Brief Information of the Cell Line and Protein
Cell Line ID: CL000025 , HEK-293T
Synonyms
Hek293T
HEK-293T
HEK 293T
HEK-293-T
HEK 293 T
293-T
293 T
293T
Human Embryonic Kidney 293T
293tsA1609neo
Category Transformed cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0063
Protein ID: PT01020 , Beta-secretase 1
Gene Name BACE1
Organism Homo sapiens, Human
Protein Classification Enzyme
Uniprot ID P56817
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000025  Protein ID: PT01020
 
Compound ID Compound Name Compound Formula
CP0087522
(12S)-12-[(1R)-2-[[(4S)-6-ethylspiro[3,4-dihydrochromene-2,1'-cyclobutane]-4-yl]amino]-1-hydroxyethyl]-17-pyrrolidin-1-yl-1,13-diazatricyclo[13.3.1.16,10]icosa-6(20),7,9,15(19),16-pentaene-14,18-dione
   Show/Hide
C38H48N4O4
 1
1
IC50 = 2 nM
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CP0213546
(4S)-4'-fluoro-7'-(2-fluoropyridin-3-yl)-2'-[(3-methyloxetan-3-yl)methoxy]spiro[5H-1,3-oxazole-4,9'-xanthene]-2-amine
   Show/Hide
C25H21F2N3O4
 1
1
IC50 = 3 nM
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CP0511976
(4S)-4'-fluoro-7'-(2-fluoropyridin-3-yl)-2'-(1-methylpyrazol-4-yl)spiro[5H-1,3-oxazole-4,9'-xanthene]-2-amine
   Show/Hide
C24H17F2N5O2
 1
1
IC50 = 3 nM
   TI
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   TS
CP0513000
(4S)-2'-(3,6-dihydro-2H-pyran-5-yl)-4'-fluoro-7'-(2-fluoropyridin-3-yl)spiro[5H-1,3-oxazole-4,9'-xanthene]-2-amine
   Show/Hide
C25H19F2N3O3
 1
1
IC50 = 3 nM
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   TS
CP0190650
(4S)-2'-(3,6-dihydro-2H-pyran-4-yl)-4'-fluoro-7'-(2-fluoropyridin-3-yl)spiro[5H-1,3-oxazole-4,9'-xanthene]-2-amine
   Show/Hide
C25H19F2N3O3
 2
1
IC50 = 4 nM
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2
IC50 = 4.1 nM
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CP0541959
(4S)-4'-fluoro-2'-[(3-methyloxetan-3-yl)methoxy]-7'-pyridin-3-ylspiro[5H-1,3-oxazole-4,9'-xanthene]-2-amine
   Show/Hide
C25H22FN3O4
 1
1
IC50 = 4 nM
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   TS
CP0183053
(4S)-3'-(3,3-difluoropyrrolidin-1-yl)-7'-(2-fluoropyridin-3-yl)spiro[5H-1,3-oxazole-4,5'-chromeno[2,3-c]pyridine]-2-amine
   Show/Hide
C23H18F3N5O2
 1
1
IC50 = 4.1 nM
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CP0148441
(4S)-3'-(3,6-dihydro-2H-pyran-4-yl)-7'-(2-fluoropyridin-3-yl)spiro[5H-1,3-oxazole-4,5'-chromeno[2,3-c]pyridine]-2-amine
   Show/Hide
C24H19FN4O3
 1
1
IC50 = 4.2 nM
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CP0071569
(4S)-7'-(2-fluoropyridin-3-yl)-3'-[(3R)-3-fluoropyrrolidin-1-yl]spiro[5H-1,3-oxazole-4,5'-chromeno[2,3-c]pyridine]-2-amine
   Show/Hide
C23H19F2N5O2
 1
1
IC50 = 4.9 nM
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   TS
CP0399532
(4S)-4'-fluoro-7'-(2-fluoropyridin-3-yl)-2'-morpholin-4-ylspiro[5H-1,3-oxazole-4,9'-xanthene]-2-amine
   Show/Hide
C24H20F2N4O3
 1
1
IC50 = 5 nM
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   TS
CP0720644
(12S)-12-[(1R)-2-{[(4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridine]-4'-yl]amino}-1-hydroxyethyl]-1,13-diazatricyclo[13.3.1.1^{6,10}]icosa-6,8,10(20),15(19),16-pentaene-14,18-dione
   Show/Hide
C36H46N4O4
