(2S)-N-[(1S)-1-cyano-2-[4-(4-cyano-3-methylsulfanylphenyl)phenyl]ethyl]piperidine-2-carboxamide

N-[5-[6-[4-[4-(dimethylamino)piperidin-1-yl]-2-methoxyanilino]-3-piperidin-1-ylpyridin-2-yl]oxy-2-methylphenyl]prop-2-enamide

N-[5-[6-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]-3-piperidin-1-ylpyridin-2-yl]oxy-2-(trifluoromethyl)phenyl]prop-2-enamide

N-[5-[6-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]-3-piperidin-1-ylpyridin-2-yl]oxy-2-methylphenyl]prop-2-enamide

N-[2-methyl-5-[6-[4-(4-methylpiperazin-1-yl)anilino]-3-piperidin-1-ylpyridin-2-yl]oxyphenyl]prop-2-enamide

N-[5-[6-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]-3-(4-methylpiperazin-1-yl)pyridin-2-yl]oxy-2-methylphenyl]prop-2-enamide

1-amino-N-[(1S)-1-cyano-2-[4-(4-cyanophenyl)phenyl]ethyl]cyclohexane-1-carboxamide

N-[5-[6-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]-3-morpholin-4-ylpyridin-2-yl]oxy-2-methylphenyl]prop-2-enamide

N-[5-[3-(3-hydroxypiperidin-1-yl)-6-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyridin-2-yl]oxy-2-methylphenyl]prop-2-enamide

4-amino-N-[(1S)-1-cyano-2-[4-(4-cyanophenyl)phenyl]ethyl]oxane-4-carboxamide

N-[5-[6-[[2-methoxy-6-(4-methylpiperazin-1-yl)pyridin-3-yl]amino]-3-piperidin-1-ylpyridin-2-yl]oxy-2-methylphenyl]prop-2-enamide

N-[5-[6-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]-3-pyrrolidin-1-ylpyridin-2-yl]oxy-2-(trifluoromethyl)phenyl]prop-2-enamide

(2S)-N-[(1S)-1-cyano-2-[4-(2-methyl-1-oxo-3H-isoindol-5-yl)phenyl]ethyl]piperidine-2-carboxamide

4-amino-N-[(1S)-1-cyano-2-[4-(3-methylsulfonylphenyl)phenyl]ethyl]oxane-4-carboxamide

(2S)-N-[(1S)-1-cyano-2-[4-(4-cyanophenyl)phenyl]ethyl]piperidine-2-carboxamide

(2S)-N-[(1S)-1-cyano-2-[4-(3-methyl-2-oxo-1,3-benzoxazol-5-yl)phenyl]ethyl]-1,4-oxazepane-2-carboxamide

N-[5-[6-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]-3-pyrrolidin-1-ylpyridin-2-yl]oxy-2-methylphenyl]prop-2-enamide

(2S,4S)-N-[(1S)-1-cyano-2-[4-(4-cyanophenyl)phenyl]ethyl]-4-hydroxypiperidine-2-carboxamide

N-[2-methoxy-5-[6-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]-3-pyrrolidin-1-ylpyridin-2-yl]oxyphenyl]prop-2-enamide

5-chloro-2-N-[5-(4-methylpiperazin-1-yl)pyridin-2-yl]-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine

N-[5-[3-(3-hydroxypyrrolidin-1-yl)-6-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyridin-2-yl]oxy-2-methylphenyl]prop-2-enamide

4-amino-N-[(1S)-1-cyano-2-(4-phenylphenyl)ethyl]oxane-4-carboxamide

5-chloro-2-N-[5-(4-ethylpiperazin-1-yl)pyridin-2-yl]-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine

(2S,4S)-N-[(1S)-1-cyano-2-[4-(2-methyl-1-oxo-3H-isoindol-5-yl)phenyl]ethyl]-4-hydroxypiperidine-2-carboxamide

5-chloro-2-N-(5-thiophen-3-ylpyridin-2-yl)-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine

5-chloro-2-N-[5-[4-(dimethylamino)piperidin-1-yl]pyridin-2-yl]-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine

4-amino-N-[(1S)-1-cyano-2-[4-(2-methyl-3-oxo-1H-isoindol-5-yl)phenyl]ethyl]oxane-4-carboxamide

5-chloro-2-N-(5-piperazin-1-ylpyridin-2-yl)-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine

(S)-2-amino-N-((S)-2-(biphenyl-4-yl)-1-cyanoethyl)butanamide

N-[4-[[5-chloro-2-[(5-thiophen-3-ylpyridin-2-yl)amino]pyrimidin-4-yl]amino]phenyl]acetamide

