General Information of the Compound
Compound ID
CP0146867
Compound Name
CHEMBL2322135
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Formula
C14H16N4
Molecular Weight
240.31
Canonical SMILES
C1CCC(CC1)c1n[nH]c2cnc3[nH]ccc3c12
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InChI
InChI=1S/C14H16N4/c1-2-4-9(5-3-1)13-12-10-6-7-15-14(10)16-8-11(12)17-18-13/h6-9H,1-5H2,(H,15,16)(H,17,18)
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InChIKey
NQKQBQVEFPTHFU-UHFFFAOYSA-N
Physicochemical Property
logP
3.4869
Rotatable Bonds
1
Heavy Atom Count
18
Polar Areas
57.36
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
2
Complexity
18

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
SID: 163513871
ChEMBL ID
CHEMBL2322135
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01659, Tyrosine-protein kinase JAK1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000128 TF-1 Homo sapiens (Human)  1
1
EC50 = 170 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 3 nM
Protein ID: PT01214, Tyrosine-protein kinase JAK2
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000545 UT-7 Homo sapiens (Human)  1
1
EC50 = 4200 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 10 nM