 1
1
IC50 = 5.1 nM
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CP0156925
(3S)-3-[(1R)-2-[[(4S)-6-(2,2-dimethylpropyl)spiro[3,4-dihydropyrano[2,3-b]pyridine-2,1'-cyclobutane]-4-yl]amino]-1-hydroxyethyl]-4-azabicyclo[10.3.1]hexadeca-1(15),12(16),13-trien-5-one
   Show/Hide
C33H47N3O3
 1
1
IC50 = 5.9 nM
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CP0381661
(4S)-4'-fluoro-7'-(2-fluoropyridin-3-yl)-2'-[(3S)-3-fluoropyrrolidin-1-yl]spiro[5H-1,3-oxazole-4,9'-xanthene]-2-amine
   Show/Hide
C24H19F3N4O2
 1
1
IC50 = 7 nM
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CP0190509
(4S)-3'-(6,6-dimethyl-2,3-dihydropyran-4-yl)-7'-(2-fluoropyridin-3-yl)spiro[5H-1,3-oxazole-4,5'-chromeno[2,3-c]pyridine]-2-amine
   Show/Hide
C26H23FN4O3
 1
1
IC50 = 7.4 nM
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CP0156934
(11S)-11-[(1R)-2-[[(4S)-6-(2,2-dimethylpropyl)spiro[3,4-dihydropyrano[2,3-b]pyridine-2,1'-cyclobutane]-4-yl]amino]-1-hydroxyethyl]-1,12-diazatricyclo[12.3.1.15,9]nonadeca-5(19),6,8,14(18),15-pentaene-13,17-dione
   Show/Hide
C35H44N4O4
 1
1
IC50 = 7.8 nM
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CP0183057
(4S)-3'-(3,6-dihydro-2H-pyran-5-yl)-7'-(2-fluoropyridin-3-yl)spiro[5H-1,3-oxazole-4,5'-chromeno[2,3-c]pyridine]-2-amine
   Show/Hide
C24H19FN4O3
 1
1
IC50 = 7.9 nM
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   TS
CP0294347
(4S)-3'-(4,4-difluoropiperidin-1-yl)-7'-(2-fluoropyridin-3-yl)spiro[5H-1,3-oxazole-4,5'-chromeno[2,3-c]pyridine]-2-amine
   Show/Hide
C24H20F3N5O2
 1
1
IC50 = 8.7 nM
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   TS
CP0419491
(4S)-4'-fluoro-2'-(2-fluoro-2-methylpropoxy)-7'-(2-fluoropyridin-3-yl)spiro[5H-1,3-oxazole-4,9'-xanthene]-2-amine
   Show/Hide
C24H20F3N3O3
 1
1
IC50 = 9 nM
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   TS
CP0245981
(4S)-7'-(2-fluoropyridin-3-yl)-3'-[(3S)-3-fluoropyrrolidin-1-yl]spiro[5H-1,3-oxazole-4,5'-chromeno[2,3-c]pyridine]-2-amine
   Show/Hide
C23H19F2N5O2
 1
1
IC50 = 9.6 nM
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CP0131935
(4S)-2'-[(3-methyloxetan-3-yl)methoxy]-7'-pyrimidin-5-ylspiro[5H-1,3-oxazole-4,9'-xanthene]-2-amine
   Show/Hide
C24H22N4O4
 1
1
IC50 = 10 nM
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CP0259734
(4S)-2'-(2-methoxy-2-methylpropoxy)-7'-pyrimidin-5-ylspiro[5H-1,3-oxazole-4,9'-xanthene]-2-amine
   Show/Hide
C24H24N4O4
 1
1
IC50 = 10 nM
   TI
   LI
   LO
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CP0320494
(4S)-3'-fluoro-2'-[(3-methyloxetan-3-yl)methoxy]-7'-pyridin-3-ylspiro[5H-1,3-oxazole-4,9'-xanthene]-2-amine
   Show/Hide
C25H22FN3O4
 1
1
IC50 = 12 nM
   TI
   LI
   LO
   TS
CP0433580
(4S)-4'-fluoro-7'-(2-fluoropyridin-3-yl)-2'-pyridin-2-ylspiro[5H-1,3-oxazole-4,9'-xanthene]-2-amine
   Show/Hide
C25H16F2N4O2
 1
1
IC50 = 12 nM
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   TS
CP0278588
(12S)-12-[(1R)-2-[[(4S)-6-ethylspiro[3,4-dihydrochromene-2,1'-cyclobutane]-4-yl]amino]-1-hydroxyethyl]-17-pyridin-2-yl-1,13-diazatricyclo[13.3.1.16,10]icosa-6(20),7,9,15(19),16-pentaene-14,18-dione
   Show/Hide
C39H44N4O4
 1
1
IC50 = 14 nM
