| Compound ID |
Compound Name |
Compound Formula |
|
CP0845545
|
(S)-3-(2',2'-Dimethyl-dodecanoyl)amino-caprolactam
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|
C20H38N2O2
|
1
|
| 1 |
ED50 = 0.15 nM
|
|
|
|
CP0428267
|
N-[5-chloro-2-[(E)-3-[(2R,5S)-4-[(4-fluorophenyl)methyl]-2,5-dimethylpiperazin-1-yl]-3-oxoprop-1-enyl]phenyl]acetamide
Show/Hide
|
C24H27ClFN3O2
|
1
|
| 1 |
IC50 = 0.1 nM
|
|
|
|
CP0449101
|
N-[2-[(2S)-3-(5-chlorospiro[3H-1-benzofuran-2,4'-piperidine]-1'-yl)-2-hydroxypropoxy]-4-hydroxyphenyl]acetamide
Show/Hide
|
C23H27ClN2O5
|
2
|
| 1 |
IC50 = 0.36 nM
|
|
|
| 2 |
IC50 = 2 nM
|
|
|
|
CP0853916
|
BX 471
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|
C21H25Cl2FN4O3
|
1
|
| 1 |
IC50 = 0.4 nM
|
|
|
|
CP0434738
|
N-[2-[(2S)-3-(5-fluorospiro[3H-1-benzofuran-2,4'-piperidine]-1'-yl)-2-hydroxypropoxy]-4-hydroxyphenyl]acetamide
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|
C23H27FN2O5
|
2
|
| 1 |
IC50 = 0.52 nM
|
|
|
| 2 |
IC50 = 2.6 nM
|
|
|
|
CP0533941
|
US8536198, 106
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|
C26H40ClN3O4
|
1
|
| 1 |
IC50 = 0.7 nM
|
|
|
|
CP0067613
|
1-[4-(4-chloro-3-methoxyphenyl)piperazin-1-yl]-2-[4-chloro-5-methyl-3-(trifluoromethyl)pyrazol-1-yl]ethanone
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|
C18H19Cl2F3N4O2
|
8
|
| 1 |
IC50 = 0.8 nM
|
|
|
| 2 |
IC50 = 1.5 nM
|
|
|
| 3 |
IC50 = 2.5 nM
|
|
|
| 4 |
IC50 = 3.9 nM
|
|
|
| 5 |
IC50 = 4 nM
|
|
|
| 6 |
IC50 = 4.8 nM
|
|
|
| 7 |
IC50 = 5.5 nM
|
|
|
| 8 |
IC50 = 12 nM
|
|
|
|
CP0378206
|
(R)-1-(2-(3-(4-(4-fluorobenzyl)-2-methylpiperazin-1-yl)-3-oxoprop-1-enyl)-5-chlorophenyl)urea
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|
C22H24ClFN4O2
|
1
|
| 1 |
IC50 = 0.9 nM
|
|
|
|
CP0318827
|
[5-chloro-2-[(2S)-3-(5-chlorospiro[3H-1-benzofuran-2,4'-piperidine]-1'-yl)-2-hydroxypropoxy]-4-hydroxyphenyl]-[(3S)-3-hydroxypyrrolidin-1-yl]methanone
Show/Hide
|
C26H30Cl2N2O6
|
1
|
| 1 |
IC50 = 0.92 nM
|
|
|
|
CP0050382
|
(R)-N-(2-(3-(4-(4-fluorobenzyl)-2-methylpiperazin-1-yl)-3-oxoprop-1-enyl)-5-chlorophenyl)acetamide
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|
C23H25ClFN3O2
|
1
|
| 1 |
IC50 = 1 nM
|
|
|
|
CP0392271
|
N-[5-chloro-2-[(E)-3-[(2S,5R)-4-[(4-fluorophenyl)methyl]-2,5-dimethylpiperazin-1-yl]-3-oxoprop-1-enyl]phenyl]acetamide
Show/Hide
|
C24H27ClFN3O2
|
1
|
| 1 |
IC50 = 1 nM
|
|
|
|
CP0053909
|
1-[(2R)-1-[(4S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl]-3-methyl-1-oxobutan-2-yl]-3-(2-hydroxy-2-methylpropyl)urea
Show/Hide
|
C23H36ClN3O4
|
10
|
| 1 |
IC50 = 1 nM
|
|
|
| 2 |
IC50 = 1.5 nM
|
|
|
| 3 |
IC50 = 3.2 nM
|
|
|
| 4 |
IC50 = 3.3 nM
|
|
|
| 5 |
IC50 = 5.5 nM
|
|
|
| 6 |
IC50 = 6 nM
|
|
|
| 7 |
IC50 = 7.5 nM
|
|
|
| 8 |
IC50 = 9.3 nM
|
|
|
| 9 |
IC50 = 14.3 nM
|
|
|
| 10 |
IC50 = 16.2 nM
|
|
|
|
CP0540822
|
1-benzyl-3-[(2R)-1-[(4S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl]-3-methyl-1-oxobutan-2-yl]urea
Show/Hide
|
C26H34ClN3O3
|
1
|
| 1 |
IC50 = 1 nM
|
|
|
|
CP0218244
|
US8536198, 80
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|
C26H32ClN3O5S
|
1
|
| 1 |
IC50 = 1 nM
|
|
|
|
CP0491645
|
[2-[(2S)-3-(5-chlorospiro[3H-1-benzofuran-2,4'-piperidine]-1'-yl)-2-hydroxypropoxy]-4-hydroxyphenyl]-(4-hydroxypiperidin-1-yl)methanone
Show/Hide
|
C27H33ClN2O6
|
1
|
| 1 |
IC50 = 1.1 nM
|
|
|
|
CP0215327
|
(R)-1-(2-(2-(4-(4-fluorobenzyl)-2-methylpiperazin-1-yl)-2-oxoethoxy)-5-chlorophenyl)urea hydrochloride
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|
C21H24ClFN4O3
|
3
|
| 1 |
IC50 = 1.1 nM
|
|
|
| 2 |
IC50 = 1.5 nM
|
|
|
| 3 |
IC50 = 18 nM
|
|
|
|
CP0380721
|
[2-[(2S)-3-(5-chlorospiro[3H-1-benzofuran-2,4'-piperidine]-1'-yl)-2-hydroxypropoxy]-4-hydroxyphenyl]-[(3R)-3-(dimethylamino)pyrrolidin-1-yl]methanone
Show/Hide
|
C28H36ClN3O5
|
1
|
| 1 |
IC50 = 1.3 nM
|
|
|
|
CP0324165
|
US8536198, 86
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|
C25H35ClN2O3
|
1
|
| 1 |
IC50 = 1.3 nM
|
|
|
|
CP0347499
|
2-[(2S)-3-(5-chlorospiro[3H-1-benzofuran-2,4'-piperidine]-1'-yl)-2-hydroxypropoxy]-N-cyclopropyl-4-hydroxybenzamide
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|
C25H29ClN2O5
|
1
|
| 1 |
IC50 = 1.4 nM
|
|
|
|
CP0529620
|
2-[(2S)-3-(5-chlorospiro[3H-1-benzofuran-2,4'-piperidine]-1'-yl)-2-hydroxypropoxy]-N-cyclopropyl-4-fluorobenzamide
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|
C25H28ClFN2O4
|
1
|
| 1 |
IC50 = 1.4 nM
|
|
|
|
CP0378207
|
(R)-N-(2-(3-(4-(4-fluorobenzyl)-2-methylpiperazin-1-yl)-3-oxoprop-1-enyl)-5-chloro-4-methoxyphenyl)acetamide
Show/Hide
|
C24H27ClFN3O3
|
1
|
| 1 |
IC50 = 1.5 nM
|
|
|
|
CP0959238
|
(S)-N-(4-(4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-2-methyl-4-oxobutan-2-yl)-4,6-dimethylnicotinamide trifluoroacetate
Show/Hide
|
C28H35ClF3N3O5
|
1
|
| 1 |
IC50 = 1.5 nM
|
|
|
|
CP0576017
|
US8536198, 84
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|
C25H35ClN2O4
|
1
|
| 1 |
IC50 = 1.5 nM
|
|
|
|
CP0188479
|
US8536198, 85
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|
C27H31ClN2O5
|
1
|
| 1 |
IC50 = 1.6 nM
|
|
|
|
CP0944248
|
(S)-N-(4-(4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-2-methyl-4-oxobutan-2-yl)cyclopentanecarboxamide
Show/Hide
|
C24H35ClN2O3
|
1
|
| 1 |
IC50 = 1.7 nM
|
|
|
|
CP0359839
|
2-[(2S)-3-(5-chlorospiro[3H-1-benzofuran-2,4'-piperidine]-1'-yl)-2-hydroxypropoxy]-4-hydroxy-N-methylbenzamide
Show/Hide
|
C23H27ClN2O5
|
1
|
| 1 |
IC50 = 1.8 nM
|
|
|
|
CP0545844
|
[2-[(2S)-3-(5-chlorospiro[3H-1-benzofuran-2,4'-piperidine]-1'-yl)-2-hydroxypropoxy]-4-hydroxyphenyl]-pyrrolidin-1-ylmethanone
Show/Hide
|
C26H31ClN2O5
|
1
|
| 1 |
IC50 = 1.8 nM
|
|
|
|
CP0530986
|
(4S)-4-(4-chlorophenyl)-1-[(3Z)-3-[9-(2-hydroxypropan-2-yl)-5H-[1]benzoxepino[3,4-b]pyridin-11-ylidene]propyl]-3,3-dimethylpiperidin-4-ol
Show/Hide
|
C32H37ClN2O3
|
1
|
| 1 |
IC50 = 1.8 nM
|
|
|
|
CP0960325
|
(S)-N1-(4-(4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-2-methyl-4-oxobutan-2-yl)isophthalamide
Show/Hide
|
C26H32ClN3O4
|
1
|
| 1 |
IC50 = 1.8 nM
|
|
|
|
CP0544478
|
US8536198, 89
Show/Hide
|
C27H32ClN3O4
|
1
|
| 1 |
IC50 = 1.8 nM
|
|
|
|
CP0369450
|
[2-[(2S)-3-(5-chlorospiro[3H-1-benzofuran-2,4'-piperidine]-1'-yl)-2-hydroxypropoxy]-4-hydroxyphenyl]-[(3S)-3-hydroxypyrrolidin-1-yl]methanone
Show/Hide
|
C26H31ClN2O6
|
1
|
| 1 |
IC50 = 1.9 nM
|
|
|
|
CP0944226
|
1-(4-((S)-4-(4-Chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-2-methyl-4-oxobutan-2-yl)-3-((S)-3-hydroxy-3-methylbutan-2-yl)urea
Show/Hide
|
C24H38ClN3O4
|
1
|
| 1 |
IC50 = 1.9 nM
|
|
|
|
CP0558462
|
1-[(2S)-4-(4-chloro-3-methoxyphenyl)-2-methylpiperazin-1-yl]-2-[4-chloro-5-methyl-3-(trifluoromethyl)pyrazol-1-yl]ethanone
Show/Hide
|
C19H21Cl2F3N4O2
|
1
|
| 1 |
IC50 = 2 nM
|
|
|
|
CP0410402
|
1-[(2S)-butan-2-yl]-3-[(2R)-1-[(4S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl]-3-methyl-1-oxobutan-2-yl]urea
Show/Hide
|
C23H36ClN3O3
|
1
|
| 1 |
IC50 = 2 nM
|
|
|
|
CP0379828
|
1-[(2R)-1-[(4S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl]-3-methyl-1-oxobutan-2-yl]-3-[(2S)-2-hydroxypropyl]urea
Show/Hide
|
C22H34ClN3O4
|
2
|
| 1 |
IC50 = 2 nM
|
|
|
| 2 |
IC50 = 7 nM
|
|
|
|
CP0410400
|
1-[(2R)-1-[(4S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl]-3-methyl-1-oxobutan-2-yl]-3-[(1R,3S)-3-hydroxycyclopentyl]urea
Show/Hide
|
C24H36ClN3O4
|
2
|
| 1 |
IC50 = 2 nM
|
|
|
| 2 |
IC50 = 4 nM
|
|
|
|
CP0494325
|
(3R)-N-[(2R)-1-[(4S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl]-3-methyl-1-oxobutan-2-yl]-3-hydroxybutanamide
Show/Hide
|
C22H33ClN2O4
|
1
|
| 1 |
IC50 = 2 nM
|
|
|
|
CP0533048
|
N-[(2R)-1-[(4S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl]-3-methyl-1-oxobutan-2-yl]-4-hydroxy-4-methylpentanamide
Show/Hide
|
C24H37ClN2O4
|
2
|
| 1 |
IC50 = 2 nM
|
|
|
| 2 |
IC50 = 22 nM
|
|
|
|
CP0547485
|
1-[(2R)-1-[(4S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl]-3-methyl-1-oxobutan-2-yl]-3-cyclopentylurea
Show/Hide
|
C24H36ClN3O3
|
2
|
| 1 |
IC50 = 2 nM
|
|
|
| 2 |
IC50 = 3 nM
|
|
|
|
CP0547486
|
1-[(2R)-1-[(4S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl]-3-methyl-1-oxobutan-2-yl]-3-[(2R)-2-hydroxypropyl]urea
Show/Hide
|
C22H34ClN3O4
|
2
|
| 1 |
IC50 = 2 nM
|
|
|
| 2 |
IC50 = 6 nM
|
|
|
|
CP0530142
|
US8536198, 2
Show/Hide
|
C27H33ClN2O3
|
1
|
| 1 |
IC50 = 2.1 nM
|
|
|
|
CP0882223
|
(S)-N-(4-(4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-2-methyl-4-oxobutan-2-yl)-3-(1H-tetrazol-1-yl)benzamide
Show/Hide
|
C26H31ClN6O3
|
1
|
| 1 |
IC50 = 2.2 nM
|
|
|
|
CP0378007
|
(R)-N-(2-(2-(4-(4-fluorobenzyl)-2-methylpiperazin-1-yl)-2-oxoethylamino)-5-chlorophenyl)acetamide
Show/Hide
|
C22H26ClFN4O2
|
1
|
| 1 |
IC50 = 2.4 nM
|
|
|
|
CP0105187
|
[2-[(2S)-3-(5-chlorospiro[3H-1-benzofuran-2,4'-piperidine]-1'-yl)-2-hydroxypropoxy]-4-fluorophenyl]-[(3S)-3-hydroxypyrrolidin-1-yl]methanone
Show/Hide
|
C26H30ClFN2O5
|
1
|
| 1 |
IC50 = 2.5 nM
|
|
|
|
CP0304108
|
2-[(2S)-3-(5-chlorospiro[3H-1-benzofuran-2,4'-piperidine]-1'-yl)-2-hydroxypropoxy]-N-cyclopropyl-4-methoxybenzamide
Show/Hide
|
C26H31ClN2O5
|
1
|
| 1 |
IC50 = 2.5 nM
|
|
|
|
CP0375134
|
2-[(2S)-3-(5-chlorospiro[3H-1-benzofuran-2,4'-piperidine]-1'-yl)-2-hydroxypropoxy]-N-cyclopropylbenzamide
Show/Hide
|
C25H29ClN2O4
|
1
|
| 1 |
IC50 = 2.8 nM
|
|
|
|
CP0216103
|
(R)-2-(4-(4-chlorobenzyl)-5-methyl-4H-1,2,4-triazol-3-yl)-N-(4-(trifluoromethyl)phenyl)pyrrolidine-1-carboxamide
Show/Hide
|
C22H21ClF3N5O
|
1
|
| 1 |
IC50 = 2.9 nM
|
|
|
|
CP0087963
|
N-[(2R)-1-[(4S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl]-3-methyl-1-oxobutan-2-yl]-3-hydroxy-3-methylbutanamide
Show/Hide
|
C23H35ClN2O4
|
2
|
| 1 |
IC50 = 3 nM
|
|
|
| 2 |
Ki = 3.7 nM
|
|
|
|
CP0406205
|
US8633226, 897
Show/Hide
|
C23H36ClN3O3
|
3
|
| 1 |
IC50 = 3 nM
|
|
|
| 2 |
IC50 = 6 nM
|
|
|
| 3 |
Ki = 2.1 nM
|
|
|
|
CP0410401
|
1-[(2R)-1-[(4S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl]-3-methyl-1-oxobutan-2-yl]-3-[(1S,3R)-3-hydroxycyclopentyl]urea
Show/Hide
|
C24H36ClN3O4
|
2
|
| 1 |
IC50 = 3 nM
|
|
|
| 2 |
IC50 = 6 nM
|
|
|
|
CP0553562
|
1-[(2R)-1-[(4S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl]-3-methyl-1-oxobutan-2-yl]-3-[(1S,3S)-3-hydroxycyclopentyl]urea
Show/Hide
|
C24H36ClN3O4
|
2
|
| 1 |
IC50 = 3 nM
|
|
|
| 2 |
IC50 = 10 nM
|
|
|
|
CP0105188
|
2-[(2S)-3-(5-fluorospiro[3H-1-benzofuran-2,4'-piperidine]-1'-yl)-2-hydroxypropoxy]-4-hydroxy-N-methylbenzamide
Show/Hide
|
C23H27FN2O5
|
1
|
| 1 |
IC50 = 3.2 nM
|
|
|
|
CP0296778
|
(R)-3-(2-(2-(4-(4-fluorobenzyl)-2-methylpiperazin-1-yl)-2-oxoethoxy)-5-chlorophenylamino)-4-aminocyclobut-3-ene-1,2-dione
Show/Hide
|
C24H24ClFN4O4
|
3
|
| 1 |
IC50 = 4 nM
|
|
|
| 2 |
IC50 = 7 nM
|
|
|
| 3 |
IC50 = 10 nM
|
|
|
|
CP0477552
|
(R)-2-(4-(4-chlorobenzyl)-4H-1,2,4-triazol-3-yl)-N-(4-(trifluoromethyl)phenyl)pyrrolidine-1-carboxamide
Show/Hide
|
C21H19ClF3N5O
|
1
|
| 1 |
IC50 = 4 nM
|
|
|
|
CP0406206
|
1-[(2R)-1-[(4S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl]-3-methyl-1-oxobutan-2-yl]-3-[(1R,3R)-3-hydroxycyclopentyl]urea
Show/Hide
|
C24H36ClN3O4
|
2
|
| 1 |
IC50 = 4 nM
|
|
|
| 2 |
IC50 = 19 nM
|
|
|
|
CP0557774
|
1-[4-(4-chloro-3-methoxyphenyl)piperazin-1-yl]-2-[3-(1H-imidazol-2-yl)pyrazolo[3,4-b]pyridin-1-yl]ethanone
Show/Hide
|
C22H22ClN7O2
|
1
|
| 1 |
IC50 = 4 nM
|
|
|
|
CP0144183
|
(R)-3-(2-(2-(4-(4-fluorobenzyl)-2-methylpiperazin-1-yl)-2-oxoethoxy)-5-chlorophenylamino)-4-(2-(piperazin-1-yl)ethylamino)cyclobut-3-ene-1,2-dione
Show/Hide
|
C30H36ClFN6O4
|
3
|
| 1 |
IC50 = 5 nM
|
|
|
| 2 |
IC50 = 39 nM
|
|
|
| 3 |
IC50 = 50 nM
|
|
|
|
CP0483884
|
1-[4-(4-chloro-3-methoxyphenyl)piperazin-1-yl]-2-[4-fluoro-5-methyl-3-(trifluoromethyl)pyrazol-1-yl]ethanone
Show/Hide
|
C18H19ClF4N4O2
|
1
|
| 1 |
IC50 = 5 nM
|
|
|
|
CP0540295
|
1-[4-(4-chloro-3-fluoro-5-methoxyphenyl)piperazin-1-yl]-2-[4-chloro-5-methyl-3-(trifluoromethyl)pyrazol-1-yl]ethanone
Show/Hide
|
C18H18Cl2F4N4O2
|
1
|
| 1 |
IC50 = 5 nM
|
|
|
|
CP0541189
|
[2-[(2S)-3-(5-chlorospiro[3H-1-benzofuran-2,4'-piperidine]-1'-yl)-2-hydroxypropoxy]-4-methylphenyl]-[(3S)-3-hydroxypyrrolidin-1-yl]methanone
Show/Hide
|
C27H33ClN2O5
|
1
