
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CP0916701
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4-tert-Butyl-6-(4-methylpiperidin-1-yl)pyrimidin-2-ylamine
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C14H24N4
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1
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| 1 |
EC50 = 23442.29 nM
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