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CP0334611
(4S)-7'-(2-fluoropyridin-3-yl)-3'-[(2R)-oxan-2-yl]spiro[5H-1,3-oxazole-4,5'-chromeno[2,3-c]pyridine]-2-amine
   Show/Hide
C24H21FN4O3
 1
1
IC50 = 14.3 nM
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CP0426814
1-[(4S)-2-amino-7'-pyrimidin-5-ylspiro[5H-1,3-oxazole-4,9'-xanthene]-2'-yl]oxy-2-methylpropan-2-ol
   Show/Hide
C23H22N4O4
 1
1
IC50 = 15 nM
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CP0541958
(4S)-2'-[(3-methyloxetan-3-yl)methoxy]-7'-pyridin-3-ylspiro[5H-1,3-oxazole-4,9'-xanthene]-2-amine
   Show/Hide
C25H23N3O4
 1
1
IC50 = 15 nM
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CP0071777
(4S)-7'-(2-fluoropyridin-3-yl)-3'-(2-methylpyridin-4-yl)spiro[5H-1,3-oxazole-4,5'-chromeno[2,3-c]pyridine]-2-amine
   Show/Hide
C25H18FN5O2
 1
1
IC50 = 15 nM
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CP0260092
(4R)-2'-(3,6-dihydro-2H-pyran-4-yl)-7'-pyrimidin-5-ylspiro[5H-1,3-oxazole-4,9'-xanthene]-2-amine
   Show/Hide
C24H20N4O3
 1
1
IC50 = 16 nM
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CP0116390
(4S)-7'-(2-fluoropyridin-3-yl)-3'-pyridin-4-ylspiro[5H-1,3-oxazole-4,5'-chromeno[2,3-c]pyridine]-2-amine
   Show/Hide
C24H16FN5O2
 1
1
IC50 = 16 nM
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CP0186357
1-N-[(1R)-1-(4-fluorophenyl)ethyl]-5-(N-methylmethanesulfonamido)-3-N-[(2S)-1-{[(1S)-1-[(2-methylpropyl)carbamoyl]butyl]amino}-3-phenylpropan-2-yl]benzene-1,3-dicarboxamide
   Show/Hide
C36H48FN5O5S
 1
1
IC50 = 17 nM
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CP0177470
(4S)-7'-(2-fluoropyridin-3-yl)-3'-pyridin-3-ylspiro[5H-1,3-oxazole-4,5'-chromeno[2,3-c]pyridine]-2-amine
   Show/Hide
C24H16FN5O2
 1
1
IC50 = 17.4 nM
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CP0183054
(4R)-2'-(3,6-dihydro-2H-pyran-4-yl)-7'-(2-fluoropyridin-3-yl)spiro[5H-1,3-oxazole-4,9'-xanthene]-2-amine
   Show/Hide
C25H20FN3O3
 1
1
IC50 = 18.5 nM
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CP0131922
(4R)-2'-(3-methoxy-3-methylbut-1-ynyl)-7'-pyrimidin-5-ylspiro[5H-1,3-oxazole-4,9'-xanthene]-2-amine
   Show/Hide
C25H22N4O3
 1
1
IC50 = 19 nM
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CP0352504
1-N-[(1R)-1-(4-fluorophenyl)ethyl]-5-(N-methylmethanesulfonamido)-3-N-[(2S)-1-{[(1S)-1-[(2-methylpropyl)carbamoyl]propyl]amino}-3-phenylpropan-2-yl]benzene-1,3-dicarboxamide
   Show/Hide
C35H46FN5O5S
 1
1
IC50 = 20 nM
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CP0318084
4-[(4R)-2-amino-7'-pyrimidin-5-ylspiro[5H-1,3-oxazole-4,9'-xanthene]-2'-yl]-2-methylbut-3-yn-2-ol
   Show/Hide
C24H20N4O3
 1
1
IC50 = 20 nM
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CP0294346
(4S)-7'-(2-fluoropyridin-3-yl)-3'-morpholin-4-ylspiro[5H-1,3-oxazole-4,5'-chromeno[2,3-c]pyridine]-2-amine
   Show/Hide
C23H20FN5O3
 1
1
IC50 = 20.5 nM
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CP0054828
3-[(4S)-2-amino-7'-pyrimidin-5-ylspiro[5H-1,3-oxazole-4,9'-xanthene]-2'-yl]oxy-2,2-dimethylpropanenitrile
   Show/Hide
C24H21N5O3
 1
1
IC50 = 21 nM
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CP0190651
