Compound ID |
Compound Name |
Compound Formula |
CP0108652
|
2-[4-[4-[(1R)-1-hydroxyethyl]-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-3-yl]cyclohexyl]acetonitrile
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|
C18H21N5O
|
2
|
1 |
EC50 = 5.7 nM
|
|
|
2 |
EC50 = 28 nM
|
|
|
CP0088219
|
N-[[3-[(1R,2R,4S)-2-bicyclo[2.2.1]heptanyl]-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-4-yl]methyl]methanesulfonamide
Show/Hide
|
C17H21N5O2S
|
2
|
1 |
EC50 = 13 nM
|
|
|
2 |
EC50 = 118 nM
|
|
|
CP0012129
|
INCB-018424
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|
C17H18N6
|
1
|
1 |
EC50 = 24 nM
|
|
|
CP0255798
|
3-[4-(4-methyl-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-3-yl)piperidin-1-yl]propanenitrile
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|
C17H20N6
|
1
|
1 |
EC50 = 26 nM
|
|
|
CP0084964
|
(1R)-1-[3-[4-(2,2,2-trifluoroethylamino)cyclohexyl]-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-4-yl]ethanol
Show/Hide
|
C18H22F3N5O
|
2
|
1 |
EC50 = 28 nM
|
|
|
2 |
EC50 = 29 nM
|
|
|
CP0087139
|
3-[4-[4-[(1R)-1-hydroxyethyl]-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-3-yl]cyclohexyl]propanenitrile
Show/Hide
|
C19H23N5O
|
2
|
1 |
EC50 = 33 nM
|
|
|
2 |
EC50 = 43 nM
|
|
|
CP0260731
|
3-(1-benzylpiperidin-4-yl)-4-methyl-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaene
Show/Hide
|
C21H23N5
|
1
|
1 |
EC50 = 35 nM
|
|
|
CP0079525
|
3-[4-(3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-3-yl)piperidin-1-yl]propanenitrile
Show/Hide
|
C16H18N6
|
1
|
1 |
EC50 = 43 nM
|
|
|
CP0002393
|
3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile
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|
C16H20N6O
|
2
|
1 |
EC50 = 43 nM
|
|
|
2 |
EC50 = 53 nM
|
|
|
CP0266379
|
(1R)-1-(3-cyclohexyl-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-4-yl)ethanol
Show/Hide
|
C16H20N4O
|
2
|
1 |
EC50 = 47 nM
|
|
|
2 |
EC50 = 330 nM
|
|
|
CP0261449
|
4-[4-[(1R)-1-hydroxyethyl]-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-3-yl]cyclohexane-1-carbonitrile
Show/Hide
|
C17H19N5O
|
2
|
1 |
EC50 = 49 nM
|
|
|
2 |
EC50 = 78 nM
|
|
|
CP0329529
|
N-[2-[3-(2-bicyclo[2.2.1]heptanyl)-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-4-yl]ethyl]methanesulfonamide
Show/Hide
|
C18H23N5O2S
|
1
|
1 |
EC50 = 50 nM
|
|
|
CP0087579
|
(1R)-1-[3-[(1S,3R)-3-(2,2,2-trifluoroethylamino)cyclopentyl]-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-4-yl]ethanol
Show/Hide
|
C17H20F3N5O
|
2
|
1 |
EC50 = 51 nM
|
|
|
2 |
EC50 = 70 nM
|
|
|
CP0315771
|
3-[(3R,4R)-3-fluoropiperidin-4-yl]-4-methyl-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaene
Show/Hide
|
C14H16FN5
|
1
|
1 |
EC50 = 57 nM
|
|
|
CP0265330
|
(1R)-1-[3-[4-(2,2-difluoroethylamino)cyclohexyl]-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-4-yl]ethanol
Show/Hide
|
C18H23F2N5O
|
2
|
1 |
EC50 = 57 nM
|
|
|
2 |
EC50 = 62 nM
|
|
|
CP0084967
|
