Brief Information of the Compound and Protein
Compound Name
 Compound Info 
1-[(2R)-1-[(4S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl]-3-methyl-1-oxobutan-2-yl]-3-(2-hydroxy-2-methylpropyl)urea
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 PubChem ID
CID: 44537841
SID: 87219246
Canonical SMILES
CC(C)[C@@H](NC(=O)NCC(C)(C)O)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1
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Compound Formula C23H36ClN3O4
Compound Structure
Protein Name
 Protein Info 
C-C chemokine receptor type 1
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Peptide receptor (family A GPCR)
>
Chemokine receptor
>
CC chemokine receptor
Uniprot ID
P32246
Gene Name
CCR1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000040 THP-1
 Cell Line Info 
Homo sapiens (Human)  10
1
IC50 = 1 nM
   TI
   LI
   LO
   TS
2
IC50 = 1.5 nM
   TI
   LI
   LO
   TS
3
IC50 = 3.2 nM
   TI
   LI
   LO
   TS
4
IC50 = 3.3 nM
   TI
   LI
   LO
   TS
5
IC50 = 5.5 nM
   TI
   LI
   LO
   TS
6
IC50 = 6 nM
   TI
   LI
   LO
   TS
7
IC50 = 7.5 nM
   TI
   LI
   LO
   TS
8
IC50 = 9.3 nM
   TI
   LI
   LO
   TS
9
IC50 = 14.3 nM
   TI
   LI
   LO
   TS
10
IC50 = 16.2 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 4.2 nM
2 IC50 = 25 nM
3 IC50 = 42 nM