General Information of the Compound
Compound ID
CP0260092
Compound Name
(4R)-2'-(3,6-dihydro-2H-pyran-4-yl)-7'-pyrimidin-5-ylspiro[5H-1,3-oxazole-4,9'-xanthene]-2-amine
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Structure
Formula
C24H20N4O3
Molecular Weight
412.449
Canonical SMILES
NC1=N[C@]2(CO1)c1cc(ccc1Oc1ccc(cc21)-c1cncnc1)C1=CCOCC1
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InChI
InChI=1S/C24H20N4O3/c25-23-28-24(13-30-23)19-9-16(15-5-7-29-8-6-15)1-3-21(19)31-22-4-2-17(10-20(22)24)18-11-26-14-27-12-18/h1-5,9-12,14H,6-8,13H2,(H2,25,28)/t24-/m1/s1
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InChIKey
NZVBDKMMLGEBPO-XMMPIXPASA-N
Physicochemical Property
logP
3.6415
Rotatable Bonds
2
Heavy Atom Count
31
Polar Areas
91.85
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
7
Complexity
31

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 45256653
SID: 92726040
ChEMBL ID
CHEMBL3354693
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01020, Beta-secretase 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000025 HEK-293T Homo sapiens (Human)  1
1
IC50 = 16 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 4 nM
Protein ID: PT00897, Potassium voltage-gated channel subfamily H member 2
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 10700 nM
   TI
   LI
   LO
   TS