(3-cyclohexyl-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-4-yl)methanol
Show/Hide
|
C15H18N4O
|
2
|
1 |
EC50 = 64 nM
|
|
|
2 |
EC50 = 313 nM
|
|
|
CP0369955
|
(1S)-1-(3-cyclohexyl-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-4-yl)ethane-1,2-diol
Show/Hide
|
C16H20N4O2
|
2
|
1 |
EC50 = 69 nM
|
|
|
2 |
EC50 = 220 nM
|
|
|
CP0285868
|
(1R)-1-[3-[(1S,3S)-3-(2,2,2-trifluoroethylamino)cyclopentyl]-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-4-yl]ethanol
Show/Hide
|
C17H20F3N5O
|
2
|
1 |
EC50 = 74 nM
|
|
|
2 |
EC50 = 82 nM
|
|
|
CP0359333
|
(1R)-1-(3-cyclohexyl-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-4-yl)propan-1-ol
Show/Hide
|
C17H22N4O
|
2
|
1 |
EC50 = 84 nM
|
|
|
2 |
EC50 = 1600 nM
|
|
|
CP0247748
|
3-(1-benzylpiperidin-4-yl)-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaene
Show/Hide
|
C20H21N5
|
1
|
1 |
EC50 = 86 nM
|
|
|
CP0120553
|
(1R,3R)-3-(4-methyl-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-3-yl)cyclohexan-1-ol
Show/Hide
|
C15H18N4O
|
2
|
1 |
EC50 = 87 nM
|
|
|
2 |
EC50 = 160 nM
|
|
|
CP0261451
|
(1R)-1-[3-(1-ethyl-3,3-difluoropiperidin-4-yl)-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-4-yl]ethanol
Show/Hide
|
C17H21F2N5O
|
2
|
1 |
EC50 = 88 nM
|
|
|
2 |
EC50 = 330 nM
|
|
|
CP0146865
|
3-cyclohexyl-4-methyl-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaene
Show/Hide
|
C15H18N4
|
2
|
1 |
EC50 = 100 nM
|
|
|
2 |
EC50 = 180 nM
|
|
|
CP0178056
|
3-[[4-(4-methyl-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-3-yl)cyclohexyl]amino]propanenitrile
Show/Hide
|
C18H22N6
|
1
|
1 |
EC50 = 110 nM
|
|
|
CP0108487
|
(1R)-1-[3-[(3S)-oxan-3-yl]-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-4-yl]ethanol
Show/Hide
|
C15H18N4O2
|
2
|
1 |
EC50 = 110 nM
|
|
|
2 |
EC50 = 180 nM
|
|
|
CP0266378
|
(1R)-1-[3-[1-(2,2,2-trifluoroethyl)piperidin-4-yl]-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-4-yl]ethanol
Show/Hide
|
C17H20F3N5O
|
2
|
1 |
EC50 = 110 nM
|
|
|
2 |
EC50 = 820 nM
|
|
|
CP0108702
|
3-oxo-3-[(3R)-3-(3,4,5,8,10-pentazatricyclo[7.3.0.02,6]dodeca-1,5,7,9,11-pentaen-3-yl)piperidin-1-yl]propanenitrile
Show/Hide
|
C15H15N7O
|
1
|
1 |
EC50 = 114 nM
|
|
|
CP0102822
|
4-[4-[(1R)-1-hydroxyethyl]-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-3-yl]cyclohexane-1-carbonitrile
Show/Hide
|
C17H19N5O
|
2
|
1 |
EC50 = 120 nM
|
|
|
2 |
EC50 = 130 nM
|
|
|
CP0198952
|
(1R,3R)-3-[4-[(1R)-1-hydroxyethyl]-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-3-yl]cyclohexan-1-ol
Show/Hide
|
C16H20N4O2
|
2
|
1 |
EC50 = 120 nM
|
|
|
2 |
EC50 = 140 nM
|
|
|
CP0217586
|
CHEMBL2392487
Show/Hide
|
C19H20N6
|
1
|
1 |
EC50 = 121 nM
|
|
|
CP0104959
|
tert-butyl N-[(1R,3R)-3-(3,4,5,8,10-pentazatricyclo[7.3.0.02,6]dodeca-1,5,7,9,11-pentaen-3-yl)cyclopentyl]carbamate
Show/Hide
|
C17H22N6O2
|
1
|
1 |
EC50 = 127 nM
|
|
|
CP0257219
|
N-(cyclopropylmethyl)-4-(3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-3-yl)cyclohexan-1-amine