|
| 1 |
IC50 = 5 nM
|
|
|
|
CP0481604
|
(R)-N2-(4-Chlorobenzyl)-N1-[2,6-dimethyl-4-(trifluoromethyl)phenyl]-N2-methylpyrrolidine-1,2-dicarboxamide
Show/Hide
|
C23H25ClF3N3O2
|
1
|
| 1 |
IC50 = 6 nM
|
|
|
|
CP0144184
|
(R)-3-(2-(2-(4-(4-fluorobenzyl)-2-methylpiperazin-1-yl)-2-oxoethoxy)-5-chlorophenylamino)-4-(2-aminoethylamino)cyclobut-3-ene-1,2-dione
Show/Hide
|
C26H29ClFN5O4
|
3
|
| 1 |
IC50 = 6 nM
|
|
|
| 2 |
IC50 = 18 nM
|
|
|
| 3 |
IC50 = 23 nM
|
|
|
|
CP0444718
|
(R,E)-3-(2-(3-(4-(4-fluorobenzyl)-2-methylpiperazin-1-yl)-3-oxoprop-1-enyl)-5-chlorophenylamino)-4-aminocyclobut-3-ene-1,2-dione
Show/Hide
|
C25H24ClFN4O3
|
2
|
| 1 |
IC50 = 6 nM
|
|
|
| 2 |
IC50 = 7 nM
|
|
|
|
CP0497444
|
1-[2-[4-(4-chloro-3-methoxyphenyl)piperazin-1-yl]-2-oxoethyl]-5-methyl-3-(trifluoromethyl)pyrazole-4-carbonitrile
Show/Hide
|
C19H19ClF3N5O2
|
1
|
| 1 |
IC50 = 6 nM
|
|
|
|
CP0497208
|
(R)-2-(1-(4-chlorobenzyl)-1H-tetrazol-5-yl)-N-(4-(trifluoromethyl)phenyl)pyrrolidine-1-carboxamide
Show/Hide
|
C20H18ClF3N6O
|
1
|
| 1 |
IC50 = 6.5 nM
|
|
|
|
CP0497445
|
1-[4-(4-chloro-3-methoxyphenyl)piperazin-1-yl]-2-[4-iodo-5-methyl-3-(trifluoromethyl)pyrazol-1-yl]ethanone
Show/Hide
|
C18H19ClF3IN4O2
|
1
|
| 1 |
IC50 = 7 nM
|
|
|
|
CP0359837
|
[2-[(2S)-3-(5-chlorospiro[3H-1-benzofuran-2,4'-piperidine]-1'-yl)-2-hydroxypropoxy]-4-hydroxyphenyl]-piperidin-1-ylmethanone
Show/Hide
|
C27H33ClN2O5
|
1
|
| 1 |
IC50 = 7.1 nM
|
|
|
|
CP0347497
|
[2-[(2S)-3-(5-chlorospiro[3H-1-benzofuran-2,4'-piperidine]-1'-yl)-2-hydroxypropoxy]-4-hydroxyphenyl]-[(3R)-3-hydroxypyrrolidin-1-yl]methanone
Show/Hide
|
C26H31ClN2O6
|
1
|
| 1 |
IC50 = 7.9 nM
|
|
|
|
CP0491644
|
[2-[(2S)-3-(5-chlorospiro[3H-1-benzofuran-2,4'-piperidine]-1'-yl)-2-hydroxypropoxy]-4-hydroxyphenyl]-[(3S)-3-methoxypyrrolidin-1-yl]methanone
Show/Hide
|
C27H33ClN2O6
|
1
|
| 1 |
IC50 = 7.9 nM
|
|
|
|
CP0144182
|
(R)-3-(2-(2-(4-(4-fluorobenzyl)-2-methylpiperazin-1-yl)-2-oxoethoxy)-5-chlorophenylamino)-4-(pyridin-3-ylmethylamino)cyclobut-3-ene-1,2-dione
Show/Hide
|
C30H29ClFN5O4
|
3
|
| 1 |
IC50 = 8 nM
|
|
|
| 2 |
IC50 = 38 nM
|
|
|
| 3 |
IC50 = 42 nM
|
|
|
|
CP0493981
|
N-[(2R)-1-[4-(4-chlorophenyl)piperidin-1-yl]-3-methyl-1-oxobutan-2-yl]-2-cyclohexylacetamide
Show/Hide
|
C24H35ClN2O2
|
1
|
| 1 |
IC50 = 8 nM
|
|
|
|
CP0450252
|
2-[4-bromo-5-methyl-3-(trifluoromethyl)pyrazol-1-yl]-1-[4-(4-chloro-3-methoxyphenyl)piperazin-1-yl]ethanone
Show/Hide
|
C18H19BrClF3N4O2
|
1
|
| 1 |
IC50 = 8 nM
|
|
|
|
CP0558463
|
1-[4-(4-chloro-3-methoxyphenyl)piperazin-1-yl]-2-(4-chloro-5-methyl-3-propan-2-ylpyrazol-1-yl)ethanone
Show/Hide
|
C20H26Cl2N4O2
|
1
|
| 1 |
IC50 = 8 nM
|
|
|
|
CP0405972
|
[2-[(2S)-3-(5-fluorospiro[3H-1-benzofuran-2,4'-piperidine]-1'-yl)-2-hydroxypropoxy]-4-methylphenyl]-[(3S)-3-hydroxypyrrolidin-1-yl]methanone
Show/Hide
|
C27H33FN2O5
|
1
|
| 1 |
IC50 = 8.9 nM
|
|
|
|
CP0378208
|
N-[5-chloro-2-[(E)-3-[3-[(4-fluorophenyl)methyl]-3,8-diazabicyclo[3.2.1]octan-8-yl]-3-oxoprop-1-enyl]phenyl]-2-(dimethylamino)acetamide
Show/Hide
|
C26H30ClFN4O2
|
1
|
| 1 |
IC50 = 9 nM
|
|
|
|
CP0540824
|
N-[(2R)-1-[(4S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl]-3-methyl-1-oxobutan-2-yl]pyrrolidine-1-carboxamide
Show/Hide
|
C23H34ClN3O3
|
1
|
| 1 |
IC50 = 9 nM
|
|
|
|
CP0378209
|
(R)-N-(2-(1-(4-fluorobenzyl)-3-methylpiperazine-4-carbonyl)-5-chloro-1H-indol-7-yl)acetamide
Show/Hide
|
C23H24ClFN4O2
|
1
|
| 1 |
IC50 = 9.6 nM
|
|
|
|
CP0448831
|
1-[4-(4-chloro-3-methoxyphenyl)piperazin-1-yl]-2-(4-chloro-5-methyl-3-methylsulfonylpyrazol-1-yl)ethanone
Show/Hide
|
C18H22Cl2N4O4S
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0450236
|
2-[4-chloro-5-methyl-3-(trifluoromethyl)pyrazol-1-yl]-1-[4-(3,4-dichloro-5-methoxyphenyl)piperazin-1-yl]ethanone
Show/Hide
|
C18H18Cl3F3N4O2
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0497442
|
4-chloro-1-[2-[4-(4-chloro-3-methoxyphenyl)piperazin-1-yl]-2-oxoethyl]-5-methylpyrazole-3-carbonitrile
Show/Hide
|
C18H19Cl2N5O2
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0506987
|
2-[4-chloro-5-(hydroxymethyl)-3-(trifluoromethyl)pyrazol-1-yl]-1-[4-(4-chloro-3-methoxyphenyl)piperazin-1-yl]ethanone
Show/Hide
|
C18H19Cl2F3N4O3
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0497458
|
1-[(2S)-4-(4-chloro-3-methoxyphenyl)-2-(hydroxymethyl)piperazin-1-yl]-2-[4-chloro-5-methyl-3-(trifluoromethyl)pyrazol-1-yl]ethanone
Show/Hide
|
C19H21Cl2F3N4O3
|
1
|
| 1 |
IC50 = 11 nM
|
|
|
|
CP0379829
|
(3S)-N-[(2R)-1-[(4S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl]-3-methyl-1-oxobutan-2-yl]-3-hydroxybutanamide
Show/Hide
|
C22H33ClN2O4
|
1
|
| 1 |
IC50 = 11 nM
|
|
|
|
CP0960328
|
3-((1R,2S)-2-((S)-4-(4-Cyanophenyl)-4-hydroxy-3,3-dimethylpiperidine-1-carbonyl)cyclohexylcarbamoyl)benzoic acid
Show/Hide
|
C29H33N3O5
|
1
|
| 1 |
IC50 = 11.3 nM
|
|
|
|
CP0365664
|
US8536198, 9
Show/Hide
|
C26H32ClN3O3
|
1
|
| 1 |
IC50 = 11.5 nM
|
|
|
|
CP0199955
|
(R)-3-(2-(2-(4-(4-fluorobenzyl)-2-methylpiperazin-1-yl)-2-oxoethoxy)-5-chlorophenylamino)-4-(2-morpholinoethylamino)cyclobut-3-ene-1,2-dione
Show/Hide
|
C30H35ClFN5O5
|
1
|
| 1 |
IC50 = 12 nM
|
|
|
|
CP0450237
|
1-[4-(4-chloro-3-ethoxyphenyl)piperazin-1-yl]-2-[4-chloro-5-methyl-3-(trifluoromethyl)pyrazol-1-yl]ethanone
Show/Hide
|
C19H21Cl2F3N4O2
|
1
|
| 1 |
IC50 = 12 nM
|
|
|
|
CP0544023
|
1-[4-[4-chloro-3-(hydroxymethyl)-5-methoxyphenyl]piperazin-1-yl]-2-[4-chloro-5-methyl-3-(trifluoromethyl)pyrazol-1-yl]ethanone
Show/Hide
|
C19H21Cl2F3N4O3
|
1
|
| 1 |
IC50 = 12 nM
|
|
|
|
CP0491643
|
[4-fluoro-2-[(2S)-3-(5-fluorospiro[3H-1-benzofuran-2,4'-piperidine]-1'-yl)-2-hydroxypropoxy]phenyl]-[(3S)-3-hydroxypyrrolidin-1-yl]methanone
Show/Hide
|
C26H30F2N2O5
|
1
|
| 1 |
IC50 = 12 nM
|
|
|
|
CP0541188
|
2-[(2S)-3-(5-chlorospiro[3H-1-benzofuran-2,4'-piperidine]-1'-yl)-2-hydroxypropoxy]-4-hydroxy-N-(2-hydroxyethyl)benzamide
Show/Hide
|
C24H29ClN2O6
|
1
|
| 1 |
IC50 = 12 nM
|
|
|
|
CP0328895
|
US8536198, 7
Show/Hide
|
C24H35ClN2O4
|
1
|
| 1 |
IC50 = 12.1 nM
|
|
|
|
CP0428270
|
(R)-N-(3-(3-(4-(4-fluorobenzyl)-2-methylpiperazin-1-yl)-3-oxoprop-1-enyl)naphthalen-2-yl)acetamide
Show/Hide
|
C27H28FN3O2
|
1
|
| 1 |
IC50 = 13 nM
|
|
|
|
CP0167358
|
(R)-3-(2-(2-(4-(4-fluorobenzyl)-2-methylpiperazin-1-yl)-2-oxoethoxy)-5-chlorophenylamino)-4-(2-hydroxyethylamino)cyclobut-3-ene-1,2-dione
Show/Hide
|
C26H28ClFN4O5
|
3
|
| 1 |
IC50 = 13 nM
|
|
|
| 2 |
IC50 = 20 nM
|
|
|
| 3 |
IC50 = 47 nM
|
|
|
|
CP0513972
|
N-[(2R)-1-[4-(4-chlorophenyl)piperidin-1-yl]-3-methyl-1-oxobutan-2-yl]-2-(2-fluorophenyl)acetamide
Show/Hide
|
C24H28ClFN2O2
|
1
|
| 1 |
IC50 = 13 nM
|
|
|
|
CP0461447
|
(R)-3-(2-(2-(4-(4-fluorobenzyl)-2-methylpiperazin-1-yl)-2-oxoethoxy)-5-bromophenylamino)-4-(methylamino)cyclobut-3-ene-1,2-dione
Show/Hide
|
C25H26BrFN4O4
|
2
|
| 1 |
IC50 = 14 nM
|
|
|
| 2 |
IC50 = 25 nM
|
|
|
|
CP0521113
|
N-[(2R)-1-[4-(4-chlorophenyl)piperidin-1-yl]-3-methyl-1-oxobutan-2-yl]-3,4-difluorobenzamide
Show/Hide
|
C23H25ClF2N2O2
|
1
|
| 1 |
IC50 = 14 nM
|
|
|
|
CP0450253
|
1-[4-(3-bromo-4-chloro-5-methoxyphenyl)piperazin-1-yl]-2-[4-chloro-5-methyl-3-(trifluoromethyl)pyrazol-1-yl]ethanone
Show/Hide
|
C18H18BrCl2F3N4O2
|
1
|
| 1 |
IC50 = 14 nM
|
|
|
|
CP0533942
|
US8536198, 83
Show/Hide
|
C25H35ClN2O4
|
1
|
| 1 |
IC50 = 14 nM
|
|
|
|
CP0346252
|
US8536198, 76
Show/Hide
|
C24H36ClN3O4
|
1
|
| 1 |
IC50 = 14.6 nM
|
|
|
|
CP0485080
|
(R)-3-(2-(2-(4-(4-fluorobenzyl)-2-methylpiperazin-1-yl)-2-oxoethoxy)-5-chlorophenylamino)-4-(pyridin-2-ylmethylamino)cyclobut-3-ene-1,2-dione
Show/Hide
|
C30H29ClFN5O4
|
1
|
| 1 |
IC50 = 15 nM
|
|
|
|
CP0087964
|
N-[(2R)-1-[4-(4-chlorophenyl)piperidin-1-yl]-3-methyl-1-oxobutan-2-yl]benzamide
Show/Hide
|
C23H27ClN2O2
|
4
|
| 1 |
IC50 = 15 nM
|
|
|
| 2 |
IC50 = 28 nM
|
|
|
| 3 |
IC50 = 78 nM
|
|
|
| 4 |
IC50 = 85 nM
|
|
|
|
CP0561610
|
US8536198, 60
Show/Hide
|
C29H37ClN2O3
|
1
|
| 1 |
IC50 = 15.7 nM
|
|
|
|
CP0519220
|
(R)-N2-(4-Chlorobenzyl)-N2-methyl-N1-[2-methyl-4-(trifluoromethyl)phenyl]pyrrolidine-1,2-dicarboxamide
Show/Hide
|
C22H23ClF3N3O2
|
1
|
| 1 |
IC50 = 16 nM
|
|
|
|
CP0502267
|
2-(1-(4-chlorobenzyl)-1H-imidazol-2-yl)-N-(4-(trifluoromethyl)phenyl)pyrrolidine-1-carboxamide
Show/Hide
|
C22H20ClF3N4O
|
1
|
| 1 |
IC50 = 16 nM
|
|
|
|
CP0544020
|
2-[4-chloro-3-(2-hydroxypropan-2-yl)-5-methylpyrazol-1-yl]-1-[4-(4-chloro-3-methoxyphenyl)piperazin-1-yl]ethanone
Show/Hide
|
C20H26Cl2N4O3
|
1
|
| 1 |
IC50 = 16 nM
|
|
|
|
CP0544022
|
1-[4-[3-(aminomethyl)-4-chloro-5-methoxyphenyl]piperazin-1-yl]-2-[4-chloro-5-methyl-3-(trifluoromethyl)pyrazol-1-yl]ethanone
Show/Hide
|
C19H22Cl2F3N5O2
|
1
|
| 1 |
IC50 = 16 nM
|
|
|
|
CP0201991
|
(R)-3-(2-(2-(4-(4-fluorobenzyl)-2-methylpiperazin-1-yl)-2-oxoethoxy)-5-chlorophenylamino)-4-(methylamino)cyclobut-3-ene-1,2-dione
Show/Hide
|
C25H26ClFN4O4
|
3
|
| 1 |
IC50 = 17 nM
|
|
|
| 2 |
IC50 = 18 nM
|
|
|
| 3 |
IC50 = 26 nM
|
|
|
|
CP0390696
|
US8536198, 11
Show/Hide
|
C27H31ClN2O4
|
1
|
| 1 |
IC50 = 17.2 nM
|
|
|
|
CP0482452
|
N-[(2R)-1-[4-(4-chlorophenyl)piperidin-1-yl]-3-methyl-1-oxobutan-2-yl]-1,3-benzothiazole-2-carboxamide
Show/Hide
|
C24H26ClN3O2S
|
1
|
| 1 |
IC50 = 18 nM
|
|
|
|
CP0521112
|
N-[(2R)-1-[4-(4-chlorophenyl)piperidin-1-yl]-3-methyl-1-oxobutan-2-yl]-3-(2-fluorophenyl)propanamide
Show/Hide
|
C25H30ClFN2O2
|
1
|
| 1 |
IC50 = 18 nM
|
|
|
|
CP0540762
|
1-[4-(4-chloro-3-methoxyphenyl)piperazin-1-yl]-2-[4-chloro-3-(trifluoromethyl)pyrazol-1-yl]ethanone
Show/Hide
|
C17H17Cl2F3N4O2
|
1
|
| 1 |
IC50 = 18 nM
|
|
|
|
CP0443758
|
US8536198, 35
Show/Hide
|
C27H34ClN3O3
|
1
|
| 1 |
IC50 = 18.5 nM
|
|
|
|
CP0263817
|
US8536198, 57
Show/Hide
|
C25H31ClN4O3
|
1
|
| 1 |
IC50 = 18.7 nM
|
|
|
|
CP0485415
|
(R)-3-(2-(2-(4-(4-fluorobenzyl)-2-methylpiperazin-1-yl)-2-oxoethoxy)-5-chlorophenylamino)-4-(2-methoxyethylamino)cyclobut-3-ene-1,2-dione
Show/Hide
|
C27H30ClFN4O5
|
3
|
| 1 |
IC50 = 19 nM
|
|
|
| 2 |
IC50 = 54 nM
|
|
|
| 3 |
IC50 = 63 nM
|
|
|
|
CP0513971
|
N-[(2R)-1-[4-(4-chlorophenyl)piperidin-1-yl]-3-methyl-1-oxobutan-2-yl]-3-(2-methylphenyl)propanamide
Show/Hide
|
C26H33ClN2O2
|
1
|
| 1 |
IC50 = 19 nM
|
|
|
|
CP0483885
|
1-[4-(4-chloro-3-methoxyphenyl)piperazin-1-yl]-2-[5-methyl-3-(trifluoromethyl)pyrazol-1-yl]ethanone
Show/Hide
|
C18H20ClF3N4O2
|
1
|
| 1 |
IC50 = 19 nM
|
|
|
|
CP0442404
|
(R)-N-(6-(3-(4-(4-fluorobenzyl)-2-methylpiperazin-1-yl)-3-oxoprop-1-enyl)quinolin-7-yl)acetamide
Show/Hide
|
C26H27FN4O2
|
1
|
| 1 |
IC50 = 20 nM
|
|
|
|
CP0486637
|
N-[(2R)-1-[4-(4-chlorophenyl)piperidin-1-yl]-3-methyl-1-oxobutan-2-yl]-2-cyclopentylacetamide
Show/Hide
|
C23H33ClN2O2
|
1
|
| 1 |
IC50 = 20 nM
|
|
|
|
CP0544019
|
2-(3-bromo-4-chloro-5-methylpyrazol-1-yl)-1-[4-(4-chloro-3-methoxyphenyl)piperazin-1-yl]ethanone
Show/Hide
|
C17H19BrCl2N4O2
|
1
|
| 1 |
IC50 = 20 nM
|
|
|
|
CP0410399
|
1-[(2R)-1-[(4S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl]-3-methyl-1-oxobutan-2-yl]-3-phenylurea
Show/Hide
|
C25H32ClN3O3
|
1
|
| 1 |
IC50 = 20 nM
|
|
|
|
CP0123841
|
(1S)-N1-(4-chlorobenzyl)-N1-methyl-N2-(4-(trifluoromethyl)phenyl)cyclopentane-1,2-dicarboxamide
Show/Hide
|
C21H21ClF3N3O2
|
1
|
| 1 |
IC50 = 22 nM
|
|
|
|
CP0415595
|
(R)-N2-(4-Chlorobenzyl)-N1-[2-fluoro-4-(trifluoromethyl)phenyl]-N2-methylpyrrolidine-1,2-dicarboxamide
Show/Hide
|
C21H20ClF4N3O2
|
1
|
| 1 |
IC50 = 22 nM
|
|
|
|
CP0502268
|
(R)-2-(1-(4-chlorobenzyl)-1H-1,2,4-triazol-5-yl)-N-(4-(trifluoromethyl)phenyl)pyrrolidine-1-carboxamide
Show/Hide
|
C21H19ClF3N5O
|
1
|
| 1 |
IC50 = 22 nM
|
|
|
|
CP0446126
|
N-[(2R)-1-[4-(4-chlorophenyl)piperidin-1-yl]-3-methyl-1-oxobutan-2-yl]-3-(3-methylphenyl)propanamide
Show/Hide
|
C26H33ClN2O2
|
1
|
| 1 |
IC50 = 22 nM
|
|
|
|
CP0483882
|
1-[(3S)-4-(4-chloro-3-methoxyphenyl)-3-methylpiperazin-1-yl]-2-[4-chloro-5-methyl-3-(trifluoromethyl)pyrazol-1-yl]ethanone
Show/Hide
|
C19H21Cl2F3N4O2
|
1
|
| 1 |
IC50 = 23 nM
|
|
|
|
CP0446129
|
N-[(2R)-1-[4-(4-chlorophenyl)piperidin-1-yl]-3-methyl-1-oxobutan-2-yl]-3-fluorobenzamide
Show/Hide
|
C23H26ClFN2O2
|
1
|
| 1 |
IC50 = 24 nM
|
|
|
|
CP0500523
|
N-[(2R)-1-[4-(4-chlorophenyl)piperidin-1-yl]-3-methyl-1-oxobutan-2-yl]-4-methylbenzamide
