General Information of the Protein
| Protein ID |
PT03628
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| Protein Name |
Endothelial PAS domain-containing protein 1
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| Secondarily Protein Name |
Basic-helix-loop-helix-PAS protein MOP2
Class E basic helix-loop-helix protein 73
HIF-1-alpha-like factor
Hypoxia-inducible factor 2-alpha
Member of PAS protein 2
PAS domain-containing protein 2
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| Gene Name |
EPAS1
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| Secondarily Gene Name |
BHLHE73
HIF2A
MOP2
PASD2
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| Sequence |
MTADKEKKRSSSERRKEKSRDAARCRRSKETEVFYELAHELPLPHSVSSHLDKASIMRLAISFLRTHKLLSSVCSENESEAEADQQMDNLYLKALEGFIAVVTQDGDMIFLSENISKFMGLTQVELTGHSIFDFTHPCDHEEIRENLSLKNGSGFGKKSKDMSTERDFFMRMKCTVTNRGRTVNLKSATWKVLHCTGQVKVYNNCPPHNSLCGYKEPLLSCLIIMCEPIQHPSHMDIPLDSKTFLSRHSMDMKFTYCDDRITELIGYHPEELLGRSAYEFYHALDSENMTKSHQNLCTKGQVVSGQYRMLAKHGGYVWLETQGTVIYNPRNLQPQCIMCVNYVLSEIEKNDVVFSMDQTESLFKPHLMAMNSIFDSSGKGAVSEKSNFLFTKLKEEPEELAQLAPTPGDAIISLDFGNQNFEESSAYGKAILPPSQPWATELRSHSTQSEAGSLPAFTVPQAAAPGSTTPSATSSSSSCSTPNSPEDYYTSLDNDLKIEVIEKLFAMDTEAKDQCSTQTDFNELDLETLAPYIPMDGEDFQLSPICPEERLLAENPQSTPQHCFSAMTNIFQPLAPVAPHSPFLLDKFQQQLESKKTEPEHRPMSSIFFDAGSKASLPPCCGQASTPLSSMGGRSNTQWPPDPPLHFGPTKWAVGDQRTEFLGAAPLGPPVSPPHVSTFKTRSAKGFGARGPDVLSPAMVALSNKLKLKRQLEYEEQAFQDLSGGDPPGGSTSHLMWKRMKNLRGGSCPLMPDKPLSANVPNDKFTQNPMRGLGHPLRHLPLPQPPSAISPGENSKSRFPPQCYATQYQDYSLSSAHKVSGMASRLLGPSFESYLLPELTRYDCEVNVPVLGSSTLLQGGDLLRALDQAT
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| Organism |
Homo sapiens, Human
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| Protein Classification |
Transcription factor
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| Function |
Transcription factor involved in the induction of oxygen regulated genes. Heterodimerizes with ARNT; heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters (By similarity). Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier. Potent activator of the Tie-2 tyrosine kinase expression. Activation requires recruitment of transcriptional coactivators such as CREBBP and probably EP300. Interaction with redox regulatory protein APEX1 seems to activate CTAD (By similarity).
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| Uniprot ID |
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| HGNC ID | |||||
| Subcellular Location |
Nucleus
Nucleus speckle
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Map of Molecular Bioactivity Related to the Protein
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Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity |
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Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000244 , 786-O
Biochemical Assays
Clinical Information about the Protein
Target 1 ( HIF2-alpha messenger RNA (EPAS1 mRNA) )
| Target Type | Clinical trial Target | ||||
|---|---|---|---|---|---|
| Disease | 1 Target-related Disease | 1 | |||
| 1 | Recurrent glioblastoma [ICD-11: 2A00.00] | ||||
| Clinical Trial Drug(s) | 1 Clinical Trial Drug | 1 | |||
| 1 | PT2385 | Phase 2 | |||
Target 2 ( Hypoxia-inducible factor 2 alpha (HIF-2A) )
| Target Type | Successful Target | ||||
|---|---|---|---|---|---|
| Disease | 2 Target-related Diseases | 2 | |||
| 1 | Recurrent glioblastoma [ICD-11: 2A00.00] | ||||
| 2 | Renal cell carcinoma [ICD-11: 2C90] | ||||
| Approved Drug(s) | 1 Approved Drug | 1 | |||
| 1 | Belzutifan | Approved | |||
| Clinical Trial Drug(s) | 1 Clinical Trial Drug | 1 | |||
| 1 | PT2385 | Phase 2 | |||