Show/Hide
|
C18H23N5
|
1
|
1 |
EC50 = 130 nM
|
|
|
CP0329462
|
N-[(3-cycloheptyl-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-4-yl)methyl]methanesulfonamide
Show/Hide
|
C17H23N5O2S
|
1
|
1 |
EC50 = 130 nM
|
|
|
CP0266430
|
2-(3-cyclohexyl-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-4-yl)ethanol
Show/Hide
|
C16H20N4O
|
2
|
1 |
EC50 = 130 nM
|
|
|
2 |
EC50 = 1500 nM
|
|
|
CP0086382
|
3-[4-(3,4,5,8,10-pentazatricyclo[7.3.0.02,6]dodeca-1,5,7,9,11-pentaen-3-yl)piperidin-1-yl]propanenitrile
Show/Hide
|
C15H17N7
|
1
|
1 |
EC50 = 138 nM
|
|
|
CP0355897
|
3-(1-methylsulfonylpiperidin-4-yl)-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaene
Show/Hide
|
C14H17N5O2S
|
1
|
1 |
EC50 = 140 nM
|
|
|
CP0179649
|
methyl N-[(1R,3R)-3-(3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-3-yl)cyclopentyl]carbamate
Show/Hide
|
C15H17N5O2
|
1
|
1 |
EC50 = 150 nM
|
|
|
CP0130638
|
12-cyclohexyl-1,5,7,10-tetrazatricyclo[7.3.0.02,6]dodeca-2(6),3,7,9,11-pentaene
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|
C14H16N4
|
1
|
1 |
EC50 = 150 nM
|
|
|
CP0335391
|
3-[1-(2,2,2-trifluoroethyl)piperidin-4-yl]-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaene
Show/Hide
|
C15H16F3N5
|
1
|
1 |
EC50 = 160 nM
|
|
|
CP0120790
|
N-[[3-[(1S,2S,4R)-2-bicyclo[2.2.1]heptanyl]-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-4-yl]methyl]methanesulfonamide
Show/Hide
|
C17H21N5O2S
|
1
|
1 |
EC50 = 160 nM
|
|
|
CP0175649
|
3-[4-(4-cyclopropyl-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-3-yl)piperidin-1-yl]propanenitrile
Show/Hide
|
C19H22N6
|
1
|
1 |
EC50 = 160 nM
|
|
|
CP0204289
|
N-[[3-(2-bicyclo[2.2.1]heptanyl)-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-4-yl]methyl]acetamide
Show/Hide
|
C18H21N5O
|
1
|
1 |
EC50 = 160 nM
|
|
|
CP0086377
|
3-[[4-(3,4,5,8,10-pentazatricyclo[7.3.0.02,6]dodeca-1,5,7,9,11-pentaen-3-yl)cyclohexyl]amino]propanenitrile
Show/Hide
|
C16H19N7
|
1
|
1 |
EC50 = 165 nM
|
|
|
CP0146867
|
3-cyclohexyl-4,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1(12),2,6,8,10-pentaene
Show/Hide
|
C14H16N4
|
1
|
1 |
EC50 = 170 nM
|
|
|
CP0186393
|
3-oxo-3-[(3R)-3-(3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-3-yl)piperidin-1-yl]propanenitrile
Show/Hide
|
C16H16N6O
|
1
|
1 |
EC50 = 180 nM
|
|
|
CP0270172
|
3-[[[4-(3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-3-yl)cyclohexyl]amino]methyl]benzonitrile
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|
C22H22N6
|
1
|
1 |
EC50 = 180 nM
|
|
|
CP0335392
|
tert-butyl N-[4-(3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-3-yl)cyclohexyl]carbamate
Show/Hide
|
C19H25N5O2
|
1
|
1 |
EC50 = 180 nM
|
|
|
CP0356714
|
4-[4-(3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-3-yl)cyclohexyl]morpholine
Show/Hide
|
C18H23N5O
|
1
|
1 |
EC50 = 180 nM
|
|
|
CP0120685
|
(1R,3R)-3-(4-methyl-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-3-yl)cyclopentan-1-ol