Show/Hide
|
C24H29ClN2O2
|
1
|
| 1 |
IC50 = 25 nM
|
|
|
|
CP0524523
|
(R)-3-(2-(2-(4-(4-fluorobenzyl)-2-methylpiperazin-1-yl)-2-oxoethoxy)-5-chlorophenylamino)-4-(pyridin-4-ylmethylamino)cyclobut-3-ene-1,2-dione
Show/Hide
|
C30H29ClFN5O4
|
1
|
| 1 |
IC50 = 26 nM
|
|
|
|
CP0513973
|
N-[(2R)-1-[4-(4-chlorophenyl)piperidin-1-yl]-3-methyl-1-oxobutan-2-yl]-4-methylpentanamide
Show/Hide
|
C22H33ClN2O2
|
1
|
| 1 |
IC50 = 26 nM
|
|
|
|
CP0428291
|
(R)-N-(2-(1-(4-fluorobenzyl)-3-methylpiperazine-4-carbonyl)-5-chlorobenzofuran-7-yl)acetamide
Show/Hide
|
C23H23ClFN3O3
|
1
|
| 1 |
IC50 = 28 nM
|
|
|
|
CP0457670
|
2,6-dichloro-N-[3-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]propyl]benzenesulfonamide
Show/Hide
|
C20H23Cl3N2O3S
|
2
|
| 1 |
IC50 = 30 nM
|
|
|
| 2 |
IC50 = 80 nM
|
|
|
|
CP0516561
|
N-[3-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]propyl]-2-methylbenzenesulfonamide
Show/Hide
|
C21H27ClN2O3S
|
2
|
| 1 |
IC50 = 30 nM
|
|
|
| 2 |
IC50 = 150 nM
|
|
|
|
CP0453963
|
N-[(2R)-1-[4-(4-chlorophenyl)piperidin-1-yl]-3-methyl-1-oxobutan-2-yl]-2-phenylacetamide
Show/Hide
|
C24H29ClN2O2
|
1
|
| 1 |
IC50 = 30 nM
|
|
|
|
CP0482383
|
N-[(2R)-1-[4-(4-chlorophenyl)piperidin-1-yl]-3-methyl-1-oxobutan-2-yl]-3-methylbutanamide
Show/Hide
|
C21H31ClN2O2
|
1
|
| 1 |
IC50 = 32 nM
|
|
|
|
CP0500524
|
N-[(2R)-1-[4-(4-chlorophenyl)piperidin-1-yl]-3-methyl-1-oxobutan-2-yl]-2-methylbenzamide
Show/Hide
|
C24H29ClN2O2
|
1
|
| 1 |
IC50 = 32 nM
|
|
|
|
CP0508644
|
[2-[(2S)-3-(5-chlorospiro[3H-1-benzofuran-2,4'-piperidine]-1'-yl)-2-hydroxypropoxy]-4-hydroxyphenyl]-morpholin-4-ylmethanone
Show/Hide
|
C26H31ClN2O6
|
1
|
| 1 |
IC50 = 32 nM
|
|
|
|
CP0482382
|
N-[(2R,3R)-1-[4-(4-chlorophenyl)piperidin-1-yl]-3-methyl-1-oxopentan-2-yl]-3-methylbutanamide
Show/Hide
|
C22H33ClN2O2
|
1
|
| 1 |
IC50 = 34 nM
|
|
|
|
CP0377457
|
(R)-N2-(4-Chlorobenzyl)-N1-[2-chloro-4-(trifluoromethyl)phenyl]-N2-methylpyrrolidine-1,2-dicarboxamide
Show/Hide
|
C21H20Cl2F3N3O2
|
1
|
| 1 |
IC50 = 35 nM
|
|
|
|
CP0915170
|
(D,L)-N-(1-(4-(4-Chlorophenyl)piperidin-1-yl)-3-methyl-1-oxobutan-2-yl)-3-phenylpropanamide
Show/Hide
|
C25H31ClN2O2
|
1
|
| 1 |
IC50 = 35 nM
|
|
|
|
CP0852049
|
N-(1-(4-(4-Chlorophenyl)piperidin-1-yl)-3-methyl-1-oxobutan-2-yl)-2-methylbenzamide
Show/Hide
|
C24H29ClN2O2
|
1
|
| 1 |
IC50 = 36 nM
|
|
|
|
CP0473558
|
1-[(2R)-4-(4-chloro-3-methoxyphenyl)-2-methylpiperazin-1-yl]-2-[4-chloro-5-methyl-3-(trifluoromethyl)pyrazol-1-yl]ethanone
Show/Hide
|
C19H21Cl2F3N4O2
|
1
|
| 1 |
IC50 = 37 nM
|
|
|
|
CP0395655
|
N-[(2R,3R)-1-[4-(4-chlorophenyl)piperidin-1-yl]-3-methyl-1-oxopentan-2-yl]-2-phenylacetamide
Show/Hide
|
C25H31ClN2O2
|
1
|
| 1 |
IC50 = 38 nM
|
|
|
|
CP0145810
|
N-[(2S,3S,5R)-5-carbamoyl-1-(3-fluorophenyl)-3,8-dihydroxy-8-methylnonan-2-yl]quinoxaline-2-carboxamide
Show/Hide
|
C26H31FN4O4
|
1
|
| 1 |
IC50 = 39 nM
|
|
|
|
CP0422642
|
2-chloro-N-[3-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]propyl]-6-methylbenzenesulfonamide
Show/Hide
|
C21H26Cl2N2O3S
|
2
|
| 1 |
IC50 = 40 nM
|
|
|
| 2 |
IC50 = 90 nM
|
|
|
|
CP0486759
|
2-chloro-N-[3-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]propyl]benzenesulfonamide
Show/Hide
|
C20H24Cl2N2O3S
|
2
|
| 1 |
IC50 = 40 nM
|
|
|
| 2 |
IC50 = 110 nM
|
|
|
|
CP0511489
|
N-[(2R)-1-[4-(4-chlorophenyl)piperidin-1-yl]-3-methyl-1-oxobutan-2-yl]-3-phenylpropanamide
Show/Hide
|
C25H31ClN2O2
|
1
|
| 1 |
IC50 = 40 nM
|
|
|
|
CP0856471
|
(D,L)-N-(1-(4-(4-Chlorophenyl)piperidin-1-yl)-3-methyl-1-oxobutan-2-yl)-2-phenylacetamide
Show/Hide
|
C24H29ClN2O2
|
1
|
| 1 |
IC50 = 40 nM
|
|
|
|
CP0483883
|
2-(4-chloro-3,5-dimethylpyrazol-1-yl)-1-[4-(4-chloro-3-methoxyphenyl)piperazin-1-yl]ethanone
Show/Hide
|
C18H22Cl2N4O2
|
1
|
| 1 |
IC50 = 40 nM
|
|
|
|
CP0968404
|
(S)-N-(3-(4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-3-oxopropyl)benzamide
Show/Hide
|
C23H27ClN2O3
|
1
|
| 1 |
IC50 = 41.6 nM
|
|
|
|
CP0903136
|
N-(3-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-2-methyl-3-oxopropyl)cyclopentanecarboxamide
Show/Hide
|
C23H33ClN2O3
|
1
|
| 1 |
IC50 = 42 nM
|
|
|
|
CP0961296
|
(1R,3R)-3-Acetamido-N-((R)-4-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-4-oxobutan-2-yl)cyclopentanecarboxamide
Show/Hide
|
C25H36ClN3O4
|
1
|
| 1 |
IC50 = 43.9 nM
|
|
|
|
CP0493980
|
N-[(2R)-1-[4-(4-chlorophenyl)piperidin-1-yl]-3-methyl-1-oxobutan-2-yl]-2-(3-fluorophenyl)acetamide
Show/Hide
|
C24H28ClFN2O2
|
1
|
| 1 |
IC50 = 44 nM
|
|
|
|
CP0462588
|
N-[(2R,3R)-1-[4-(4-chlorophenyl)piperidin-1-yl]-3-methyl-1-oxopentan-2-yl]benzamide
Show/Hide
|
C24H29ClN2O2
|
1
|
| 1 |
IC50 = 45 nM
|
|
|
|
CP0493979
|
2-(3-chlorophenyl)-N-[(2R)-1-[4-(4-chlorophenyl)piperidin-1-yl]-3-methyl-1-oxobutan-2-yl]acetamide
Show/Hide
|
C24H28Cl2N2O2
|
1
|
| 1 |
IC50 = 45 nM
|
|
|
|
CP0960326
|
N-(4-(4-(4-cyanophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-2-methyl-4-oxobutan-2-yl)benzamide
Show/Hide
|
C26H31N3O3
|
1
|
| 1 |
IC50 = 45.3 nM
|
|
|
|
CP0493888
|
N-[(2R)-1-[4-(4-chlorophenyl)piperidin-1-yl]-3-methyl-1-oxobutan-2-yl]-2-cyclopropylacetamide
Show/Hide
|
C21H29ClN2O2
|
1
|
| 1 |
IC50 = 46 nM
|
|
|
|
CP0903135
|
tert-butyl (1R,3R)-3-((R)-4-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-4-oxobutan-2-ylcarbamoyl)cyclopentylcarbamate
Show/Hide
|
C28H42ClN3O5
|
1
|
| 1 |
IC50 = 46.7 nM
|
|
|
|
CP0497443
|
2-[4-chloro-5-[(dimethylamino)methyl]-3-(trifluoromethyl)pyrazol-1-yl]-1-[4-(4-chloro-3-methoxyphenyl)piperazin-1-yl]ethanone
Show/Hide
|
C20H24Cl2F3N5O2
|
1
|
| 1 |
IC50 = 47 nM
|
|
|
|
CP0378981
|
N-[3-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]propyl]-2-(trifluoromethyl)benzenesulfonamide
Show/Hide
|
C21H24ClF3N2O3S
|
2
|
| 1 |
IC50 = 50 nM
|
|
|
| 2 |
IC50 = 250 nM
|
|
|
|
CP0435973
|
N-[(2R)-1-[4-(4-chlorophenyl)piperidin-1-yl]-1-oxobutan-2-yl]-2-phenylacetamide
Show/Hide
|
C23H27ClN2O2
|
1
|
| 1 |
IC50 = 50 nM
|
|
|
|
CP0540761
|
2-[5-(aminomethyl)-4-chloro-3-(trifluoromethyl)pyrazol-1-yl]-1-[4-(4-chloro-3-methoxyphenyl)piperazin-1-yl]ethanone
Show/Hide
|
C18H20Cl2F3N5O2
|
1
|
| 1 |
IC50 = 50 nM
|
|
|
|
CP0540294
|
2-chloro-5-[4-[2-[4-chloro-5-methyl-3-(trifluoromethyl)pyrazol-1-yl]acetyl]piperazin-1-yl]-3-methoxybenzamide
Show/Hide
|
C19H20Cl2F3N5O3
|
1
|
| 1 |
IC50 = 52 nM
|
|
|
|
CP0874500
|
(D,L)-N-(1-(4-(4-Chlorophenyl)piperidin-1-yl)-3-methyl-1-oxobutan-2-yl)benzamide
Show/Hide
|
C23H27ClN2O2
|
1
|
| 1 |
IC50 = 55 nM
|
|
|
|
CP0445798
|
N-[5-chloro-2-[(E)-3-[4-[(4-fluorophenyl)methyl]piperazin-1-yl]-3-oxoprop-1-enyl]phenyl]acetamide
Show/Hide
|
C22H23ClFN3O2
|
1
|
| 1 |
IC50 = 58 nM
|
|
|
|
CP0513970
|
N-[(2R)-1-[4-(4-chlorophenyl)piperidin-1-yl]-3-methyl-1-oxobutan-2-yl]-1-benzothiophene-2-carboxamide
Show/Hide
|
C25H27ClN2O2S
|
1
|
| 1 |
IC50 = 58 nM
|
|
|
|
CP0562590
|
(R)-3-(2-(2-(4-(4-fluorobenzyl)-2-methylpiperazin-1-yl)-2-oxoethoxy)-5-chlorophenylamino)-4-(2-(pyrrolidin-1-yl)ethylamino)cyclobut-3-ene-1,2-dione
Show/Hide
|
C30H35ClFN5O4
|
1
|
| 1 |
IC50 = 64 nM
|
|
|
|
CP0511200
|
N-[(2R,3R)-1-[4-(4-chlorophenyl)piperidin-1-yl]-3-methyl-1-oxopentan-2-yl]-3-phenylpropanamide
Show/Hide
|
C26H33ClN2O2
|
1
|
| 1 |
IC50 = 66 nM
|
|
|
|
CP0448832
|
N-[[4-chloro-2-[2-[4-(4-chloro-3-methoxyphenyl)piperazin-1-yl]-2-oxoethyl]-5-(trifluoromethyl)pyrazol-3-yl]methyl]acetamide
Show/Hide
|
C20H22Cl2F3N5O3
|
1
|
| 1 |
IC50 = 68 nM
|
|
|
|
CP0411037
|
N-[2-[(2S)-2-amino-3-spiro[3H-1-benzofuran-2,4'-piperidine]-1'-ylpropoxy]-4-hydroxyphenyl]acetamide
Show/Hide
|
C23H29N3O4
|
1
|
| 1 |
IC50 = 68 nM
|
|
|
|
CP0464306
|
N-[3-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]propyl]thiophene-2-sulfonamide
Show/Hide
|
C18H23ClN2O3S2
|
2
|
| 1 |
IC50 = 70 nM
|
|
|
| 2 |
IC50 = 160 nM
|
|
|
|
CP0423614
|
N-[(2R)-1-[4-(4-chlorophenyl)piperidin-1-yl]-3-methyl-1-oxobutan-2-yl]-3-(4-fluorophenyl)propanamide
Show/Hide
|
C25H30ClFN2O2
|
1
|
| 1 |
IC50 = 70 nM
|
|
|
|
CP0453475
|
N-[(2R)-1-[4-(4-chlorophenyl)piperidin-1-yl]-3-methyl-1-oxobutan-2-yl]cyclopentanecarboxamide
Show/Hide
|
C22H31ClN2O2
|
1
|
| 1 |
IC50 = 70 nM
|
|
|
|
CP0397154
|
N-(2-acetamidoethyl)-2-[(2S)-3-(5-chlorospiro[3H-1-benzofuran-2,4'-piperidine]-1'-yl)-2-hydroxypropoxy]-4-hydroxybenzamide
Show/Hide
|
C26H32ClN3O6
|
1
|
| 1 |
IC50 = 71 nM
|
|
|
|
CP0553916
|
(R)-3-(2-(2-(4-(4-fluorobenzyl)-2-methylpiperazin-1-yl)-2-oxoethoxy)-5-chlorophenylamino)-4-(ethylamino)cyclobut-3-ene-1,2-dione
Show/Hide
|
C26H28ClFN4O4
|
1
|
| 1 |
IC50 = 72 nM
|
|
|
|
CP0485413
|
(R,E)-3-(2-(3-(4-(4-fluorobenzyl)-2-methylpiperazin-1-yl)-3-oxoprop-1-enyl)-5-chlorophenylamino)-4-(methylamino)cyclobut-3-ene-1,2-dione
Show/Hide
|
C26H26ClFN4O3
|
1
|
| 1 |
IC50 = 76 nM
|
|
|
|
CP0558466
|
2-[4-chloro-5-methyl-3-(trifluoromethyl)pyrazol-1-yl]-1-[4-(4-chloro-3-propan-2-yloxyphenyl)piperazin-1-yl]ethanone
Show/Hide
|
C20H23Cl2F3N4O2
|
1
|
| 1 |
IC50 = 77 nM
|
|
|
|
CP0493625
|
(R)-3-(2-(2-(4-(4-chlorobenzyl)-2-methylpiperazin-1-yl)-2-oxoethoxy)-5-chlorophenylamino)-4-(methylamino)cyclobut-3-ene-1,2-dione
Show/Hide
|
C25H26Cl2N4O4
|
1
|
| 1 |
IC50 = 78 nM
|
|
|
|
CP0422636
|
N-[3-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]propyl]-2-fluorobenzenesulfonamide
Show/Hide
|
C20H24ClFN2O3S
|
2
|
| 1 |
IC50 = 80 nM
|
|
|
| 2 |
IC50 = 580 nM
|
|
|
|
CP0513975
|
N-[1-[4-(4-chlorophenyl)piperidin-1-yl]-3-methyl-1-oxobutan-2-yl]naphthalene-2-carboxamide
Show/Hide
|
C27H29ClN2O2
|
1
|
| 1 |
IC50 = 80 nM
|
|
|
|
CP0379029
|
N-[3-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]propyl]-2-phenylbenzenesulfonamide
Show/Hide
|
C26H29ClN2O3S
|
2
|
| 1 |
IC50 = 84 nM
|
|
|
| 2 |
IC50 = 600 nM
|
|
|
|
CP0482453
|
N-[(2R)-1-[4-(4-chlorophenyl)piperidin-1-yl]-1-oxobutan-2-yl]-3-phenylpropanamide
Show/Hide
|
C24H29ClN2O2
|
1
|
| 1 |
IC50 = 85 nM
|
|
|
|
CP0460086
|
N-[1-[4-(4-chlorophenyl)piperidin-1-yl]-4-methyl-1-oxopentan-2-yl]-2-methylbenzamide
Show/Hide
|
C25H31ClN2O2
|
1
|
| 1 |
IC50 = 88 nM
|
|
|
|
CP0529619
|
N-[(3S)-1-[2-[(2S)-3-(5-chlorospiro[3H-1-benzofuran-2,4'-piperidine]-1'-yl)-2-hydroxypropoxy]-4-hydroxybenzoyl]pyrrolidin-3-yl]acetamide
Show/Hide
|
C28H34ClN3O6
|
1
|
| 1 |
IC50 = 89 nM
|
|
|
|
CP0516569
|
1-[1-(2-bromophenyl)sulfonylpiperidin-4-yl]-4-(4-chlorophenyl)piperidin-4-ol
Show/Hide
|
C22H26BrClN2O3S
|
1
|
| 1 |
IC50 = 90 nM
|
|
|
|
CP0486757
|
N-[3-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]propyl]benzenesulfonamide
Show/Hide
|
C20H25ClN2O3S
|
2
|
| 1 |
IC50 = 90 nM
|
|
|
| 2 |
IC50 = 300 nM
|
|
|
|
CP0505559
|
(R)-3-(2-(2-(4-(4-fluorobenzyl)-2-methylpiperazin-1-yl)-2-oxoethoxy)-5-methylphenylamino)-4-(methylamino)cyclobut-3-ene-1,2-dione
Show/Hide
|
C26H29FN4O4
|
1
|
| 1 |
IC50 = 90 nM
|
|
|
|
CP0544017
|
1-[(3R)-4-(4-chloro-3-methoxyphenyl)-3-methylpiperazin-1-yl]-2-[4-chloro-5-methyl-3-(trifluoromethyl)pyrazol-1-yl]ethanone
Show/Hide
|
C19H21Cl2F3N4O2
|
1
|
| 1 |
IC50 = 92 nM
|
|
|
|
CP0473559
|
2-[4-chloro-5-methyl-3-(trifluoromethyl)pyrazol-1-yl]-1-[4-(4-fluorophenyl)piperazin-1-yl]ethanone
Show/Hide
|
C17H17ClF4N4O
|
3
|
| 1 |
IC50 = 93 nM
|
|
|
| 2 |
IC50 = 307 nM
|
|
|
| 3 |
IC50 = 310 nM
|
|
|
|
CP0395658
|
N-[(2R)-1-[4-(4-chlorophenyl)piperidin-1-yl]-3-methyl-1-oxobutan-2-yl]-4-phenylbutanamide
Show/Hide
|
C26H33ClN2O2
|
1
|
| 1 |
IC50 = 95 nM
|
|
|
|
CP0493624
|
(R)-3-(2-(2-(4-(3,4-difluorobenzyl)-2-methylpiperazin-1-yl)-2-oxoethoxy)-5-chlorophenylamino)-4-(methylamino)cyclobut-3-ene-1,2-dione
Show/Hide
|
C25H25ClF2N4O4
|
1
|
| 1 |
IC50 = 97 nM
|
|
|
|
CP0544018
|
2-[4-chloro-3-(hydroxymethyl)-5-methylpyrazol-1-yl]-1-[4-(4-chloro-3-methoxyphenyl)piperazin-1-yl]ethanone
Show/Hide
|
C18H22Cl2N4O3
|
1
|
| 1 |
IC50 = 97 nM
|
|
|
|
CP0497447
|
2-[4-chloro-5-methyl-3-(trifluoromethyl)pyrazol-1-yl]-1-[4-(4-chlorophenyl)piperazin-1-yl]ethanone
Show/Hide
|
C17H17Cl2F3N4O
|
1
|
| 1 |
IC50 = 98 nM
|
|
|
|
CP0372321
|
3-chloro-N-[3-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]propyl]benzenesulfonamide
Show/Hide
|
C20H24Cl2N2O3S
|
2
|
| 1 |
IC50 = 100 nM
|
|
|
| 2 |
IC50 = 380 nM
|
|
|
|
CP0464309
|
2-chloro-N-[3-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]propyl]-4-fluorobenzenesulfonamide
