Brief Information of the Compound and Protein
Compound Name
1-[4-(4-chloro-3-methoxyphenyl)piperazin-1-yl]-2-[4-chloro-5-methyl-3-(trifluoromethyl)pyrazol-1-yl]ethanone
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PubChem ID
CID: 21070989
SID: 136331936
Canonical SMILES
COc1cc(ccc1Cl)N1CCN(CC1)C(=O)Cn1nc(c(Cl)c1C)C(F)(F)F
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Compound Formula C18H19Cl2F3N4O2
Compound Structure
Protein Name
C-C chemokine receptor type 1
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
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Peptide receptor (family A GPCR)
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Chemokine receptor
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CC chemokine receptor
Uniprot ID
P32246
Gene Name
CCR1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000040 THP-1 Homo sapiens (Human)  8
1
IC50 = 0.8 nM
   TI
   LI
   LO
   TS
2
IC50 = 1.5 nM
   TI
   LI
   LO
   TS
3
IC50 = 2.5 nM
   TI
   LI
   LO
   TS
4
IC50 = 3.9 nM
   TI
   LI
   LO
   TS
5
IC50 = 4 nM
   TI
   LI
   LO
   TS
6
IC50 = 4.8 nM
   TI
   LI
   LO
   TS
7
IC50 = 5.5 nM
   TI
   LI
   LO
   TS
8
IC50 = 12 nM
   TI
   LI
   LO
   TS