Show/Hide
|
C14H16N4O
|
1
|
1 |
EC50 = 180 nM
|
|
|
CP0171798
|
N-[2-(3-cyclohexyl-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-4-yl)ethyl]methanesulfonamide
Show/Hide
|
C17H23N5O2S
|
1
|
1 |
EC50 = 180 nM
|
|
|
CP0120684
|
(1R,3S)-3-(4-methyl-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-3-yl)cyclopentan-1-ol
Show/Hide
|
C14H16N4O
|
1
|
1 |
EC50 = 190 nM
|
|
|
CP0088169
|
N-[(3-cyclohexyl-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-4-yl)methyl]methanesulfonamide
Show/Hide
|
C16H21N5O2S
|
1
|
1 |
EC50 = 190 nM
|
|
|
CP0255709
|
3-(4-methyl-1-methylsulfonylpiperidin-4-yl)-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaene
Show/Hide
|
C15H19N5O2S
|
1
|
1 |
EC50 = 210 nM
|
|
|
CP0323372
|
N-[2-(3-cyclohexyl-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-4-yl)ethyl]acetamide
Show/Hide
|
C18H23N5O
|
1
|
1 |
EC50 = 210 nM
|
|
|
CP0168169
|
1-cyclohexyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine (2)
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|
C14H16N4
|
1
|
1 |
EC50 = 210 nM
|
|
|
CP0305359
|
3-(4-methyl-1-methylsulfonylpiperidin-4-yl)-3,4,5,8,10-pentazatricyclo[7.3.0.02,6]dodeca-1,5,7,9,11-pentaene
Show/Hide
|
C14H18N6O2S
|
1
|
1 |
EC50 = 220 nM
|
|
|
CP0107727
|
CHEMBL2386628
Show/Hide
|
C17H22N4O2
|
2
|
1 |
EC50 = 240 nM
|
|
|
2 |
EC50 = 280 nM
|
|
|
CP0086379
|
3-(1-methylsulfonylpiperidin-4-yl)-3,4,5,8,10-pentazatricyclo[7.3.0.02,6]dodeca-1,5,7,9,11-pentaene
Show/Hide
|
C13H16N6O2S
|
1
|
1 |
EC50 = 249 nM
|
|
|
CP0100650
|
4-methyl-3-piperidin-4-yl-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaene
Show/Hide
|
C14H17N5
|
1
|
1 |
EC50 = 250 nM
|
|
|
CP0161562
|
4-(4-methyl-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-3-yl)cyclohexan-1-ol
Show/Hide
|
C15H18N4O
|
1
|
1 |
EC50 = 250 nM
|
|
|
CP0334376
|
4-(3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-3-yl)cyclohexan-1-amine
Show/Hide
|
C14H17N5
|
1
|
1 |
EC50 = 260 nM
|
|
|
CP0302958
|
tert-butyl N-[(1S,3R)-3-(3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-3-yl)cyclopentyl]carbamate
Show/Hide
|
C18H23N5O2
|
1
|
1 |
EC50 = 270 nM
|
|
|
CP0178017
|
4-(4-methyl-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-3-yl)cyclohexan-1-ol
Show/Hide
|
C15H18N4O
|
1
|
1 |
EC50 = 270 nM
|
|
|
CP0334795
|
3-[4-(4-propyl-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-3-yl)piperidin-1-yl]propanenitrile
Show/Hide
|
C19H24N6
|
1
|
1 |
EC50 = 275 nM
|
|
|
CP0159699
|
CHEMBL2159208
Show/Hide
|
C17H21N5O2
|
1
|
1 |
EC50 = 280 nM
|
|
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CP0315684
|
(1R,3S)-3-(4-methyl-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-3-yl)cyclohexan-1-ol
Show/Hide
|
C15H18N4O
|
1
|
1 |
EC50 = 310 nM
|
|
|
CP0369957
|
3-[4-[4-[(1R)-1-hydroxyethyl]-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-3-yl]piperidin-1-yl]propanenitrile
Show/Hide
|
C18H22N6O