Show/Hide
|
C20H23Cl2FN2O3S
|
2
|
| 1 |
IC50 = 100 nM
|
|
|
| 2 |
IC50 = 360 nM
|
|
|
|
CP0423615
|
N-[(2R)-1-[4-(4-chlorophenyl)piperidin-1-yl]-3-methyl-1-oxobutan-2-yl]-2,3-dimethylbenzamide
Show/Hide
|
C25H31ClN2O2
|
1
|
| 1 |
IC50 = 100 nM
|
|
|
|
CP0483887
|
1-[4-(4-chloro-3-methylphenyl)piperazin-1-yl]-2-[4-chloro-5-methyl-3-(trifluoromethyl)pyrazol-1-yl]ethanone
Show/Hide
|
C18H19Cl2F3N4O
|
1
|
| 1 |
IC50 = 100 nM
|
|
|
|
CP0493977
|
N-[(2R)-1-[4-(4-chlorophenyl)piperidin-1-yl]-3-methyl-1-oxobutan-2-yl]-3-(4-methylphenyl)propanamide
Show/Hide
|
C26H33ClN2O2
|
1
|
| 1 |
IC50 = 105 nM
|
|
|
|
CP0483886
|
1-[4-(4-chloro-3-methoxy-5-methylphenyl)piperazin-1-yl]-2-[4-chloro-5-methyl-3-(trifluoromethyl)pyrazol-1-yl]ethanone
Show/Hide
|
C19H21Cl2F3N4O2
|
1
|
| 1 |
IC50 = 107 nM
|
|
|
|
CP0500728
|
N-[3-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]propyl]-2-thiophen-3-ylbenzenesulfonamide
Show/Hide
|
C24H27ClN2O3S2
|
2
|
| 1 |
IC50 = 110 nM
|
|
|
| 2 |
IC50 = 350 nM
|
|
|
|
CP0491642
|
[2-[(2S)-3-(5-chlorospiro[3H-1-benzofuran-2,4'-piperidine]-1'-yl)-2-hydroxypropoxy]-4-hydroxyphenyl]-[(3S)-3-(dimethylamino)pyrrolidin-1-yl]methanone
Show/Hide
|
C28H36ClN3O5
|
1
|
| 1 |
IC50 = 110 nM
|
|
|
|
CP0493978
|
2-(4-chlorophenyl)-N-[(2R)-1-[4-(4-chlorophenyl)piperidin-1-yl]-3-methyl-1-oxobutan-2-yl]acetamide
Show/Hide
|
C24H28Cl2N2O2
|
1
|
| 1 |
IC50 = 115 nM
|
|
|
|
CP0453474
|
N-[(2R)-1-[4-(4-chlorophenyl)piperidin-1-yl]-3-methyl-1-oxobutan-2-yl]-4-fluorobenzamide
Show/Hide
|
C23H26ClFN2O2
|
1
|
| 1 |
IC50 = 118 nM
|
|
|
|
CP0422638
|
N-[3-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]propyl]-4-methylbenzenesulfonamide
Show/Hide
|
C21H27ClN2O3S
|
2
|
| 1 |
IC50 = 120 nM
|
|
|
| 2 |
IC50 = 430 nM
|
|
|
|
CP0538466
|
1-[1-(2-bromophenyl)sulfonyl-2-methylpiperidin-4-yl]-4-(4-chlorophenyl)piperidin-4-ol
Show/Hide
|
C23H28BrClN2O3S
|
2
|
| 1 |
IC50 = 120 nM
|
|
|
| 2 |
IC50 = 220 nM
|
|
|
|
CP0430178
|
N-[1-[4-(4-chlorophenyl)piperidin-1-yl]-1-oxopentan-2-yl]benzamide
Show/Hide
|
C23H27ClN2O2
|
1
|
| 1 |
IC50 = 120 nM
|
|
|
|
CP0463720
|
2-[3-(aminomethyl)-4-chloro-5-methylpyrazol-1-yl]-1-[4-(4-chloro-3-methoxyphenyl)piperazin-1-yl]ethanone
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C18H23Cl2N5O2
|
1
|
| 1 |
IC50 = 120 nM
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CP0544021
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1-[4-(4-chloro-3-methoxyphenyl)piperazin-1-yl]-2-(4-chloro-5-methylpyrazol-1-yl)ethanone
Show/Hide
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C17H20Cl2N4O2
|
1
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| 1 |
IC50 = 120 nM
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CP0457013
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N-[(2R)-1-[4-(4-chlorophenyl)piperidin-1-yl]-1-oxobutan-2-yl]benzamide
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C22H25ClN2O2
|
1
|
| 1 |
IC50 = 121 nM
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CP0462587
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N-[(1R)-2-[4-(4-chlorophenyl)piperidin-1-yl]-1-cyclohexyl-2-oxoethyl]benzamide
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C26H31ClN2O2
|
1
|
| 1 |
IC50 = 121 nM
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CP0454139
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4-(4-chlorophenyl)-1-[1-(2-chlorophenyl)sulfonylpiperidin-4-yl]piperidin-4-ol
Show/Hide
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C22H26Cl2N2O3S
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2
|
| 1 |
IC50 = 130 nM
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| 2 |
IC50 = 200 nM
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CP0516560
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4-(4-chlorophenyl)-1-[1-(2-chlorophenyl)sulfonylpiperidin-4-yl]azepan-4-ol
Show/Hide
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C23H28Cl2N2O3S
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2
|
| 1 |
IC50 = 130 nM
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| 2 |
IC50 = 400 nM
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CP0388172
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N-[1-[4-(4-chlorophenyl)piperidin-1-yl]-4-methyl-1-oxopentan-2-yl]benzamide
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C24H29ClN2O2
|
1
|
| 1 |
IC50 = 130 nM
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CP0529618
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[4-fluoro-2-[(2S)-2-hydroxy-3-spiro[3H-1-benzofuran-2,4'-piperidine]-1'-ylpropoxy]phenyl]-[(3S)-3-hydroxypyrrolidin-1-yl]methanone
Show/Hide
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C26H31FN2O5
|
1
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| 1 |
IC50 = 130 nM
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CP0486758
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2-bromo-N-[3-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]propyl]benzenesulfonamide
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C20H24BrClN2O3S
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2
|
| 1 |
IC50 = 140 nM
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| 2 |
IC50 = 520 nM
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CP0505558
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(R)-3-(2-(2-(4-(4-fluorobenzyl)-2-methylpiperazin-1-yl)-2-oxoethoxy)-4,5-difluorophenylamino)-4-(methylamino)cyclobut-3-ene-1,2-dione
Show/Hide
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C25H25F3N4O4
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1
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| 1 |
IC50 = 140 nM
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CP0486729
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N-[(2R)-1-[4-(4-chlorophenyl)piperidin-1-yl]-3-methyl-1-oxobutan-2-yl]-2-(4-methylphenyl)acetamide
Show/Hide
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C25H31ClN2O2
|
1
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| 1 |
IC50 = 140 nM
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CP0450005
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N-[1-[4-(4-chlorophenyl)piperidin-1-yl]-1-oxopentan-2-yl]-2-methylbenzamide
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C24H29ClN2O2
|
1
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| 1 |
IC50 = 152 nM
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CP0457014
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N-[(2R)-1-[4-(4-chlorophenyl)piperidin-1-yl]-1-oxobutan-2-yl]-3-methylbutanamide
Show/Hide
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C20H29ClN2O2
|
1
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| 1 |
IC50 = 152 nM
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CP0485414
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(R)-3-(2-(2-(4-(4-fluorobenzyl)-2-methylpiperazin-1-yl)-2-oxoethoxy)-5-chlorophenylamino)-4-(2-(dimethylamino)ethylamino)cyclobut-3-ene-1,2-dione
Show/Hide
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C28H33ClFN5O4
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1
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| 1 |
IC50 = 160 nM
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CP0553917
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(R)-3-(2-(2-(4-(4-fluorobenzyl)-2-methylpiperazin-1-yl)-2-oxoethoxy)-5-fluorophenylamino)-4-(methylamino)cyclobut-3-ene-1,2-dione
Show/Hide
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C25H26F2N4O4
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1
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| 1 |
IC50 = 160 nM
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CP0427590
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(R)-3-(2-(2-(4-(4-fluorobenzyl)-2-methylpiperazin-1-yl)-2-oxoethoxy)-5-chlorophenylamino)-4-(propylamino)cyclobut-3-ene-1,2-dione
Show/Hide
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C27H30ClFN4O4
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1
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| 1 |
IC50 = 170 nM
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CP0544322
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N-[1-[4-(4-bromophenyl)-4-hydroxypiperidin-1-yl]-3-methyl-1-oxobutan-2-yl]benzamide
Show/Hide
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C23H27BrN2O3
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1
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| 1 |
IC50 = 172 nM
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CP0446128
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N-[(2R)-1-[4-(4-chlorophenyl)piperidin-1-yl]-3-methyl-1-oxobutan-2-yl]-2,6-dimethylbenzamide
Show/Hide
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C25H31ClN2O2
|
1
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| 1 |
IC50 = 177 nM
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CP0405075
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1-[1-(2-chlorophenyl)sulfonylpiperidin-4-yl]-4-(3,4-dichlorophenyl)piperidin-4-ol
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C22H25Cl3N2O3S
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2
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| 1 |
IC50 = 180 nM
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| 2 |
IC50 = 890 nM
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CP0486756
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N-[3-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]propyl]naphthalene-1-sulfonamide
Show/Hide
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C24H27ClN2O3S
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2
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| 1 |
IC50 = 180 nM
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| 2 |
IC50 = 680 nM
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CP0538467
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4-(4-chlorophenyl)-1-[1-(2-methylphenyl)sulfonylpiperidin-4-yl]piperidin-4-ol
Show/Hide
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C23H29ClN2O3S
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2
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| 1 |
IC50 = 180 nM
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| 2 |
IC50 = 500 nM
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CP0541192
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4-(4-bromophenyl)-1-[1-(2-chlorophenyl)sulfonylpiperidin-4-yl]piperidin-4-ol
Show/Hide
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C22H26BrClN2O3S
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2
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| 1 |
IC50 = 180 nM
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| 2 |
IC50 = 440 nM
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CP0477042
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1-benzyl-3-[(2R)-1-[4-(4-chlorophenyl)piperidin-1-yl]-3-methyl-1-oxobutan-2-yl]urea
Show/Hide
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C24H30ClN3O2
|
1
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| 1 |
IC50 = 180 nM
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CP0513867
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N-[1-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-3-methyl-1-oxobutan-2-yl]benzamide
Show/Hide
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C23H27ClN2O3
|
1
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| 1 |
IC50 = 180 nM
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CP0459916
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1-[4-(4-bromophenyl)piperazin-1-yl]-2-[4-chloro-5-methyl-3-(trifluoromethyl)pyrazol-1-yl]ethanone
Show/Hide
|
C17H17BrClF3N4O
|
1
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| 1 |
IC50 = 182 nM
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CP0553308
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N-[1-[4-(4-chlorophenyl)-3,6-dihydro-2H-pyridin-1-yl]-3-methyl-1-oxobutan-2-yl]benzamide
Show/Hide