(4S)-7'-(2-fluoropyridin-3-yl)-3'-(2-fluoropyridin-4-yl)spiro[5H-1,3-oxazole-4,5'-chromeno[2,3-c]pyridine]-2-amine
   Show/Hide
C24H15F2N5O2
 1
1
IC50 = 21.2 nM
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CP0369558
1-N-[(1R)-1-(4-fluorophenyl)ethyl]-5-(N-methylmethanesulfonamido)-3-N-[(2S)-1-{[(1S)-1-[(2-methylpropyl)carbamoyl]ethyl]amino}-3-phenylpropan-2-yl]benzene-1,3-dicarboxamide
   Show/Hide
C34H44FN5O5S
 1
1
IC50 = 22 nM
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CP0148442
(4S)-3'-(2,2-dimethylmorpholin-4-yl)-7'-(2-fluoropyridin-3-yl)spiro[5H-1,3-oxazole-4,5'-chromeno[2,3-c]pyridine]-2-amine
   Show/Hide
C25H24FN5O3
 1
1
IC50 = 22 nM
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CP0737228
N-((S)-3-((S)-1-(isobutylamino)-1-oxopropan-2-ylamino)-1-phenylpropan-2-yl)-3-(2-((1S,2S)-2-methylcyclopropyl)ethyl)-5-(N-methylmethan-5-ylsulfonamido)benzamide
   Show/Hide
C31H46N4O4S
 1
1
IC50 = 23 nM
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CP0042944
(4S)-2'-(2,2-dimethylpropoxy)-7'-pyrimidin-5-ylspiro[5H-1,3-oxazole-4,9'-xanthene]-2-amine
   Show/Hide
C24H24N4O3
 1
1
IC50 = 25 nM
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CP0054765
(4S)-7'-(2-fluoropyridin-3-yl)-3'-phenylspiro[5H-1,3-oxazole-4,5'-chromeno[2,3-c]pyridine]-2-amine
   Show/Hide
C25H17FN4O2
 1
1
IC50 = 25.3 nM
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CP0170345
(4S)-7'-(2-fluoropyridin-3-yl)-3'-pyridin-2-ylspiro[5H-1,3-oxazole-4,5'-chromeno[2,3-c]pyridine]-2-amine
   Show/Hide
C24H16FN5O2
 1
1
IC50 = 26.6 nM
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CP0069645
1-N-[(2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phenylbutan-2-yl]-5-(N-methylmethanesulfonamido)-3-N-[(1R)-1-phenylethyl]benzene-1,3-dicarboxamide
   Show/Hide
C31H38N4O5S
 1
1
IC50 = 29 nM
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CP0198623
(4S)-2'-(2,2-dimethylmorpholin-4-yl)-7'-pyrimidin-5-ylspiro[5H-1,3-oxazole-4,9'-xanthene]-2-amine
   Show/Hide
C25H25N5O3
 1
1
IC50 = 30 nM
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CP0198624
(4S)-2'-(2-fluoro-2-methylpropoxy)-7'-pyrimidin-5-ylspiro[5H-1,3-oxazole-4,9'-xanthene]-2-amine
   Show/Hide
C23H21FN4O3
 1
1
IC50 = 30 nM
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CP0182930
(4S)-2'-(2-methylpropoxy)-7'-pyrimidin-5-ylspiro[5H-1,3-oxazole-4,9'-xanthene]-2-amine
   Show/Hide
C23H22N4O3
 1
1
IC50 = 36 nM
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CP0198621
(4R)-2'-(3,3-dimethylbut-1-ynyl)-7'-pyrimidin-5-ylspiro[5H-1,3-oxazole-4,9'-xanthene]-2-amine
   Show/Hide
C25H22N4O2
 1
1
IC50 = 36 nM
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CP0198629
(4S)-2'-(2,2-dimethylpropoxy)-7'-(2-fluoropyridin-3-yl)spiro[5H-1,3-oxazole-4,9'-xanthene]-2-amine
   Show/Hide
C25H24FN3O3
 1
1
IC50 = 39 nM
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CP0412286
5-[(4S)-2-amino-7'-(2,2-dimethylpropoxy)spiro[5H-1,3-oxazole-4,9'-xanthene]-2'-yl]pyridine-3-carbonitrile
   Show/Hide
C26H24N4O3
 1
1
IC50 = 40 nM
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CP0371121
(4S)-2'-(2,4-difluoropyridin-3-yl)-7'-(2,2-dimethylpropoxy)spiro[5H-1,3-oxazole-4,9'-xanthene]-2-amine
   Show/Hide