|
2
|
1 |
EC50 = 320 nM
|
|
|
2 |
EC50 = 510 nM
|
|
|
CP0285853
|
(1R)-1-(3-cyclohexyl-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-4-yl)ethane-1,2-diol
Show/Hide
|
C16H20N4O2
|
1
|
1 |
EC50 = 320 nM
|
|
|
CP0088171
|
N-[[3-[1-(2,2,2-trifluoroethyl)piperidin-4-yl]-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-4-yl]methyl]methanesulfonamide
Show/Hide
|
C17H21F3N6O2S
|
1
|
1 |
EC50 = 325 nM
|
|
|
CP0100646
|
2-(3-cyclohexyl-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-4-yl)propan-2-ol
Show/Hide
|
C17H22N4O
|
1
|
1 |
EC50 = 330 nM
|
|
|
CP0340065
|
4-(3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-3-yl)cyclohexan-1-amine
Show/Hide
|
C14H17N5
|
1
|
1 |
EC50 = 340 nM
|
|
|
CP0339507
|
3-[1-(pyrimidin-5-ylmethyl)piperidin-4-yl]-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaene
Show/Hide
|
C18H19N7
|
1
|
1 |
EC50 = 350 nM
|
|
|
CP0142992
|
4-methyl-3-[(3S)-oxan-3-yl]-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaene
Show/Hide
|
C14H16N4O
|
1
|
1 |
EC50 = 350 nM
|
|
|
CP0315770
|
3-(3,3-difluoropiperidin-4-yl)-4-methyl-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaene
Show/Hide
|
C14H15F2N5
|
1
|
1 |
EC50 = 350 nM
|
|
|
CP0108248
|
12-cyclohexyl-1,5,7,10,11-pentazatricyclo[7.3.0.02,6]dodeca-2(6),3,7,9,11-pentaene
Show/Hide
|
C13H15N5
|
1
|
1 |
EC50 = 350 nM
|
|
|
CP0086380
|
3-methyl-N-[4-(3,4,5,8,10-pentazatricyclo[7.3.0.02,6]dodeca-1,5,7,9,11-pentaen-3-yl)cyclohexyl]butanamide
Show/Hide
|
C18H24N6O
|
1
|
1 |
EC50 = 350 nM
|
|
|
CP0107726
|
(1S)-1-(3-cyclohexyl-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-4-yl)ethanol
Show/Hide
|
C16H20N4O
|
1
|
1 |
EC50 = 360 nM
|
|
|
CP0146866
|
12-cyclohexyl-1,5,7,11-tetrazatricyclo[7.3.0.02,6]dodeca-2(6),3,7,9,11-pentaene
Show/Hide
|
C14H16N4
|
1
|
1 |
EC50 = 370 nM
|
|
|
CP0369956
|
CHEMBL2386626
Show/Hide
|
C16H20N4O2
|
1
|
1 |
EC50 = 380 nM
|
|
|
CP0087922
|
methyl N-[(1R,3R)-3-(3,4,5,8,10-pentazatricyclo[7.3.0.02,6]dodeca-1,5,7,9,11-pentaen-3-yl)cyclopentyl]carbamate
Show/Hide
|
C14H16N6O2
|
1
|
1 |
EC50 = 395 nM
|
|
|
CP0508197
|
methyl N-[4-(3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-3-yl)cyclohexyl]carbamate
Show/Hide
|
C16H19N5O2
|
1
|
1 |
EC50 = 400 nM
|
|
|
CP0334377
|
2-methyl-N-[4-(3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-3-yl)cyclohexyl]propanamide
Show/Hide
|
C18H23N5O
|
1
|
1 |
EC50 = 410 nM
|
|
|
CP0310453
|
3-[4-(4-propan-2-yl-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-3-yl)piperidin-1-yl]propanenitrile
Show/Hide
|
C19H24N6
|
1
|
1 |
EC50 = 410 nM
|
|
|
CP0112715
|
(1S)-1-(3-cyclohexyl-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-4-yl)propan-1-ol
Show/Hide
|
C17H22N4O
|
1
|
1 |
EC50 = 410 nM
|
|
|
CP0261450
|
4-[4-[(1R)-1-hydroxyethyl]-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-3-yl]cyclohexan-1-ol
Show/Hide
|
C16H20N4O2
|
2
|
1 |
EC50 = 410 nM
|
|
|
2 |
EC50 = 730 nM
|
|
|
CP0157841