|
C23H25ClN2O2
|
1
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| 1 |
IC50 = 185 nM
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CP0372360
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N-[3-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]propyl]-2-(trifluoromethoxy)benzenesulfonamide
Show/Hide
|
C21H24ClF3N2O4S
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2
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| 1 |
IC50 = 190 nM
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| 2 |
IC50 = 350 nM
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CP0513976
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N-[1-[4-(4-chlorophenyl)piperidin-1-yl]-1-oxopentan-2-yl]naphthalene-2-carboxamide
Show/Hide
|
C27H29ClN2O2
|
1
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| 1 |
IC50 = 191 nM
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CP0562592
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3-(2-(2-(4-(4-chlorobenzyl)piperazin-1-yl)-2-oxoethoxy)-5-chlorophenylamino)-4-(methylamino)cyclobut-3-ene-1,2-dione
Show/Hide
|
C24H24Cl2N4O4
|
1
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| 1 |
IC50 = 200 nM
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CP0529912
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N-[3-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]propyl]-4-fluorobenzenesulfonamide
Show/Hide
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C20H24ClFN2O3S
|
2
|
| 1 |
IC50 = 210 nM
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| 2 |
IC50 = 910 nM
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CP0558465
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2-chloro-5-[4-[2-[4-chloro-5-methyl-3-(trifluoromethyl)pyrazol-1-yl]acetyl]piperazin-1-yl]-3-methoxy-N-methylbenzamide
Show/Hide
|
C20H22Cl2F3N5O3
|
1
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| 1 |
IC50 = 210 nM
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CP0421853
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(R)-3-(5-chloro-2-(2-(4-((5-chlorothiophen-2-yl)methyl)-2-methylpiperazin-1-yl)-2-oxoethoxy)phenylamino)-4-(methylamino)cyclobut-3-ene-1,2-dione
Show/Hide
|
C23H24Cl2N4O4S
|
1
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| 1 |
IC50 = 220 nM
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CP0558464
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2-chloro-5-[4-[2-[4-chloro-5-methyl-3-(trifluoromethyl)pyrazol-1-yl]acetyl]piperazin-1-yl]-3-methoxy-N,N-dimethylbenzamide
Show/Hide
|
C21H24Cl2F3N5O3
|
1
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| 1 |
IC50 = 220 nM
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CP0486761
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N-[3-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]propyl]-2-thiophen-2-ylbenzenesulfonamide
Show/Hide
|
C24H27ClN2O3S2
|
2
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| 1 |
IC50 = 230 nM
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| 2 |
IC50 = 240 nM
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CP0465408
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N-[1-[4-(4-chlorophenyl)piperidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]benzamide
Show/Hide
|
C24H29ClN2O2
|
1
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| 1 |
IC50 = 259 nM
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CP0413812
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N-[1-[4-(4-chlorophenyl)piperidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]-2-methylbenzamide
Show/Hide
|
C25H31ClN2O2
|
1
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| 1 |
IC50 = 262 nM
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CP0477043
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phenyl N-[1-[4-(4-chlorophenyl)piperidin-1-yl]-3-methyl-1-oxobutan-2-yl]carbamate
Show/Hide
|
C23H27ClN2O3
|
1
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| 1 |
IC50 = 265 nM
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CP0510629
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1-[(3R)-1-(2-chloro-6-methylphenyl)sulfonylpiperidin-3-yl]-4-(4-chlorophenyl)piperidin-4-ol
Show/Hide
|
C23H28Cl2N2O3S
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2
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| 1 |
IC50 = 270 nM
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| 2 |
IC50 = 390 nM
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CP0505561
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(R)-3-(2-(2-(4-(4-bromobenzyl)-2-methylpiperazin-1-yl)-2-oxoethoxy)-5-chlorophenylamino)-4-(methylamino)cyclobut-3-ene-1,2-dione
Show/Hide
|
C25H26BrClN4O4
|
1
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| 1 |
IC50 = 270 nM
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CP0510630
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2,5-dichloro-N-[3-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]propyl]benzenesulfonamide
Show/Hide
|
C20H23Cl3N2O3S
|
2
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| 1 |
IC50 = 280 nM
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| 2 |
IC50 = 540 nM
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CP0529892
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4-(4-chlorophenyl)-1-[1-(2-chlorophenyl)sulfonyl-2-methylpiperidin-4-yl]piperidin-4-ol
Show/Hide
|
C23H28Cl2N2O3S
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2
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| 1 |
IC50 = 280 nM
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| 2 |
IC50 = 320 nM
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CP0486705
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N-[1-[4-(4-chlorophenyl)piperidin-1-yl]-3-methyl-1-oxobutan-2-yl]-1-phenylmethanesulfonamide
Show/Hide
|
C23H29ClN2O3S
|
1
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| 1 |
IC50 = 303 nM
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CP0413815
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N-[1-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-4-methyl-1-oxopentan-2-yl]benzamide
Show/Hide
|
C24H29ClN2O3
|
1
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| 1 |
IC50 = 324 nM
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CP0422643
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1-[1-(2-bromo-4,6-difluorophenyl)sulfonylpiperidin-4-yl]-4-(4-chlorophenyl)piperidin-4-ol
Show/Hide
|
C22H24BrClF2N2O3S
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2
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| 1 |
IC50 = 330 nM
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| 2 |
IC50 = 1120 nM
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CP0505624
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2-(3-amino-4-chloro-5-methylpyrazol-1-yl)-1-[4-(4-chloro-3-methoxyphenyl)piperazin-1-yl]ethanone
Show/Hide
|
C17H21Cl2N5O2
|
1
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| 1 |
IC50 = 340 nM
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CP0486763
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2,3-dichloro-N-[3-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]propyl]benzenesulfonamide
Show/Hide
|
C20H23Cl3N2O3S
|
2
|
| 1 |
IC50 = 350 nM
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| 2 |
IC50 = 510 nM
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CP0456742
|
(R)-3-(2-(2-(4-benzyl-2-methylpiperazin-1-yl)-2-oxoethoxy)-5-chlorophenylamino)-4-(methylamino)cyclobut-3-ene-1,2-dione
Show/Hide
|
C25H27ClN4O4
|
1
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| 1 |
IC50 = 350 nM
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CP0457668
|
2,4-dichloro-N-[3-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]propyl]benzenesulfonamide
Show/Hide
|
C20H23Cl3N2O3S
|
2
|
| 1 |
IC50 = 360 nM
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| 2 |
IC50 = 410 nM
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CP0486765
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1-[1-(2-chloro-6-methylphenyl)sulfonylpiperidin-4-yl]-4-(4-chlorophenyl)piperidin-4-ol
Show/Hide
|
C23H28Cl2N2O3S
|
2
|
| 1 |
IC50 = 370 nM
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| 2 |
IC50 = 430 nM
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CP0422655
|
4-chloro-N-[3-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]propyl]benzenesulfonamide
Show/Hide
|
C20H24Cl2N2O3S
|
2
|
| 1 |
IC50 = 370 nM
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| 2 |
IC50 = 800 nM
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CP0430180
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N-[(E)-1-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-1-oxobut-2-en-2-yl]benzamide
Show/Hide
|
C22H23ClN2O3
|
1
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| 1 |
IC50 = 370 nM
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CP0460087
|
N-[1-[4-(3,4-dichlorophenyl)piperazin-1-yl]-3-methyl-1-oxobutan-2-yl]benzamide
Show/Hide
|
C22H25Cl2N3O2
|
1
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| 1 |
IC50 = 375 nM
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CP0405072
|
N-[3-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]propyl]thiophene-3-sulfonamide
Show/Hide
|
C18H23ClN2O3S2
|
2
|
| 1 |
IC50 = 385 nM
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| 2 |
IC50 = 570 nM
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CP0513866
|
N-[1-[4-(4-chlorophenyl)piperidin-1-yl]-3-methyl-1-oxobutan-2-yl]-2-methylpropanamide
Show/Hide
|
C20H29ClN2O2
|
1
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| 1 |
IC50 = 388 nM
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CP0515374
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N-(2-aminoethyl)-2-[(2S)-3-(5-chlorospiro[3H-1-benzofuran-2,4'-piperidine]-1'-yl)-2-hydroxypropoxy]-4-hydroxybenzamide
Show/Hide
|
C24H30ClN3O5
|
1
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| 1 |
IC50 = 400 nM
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CP0427885
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4-(4-chlorophenyl)-1-[1-(2,6-dichlorophenyl)sulfonylpiperidin-4-yl]piperidin-4-ol
Show/Hide
|
C22H25Cl3N2O3S
|
1
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| 1 |
IC50 = 420 nM
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CP0465645
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2-chloro-5-[4-[2-[4-chloro-5-methyl-3-(trifluoromethyl)pyrazol-1-yl]acetyl]piperazin-1-yl]-3-methoxybenzoic acid
Show/Hide
|
C19H19Cl2F3N4O4
|
1
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| 1 |
IC50 = 420 nM
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CP0413814
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N-[1-[4-(4-fluorophenyl)piperidin-1-yl]-3-methyl-1-oxobutan-2-yl]benzamide
Show/Hide
|
C23H27FN2O2
|
1
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| 1 |
IC50 = 423 nM
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CP0454141
|
1-[(3S)-1-(2-chloro-6-methylphenyl)sulfonylpiperidin-3-yl]-4-(4-chlorophenyl)piperidin-4-ol
Show/Hide
|
C23H28Cl2N2O3S
|
2
|
| 1 |
IC50 = 430 nM
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| 2 |
IC50 = 480 nM
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CP0516559
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4-(4-chloro-3-fluorophenyl)-1-[1-(2-chlorophenyl)sulfonylpiperidin-4-yl]piperidin-4-ol
Show/Hide
|
C22H25Cl2FN2O3S
|
2
|
| 1 |
IC50 = 430 nM
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| 2 |
IC50 = 610 nM
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CP0462316
|
(R)-N2-(4-Chlorobenzyl)-N1-(4-methoxyphenyl)-N2-methylpyrrolidine-1,2-dicarboxamide
Show/Hide
|
C21H24ClN3O3
|
1
|
| 1 |
IC50 = 440 nM
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CP0477857
|
1-[(3S)-1-(2-bromophenyl)sulfonylpiperidin-3-yl]-4-(4-chlorophenyl)piperidin-4-ol
Show/Hide
|
C22H26BrClN2O3S
|
2
|
| 1 |
IC50 = 460 nM
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| 2 |
IC50 = 1300 nM
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CP0448835
|