C25H23F2N3O3
 1
1
IC50 = 45 nM
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CP0054826
(4S)-2'-morpholin-4-yl-7'-pyrimidin-5-ylspiro[5H-1,3-oxazole-4,9'-xanthene]-2-amine
   Show/Hide
C23H21N5O3
 1
1
IC50 = 48 nM
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CP0162659
N-[(2S,3R)-3-amino-4-fluoro-1-phenylbutan-2-yl]-2-[[(1S,2S)-2-methylcyclopropyl]methylamino]-6-[methyl(propan-2-ylsulfonyl)amino]pyridine-4-carboxamide
   Show/Hide
C25H36FN5O3S
 1
1
IC50 = 49 nM
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CP0198622
(4R)-2'-(3,3-dimethylbutyl)-7'-pyrimidin-5-ylspiro[5H-1,3-oxazole-4,9'-xanthene]-2-amine
   Show/Hide
C25H26N4O2
 1
1
IC50 = 49 nM
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CP0170343
(4S)-7'-(2-fluoropyridin-3-yl)-3'-(oxan-4-yl)spiro[5H-1,3-oxazole-4,5'-chromeno[2,3-c]pyridine]-2-amine
   Show/Hide
C24H21FN4O3
 1
1
IC50 = 49.5 nM
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CP0087523
(12S)-12-[(1R)-2-[[(4S)-6-ethylspiro[3,4-dihydrochromene-2,1'-cyclobutane]-4-yl]amino]-1-hydroxyethyl]-1,13-diazatricyclo[13.3.1.16,10]icosa-6(20),7,9,15(19),16-pentaene-14,18-dione
   Show/Hide
C34H41N3O4
 1
1
IC50 = 54 nM
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CP0480288
8-N-[(2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phenylbutan-2-yl]-6-N-[(1R)-1-phenylethyl]-2,3,4,5-tetrahydro-1-benzoxepine-6,8-dicarboxamide
   Show/Hide
C33H39N3O4
 1
1
IC50 = 56 nM
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CP0278591
(3S)-3-[(1R)-2-[[(4S)-6-ethylspiro[3,4-dihydrochromene-2,1'-cyclobutane]-4-yl]amino]-1-hydroxyethyl]-4-azabicyclo[10.3.1]hexadeca-1(15),12(16),13-trien-5-one
   Show/Hide
C31H42N2O3
 1
1
IC50 = 58 nM
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CP0498067
7-N-[(2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phenylbutan-2-yl]-5-N-[(1R)-1-phenylethyl]-3,4-dihydro-2H-chromene-5,7-dicarboxamide
   Show/Hide
C32H37N3O4
 1
1
IC50 = 63 nM
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   TS
CP0087525
N-[(2S,3R)-4-[[(4S)-6-(2,2-dimethylpropyl)spiro[3,4-dihydropyrano[2,3-b]pyridine-2,1'-cyclobutane]-4-yl]amino]-3-hydroxy-1-(3-prop-2-enylphenyl)butan-2-yl]hex-5-enamide
   Show/Hide
C35H49N3O3
 1
1
IC50 = 66 nM
   TI
   LI
   LO
   TS
CP0198626
(4S)-2'-(2,2-dimethylpropoxy)-7'-pyridin-3-ylspiro[5H-1,3-oxazole-4,9'-xanthene]-2-amine
   Show/Hide
C25H25N3O3
 1
1
IC50 = 74 nM
   TI
   LI
   LO
   TS
CP0213541
(4S)-2'-(2,2-dimethylpropoxy)-7'-(5-fluoropyridin-3-yl)spiro[5H-1,3-oxazole-4,9'-xanthene]-2-amine
   Show/Hide
C25H24FN3O3
 1
1
IC50 = 76 nM
   TI
   LI
   LO
   TS
CP0198628
(4S)-2'-(2,2-dimethylpropoxy)-7'-(5-methoxypyridin-3-yl)spiro[5H-1,3-oxazole-4,9'-xanthene]-2-amine
   Show/Hide
C26H27N3O4
 1
1
IC50 = 80 nM
   TI
   LI
   LO
   TS
CP0156929
N-[(2S,3R)-4-[[(4S)-6-ethylspiro[3,4-dihydrochromene-2,1'-cyclobutane]-4-yl]amino]-3-hydroxy-1-(3-prop-2-enylphenyl)butan-2-yl]-6-oxo-1-prop-2-enyl-5-pyrrolidin-1-ylpyridine-3-carboxamide
   Show/Hide
C40H50N4O4
 1
1
IC50 = 85 nM
   TI
   LI
   LO
   TS
CP0459528
6-N-[(2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phenylbutan-2-yl]-8-N-[(1R)-1-phenylethyl]-2,3,4,5-tetrahydro-1-benzoxepine-6,8-dicarboxamide
