General Information of the Compound
Compound ID
CP0168665
Compound Name
N-[(2S)-1-amino-3-(3,5-difluorophenyl)propan-2-yl]-2-[(2-methylcyclopropyl)methylamino]-6-[methyl(methylsulfonyl)amino]pyridine-4-carboxamide
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Structure
Formula
C22H29F2N5O3S
Molecular Weight
481.569
Canonical SMILES
CC1CC1CNc1cc(cc(n1)N(C)S(C)(=O)=O)C(=O)N[C@H](CN)Cc1cc(F)cc(F)c1
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InChI
InChI=1S/C22H29F2N5O3S/c1-13-4-16(13)12-26-20-8-15(9-21(28-20)29(2)33(3,31)32)22(30)27-19(11-25)7-14-5-17(23)10-18(24)6-14/h5-6,8-10,13,16,19H,4,7,11-12,25H2,1-3H3,(H,26,28)(H,27,30)/t13?,16?,19-/m0/s1
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InChIKey
SGGMSEUTLOBCFL-ZVYVSMAVSA-N
Physicochemical Property
logP
2.1233
Rotatable Bonds
10
Heavy Atom Count
33
Polar Areas
117.42
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
6
Complexity
33

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44426297
ChEMBL ID
CHEMBL230250
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01020, Beta-secretase 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000025 HEK-293T Homo sapiens (Human)  1
1
IC50 = 280 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 34 nM