N-[1-[2-[4-(4-chloro-3-methoxyphenyl)piperazin-1-yl]-2-oxoethyl]-5-methyl-3-(trifluoromethyl)pyrazol-4-yl]acetamide
Show/Hide
|
C20H23ClF3N5O3
|
1
|
| 1 |
IC50 = 500 nM
|
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CP0486767
|
4-(3-chloro-4-fluorophenyl)-1-[1-(2-chlorophenyl)sulfonylpiperidin-4-yl]piperidin-4-ol
Show/Hide
|
C22H25Cl2FN2O3S
|
2
|
| 1 |
IC50 = 510 nM
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| 2 |
IC50 = 590 nM
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CP0394829
|
N-[3-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]propyl]naphthalene-2-sulfonamide
Show/Hide
|
C24H27ClN2O3S
|
2
|
| 1 |
IC50 = 520 nM
|
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| 2 |
IC50 = 1150 nM
|
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CP0462014
|
N-[1-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-1-oxopentan-2-yl]benzamide
Show/Hide
|
C23H27ClN2O3
|
1
|
| 1 |
IC50 = 521 nM
|
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|
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CP0413813
|
N-[1-[4-(4-chlorophenyl)piperazin-1-yl]-3-methyl-1-oxobutan-2-yl]benzamide
Show/Hide
|
C22H26ClN3O2
|
1
|
| 1 |
IC50 = 525 nM
|
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CP0408798
|
N-[1-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-4-methylsulfanyl-1-oxobutan-2-yl]benzamide
Show/Hide
|
C23H27ClN2O3S
|
1
|
| 1 |
IC50 = 539 nM
|
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CP0513974
|
1-[(2R)-1-[4-(4-chlorophenyl)piperidin-1-yl]-3-methyl-1-oxobutan-2-yl]-3-(2-phenylethyl)urea
Show/Hide
|
C25H32ClN3O2
|
1
|
| 1 |
IC50 = 543 nM
|
|
|
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CP0533943
|
US8536198, 68
Show/Hide
|
C28H35ClN2O4
|
1
|
| 1 |
IC50 = 580.6 nM
|
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|
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CP0538268
|
2-chloro-N-[3-[4-(4-chlorophenyl)-4-cyanopiperidin-1-yl]propyl]benzenesulfonamide
Show/Hide
|
C21H23Cl2N3O2S
|
1
|
| 1 |
IC50 = 600 nM
|
|
|
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CP0453488
|
1-[(2R)-1-[4-(4-chlorophenyl)piperidin-1-yl]-3-methyl-1-oxobutan-2-yl]-3-phenylurea
Show/Hide
|
C23H28ClN3O2
|
1
|
| 1 |
IC50 = 616 nM
|
|
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CP0486708
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4-(4-chlorophenyl)-1-[1-(2,3,4-trichlorophenyl)sulfonylpiperidin-4-yl]piperidin-4-ol
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C22H24Cl4N2O3S
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2
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| 1 |
IC50 = 670 nM
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| 2 |
IC50 = 3600 nM
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CP0506988
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2-[4-chloro-3,5-bis(trifluoromethyl)pyrazol-1-yl]-1-[4-(4-chloro-3-methoxyphenyl)piperazin-1-yl]ethanone
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C18H16Cl2F6N4O2
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1
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| 1 |
IC50 = 740 nM
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CP0324163
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US8536198, 61
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C22H31ClN2O4
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1
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| 1 |
IC50 = 767.5 nM
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CP0486764
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3,5-dichloro-N-[3-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]propyl]benzenesulfonamide
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C20H23Cl3N2O3S
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2
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| 1 |
IC50 = 780 nM
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| 2 |
IC50 = 1340 nM
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CP0951304
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N-(4-(4-(3,5-dichloropyridin-2-yl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-2-methyl-4-oxobutan-2-yl)benzamide
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C24H29Cl2N3O3
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1
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| 1 |
IC50 = 787.8 nM
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CP0562591
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(R)-3-(2-(2-(4-(4-fluorobenzyl)-2-methylpiperazin-1-yl)-2-oxoethoxy)-5-chlorophenylamino)-4-(benzylamino)cyclobut-3-ene-1,2-dione
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C31H30ClFN4O4
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1
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| 1 |
IC50 = 800 nM
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CP0869556
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N-((S)-2-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidine-1-carbonyl)-3-methylbutyl)-2-phenylacetamide
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C27H35ClN2O3
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1
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| 1 |
IC50 = 808.9 nM
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CP0317914
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US8536198, 104
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C28H35ClN2O3
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1
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| 1 |
IC50 = 818 nM
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CP0486760
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N-[3-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]propyl]-4-methoxybenzenesulfonamide
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C21H27ClN2O4S
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2
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| 1 |
IC50 = 830 nM
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| 2 |
IC50 = 3880 nM
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CP0430179
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benzyl N-[1-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-3-methyl-1-oxobutan-2-yl]carbamate
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C24H29ClN2O4
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1
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| 1 |
IC50 = 854 nM
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CP0544479
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US8536198, 67
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C28H35ClN2O4
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1
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| 1 |
IC50 = 857.8 nM
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CP0505560
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(R)-3-(2-(2-(4-(4-fluorobenzyl)-2-methylpiperazin-1-yl)-2-oxoethoxy)phenylamino)-4-(methylamino)cyclobut-3-ene-1,2-dione
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C25H27FN4O4
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1
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| 1 |
IC50 = 920 nM
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CP0354161
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US8536198, 58
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C28H42ClN3O3
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1
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| 1 |
IC50 = 931.8 nM
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CP0465409
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N-[1-[4-(4-fluorophenyl)-4-hydroxypiperidin-1-yl]-3-methyl-1-oxobutan-2-yl]benzamide
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C23H27FN2O3
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1
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| 1 |
IC50 = 933 nM
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CP0379026
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4-(4-chlorophenyl)-1-(1-thiophen-2-ylsulfonylpiperidin-4-yl)piperidin-4-ol
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C20H25ClN2O3S2
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2
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| 1 |
IC50 = 970 nM
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| 2 |
IC50 = 1020 nM
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CP0960327
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ethyl 5-(1-(3-benzamido-3-methylbutanoyl)-4-hydroxy-3,3-dimethylpiperidin-4-yl)-2-chlorobenzoate
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C28H35ClN2O5
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1
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| 1 |
IC50 = 991.4 nM
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CP0140224
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US8536198, 41
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C22H31ClN2O4
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1
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| 1 |
IC50 = 996.7 nM
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CP0471162
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4-(4-chlorophenyl)-1-[1-(2-chlorophenyl)sulfonylpiperidin-4-yl]piperidine-4-carbonitrile
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C23H25Cl2N3O2S
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1
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| 1 |
IC50 = 1000 nM
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CP0544574
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US8536198, 10
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C29H35ClN2O5
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1
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| 1 |
IC50 = 1065 nM
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CP0493982
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benzyl N-[1-[4-(4-chlorophenyl)piperidin-1-yl]-3-methyl-1-oxobutan-2-yl]carbamate
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C24H29ClN2O3
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1
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| 1 |
IC50 = 1077 nM
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CP0448834
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1-[4-(4-chloro-3-methoxyphenyl)piperazin-1-yl]-2-[4-chloro-5-propan-2-yl-3-(trifluoromethyl)pyrazol-1-yl]ethanone
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C20H23Cl2F3N4O2
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1
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| 1 |
IC50 = 1100 nM
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CP0477859
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1-[1-(2-chlorophenyl)sulfonylpiperidin-4-yl]-4-(4-fluorophenyl)piperidin-4-ol
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C22H26ClFN2O3S
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2
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| 1 |
IC50 = 1170 nM
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| 2 |
IC50 = 1250 nM
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CP0853267
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(S)-N-(4-(2-(4-(4-Chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-2-oxoethyl)tetrahydro-2H-pyran-4-yl)benzamide
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C27H33ClN2O4
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1
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| 1 |
IC50 = 1181 nM
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CP0943703
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N-(4-((S)-4-(4-Chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-3-methyl-4-oxobutan-2-yl)benzamide
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C25H31ClN2O3
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1
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| 1 |
IC50 = 1188 nM