   Show/Hide
C33H39N3O4
 1
1
IC50 = 89 nM
   TI
   LI
   LO
   TS
CP0459526
5-N-[(2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phenylbutan-2-yl]-7-N-[(1R)-1-phenylethyl]-3,4-dihydro-2H-chromene-5,7-dicarboxamide
   Show/Hide
C32H37N3O4
 1
1
IC50 = 112 nM
   TI
   LI
   LO
   TS
CP0068991
(4S)-7'-(2-fluoropyridin-3-yl)-3'-[(2S)-oxan-2-yl]spiro[5H-1,3-oxazole-4,5'-chromeno[2,3-c]pyridine]-2-amine
   Show/Hide
C24H21FN4O3
 1
1
IC50 = 112 nM
   TI
   LI
   LO
   TS
CP0198627
(4S)-2'-(2,2-dimethylpropoxy)-7'-(6-fluoropyridin-3-yl)spiro[5H-1,3-oxazole-4,9'-xanthene]-2-amine
   Show/Hide
C25H24FN3O3
 1
1
IC50 = 113 nM
   TI
   LI
   LO
   TS
CP0199370
(4S)-7'-(2-fluoropyridin-3-yl)-3'-(oxan-3-yl)spiro[5H-1,3-oxazole-4,5'-chromeno[2,3-c]pyridine]-2-amine
   Show/Hide
C24H21FN4O3
 1
1
IC50 = 123 nM
   TI
   LI
   LO
   TS
CP0044986
1-N-[(2S)-1-{[(1S)-1-(cyclopropylcarbamoyl)ethyl]amino}-3-phenylpropan-2-yl]-3-N-[(1R)-1-(4-fluorophenyl)ethyl]-5-(N-methylmethanesulfonamido)benzene-1,3-dicarboxamide
   Show/Hide
C33H40FN5O5S
 1
1
IC50 = 133 nM
   TI
   LI
   LO
   TS
CP0468415
3-N-[(2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phenylbutan-2-yl]-5-(1,1-dioxothiazinan-2-yl)-1-N-[(1R)-1-phenylethyl]benzene-1,3-dicarboxamide
   Show/Hide
C33H40N4O5S
 1
1
IC50 = 158 nM
   TI
   LI
   LO
   TS
CP0674014
1-allyl-N-((2S,3R)-1-(3-allylphenyl)-4-((S)-6-ethylspiro[chroman-2,1'-cyclobutane]-4-ylamino)-3-hydroxybutan-2-yl)-5-bromo-6-oxo-1,6-dihydropyridine-3-carboxamide
   Show/Hide
C36H42BrN3O4
 1
1
IC50 = 170 nM
   TI
   LI
   LO
   TS
CP0215666
N-[(2S,3R)-3-amino-1-(3,5-difluorophenyl)-4-methoxybutan-2-yl]-2-[methyl-[[(1S,2S)-2-methylcyclopropyl]methyl]amino]-6-[methyl(methylsulfonyl)amino]pyridine-4-carboxamide
   Show/Hide
C25H35F2N5O4S
 1
1
IC50 = 173 nM
   TI
   LI
   LO
   TS
CP0362227
(4R)-4'-fluoro-7'-[(3-methyloxetan-3-yl)methoxy]-2'-pyridin-3-ylspiro[5H-1,3-oxazole-4,9'-xanthene]-2-amine
   Show/Hide
C25H22FN3O4
 1
1
IC50 = 178 nM
   TI
   LI
   LO
   TS
CP0156935
N-[(2S,3R)-4-[[(4S)-6-ethylspiro[3,4-dihydrochromene-2,1'-cyclobutane]-4-yl]amino]-3-hydroxy-1-(3-prop-2-enylphenyl)butan-2-yl]-6-oxo-1-prop-2-enyl-5-pyridin-2-ylpyridine-3-carboxamide
   Show/Hide
C41H46N4O4
 1
1
IC50 = 210 nM
   TI
   LI
   LO
   TS
CP0263101
1-cyclopentyl-N-[(2S,3R)-3-hydroxy-1-phenyl-4-[[3-(trifluoromethyl)phenyl]methylamino]butan-2-yl]-6-oxo-5-(2-oxopyrrolidin-1-yl)pyridine-3-carboxamide
   Show/Hide
C33H37F3N4O4
 1
1
IC50 = 210 nM
   TI
   LI
   LO
   TS
CP0276656
1-N-[(2S)-1-{[(1S)-1-(ethylcarbamoyl)ethyl]amino}-3-phenylpropan-2-yl]-3-N-[(1R)-1-(4-fluorophenyl)ethyl]-5-(N-methylmethanesulfonamido)benzene-1,3-dicarboxamide
   Show/Hide
C32H40FN5O5S
 1
1
IC50 = 242 nM
   TI
   LI
   LO
   TS
CP0087521
(3S)-3-[(1R)-2-[[(4S)-6-ethylspiro[3,4-dihydrochromene-2,1'-cyclobutane]-4-yl]amino]-1-hydroxyethyl]-4-azabicyclo[9.3.1]pentadeca-1(14),11(15),12-trien-5-one
   Show/Hide
C30H40N2O3
 1
1
IC50 = 250 nM
   TI
   LI
   LO
   TS
CP0459622
8-N-[(2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phenylbutan-2-yl]-6-N-[(1R)-1-(4-fluorophenyl)ethyl]-2,3,4,5-tetrahydro-1-benzoxepine-6,8-dicarboxamide