|
CHEMBL2392490
Show/Hide
|
C18H19N7
|
1
|
1 |
EC50 = 414 nM
|
|
|
CP0426744
|
3-[4-(4-cyclobutyl-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-3-yl)piperidin-1-yl]propanenitrile
Show/Hide
|
C20H24N6
|
1
|
1 |
EC50 = 430 nM
|
|
|
CP0130641
|
3-cyclohexyl-5-oxa-4,8,10-triazatricyclo[7.3.0.02,6]dodeca-1(12),2,6,8,10-pentaene
Show/Hide
|
C14H15N3O
|
1
|
1 |
EC50 = 430 nM
|
|
|
CP0104957
|
methyl N-[4-(3,4,5,8,10-pentazatricyclo[7.3.0.02,6]dodeca-1,5,7,9,11-pentaen-3-yl)cyclohexyl]carbamate
Show/Hide
|
C15H18N6O2
|
1
|
1 |
EC50 = 433 nM
|
|
|
CP0359605
|
3-[[4-(3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-3-yl)cyclohexyl]amino]propanenitrile
Show/Hide
|
C17H20N6
|
1
|
1 |
EC50 = 440 nM
|
|
|
CP0178020
|
3-[(3S,4R)-3-fluoropiperidin-4-yl]-4-methyl-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaene
Show/Hide
|
C14H16FN5
|
1
|
1 |
EC50 = 490 nM
|
|
|
CP0079526
|
tert-butyl N-[4-(3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-3-yl)cyclohexyl]carbamate
Show/Hide
|
C19H25N5O2
|
1
|
1 |
EC50 = 500 nM
|
|
|
CP0321389
|
3-(1-ethylpiperidin-4-yl)-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaene
Show/Hide
|
C15H19N5
|
1
|
1 |
EC50 = 520 nM
|
|
|
CP0165766
|
3-[1-(benzenesulfonyl)piperidin-4-yl]-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaene
Show/Hide
|
C19H19N5O2S
|
1
|
1 |
EC50 = 540 nM
|
|
|
CP0339771
|
4-(3,4,5,8,10-pentazatricyclo[7.3.0.02,6]dodeca-1,5,7,9,11-pentaen-3-yl)cyclohexan-1-ol
Show/Hide
|
C13H15N5O
|
1
|
1 |
EC50 = 558 nM
|
|
|
CP0247830
|
3-[4-[4-[2-(oxolan-2-yl)ethyl]-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-3-yl]piperidin-1-yl]propanenitrile
Show/Hide
|
C22H28N6O
|
1
|
1 |
EC50 = 570 nM
|
|
|
CP0369176
|
ethyl N-[[3-[1-(2-cyanoethyl)piperidin-4-yl]-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-4-yl]methyl]carbamate
Show/Hide
|
C20H25N7O2
|
1
|
1 |
EC50 = 625 nM
|
|
|
CP0186394
|
3-[4-methyl-1-(pyrimidin-5-ylmethyl)piperidin-4-yl]-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaene
Show/Hide
|
C19H21N7
|
1
|
1 |
EC50 = 670 nM
|
|
|
CP0194789
|
methyl N-methyl-N-[4-(3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-3-yl)cyclohexyl]carbamate
Show/Hide
|
C17H21N5O2
|
1
|
1 |
EC50 = 670 nM
|
|
|
CP0329463
|
N-[(3-cyclohexyl-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-4-yl)methyl]acetamide
Show/Hide
|
C17H21N5O
|
1
|
1 |
EC50 = 670 nM
|
|
|
CP0356271
|
N-[4-(3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-3-yl)cyclohexyl]methanesulfonamide
Show/Hide
|
C15H19N5O2S
|
1
|
1 |
EC50 = 700 nM
|
|
|
CP0217584
|
4-(3,4,5,8,10-pentazatricyclo[7.3.0.02,6]dodeca-1,5,7,9,11-pentaen-3-yl)cyclohexan-1-amine
Show/Hide
|
C13H16N6
|
1
|
1 |
EC50 = 729 nM
|
|
|
CP0323371
|
N-[(3-cyclopentyl-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-4-yl)methyl]methanesulfonamide
Show/Hide
|
C15H19N5O2S
|
1
|
1 |
EC50 = 815 nM
|
|
|
CP0525615
|