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CP0455176
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1-(3,4-dichlorophenyl)-5-methyl-N-[[3-(trifluoromethyl)phenyl]methyl]pyrazole-4-carboxamide
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C19H14Cl2F3N3O
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1
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| 1 |
IC50 = 1200 nM
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CP0372878
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1-[1-(benzenesulfonyl)piperidin-4-yl]-4-(4-chlorophenyl)piperidin-4-ol
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C22H27ClN2O3S
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2
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| 1 |
IC50 = 1240 nM
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| 2 |
IC50 = 1270 nM
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CP0427883
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4-(4-chlorophenyl)-1-[(3R)-1-(2-chlorophenyl)sulfonylpiperidin-3-yl]piperidin-4-ol
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C22H26Cl2N2O3S
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2
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| 1 |
IC50 = 1290 nM
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| 2 |
IC50 = 1980 nM
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CP0405078
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1-[1-(2-chlorophenyl)sulfonylpiperidin-4-yl]-4-(3,4,5-trifluorophenyl)piperidin-4-ol
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C22H24ClF3N2O3S
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2
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| 1 |
IC50 = 1330 nM
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| 2 |
IC50 = 2550 nM
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CP0422644
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1-[(3R)-1-(2-bromophenyl)sulfonylpiperidin-3-yl]-4-(4-chlorophenyl)piperidin-4-ol
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C22H26BrClN2O3S
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1
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| 1 |
IC50 = 1400 nM
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CP0486755
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N-[3-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]propyl]naphthalene-2-carboxamide
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C25H27ClN2O2
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2
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| 1 |
IC50 = 1650 nM
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| 2 |
IC50 = 5830 nM
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CP0541191
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3,4-dichloro-N-[3-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]propyl]benzenesulfonamide
Show/Hide
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C20H23Cl3N2O3S
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2
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| 1 |
IC50 = 1850 nM
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| 2 |
IC50 = 2460 nM
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CP0486766
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4-(4-chlorophenyl)-1-[(3S)-1-(2-chlorophenyl)sulfonylpiperidin-3-yl]piperidin-4-ol
Show/Hide
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C22H26Cl2N2O3S
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2
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| 1 |
IC50 = 1900 nM
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| 2 |
IC50 = 2040 nM
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CP0422640
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N-[3-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]propyl]-4-(trifluoromethyl)benzenesulfonamide
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C21H24ClF3N2O3S
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2
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| 1 |
IC50 = 2200 nM
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| 2 |
IC50 = 9400 nM
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CP0405079
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4-(4-chlorophenyl)-1-[1-(2-chlorophenyl)sulfonyl-4-methylpiperidin-4-yl]piperidin-4-ol
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C23H28Cl2N2O3S
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2
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| 1 |
IC50 = 2260 nM
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| 2 |
IC50 = 5150 nM
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CP0454140
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1-[1-(2-chloro-6-methylphenyl)sulfonyl-4-methylpiperidin-4-yl]-4-(4-chlorophenyl)piperidin-4-ol
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C24H30Cl2N2O3S
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2
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| 1 |
IC50 = 2260 nM
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| 2 |
IC50 = 3570 nM
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CP0524524
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(R)-3-(2-(2-(4-(2-fluorobenzyl)-2-methylpiperazin-1-yl)-2-oxoethoxy)-5-chlorophenylamino)-4-(methylamino)cyclobut-3-ene-1,2-dione
Show/Hide
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C25H26ClFN4O4
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1
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| 1 |
IC50 = 2340 nM
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CP0497446
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2-[4-chloro-5-methyl-3-(trifluoromethyl)pyrazol-1-yl]-1-[4-(3-methoxyphenyl)piperazin-1-yl]ethanone
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C18H20ClF3N4O2
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1
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| 1 |
IC50 = 2700 nM
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CP0396588
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N-[1-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-3-hydroxy-1-oxobutan-2-yl]benzamide
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C22H25ClN2O4
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1
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| 1 |
IC50 = 2832 nM
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CP0456741
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(R)-3-(2-(2-(4-(3-fluorobenzyl)-2-methylpiperazin-1-yl)-2-oxoethoxy)-5-chlorophenylamino)-4-(methylamino)cyclobut-3-ene-1,2-dione
Show/Hide
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C25H26ClFN4O4
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1
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| 1 |
IC50 = 2910 nM
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CP0544024
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2-[4-chloro-5-methyl-3-(trifluoromethyl)pyrazol-1-yl]-1-[4-(3-methylphenyl)piperazin-1-yl]ethanone
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C18H20ClF3N4O
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1
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| 1 |
IC50 = 3300 nM
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CP0448833
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1-[4-(4-chloro-3-methoxyphenyl)piperazin-1-yl]-2-[4-chloro-5-phenyl-3-(trifluoromethyl)pyrazol-1-yl]ethanone
Show/Hide
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C23H21Cl2F3N4O2
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1
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| 1 |
IC50 = 3400 nM
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CP0515051
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N-[3-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]propyl]-4-(trifluoromethoxy)benzenesulfonamide
Show/Hide
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C21H24ClF3N2O4S
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2
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| 1 |
IC50 = 3650 nM
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| 2 |
IC50 = 9000 nM
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CP0463749
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2-[4-chloro-5-methyl-3-(trifluoromethyl)pyrazol-1-yl]-1-[4-(4-methylphenyl)piperazin-1-yl]ethanone
Show/Hide
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C18H20ClF3N4O
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1
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| 1 |
IC50 = 3650 nM
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CP0379027
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4-(4-chlorophenyl)-1-[1-(2,6-dichlorophenyl)sulfonyl-4-methylpiperidin-4-yl]piperidin-4-ol
Show/Hide
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C23H27Cl3N2O3S
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2
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| 1 |
IC50 = 4200 nM
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| 2 |
IC50 = 4650 nM
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CP0497441
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4-chloro-1-[2-[4-(4-chloro-3-methoxyphenyl)piperazin-1-yl]-2-oxoethyl]-5-methylpyrazole-3-carboxylic acid
Show/Hide
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C18H20Cl2N4O4
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1
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| 1 |
IC50 = 5200 nM
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CP0483890
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2-[4-chloro-5-methyl-3-(trifluoromethyl)pyrazol-1-yl]-1-(4-phenylpiperazin-1-yl)ethanone
Show/Hide
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C17H18ClF3N4O
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1
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| 1 |
IC50 = 5600 nM
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CP0483888
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2-[4-chloro-5-methyl-3-(trifluoromethyl)pyrazol-1-yl]-1-[4-(4-nitrophenyl)piperazin-1-yl]ethanone
Show/Hide
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C17H17ClF3N5O3
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1
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| 1 |
IC50 = 5650 nM
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CP0405074
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4-(3-chlorophenyl)-1-[1-(2-chlorophenyl)sulfonylpiperidin-4-yl]piperidin-4-ol
Show/Hide
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C22H26Cl2N2O3S
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2
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| 1 |
IC50 = 6210 nM
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| 2 |
IC50 = 7000 nM
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CP0450238
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2-[4-chloro-5-methyl-3-(trifluoromethyl)pyrazol-1-yl]-1-[4-(4-methylsulfonylphenyl)piperazin-1-yl]ethanone
Show/Hide
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C18H20ClF3N4O3S
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1
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| 1 |
IC50 = 6400 nM
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CP0403170
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4-(4-chlorophenyl)-1-(4-methyl-1-thiophen-2-ylsulfonylpiperidin-4-yl)piperidin-4-ol
Show/Hide
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C21H27ClN2O3S2
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2
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| 1 |
IC50 = 7330 nM
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| 2 |
IC50 > 10000 nM
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CP0486768
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1-[1-(2-chlorophenyl)sulfonylpiperidin-4-yl]-4-(4-methylsulfanylphenyl)piperidin-4-ol
Show/Hide
