Brief Information of the Compound and Protein
Compound Name
 Compound Info 
US10597366, Compound 63
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 PubChem ID
CID: 117947049
Canonical SMILES
O[C@H]1c2c(CC1(F)F)c(Oc1cc(F)cc(c1)C#N)ccc2S(=O)(=O)CF
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Compound Formula C17H11F4NO4S
Compound Structure
Protein Name
 Protein Info 
Endothelial PAS domain-containing protein 1
Protein Classification
Transcription factor
Uniprot ID
Q99814
Gene Name
EPAS1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000244 786-O
 Cell Line Info 
Homo sapiens (Human)  3
1
EC50 = 9 nM
   TI
   LI
   LO
   TS
2
EC50 = 20 nM
   TI
   LI
   LO
   TS
3
EC50 = 182 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 < 5 nM