   Show/Hide
C33H38FN3O4
 1
1
IC50 = 262 nM
   TI
   LI
   LO
   TS
CP0260100
(4S)-2'-(cyclohexylmethoxy)-7'-pyrimidin-5-ylspiro[5H-1,3-oxazole-4,9'-xanthene]-2-amine
   Show/Hide
C26H26N4O3
 1
1
IC50 = 269 nM
   TI
   LI
   LO
   TS
CP0168665
N-[(2S)-1-amino-3-(3,5-difluorophenyl)propan-2-yl]-2-[(2-methylcyclopropyl)methylamino]-6-[methyl(methylsulfonyl)amino]pyridine-4-carboxamide
   Show/Hide
C22H29F2N5O3S
 1
1
IC50 = 280 nM
   TI
   LI
   LO
   TS
CP0260416
N-[(2S,3R)-4-[[(4S)-6-ethylspiro[3,4-dihydrochromene-2,1'-cyclobutane]-4-yl]amino]-3-hydroxy-1-phenylbutan-2-yl]acetamide
   Show/Hide
C26H34N2O3
 1
1
IC50 = 370 nM
   TI
   LI
   LO
   TS
CP0439793
6-N-[(2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phenylbutan-2-yl]-2-methyl-4-N-[(1R)-1-phenylethyl]-1-benzofuran-4,6-dicarboxamide
   Show/Hide
C32H35N3O4
 1
1
IC50 = 524 nM
   TI
   LI
   LO
   TS
CP0366608
(4S)-2'-(2,2-dimethylpropoxy)-7'-pyridin-2-ylspiro[5H-1,3-oxazole-4,9'-xanthene]-2-amine
   Show/Hide
C25H25N3O3
 1
1
IC50 = 583 nM
   TI
   LI
   LO
   TS
CP0352998
1-N-[(2S)-1-{[(1S)-1-(benzylcarbamoyl)ethyl]amino}-3-phenylpropan-2-yl]-3-N-[(1R)-1-(4-fluorophenyl)ethyl]-5-(N-methylmethanesulfonamido)benzene-1,3-dicarboxamide
   Show/Hide
C37H42FN5O5S
 1
1
IC50 = 731 nM
   TI
   LI
   LO
   TS
CP0457608
7-N-[(2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phenylbutan-2-yl]-5-N-[(1R)-1-(4-fluorophenyl)ethyl]-3,4-dihydro-2H-chromene-5,7-dicarboxamide
   Show/Hide
C32H36FN3O4
 1
1
IC50 = 740 nM
   TI
   LI
   LO
   TS
CP0275054
1-N-[(1R)-1-(4-fluorophenyl)ethyl]-3-N-[(2S)-1-{[(1S)-3-hydroxy-1-[(2-methylpropyl)carbamoyl]propyl]amino}-3-phenylpropan-2-yl]-5-(N-methylmethanesulfonamido)benzene-1,3-dicarboxamide
   Show/Hide
C35H46FN5O6S
 1
1
IC50 = 751 nM
   TI
   LI
   LO
   TS
CP0087531
N-[(2S,3R)-4-[[(4S)-6-ethylspiro[3,4-dihydrochromene-2,1'-cyclobutane]-4-yl]amino]-3-hydroxy-1-(3-prop-2-enylphenyl)butan-2-yl]hex-5-enamide
   Show/Hide
C33H44N2O3
 1
1
IC50 = 810 nM
   TI
   LI
   LO
   TS
CP0439792
4'-Chloro-biphenyl-3,5-dicarboxylic acid 3-[((1S,2R)-1-benzyl-3-cyclopropylamino-2-hydroxy-propyl)-amide] 5-[((R)-1-phenyl-ethyl)-amide]
   Show/Hide
C35H36ClN3O3
 1
1
IC50 = 811 nM
   TI
   LI
   LO
   TS
CP0388217
3-N-[(2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phenylbutan-2-yl]-5-ethynyl-1-N-[(1R)-1-phenylethyl]benzene-1,3-dicarboxamide
   Show/Hide
C31H33N3O3
 1
1
IC50 = 889 nM
   TI
   LI
   LO
   TS
CP0316465
N-[(2S,3R)-3-amino-1-(3,5-difluorophenyl)-4-fluorobutan-2-yl]-2-[methyl-[[(1S,2S)-2-methylcyclopropyl]methyl]amino]-6-[methyl(propan-2-ylsulfonyl)amino]pyridine-4-carboxamide
   Show/Hide
C26H36F3N5O3S
 1
1
IC50 = 910 nM
   TI
   LI
   LO
   TS
CP0087524
(3S)-3-[(1R)-2-[[(4S)-6-ethylspiro[3,4-dihydrochromene-2,1'-cyclobutane]-4-yl]amino]-1-hydroxyethyl]-4-azabicyclo[11.3.1]heptadeca-1(16),13(17),14-trien-5-one
   Show/Hide
C32H44N2O3
 1
1
IC50 = 960 nM
   TI
   LI
   LO
   TS
CP0388218
4-N-[(2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phenylbutan-2-yl]-2-methyl-6-N-[(1R)-1-phenylethyl]-1-benzofuran-4,6-dicarboxamide
   Show/Hide
C32H35N3O4
 1
1
IC50 = 998 nM
   TI
   LI
   LO
   TS
CP0424081
