Brief Information of the Compound and Protein
Compound Name
 Compound Info 
(R)-3-((4-(difluoromethyl)-2,2-difluoro-3-hydroxy- 1,1-dioxido-2,3-dihydrobenzo[b]thiophen-5-yl)oxy)- 5-fluorobenzonitrile
    Show/Hide
 PubChem ID
CID: 91810395
Canonical SMILES
O[C@@H]1c2c(ccc(Oc3cc(F)cc(c3)C#N)c2C(F)F)S(=O)(=O)C1(F)F
    Show/Hide
Compound Formula C16H8F5NO4S
Compound Structure
Protein Name
 Protein Info 
Endothelial PAS domain-containing protein 1
Protein Classification
Transcription factor
Uniprot ID
Q99814
Gene Name
EPAS1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000244 786-O
 Cell Line Info 
Homo sapiens (Human)  3
1
EC50 = 10 nM
   TI
   LI
   LO
   TS
2
EC50 = 16 nM
   TI
   LI
   LO
   TS
3
EC50 = 145 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 < 5 nM