General Information of the Compound
Compound ID
CP0565364
Compound Name
(4S)-5,5-difluoro-3-methylsulfonyl-1-[2-methyl-5-(trifluoromethyl)pyrazol-3-yl]-6,7-dihydro-4H-2-benzothiophen-4-ol
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Structure
Formula
C14H13F5N2O3S2
Molecular Weight
416.393
Canonical SMILES
Cn1nc(cc1-c1sc(c2[C@H](O)C(F)(F)CCc12)S(C)(=O)=O)C(F)(F)F
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InChI
InChI=1S/C14H13F5N2O3S2/c1-21-7(5-8(20-21)14(17,18)19)10-6-3-4-13(15,16)11(22)9(6)12(25-10)26(2,23)24/h5,11,22H,3-4H2,1-2H3/t11-/m0/s1
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InChIKey
QFZKXBTWZMBVOS-NSHDSACASA-N
Physicochemical Property
logP
3.1858
Rotatable Bonds
2
Heavy Atom Count
26
Polar Areas
72.19
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
6
Complexity
26

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 151578601
ChEMBL ID
CHEMBL4639560
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT03628, Endothelial PAS domain-containing protein 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000244 786-O Homo sapiens (Human)  1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 > 1000 nM