3-(4-methylpiperidin-4-yl)-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaene
Show/Hide
|
C14H17N5
|
1
|
1 |
EC50 = 880 nM
|
|
|
CP0178055
|
N-[4-(4-methyl-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-3-yl)cyclohexyl]methanesulfonamide
Show/Hide
|
C16H21N5O2S
|
1
|
1 |
EC50 = 890 nM
|
|
|
CP0146014
|
3-cyclohexyl-4-(trifluoromethyl)-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaene
Show/Hide
|
C15H15F3N4
|
1
|
1 |
EC50 = 970 nM
|
|
|
CP0159700
|
4-methyl-3-(oxan-4-yl)-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaene
Show/Hide
|
C14H16N4O
|
1
|
1 |
EC50 = 990 nM
|
|
|
CP0323227
|
N-[[3-[1-(2-cyanoethyl)piperidin-4-yl]-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-4-yl]methyl]-2-methylpropane-1-sulfonamide
Show/Hide
|
C21H29N7O2S
|
1
|
1 |
EC50 = 1200 nM
|
|
|
CP0146868
|
3-cyclohexyl-5-methyl-4,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1(12),2,6,8,10-pentaene
Show/Hide
|
C15H18N4
|
1
|
1 |
EC50 = 1200 nM
|
|
|
CP0274109
|
phenyl-[4-(3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-3-yl)piperidin-1-yl]methanone
Show/Hide
|
C20H19N5O
|
1
|
1 |
EC50 = 1300 nM
|
|
|
CP0369177
|
3-[4-[4-(oxolan-2-ylmethyl)-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-3-yl]piperidin-1-yl]propanenitrile
Show/Hide
|
C21H26N6O
|
1
|
1 |
EC50 = 1300 nM
|
|
|
CP0112719
|
3-piperidin-4-yl-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaene
Show/Hide
|
C13H15N5
|
1
|
1 |
EC50 = 1400 nM
|
|
|
CP0345484
|
N-[[3-[1-(2,2,2-trifluoroethyl)piperidin-4-yl]-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-4-yl]methyl]acetamide
Show/Hide
|
C18H21F3N6O
|
1
|
1 |
EC50 = 1500 nM
|
|
|
CP0186640
|
[(2S)-1-methylpiperidin-2-yl]-[4-(3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-3-yl)piperidin-1-yl]methanone
Show/Hide
|
C20H26N6O
|
1
|
1 |
EC50 = 1800 nM
|
|
|
CP0282470
|
3-methyl-1-[4-(3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-3-yl)piperidin-1-yl]butan-1-one
Show/Hide
|
C18H23N5O
|
1
|
1 |
EC50 = 1800 nM
|
|
|
CP0274441
|
3-[4-[4-(2-pyrazol-1-ylethyl)-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-3-yl]piperidin-1-yl]propanenitrile
Show/Hide
|
C21H24N8
|
1
|
1 |
EC50 = 1800 nM
|
|
|
CP0076053
|
3-[4-[4-(cyclopentylmethyl)-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-3-yl]piperidin-1-yl]propanenitrile
Show/Hide
|
C22H28N6
|
1
|
1 |
EC50 = 2000 nM
|
|
|
CP0274272
|
N-[[3-[(1R,3R)-3-hydroxycyclohexyl]-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-4-yl]methyl]methanesulfonamide
Show/Hide
|
C16H21N5O3S
|
1
|
1 |
EC50 = 2200 nM
|
|
|
CP0088180
|
3-[4-[4-(oxan-4-ylmethyl)-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-3-yl]piperidin-1-yl]propanenitrile
Show/Hide
|
C22H28N6O
|
1
|
1 |
EC50 = 2600 nM
|
|
|
CP0106619
|
3-[4-[4-[2-(1-methylpyrazol-3-yl)ethyl]-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-3-yl]piperidin-1-yl]propanenitrile
Show/Hide
|
C22H26N8
|
1
|
1 |
EC50 = 2600 nM
|
|
|
CP0315772
|
CHEMBL2159207