5-fluoro-2-N-[5-(4-methylpiperazin-1-yl)pyridin-2-yl]-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine

5-chloro-2-N-[5-(4-propylpiperazin-1-yl)pyridin-2-yl]-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine

5-chloro-N-[4-(4-methylpiperazin-1-yl)phenyl]-4-[3-(trifluoromethyl)phenoxy]pyrimidin-2-amine

5-chloro-2-N-[6-(4-methylpiperazin-1-yl)pyridin-3-yl]-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine

5-chloro-2-N-(6-thiophen-3-ylpyridazin-3-yl)-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine

5-fluoro-2-N-(5-thiophen-3-ylpyridin-2-yl)-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine

5-chloro-2-N-(5-thiophen-3-ylpyridin-2-yl)-4-N-[[4-(trifluoromethyl)phenyl]methyl]pyrimidine-2,4-diamine

5-methyl-2-N-(5-thiophen-3-ylpyridin-2-yl)-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine

2-N-(5-thiophen-3-ylpyridin-2-yl)-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine

5-methoxy-2-N-(5-thiophen-3-ylpyridin-2-yl)-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine

N-[4-[2-[(5-thiophen-3-ylpyridin-2-yl)amino]-4-[3-(trifluoromethyl)anilino]pyrimidin-5-yl]phenyl]acetamide

5-chloro-4-N-(4-fluorophenyl)-2-N-(5-thiophen-3-ylpyridin-2-yl)pyrimidine-2,4-diamine

5-chloro-2-N-(5-thiophen-3-ylpyridin-2-yl)-4-N-[4-(trifluoromethoxy)phenyl]pyrimidine-2,4-diamine

4-N-(4-aminophenyl)-5-chloro-2-N-(5-thiophen-3-ylpyridin-2-yl)pyrimidine-2,4-diamine

5-chloro-2-N-[5-[4-(dimethylamino)phenyl]pyridin-2-yl]-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine

N-[3-[[5-chloro-2-[(5-thiophen-3-ylpyridin-2-yl)amino]pyrimidin-4-yl]amino]phenyl]acetamide

5-chloro-2-N-[6-(4-methylpiperazin-1-yl)pyridazin-3-yl]-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine

5-chloro-4-N-piperidin-4-yl-2-N-(5-thiophen-3-ylpyridin-2-yl)pyrimidine-2,4-diamine

5-chloro-2-N-(5-thiophen-2-ylpyridin-2-yl)-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine

5-chloro-4-N-pyridin-2-yl-2-N-(5-thiophen-3-ylpyridin-2-yl)pyrimidine-2,4-diamine

5-chloro-N-[5-(4-methylpiperazin-1-yl)pyridin-2-yl]-4-[3-(trifluoromethyl)phenoxy]pyrimidin-2-amine

5-chloro-2-N-[2-(4-methylpiperazin-1-yl)pyrimidin-5-yl]-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine

5-methoxy-2-N-[5-(4-methylpiperazin-1-yl)pyridin-2-yl]-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine

4-N-(3-aminophenyl)-5-chloro-2-N-(5-thiophen-3-ylpyridin-2-yl)pyrimidine-2,4-diamine

(2S)-N-[(1S)-1-cyano-2-(4-phenylphenyl)ethyl]piperidine-2-carboxamide

5-chloro-4-N-(3,4-difluorophenyl)-2-N-(5-thiophen-3-ylpyridin-2-yl)pyrimidine-2,4-diamine

5-chloro-2-N-(6-thiophen-3-ylpyridin-3-yl)-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine

5-chloro-4-N-[4-fluoro-3-(trifluoromethyl)phenyl]-2-N-(5-thiophen-3-ylpyridin-2-yl)pyrimidine-2,4-diamine

5-chloro-2-N-(5-thiophen-3-ylpyridin-2-yl)-4-N-[3-(trifluoromethoxy)phenyl]pyrimidine-2,4-diamine

5-chloro-2-N-(5-thiophen-3-ylpyridin-2-yl)-4-N-[4-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine

2-N-[5-(4-aminopiperidin-1-yl)pyridin-2-yl]-5-chloro-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine

5-chloro-2-N-(3-nitro-5-thiophen-3-ylpyridin-2-yl)-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine

5-bromo-2-N-(5-thiophen-3-ylpyridin-2-yl)-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine

5-chloro-2-N-(3-thiophen-3-ylphenyl)-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine

5-chloro-2-N-pyridin-2-yl-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine

5-methyl-2-N-[5-(4-methylpiperazin-1-yl)pyridin-2-yl]-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine

2-N-[5-(1,3,4,6,7,8,9,9a-octahydropyrido[1,2-a]pyrazin-2-yl)pyridin-2-yl]-5-chloro-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine

5-chloro-2-N-(4-thiophen-3-ylpyridin-2-yl)-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine

2-N-[5-(4-aminophenyl)pyridin-2-yl]-5-chloro-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine

5-chloro-2-N-(5-phenylpyridin-2-yl)-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine

5-chloro-2-N-[5-(1-methylpyrazol-4-yl)pyridin-2-yl]-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine

5-(4-chlorophenyl)-2-N-(5-thiophen-3-ylpyridin-2-yl)-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine

5-chloro-2-N-pyridin-3-yl-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine

1-[3-[2-[(5-thiophen-3-ylpyridin-2-yl)amino]-4-[3-(trifluoromethyl)anilino]pyrimidin-5-yl]phenyl]ethanone

4-[2-[(5-thiophen-3-ylpyridin-2-yl)amino]-4-[3-(trifluoromethyl)anilino]pyrimidin-5-yl]benzamide

1-[4-[6-[[5-chloro-4-[3-(trifluoromethyl)anilino]pyrimidin-2-yl]amino]pyridin-3-yl]piperazin-1-yl]ethanone

5-chloro-2-N-phenyl-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine

5-chloro-2-N-[5-(4-cyclopropylpiperazin-1-yl)pyridin-2-yl]-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine

5-chloro-2-N-(4-fluorophenyl)-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine

5-chloro-2-N-[4-(4-methylpiperazin-1-yl)phenyl]-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine

5-chloro-2-N-phenyl-4-N-[3-(trifluoromethoxy)phenyl]pyrimidine-2,4-diamine

5-chloro-2-N-cyclohexyl-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine

5-chloro-2-N-pyridin-4-yl-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine

5-chloro-2-N-(5-thiomorpholin-4-ylpyridin-2-yl)-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine

5-chloro-2-N-pyrimidin-5-yl-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine

5-chloro-2-N-[5-(3,5-dimethyl-1,2-oxazol-4-yl)pyridin-2-yl]-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine

5-chloro-2-N-(3-phenylpropyl)-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine

5-chloro-2-N-pyridazin-3-yl-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine

5-(1-methylpyrazol-4-yl)-2-N-(5-thiophen-3-ylpyridin-2-yl)-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine

5-(3-chlorophenyl)-2-N-(5-thiophen-3-ylpyridin-2-yl)-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine

5-[4-(4-methylpiperazin-1-yl)phenyl]-2-N-(5-thiophen-3-ylpyridin-2-yl)-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine

5-chloro-2-N-(5-thiophen-3-ylpyrazin-2-yl)-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine

5-(4-aminophenyl)-2-N-(5-thiophen-3-ylpyridin-2-yl)-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine

5-chloro-2-N-(5-thiophen-3-ylpyrimidin-2-yl)-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine

5-phenyl-2-N-(5-thiophen-3-ylpyridin-2-yl)-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine

N-[3-[2-[(5-thiophen-3-ylpyridin-2-yl)amino]-4-[3-(trifluoromethyl)anilino]pyrimidin-5-yl]phenyl]acetamide

5-chloro-2-N-[5-(furan-2-yl)pyridin-2-yl]-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine

3-[2-[(5-thiophen-3-ylpyridin-2-yl)amino]-4-[3-(trifluoromethyl)anilino]pyrimidin-5-yl]benzamide

5-[4-[(4-methylpiperazin-1-yl)methyl]phenyl]-2-N-(5-thiophen-3-ylpyridin-2-yl)-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine

5-chloro-2-N-(4-thiophen-3-ylphenyl)-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine

5-(4-methylsulfonylphenyl)-2-N-(5-thiophen-3-ylpyridin-2-yl)-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine

5-pyridin-4-yl-2-N-(5-thiophen-3-ylpyridin-2-yl)-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine

5-(furan-3-yl)-2-N-(5-thiophen-3-ylpyridin-2-yl)-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine

5-(1-methyl-3,6-dihydro-2H-pyridin-4-yl)-2-N-(5-thiophen-3-ylpyridin-2-yl)-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine