Brief Information of the Compound and Protein
Compound Name
 Compound Info 
(1R)-1-[3-(1-ethyl-3,3-difluoropiperidin-4-yl)-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-4-yl]ethanol
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 PubChem ID
CID: 71681695
Canonical SMILES
CCN1CCC(n2c(nc3cnc4[nH]ccc4c23)[C@@H](C)O)C(F)(F)C1
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Compound Formula C17H21F2N5O
Compound Structure
Protein Name
 Protein Info 
Tyrosine-protein kinase JAK1
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TK protein kinase group
>
Tyrosine protein kinase JakB family
Uniprot ID
P23458
Gene Name
JAK1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000128 TF-1
 Cell Line Info 
Homo sapiens (Human)  2
1
EC50 = 88 nM
   TI
   LI
   LO
   TS
2
EC50 = 330 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Ki = 2 nM