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C23H29ClN2O3S2
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2
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| 1 |
IC50 = 7980 nM
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| 2 |
IC50 > 10000 nM
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CP0483889
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2-[4-chloro-5-methyl-3-(trifluoromethyl)pyrazol-1-yl]-1-[4-[4-(trifluoromethyl)phenyl]piperazin-1-yl]ethanone
Show/Hide
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C18H17ClF6N4O
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1
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| 1 |
IC50 = 9800 nM
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CP0486769
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1-[1-(2-chlorophenyl)sulfonylpiperidin-4-yl]-4-(4-phenylphenyl)piperidin-4-ol
Show/Hide
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C28H31ClN2O3S
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1
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| 1 |
IC50 > 10000 nM
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CP0510644
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1-[1-(2-chlorophenyl)sulfonylpiperidin-4-yl]-4-(4-phenoxyphenyl)piperidin-4-ol
Show/Hide
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C28H31ClN2O4S
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1
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| 1 |
IC50 > 10000 nM
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CP0513760
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4-(4-tert-butylphenyl)-1-[1-(2-chlorophenyl)sulfonylpiperidin-4-yl]piperidin-4-ol
Show/Hide
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C26H35ClN2O3S
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1
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| 1 |
IC50 > 10000 nM
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CP0516570
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1-[1-(2-chlorophenyl)sulfonylpiperidin-4-yl]-4-(4-methoxyphenyl)piperidin-4-ol
Show/Hide
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C23H29ClN2O4S
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1
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| 1 |
IC50 > 10000 nM
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CP0372879
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3-(4-chlorophenyl)-1-[1-(2-chlorophenyl)sulfonylpiperidin-4-yl]pyrrolidin-3-ol
Show/Hide
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C21H24Cl2N2O3S
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2
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| 1 |
IC50 > 10000 nM
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| 2 |
IC50 > 30000 nM
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CP0538267
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1-[1-(2-chloro-6-methylphenyl)sulfonylpiperidin-4-yl]-3-(4-chlorophenyl)pyrrolidin-3-ol
Show/Hide
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C22H26Cl2N2O3S
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2
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| 1 |
IC50 > 10000 nM
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| 2 |
IC50 > 30000 nM
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CP0444717
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3-(4-{2-[(R)-4-(4-fluoro-benzyl)-2-methyl-piperazin-1-yl]-2-oxo-ethoxy}-biphenyl-3-ylamino)-4-methylamino-cyclobut-3-ene-1,2-dione
Show/Hide
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C31H31FN4O4
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1
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| 1 |
IC50 > 10000 nM
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CP0558467
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2-[4-chloro-5-methyl-3-(trifluoromethyl)pyrazol-1-yl]-1-[4-(3-chlorophenyl)piperazin-1-yl]ethanone
Show/Hide
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C17H17Cl2F3N4O
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1
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| 1 |
IC50 = 11000 nM
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CP0477041
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N-[(2S)-1-[4-(4-chlorophenyl)piperidin-1-yl]-3-methyl-1-oxobutan-2-yl]benzamide
Show/Hide
|
C23H27ClN2O2
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1
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| 1 |
IC50 = 14930 nM
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CP0541190
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N-[3-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]propyl]-4-phenylbenzenesulfonamide
Show/Hide
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C26H29ClN2O3S
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1
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| 1 |
IC50 > 30000 nM
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CP0540763
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2-[4-chloro-5-methyl-3-(trifluoromethyl)pyrazol-1-yl]-1-[4-(4-methoxyphenyl)piperazin-1-yl]ethanone
Show/Hide
|
C18H20ClF3N4O2
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1
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| 1 |
IC50 = 32000 nM
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CP0382123
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2-amino-N-[2-[[(3R)-1-[(4-chlorophenyl)methyl]pyrrolidin-3-yl]amino]-2-oxoethyl]-5-(trifluoromethyl)benzamide
Show/Hide
|
C21H22ClF3N4O2
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1
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| 1 |
IC50 > 1000 nM
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CP0551374
|
US8633226, 850
Show/Hide
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C22H34ClN3O3
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1
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| 1 |
Ki = 0.5 nM
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CP0070160
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N-[(2R)-1-[(4S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl]-3-methyl-1-oxobutan-2-yl]cyclopentanecarboxamide
Show/Hide
|
C24H35ClN2O3
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1
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| 1 |
Ki = 0.7 nM
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CP0336179
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N-[(2R)-1-[(4S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl]-3-methyl-1-oxobutan-2-yl]-3-methylbutanamide
Show/Hide
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C23H35ClN2O3
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1
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| 1 |
Ki = 2.6 nM
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CP0900223
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(2R)-N-(2-(4-Chloro-5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)-1-(1-(2,4-dichloro-5-methoxyphenyl)piperidin-4-yl)ethyl)-2-hydroxypropanamide, Diastereomeric mixture
Show/Hide
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C22H26Cl3F3N4O3
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1
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| 1 |
Ki = 3.46 nM
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CP0959237
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rac-N-(2-(4-Chloro-5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)-1-(1-(2,4-dichloro-5-methoxyphenyl)piperidin-4-yl)ethyl)-2-fluoroacetamide
Show/Hide
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C21H23Cl3F4N4O2
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1
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| 1 |
Ki = 4.3 nM
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CP0960324
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rac-N-(2-(4-Chloro-5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)-1-(1-(2,4-dichloro-5-methoxyphenyl)piperidin-4-yl)ethyl)-2-hydroxyacetamide
Show/Hide
|
C21H24Cl3F3N4O3
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1
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| 1 |
Ki = 5.15 nM
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CP0943702
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rac-N-(2-(4-Chloro-5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)-1-(1-(2,4-dichloro-5-methoxyphenyl)piperidin-4-yl)ethyl)acetamide
Show/Hide
|
C21H24Cl3F3N4O2
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1
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| 1 |
Ki = 6.8 nM
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CP0951385
|
rac-1-(1-(4-Chloro-3-methoxyphenyl)piperidin-4-yl)-2-(3-(trifluoromethyl)-1H-pyrazol-1-yl)ethanol
Show/Hide
|
C18H21ClF3N3O2
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1
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| 1 |
Ki = 114 nM
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CP0968403
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rac-2-(4-Chloro-5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)-1-(1-(2,4-dichloro-5-methoxyphenyl)piperidin-4-yl)ethanamine
Show/Hide
|
C19H22Cl3F3N4O
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1
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| 1 |
Ki = 125 nM
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CP0951386
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2-amino-N-(1-(1-(4-chloro-3-methoxyphenyl)piperidin-4-yl)-2-(5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)ethyl)acetamide
Show/Hide
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C21H27ClF3N5O2
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1
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| 1 |
Ki = 145 nM
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CP0944245
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rac-1-(1-(4-Chloro-3-methoxyphenyl)piperidin-4-yl)-2-(5-methyl-3-(trifluoromethyl)-1H-1,2,4-triazol-1-yl)ethanol
Show/Hide
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C18H22ClF3N4O2
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1
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| 1 |
Ki = 156 nM
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CP0853265
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rac-2-(4-Chloro-5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)-1-(1-(3-methoxyphenyl)piperidin-4-yl)ethanol
Show/Hide
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C19H23ClF3N3O2
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1
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| 1 |
Ki = 1020 nM
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CP0853264
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rac-1-(1-(4-Chloro-3-methoxyphenyl)-4-methylpiperidin-4-yl)-2-(4-chloro-5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)ethanol
Show/Hide
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C20H24Cl2F3N3O2
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1
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| 1 |
Ki = 1250 nM
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CP0944246
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N-(1-(1-(4-chloro-3-methoxyphenyl)piperidin-4-yl)-2-(5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)ethyl)-2-hydroxyacetamide
Show/Hide
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C21H26ClF3N4O3
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1
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| 1 |
Ki = 2200 nM
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CP0951303
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rac-2-(3-Amino-1H-pyrazolo[3,4-b]pyridin-1-yl)-1-(1-(4-chloro-3-methoxyphenyl)piperidin-4-yl)ethanol
Show/Hide
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C20H24ClN5O2
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1
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| 1 |
Ki = 2220 nM
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