3-N-[(2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phenylbutan-2-yl]-1-N-[(1R)-1-phenylethyl]-5-(2-phenylethynyl)benzene-1,3-dicarboxamide
   Show/Hide
C37H37N3O3
 1
1
IC50 = 1119 nM
   TI
   LI
   LO
   TS
CP0386281
5-(1-benzyl-1H-1,2,3-triazol-4-yl)-N1-((2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phenylbutan-2-yl)-N3-((R)-1-phenylethyl)isophthalamide
   Show/Hide
C38H40N6O3
 1
1
IC50 = 1256 nM
   TI
   LI
   LO
   TS
CP0202732
N-[(2S,3R)-4-[[(4S)-6-ethylspiro[3,4-dihydrochromene-2,1'-cyclobutane]-4-yl]amino]-3-hydroxy-1-(3-prop-2-enylphenyl)butan-2-yl]pent-4-enamide
   Show/Hide
C32H42N2O3
 1
1
IC50 = 1500 nM
   TI
   LI
   LO
   TS
CP0386277
3-N-[(2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phenylbutan-2-yl]-5-hydroxy-1-N-[(1R)-1-phenylethyl]benzene-1,3-dicarboxamide
   Show/Hide
C29H33N3O4
 1
1
IC50 = 1581 nM
   TI
   LI
   LO
   TS
CP0386276
3-N-[(2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phenylbutan-2-yl]-5-(1,1-dioxo-1,2-thiazolidin-2-yl)-1-N-[(1R)-1-phenylethyl]benzene-1,3-dicarboxamide
   Show/Hide
C32H38N4O5S
 1
1
IC50 = 1774 nM
   TI
   LI
   LO
   TS
CP0457609
3-N-[(2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phenylbutan-2-yl]-1-N-[(1R)-1-phenylethyl]-5-thiophen-3-ylbenzene-1,3-dicarboxamide
   Show/Hide
C33H35N3O3S
 1
1
IC50 = 2233 nM
   TI
   LI
   LO
   TS
CP0459527
3-N-[(2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phenylbutan-2-yl]-5-methoxy-1-N-[(1R)-1-phenylethyl]benzene-1,3-dicarboxamide
   Show/Hide
C30H35N3O4
 1
1
IC50 = 2506 nM
   TI
   LI
   LO
   TS
CP0198625
(4S)-2'-(2,2-dimethylpropoxy)-7'-pyridin-4-ylspiro[5H-1,3-oxazole-4,9'-xanthene]-2-amine
   Show/Hide
C25H25N3O3
 1
1
IC50 = 2830 nM
   TI
   LI
   LO
   TS
CP0449449
1-N-[(1R)-1-(4-fluorophenyl)ethyl]-5-(N-methylmethanesulfonamido)-3-N-[(2S)-1-({[(2-methylpropyl)carbamoyl]methyl}amino)-3-phenylpropan-2-yl]benzene-1,3-dicarboxamide
   Show/Hide
C33H42FN5O5S
 1
1
IC50 = 3710 nM
   TI
   LI
   LO
   TS
CP0198882
N-[(2S,3R)-4-[[(4S)-6-ethylspiro[3,4-dihydrochromene-2,1'-cyclobutane]-4-yl]amino]-3-hydroxy-1-(3-prop-2-enylphenyl)butan-2-yl]hept-6-enamide
   Show/Hide
C34H46N2O3
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0505658
1-N-[(1R)-1-(4-fluorophenyl)ethyl]-3-N-[(2S)-1-{[(1S)-3-methanesulfonyl-1-[(2-methylpropyl)carbamoyl]propyl]amino}-3-phenylpropan-2-yl]-5-(N-methylmethanesulfonamido)benzene-1,3-dicarboxamide
   Show/Hide
C36H48FN5O7S2
 1
1
IC50 = 17500 nM
   TI
   LI
   LO
   TS
CP0921499
(S)-1-((S)-2-((S)-2-(3-(benzamido)-5-(N-methylmethan-5-ylsulfonamido)benzamido)-3-phenylpropylamino)propanoyl)pyrrolidine-2-carboxylic acid
   Show/Hide
C35H42FN5O7S
 1
1
IC50 > 20000 nM
   TI
   LI
   LO
   TS
CP0284904
N-[(2S)-1-(3,5-difluorophenyl)-3-hydroxypropan-2-yl]-2-[[(1S,2S)-2-methylcyclopropyl]methylamino]-6-[methyl(propan-2-ylsulfonyl)amino]pyridine-4-carboxamide
   Show/Hide
C24H32F2N4O4S
 1
1
IC50 > 20000 nM
   TI
   LI
   LO
   TS
CP0360374
2-[cyclopropylmethyl(propyl)amino]-N-[(2S)-1-(3,5-difluorophenyl)-3-hydroxypropan-2-yl]-6-[methyl(propan-2-ylsulfonyl)amino]pyridine-4-carboxamide
   Show/Hide
C26H36F2N4O4S
 1
1
IC50 > 20000 nM
   TI
   LI
   LO
   TS