Show/Hide
|
C17H21N5O
|
1
|
1 |
EC50 = 3600 nM
|
|
|
CP0284087
|
N-[[3-(7-oxabicyclo[2.2.1]heptan-2-yl)-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-4-yl]methyl]methanesulfonamide
Show/Hide
|
C16H19N5O3S
|
1
|
1 |
EC50 = 4200 nM
|
|
|
CP0194788
|
4-[4-(3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-3-yl)cyclohexyl]morpholine
Show/Hide
|
C18H23N5O
|
1
|
1 |
EC50 = 5200 nM
|
|
|
CP0247820
|
3-[4-[4-[2-(1-methylimidazol-2-yl)ethyl]-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-3-yl]piperidin-1-yl]propanenitrile
Show/Hide
|
C22H26N8
|
1
|
1 |
EC50 = 5200 nM
|
|
|
CP0265331
|
3-[(3R)-3-[4-[(1R)-1-hydroxyethyl]-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-3-yl]piperidin-1-yl]-3-oxopropanenitrile
Show/Hide
|
C18H20N6O2
|
1
|
1 |
EC50 = 8200 nM
|
|
|
CP0079522
|
3-oxo-3-[4-(3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-3-yl)piperidin-1-yl]propanenitrile
Show/Hide
|
C16H16N6O
|
1
|
1 |
EC50 > 10000 nM
|
|
|
CP0345485
|
N-[[3-[1-(2-cyanoethyl)piperidin-4-yl]-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-4-yl]methyl]methanesulfonamide
Show/Hide
|
C18H23N7O2S
|
1
|
1 |
EC50 > 3500 nM
|
|
|
CP0207474
|
N-[[3-[1-(2-cyanoethyl)piperidin-4-yl]-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-4-yl]methyl]acetamide
Show/Hide
|
C19H23N7O
|
1
|
1 |
EC50 > 3800 nM
|
|
|
CP0270257
|
N-[2-[3-[1-(2-cyanoethyl)piperidin-4-yl]-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-4-yl]ethyl]methanesulfonamide
Show/Hide
|
C19H25N7O2S
|
1
|
1 |
EC50 > 6000 nM
|
|
|
CP0369175
|
N-[2-[3-[1-(2-cyanoethyl)piperidin-4-yl]-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-4-yl]ethyl]acetamide
Show/Hide
|
C20H25N7O
|
1
|
1 |
EC50 > 6500 nM
|
|
|
CP0351812
|
2-(dimethylamino)-1-[4-(3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-3-yl)piperidin-1-yl]ethanone
Show/Hide
|
C17H22N6O
|
1
|
1 |
EC50 > 7100 nM
|
|
|
CP0257242
|
[(2S)-1-methylpyrrolidin-2-yl]-[4-(3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-3-yl)piperidin-1-yl]methanone
Show/Hide
|
C19H24N6O
|
1
|
1 |
EC50 > 8600 nM
|
|
|
CP0355898
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[(2S)-1-propan-2-ylpyrrolidin-2-yl]-[4-(3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-3-yl)piperidin-1-yl]methanone
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C21H28N6O
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1
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1 |
EC50 > 8800 nM
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CP0644560
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4-((cis-1-(4-Chlorobenzyl)-2-methylpiperidin-4-yl)amino)-N-methyl-1H-pyrrolo[2,3-b]pyridine-5-carboxamide
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C22H26ClN5O
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1
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1 |
IC50 = 230 nM
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